IntFold: A Controllable Foundation Model for General and Specialized Biomolecular Structure Prediction

🤗 Upvotes: 56 | cs.CL, cs.AI Authors: Kuan Li, Zhongwang Zhang, Huifeng Yin, Liwen Zhang, Litu Ou, Jialong Wu, Wenbiao Yin, Baixuan Li, Zhengwei Tao, Xinyu Wang, Weizhou Shen, Junkai Zhang, Dingchu Zhang, Xixi Wu, Yong Jiang, Ming Yan, Pengjun Xie, Fei Huang, Jingren Zhou Title: WebSailor: Navigating Super-human Reasoning for Web Agent Arxiv: http://arxiv.org/abs/2507.02592v1 Abstract: Transcending human cognitive limitations represents a critical frontier in LLM training. Proprietary agentic systems like DeepResearch have demonstrated superhuman capabilities on extremely complex information-seeking benchmarks such as BrowseComp, a feat previously unattainable. We posit that their success hinges on a sophisticated reasoning pattern absent in open-source models: the ability to systematically reduce extreme uncertainty when navigating vast information landscapes. Based on this insight, we introduce WebSailor, a complete post-training methodology designed to instill this crucial capability. Our approach involves generating novel, high-uncertainty tasks through structured sampling and information obfuscation, RFT cold start, and an efficient agentic RL training algorithm, Duplicating Sampling Policy Optimization (DUPO). With this integrated pipeline, WebSailor significantly outperforms all opensource agents in complex information-seeking tasks, matching proprietary agents' performance and closing the capability gap.

🤗 Upvotes: 45 | cs.CV Authors: Fangfu Liu, Hao Li, Jiawei Chi, Hanyang Wang, Minghui Yang, Fudong Wang, Yueqi Duan Title: LangScene-X: Reconstruct Generalizable 3D Language-Embedded Scenes with TriMap Video Diffusion Arxiv: http://arxiv.org/abs/2507.02813v1 Abstract: Recovering 3D structures with open-vocabulary scene understanding from 2D images is a fundamental but daunting task. Recent developments have achieved this by performing per-scene optimization with embedded language information. However, they heavily rely on the calibrated dense-view reconstruction paradigm, thereby suffering from severe rendering artifacts and implausible semantic synthesis when limited views are available. In this paper, we introduce a novel generative framework, coined LangScene-X, to unify and generate 3D consistent multi-modality information for reconstruction and understanding. Powered by the generative capability of creating more consistent novel observations, we can build generalizable 3D language-embedded scenes from only sparse views. Specifically, we first train a TriMap video diffusion model that can generate appearance (RGBs), geometry (normals), and semantics (segmentation maps) from sparse inputs through progressive knowledge integration. Furthermore, we propose a Language Quantized Compressor (LQC), trained on large-scale image datasets, to efficiently encode language embeddings, enabling cross-scene generalization without per-scene retraining. Finally, we reconstruct the language surface fields by aligning language information onto the surface of 3D scenes, enabling open-ended language queries. Extensive experiments on real-world data demonstrate the superiority of our LangScene-X over state-of-the-art methods in terms of quality and generalizability. Project Page: https://liuff19.github.io/LangScene-X.

🤗 Upvotes: 33 | cs.CV Authors: Nina Konovalova, Maxim Nikolaev, Andrey Kuznetsov, Aibek Alanov Title: Heeding the Inner Voice: Aligning ControlNet Training via Intermediate Features Feedback Arxiv: http://arxiv.org/abs/2507.02321v1 Abstract: Despite significant progress in text-to-image diffusion models, achieving precise spatial control over generated outputs remains challenging. ControlNet addresses this by introducing an auxiliary conditioning module, while ControlNet++ further refines alignment through a cycle consistency loss applied only to the final denoising steps. However, this approach neglects intermediate generation stages, limiting its effectiveness. We propose InnerControl, a training strategy that enforces spatial consistency across all diffusion steps. Our method trains lightweight convolutional probes to reconstruct input control signals (e.g., edges, depth) from intermediate UNet features at every denoising step. These probes efficiently extract signals even from highly noisy latents, enabling pseudo ground truth controls for training. By minimizing the discrepancy between predicted and target conditions throughout the entire diffusion process, our alignment loss improves both control fidelity and generation quality. Combined with established techniques like ControlNet++, InnerControl achieves state-of-the-art performance across diverse conditioning methods (e.g., edges, depth).

