Ep. 367 The Metabolic Health Crisis & GLP-1s with Dr. Anurag Singh

I’m honored to reconnect with Dr. Felice Gersh today! She is a multi-award-winning physician with dual board certification in OB-GYN and Integrative Medicine. We connected once before in Episode 221, where we spoke about PCOS and metabolic health. Today, Dr. Gersh joins me to dive into perimenopause and menopause. We discuss various issues surrounding the Women’s Health Initiative, and talk about estrogen as a family of hormones, estrogen-mimicking chemicals, synthetic hormones, and oral contraceptives. We get into the importance of thyroid function, the pro-inflammatory state of a loss of estrogen in perimenopause and menopause, and the importance of nutrition and exercise for the metabolism. We also speak about the lesser-known changes that occur in menopause, including changes in body odor, constipation, sarcopenia, osteoporosis, and vocal changes.  I intend to invite Dr. Gersh back to discuss women and mitochondrial health and to talk about her latest book, Menopause: The Fifty Things You Need to Know.  Stay tuned to find out what menopause really is and what it does to a woman’s metabolic system. IN THIS EPISODE YOU WILL LEARN: Dr. Gersh discusses the Women’s Health Initiative study and its devastating effects. The difference between synthetic and bioidentical hormones. How chronic diseases of aging can be delayed when hormones are incorporated along with other lifestyle refinements. What do hormones do? Why every immune cell in the body has receptors for vital hormones. Why menopause cannot be defined by a specific moment in time. Changes that occur physiologically during the perimenopause years. How hormones can change the perimenopause paradigm entirely. Why perimenopause translates into many sleep issues. Why phytoestrogens are nature’s gift to women. Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website  Connect with Dr. Felice Gersh On her website: Integrative Medical Group of Irvine On Instagram All of Dr. Gersh’s books are available on Amazon Episode 221 on PCOS with Dr. Felice Gersh Resource Mentioned Go to www.toxicology.gov to see all the ingredients in birth control pills listed as endocrine disruptors.

Today, I am delighted to connect with my dear friend, Dr. Mariza Snyder. Dr. Snyder is a best-selling author, dedicated wife, and wellness advocate passionately committed to empowering women through lifestyle changes, whole food nutrition, essential oils, and other health practices.  In our discussion today, we dive into the perimenopausal journey, looking at the warning signs and ways to rediscover ourselves. We explore the impact of lifestyle choices and the importance of understanding cravings in middle age, offering practical strategies for navigating perimenopause and menopause. We get into the benefits of continuous glucose monitors and glucometers, the critical role of fiber and fermented foods, and the supplements Dr. Snyder recommends for optimal brain health. We also address gut health and the misconception that constipation is normal.  I am confident you will find my conversation with Dr. Snyder as enlightening and enjoyable as I did. IN THIS EPISODE YOU WILL LEARN: Why women need to educate themselves about perimenopause and its symptoms Common early signs of perimenopause How lifestyle choices significantly impact the severity of perimenopause symptoms Why women must eat enough protein Importance of maintaining stable blood sugar levels Benefits of using continuous glucose monitors How strength training helps women maintain muscle mass and functional strength The benefits of fermented foods for supporting the gut microbiome Why managing stress and getting enough sleep are essential Brain-boosting supplements Dr. Snyder recommends How to avoid constipation  Bio: Dr. Mariza Snyder Dr. Mariza Snyder is a functional practitioner, women’s hormone expert, and the author of eight books: The newest book, The Essential Oils Menopause Solution, focuses on solutions for women in perimenopause and menopause and the #1 National Bestselling book, The Essential Oils Hormone Solution, focuses on balancing women’s hormones naturally. For the past fifteen years, she has lectured at wellness centers, conferences, and corporations on hormone health, metabolic health, nutrition, and detoxification. She has been featured on Dr. Oz, Oprah Magazine, Fox News Health, MindBodyGreen, and in many publications. Dr. Mariza is also the host of the top-rated Energized Podcast, (with over 11 million downloads) designed to empower women to become the CEO of their health. Check out her website, drmariza.com, for women's hormone tips, including recipes and supplementation.  Connect with Cynthia Thurlow   Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Dr. Mariza Snyder On Instagram Energized with Dr. Mariza (Podcast) Dr. Snyder’s books are available on Amazon

Today, I am thrilled to connect with Farmer Lee Jones, who oversees The Chef's Garden, a family-owned regenerative farm dedicated to cultivating the most flavorful and nutrient-rich vegetables, herbs, and microgreens.  With a legacy of over three decades, The Chef's Garden has been the go-to supplier for some of the finest chefs and restaurants worldwide.  Join us as we dive deep into the differences between regenerative agriculture and traditional industrial farming, looking at the importance of flavor-focused cultivation, the limitations of USDA guidelines in determining mineral efficacy, how the pandemic affected the operations of the Chef's Garden, the rising trends of seasonal eating in the vegetable industry, and the differences between hybrid and GMO products.  Get ready for an enlightening conversation with Farmer Lee Jones, whose infectious enthusiasm for sustainable farming practices is bound to leave you inspired. IN THIS EPISODE YOU WILL LEARN: The differences between regenerative agriculture and traditional industrial farming Why traditional industrial farming is unsustainable, and how it negatively impacts soil and human health The benefits of regenerative agriculture Why Farmer Lee grows for flavor, not just for nutritional levels The importance of maintaining healthy soil  How Farmer Lee managed to keep his team together and maintain his farming operations during the pandemic Why it is essential to pay attention to the packaging and labeling when purchasing produce The nutritional benefits of microgreens Farmer Lee explains the difference between GMO and hybrid vegetables Why we need to tune into our bodies and understand what they need instead of relying on artificially available produce throughout the year Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Farmer Lee Jones On Instagram    The Chef’s Garden on Instagram (For vegetable box subscriptions) The Culinary Vegetable Institute on Instagram

I am delighted to have Jessie Inchauspe, the Glucose Goddess, joining me on the podcast today! Metabolic health is my passion! It is a huge area of focus in my work, and Jessie is truly a gift in the space! She is a rising star author and biochemist with a clear and accessible way of explaining the science behind glucose metabolism.  Jessie joins me today to discuss the impact of glucose metabolism and spikes. We dive into her background and how an accident created her pain-to-purpose story. We discuss the role of continuous glucose monitors and how glucose spikes impact our mitochondria, inflammation, and oxidative stress. We get into glycation and aging, how weight gain is a protective aspect of glucose spikes- or hyperglycemia, and the role of vinegar, movement, and fiber. We also talk about Jessie’s new book, her opinions on fasting, and so much more.  I loved interviewing Jessie! Her enthusiasm is contagious, and it is easy to understand why she is such a beloved author in the health and wellness space! IN THIS EPISODE YOU WILL LEARN: Jessie shares how an accident led her to where she is today. How a continuous glucose monitor changed everything for Jessie. How Jessie came up with her simple principles to steady glucose levels. What is the purpose of glucose in the body? How do glucose spikes impact our mitochondria? Jessie shares a fascinating vinegar hack for reducing side effects and symptoms of glucose spikes. How being metabolically unhealthy impacts the aging process. The benefits of having savory breakfasts and eating vegetables first with every meal. Jessie talks about her new book, The Glucose Goddess Method. How gaining weight protects our bodies from the impact of glucose spikes. How walking or moving after meals balances blood sugar levels. Why is blood sugar so important? Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Connect with Jessie Inchauspe On her website   On Instagram Jessie’s books The Glucose Goddess Method Glucose Revolution