🤗 Upvotes: 32 | q-bio.BM Authors: The IntFold Team, Leon Qiao, Wayne Bai, He Yan, Gary Liu, Nova Xi, Xiang Zhang Title: IntFold: A Controllable Foundation Model for General and Specialized Biomolecular Structure Prediction Arxiv: http://arxiv.org/abs/2507.02025v1 Abstract: We introduce IntFold, a controllable foundation model for both general and specialized biomolecular structure prediction. IntFold demonstrates predictive accuracy comparable to the state-of-the-art AlphaFold3, while utilizing a superior customized attention kernel. Beyond standard structure prediction, IntFold can be adapted to predict allosteric states, constrained structures, and binding affinity through the use of individual adapters. Furthermore, we introduce a novel confidence head to estimate docking quality, offering a more nuanced assessment for challenging targets such as antibody-antigen complexes. Finally, we share insights gained during the training process of this computationally intensive model.

🤗 Upvotes: 31 | cs.CL, cs.AI, cs.LG Authors: Chris Yuhao Liu, Liang Zeng, Yuzhen Xiao, Jujie He, Jiacai Liu, Chaojie Wang, Rui Yan, Wei Shen, Fuxiang Zhang, Jiacheng Xu, Yang Liu, Yahui Zhou Title: Skywork-Reward-V2: Scaling Preference Data Curation via Human-AI Synergy Arxiv: http://arxiv.org/abs/2507.01352v2 Abstract: Despite the critical role of reward models (RMs) in reinforcement learning from human feedback (RLHF), current state-of-the-art open RMs perform poorly on most existing evaluation benchmarks, failing to capture the spectrum of nuanced and sophisticated human preferences. Even approaches that incorporate advanced training techniques have not yielded meaningful performance improvements. We hypothesize that this brittleness stems primarily from limitations in preference datasets, which are often narrowly scoped, synthetically labeled, or lack rigorous quality control. To address these challenges, we present a large-scale preference dataset comprising 40 million preference pairs, named SynPref-40M. To enable data curation at scale, we design a human-AI synergistic two-stage pipeline that leverages the complementary strengths of human annotation quality and AI scalability. In this pipeline, humans provide verified annotations, while large language models perform automatic curation based on human guidance. Training on this preference mixture, we introduce Skywork-Reward-V2, a suite of eight reward models ranging from 0.6B to 8B parameters, trained on a carefully curated subset of 26 million preference pairs from SynPref-40M. We demonstrate that Skywork-Reward-V2 is versatile across a wide range of capabilities, including alignment with human preferences, objective correctness, safety, resistance to stylistic biases, and best-of-N scaling, achieving state-of-the-art performance across seven major reward model benchmarks. Ablation studies confirm that the effectiveness of our approach stems not only from data scale but also from high-quality curation. The Skywork-Reward-V2 series represents substantial progress in open reward models, highlighting the untapped potential of existing preference datasets and demonstrating how human-AI curation synergy can unlock significantly higher data quality.