I am thrilled to present the last class of our Lipid Masterclass series today with the esteemed Dr. Thomas Dayspring. Dr. Dayspring is board-certified in internal medicine and clinical lipidology and is a fellow of the American College of Physicians and the National Lipid Association.  Today, we round things out by diving into medications for lipid abnormalities and discussing lipid physiology, with Dr. Dayspring shedding light on insulin resistance and statins and cautioning against statin use for those predisposed to diabetes or insulin resistance. He also explains why LDL particle size is not worth testing and discusses ways to identify specific laboratory abnormalities.  Be sure to stay tuned for the AMA session to follow, where Dr. Dayspring will answer listeners’ questions.  It has been a privilege engaging with Dr. Dayspring throughout this masterclass series. I know you will have learned a lot from it! IN THIS EPISODE YOU WILL LEARN: · The lack of research and consistency in addressing the needs of women in various stages of life · Dr. Dayspring discusses the use of bile acid sequestrants for lowering LDL cholesterol · Dr. Dayspring discusses the history of bile acid sequestrant use, explaining why their use is limited · How bempedoic acid and statins lower LDL cholesterol · Potential contraindications for bempedoic acid · The benefits and risks of using fibrates to reduce heart attacks · Dr. Dayspring explains why fibrates work best for genetic hypertriglyceridemia · Why reducing ApoB is essential for atherosclerosis patients, especially for high-risk patients · Dr. Dayspring explains why small LDL particles are dangerous · The ideal ApoB level for those who have no heart disease and are not diabetic  Bio: Thomas Dayspring MD is a Fellow of both the American College of Physicians and the National Lipid Association and is certified in internal medicine and clinical lipidology. After practicing in New Jersey for 37 years, in 2012, he moved to Virginia to serve as an educational director for a nonprofit cardiovascular foundation until mid-2019 as a Chief Academic Advisor for two major CV laboratories. Since then, he has served as a virtual cardiovascular/lipidology educator. Career-wise, he has given over 4000 domestic (in all 50 states) and several international lectures, including over 600 CME programs on atherothrombosis, lipids/lipoproteins (and their treatment), vascular biology, biomarker testing, and women’s cardiovascular issues. He has authored several manuscripts and lipid textbook chapters and performed several podcasts. For several years, he was an Associate Editor of the Journal of Clinical Lipidology. He received the 2011 National Lipid Association’s Presidents Award for services to clinical lipidology and the 2023 Foundation of NLA Clinician/Educator Award. He has over 34K followers on his educational Twitter (X) feed (@Drlipid). He has Gold Heart Member status as a professional member of the American Heart Association, and he serves as a Social Media Ambassador for the European Atherosclerosis Society and the National Lipid Association. Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Dr. Thomas Dayspring On Twitter (@DrLipid) On LinkedIn

I am delighted to reconnect with Dr. Anurag Singh today, the Chief Medical Officer at Timeline Nutrition. He joined me once before on Episode 268.  I invited Dr. Singh back to discuss the latest research on GLP-1 agonists like Wegovy, Semaglutide, and Ozempic, which are gaining significant traction with projected sales exceeding $100 billion by 2030, potentially affecting 9% of the US population. In our conversation, we explore the contributors to our metabolic health crisis by looking at the research surrounding GLP-1 agonists, the physiology of GLP-1 peptides, and the influencing elements Dr. Singh refers to as the trifecta. We dive into the loss of muscle mass and strength, sarcopenia, and frailty associated with these drugs, and Dr. Singh shares his concerns about their impact on bone health, the gut microbiome, and their use in younger patients. We also get into lifestyle measures, mitochondrial health, hallmarks of aging, Akkermansia, and the importance of advocacy and patient empowerment.  Today’s compelling and invaluable discussion with Dr. Anurag Singh highlights crucial insights into GLP-1 agonists and their broader health implications. I know it will provide significant value for our listeners. IN THIS EPISODE YOU WILL LEARN: Dr. Singh breaks down what GLP-1 agonist drugs are and how they work. How our modern-day lifestyles contribute to poor metabolic health The benefits and side-effects of using GLP-1 agonist treatments for improving metabolic health Why strength training is essential for preventing muscle loss and frailty in middle-aged women What are the potential long-term effects of SARMs on muscle mass and health? Why dietary counseling is essential for those taking GLP-1 agonist drugs The benefits of supplements for boosting mitochondrial health  Dr. Singh discusses a research study on combining lithium with GLP-1 agonists to improve the muscle quality of those with muscle-wasting conditions. Why akkermansia is essential for GLP production   Connect with Cynthia Thurlow   Follow on Twitter Instagram LinkedIn Check out Cynthia’s website  Submit your questions to [email protected] Connect with Dr. Anurag Singh Timeline Mitopure Email Dr. Singh: [email protected]  Previous Episode Mentioned Ep. 268: Understanding the Biology of Aging with Evolved Supplementation and Nutrition, featuring Dr. Anurag Singh

Today, I am delighted to reconnect with two previous guests, Dr. Darren Candow. Dr. Candow is a distinguished professor and an internationally renowned researcher on creatine monohydrate, nutrition, and physical activity who joined me before on Episode 301, where we spoke about creatine.  We are doing an AMA session today, delving into various themes surrounding creatine, from debunking outdated RDA recommendations to exploring the synergies between strength training and creatine efficacy. We look into the cognitive benefits of creatine, exploring how it interacts with caffeine and its implications for bone health, hydration, anabolic resistance, and metabolic health.  I trust you will find today's AMA session as enlightening and enriching as I did while recording it. IN THIS EPISODE YOU WILL LEARN: The safety and efficacy of creatine as a supplement How creatine increases muscle mass and reduces protein catabolism The benefits of combining creatine with protein  Is it better to take creatine before or after a workout? How creatine supplementation may improve brain performance and mental clarity Why exercise is essential for those who want to experience the benefits of creatine for maintaining their bone health The benefits of resistance-band workouts for post-menopausal women Are there any age-related limits for creatine supplementation? Bio: Dr. Darren Candow Dr. Darren Candow, PhD, CSEP-CEP, is Professor and Director of the Aging Muscle and Bone Health Laboratory in the Faculty of Kinesiology and Health Studies at the University of Regina, Canada. The overall objectives of Dr. Candow’s research program are to develop effective lifestyle interventions involving nutrition (primarily creatine monohydrate) and physical activity (resistance training), which have practical and clinical relevance for improving musculoskeletal aging and reducing the risk of falls and fractures. Dr. Candow has published over 120 peer-refereed journal manuscripts, supervised over 20 MSc and PhD students, and received research funding from the Canadian Institutes of Health Research, Canada Foundation for Innovation, the Saskatchewan Health Research Foundation, the National Institute of Health, and the Nutricia Research Foundation. In addition, Dr. Candow serves on the editorial review boards for the Journal of the International Society of Sports Nutrition, Nutrients, and Frontiers. Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Dr. Darren Candow On Instagram and Twitter (now X) Previous Episode Mentioned: Ep. 301 Creatine: The Best Supplement for Better Bones & Brain Health with Darren Candow, PhD, CSEP-CEP

I am honored to have Dr. Carolyn Dean joining me today. Dr. Dean is a medical doctor, naturopath, and best-selling author. She has dedicated more than 50 years to integrating the science of medicine with the gifts of nature to help her patients feel better, boost their energy, and take control of their health. Today, our conversation centers on The Flexner Report and its influence on modern medicine and the essential role of magnesium in over 80% of metabolic functions. We dive into why we are so magnesium-depleted and common disorders associated with low magnesium levels, and we explore the effects of magnesium on bone health and the microbiome and the synergistic properties of various forms of magnesium and other micronutrients.  I am confident you will find today’s discussion with Dr. Carolyn Dean as enjoyable as it is enlightening. IN THIS EPISODE YOU WILL LEARN: How the Flexner Report has impacted allopathic, functional, and integrative approaches to health and wellness Why is magnesium so poorly understood? How to get your magnesium accurately tested How our modern-day lifestyles are contributing to the current magnesium deficiency epidemic  Dr. Dean shares her formula for hydration  The potential side effects of allopathic medications and how they impact our health Why magnesium is essential for aging women The relationship between magnesium and bone health The benefits of magnesium supplementation The complex relationship between magnesium and other minerals Dr. Dean talks about Magnesium Threonate and explains how all magnesium compounds can ultimately reach the brain. Bio: Carolyn Dean, MD, ND, is a medical doctor, naturopath, and best-selling author. She has spent 50+ years committed to applying the science of medicine and the gifts of nature to help people feel better, find more energy, and take control of their personal health. Dr. Dean follows the 2017 revision of 2004's best-selling book The Magnesium Miracle® with her newest revision Magnesium: The Missing Link to Total Health®. Connect with Cynthia Thurlow    Follow on Twitter Instagram LinkedIn   Check out Cynthia’s website  Submit your questions to [email protected] Connect with Dr. Carolyn Dean On her website (For educational resources) RnA ReSet Store website Podcast  Magnesium: The Missing Link to Total Health by Dr. Carolyn Dean is available on Amazon  Recommended Publication Magnesium in the Central Nervous System

I am delighted to reconnect with Dr. Dave Rabin today. He last joined me for Episode 91 in April of 2020. Dr. Rabin is a board-certified psychiatrist and neuroscientist. He is the Co-founder and CMO at Apollo Neuroscience, the first scientifically validated wearable system to improve heart rate variability, focus, and relaxation, and helps attain meditative states. He is also Co-founder and Executive Director of the Board of Medicine and a psychedelic clinical researcher, currently evaluating the mechanism of psychedelic-assisted psychotherapy and treatment-resistant illness. Today, we examine the value of touch and sensory techniques, discussing the distinctions between sympathetic and parasympathetic vagal tone in the autonomic nervous system, changes in sex hormones during perimenopause and menopause, and how that impacts sympathetic dominance, the development of stress responses, and the concept of stress leading to personal growth. We explore the influence of the vagus nerve on systemic health, explaining what HRV is and how it can demonstrate bodily coherence, and we also dive into wearable technologies like Apollo, the disruption of psychedelic interventions, and the impact of trauma on physical and mental well-being.  I am confident that you will find today’s engaging discussion with Dr. Dave Rabin eye-opening and enlightening. IN THIS EPISODE YOU WILL LEARN: How touch helps us connect, bond, and support our autonomic nervous system How finding balance between the parasympathetic and sympathetic nervous systems can help us manage stress and anxiety Techniques for quickly restoring balance to the nervous system Why women experience more anxiety, depression, and heart arrhythmias during perimenopause How breathing techniques can improve heart rate variability  The significance of HRV metrics for understanding physical and mental health How the Apollo device activates a healing response within the body The potential of MDMA and other psychedelics hold for trauma healing Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Dr. Dave Rabin On his website Apollo Instagram Twitter (X) The Psychedelic Report Podcast Your Brain Explained Podcast Previous Episode Mentioned Ep. 91 – How To Listen To Your Body and DE-STRESS During COVID-19 – with Dr. David Rabin

I am thrilled to connect with my friend and colleague, Dr. Tony Youn today.  Dr. Youn is a nationally recognized board-certified plastic surgeon and the author of many best-selling books. He has a massive social media presence and hosts the widely acclaimed podcast The Holistic Plastic Surgery Show. In our conversation today, we dive into Dr. Youn’s new book, Younger for Life, and he offers valuable insights on skin health and overall well-being. We explore the aging process and address oxidative-free radical damage, chronic inflammation, autophagy, and the impact of processed foods. We also get into helpful supplements for skin support, examine the concept of greenwashing, and discuss sunscreen, exfoliation, in-office treatments, breast implant illness, and the power of lifestyle choices. Stay tuned for more! IN THIS EPISODE YOU WILL LEARN: How to avoid aging too quickly through nutrition and lifestyle changes How sugar and seed oils impact skin aging The benefits of collagen supplements for healthier skin  Hormonal changes that affect the metabolism and skin health after menopause The importance of screening the ingredients in skincare products How chemical sunscreens differ from physical sunblocks Using Retinol for anti-aging and skin health Non-invasive fat reduction treatments and their potential risks Dr. Youn discusses breast implant illness What you need to look out for when using Botox Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Dr. Anthony Youn On his website Youn Beauty   On Instagram, YouTube, TikTok, Facebook, and Twitter The Holistic Plastic Surgery Show Buy a copy of Younger for Life  Bookshop.Org