🤗 Upvotes: 27 | cs.CV Authors: Zhaochen Su, Peng Xia, Hangyu Guo, Zhenhua Liu, Yan Ma, Xiaoye Qu, Jiaqi Liu, Yanshu Li, Kaide Zeng, Zhengyuan Yang, Linjie Li, Yu Cheng, Heng Ji, Junxian He, Yi R. Fung Title: Thinking with Images for Multimodal Reasoning: Foundations, Methods, and Future Frontiers Arxiv: http://arxiv.org/abs/2506.23918v3 Abstract: Recent progress in multimodal reasoning has been significantly advanced by textual Chain-of-Thought (CoT), a paradigm where models conduct reasoning within language. This text-centric approach, however, treats vision as a static, initial context, creating a fundamental "semantic gap" between rich perceptual data and discrete symbolic thought. Human cognition often transcends language, utilizing vision as a dynamic mental sketchpad. A similar evolution is now unfolding in AI, marking a fundamental paradigm shift from models that merely think about images to those that can truly think with images. This emerging paradigm is characterized by models leveraging visual information as intermediate steps in their thought process, transforming vision from a passive input into a dynamic, manipulable cognitive workspace. In this survey, we chart this evolution of intelligence along a trajectory of increasing cognitive autonomy, which unfolds across three key stages: from external tool exploration, through programmatic manipulation, to intrinsic imagination. To structure this rapidly evolving field, our survey makes four key contributions. (1) We establish the foundational principles of the think with image paradigm and its three-stage framework. (2) We provide a comprehensive review of the core methods that characterize each stage of this roadmap. (3) We analyze the critical landscape of evaluation benchmarks and transformative applications. (4) We identify significant challenges and outline promising future directions. By providing this structured overview, we aim to offer a clear roadmap for future research towards more powerful and human-aligned multimodal AI.

🤗 Upvotes: 97 | cs.CV Authors: Kwai Keye Team, Biao Yang, Bin Wen, Changyi Liu, Chenglong Chu, Chengru Song, Chongling Rao, Chuan Yi, Da Li, Dunju Zang, Fan Yang, Guorui Zhou, Hao Peng, Haojie Ding, Jiaming Huang, Jiangxia Cao, Jiankang Chen, Jingyun Hua, Jin Ouyang, Kaibing Chen, Kaiyu Jiang, Kaiyu Tang, Kun Gai, Shengnan Zhang, Siyang Mao, Sui Huang, Tianke Zhang, Tingting Gao, Wei Chen, Wei Yuan, Xiangyu Wu, Xiao Hu, Xingyu Lu, Yang Zhou, Yi-Fan Zhang, Yiping Yang, Yulong Chen, Zhenhua Wu, Zhenyu Li, Zhixin Ling, Ziming Li, Dehua Ma, Di Xu, Haixuan Gao, Hang Li, Jiawei Guo, Jing Wang, Lejian Ren, Muhao Wei, Qianqian Wang, Qigen Hu, Shiyao Wang, Tao Yu, Xinchen Luo, Yan Li, Yiming Liang, Yuhang Hu, Zeyi Lu, Zhuoran Yang, Zixing Zhang Title: Kwai Keye-VL Technical Report Arxiv: http://arxiv.org/abs/2507.01949v1 Abstract: While Multimodal Large Language Models (MLLMs) demonstrate remarkable capabilities on static images, they often fall short in comprehending dynamic, information-dense short-form videos, a dominant medium in today's digital landscape. To bridge this gap, we introduce \textbf{Kwai Keye-VL}, an 8-billion-parameter multimodal foundation model engineered for leading-edge performance in short-video understanding while maintaining robust general-purpose vision-language abilities. The development of Keye-VL rests on two core pillars: a massive, high-quality dataset exceeding 600 billion tokens with a strong emphasis on video, and an innovative training recipe. This recipe features a four-stage pre-training process for solid vision-language alignment, followed by a meticulous two-phase post-training process. The first post-training stage enhances foundational capabilities like instruction following, while the second phase focuses on stimulating advanced reasoning. In this second phase, a key innovation is our five-mode ``cold-start'' data mixture, which includes ``thinking'', ``non-thinking'', ``auto-think'', ``think with image'', and high-quality video data. This mixture teaches the model to decide when and how to reason. Subsequent reinforcement learning (RL) and alignment steps further enhance these reasoning capabilities and correct abnormal model behaviors, such as repetitive outputs. To validate our approach, we conduct extensive evaluations, showing that Keye-VL achieves state-of-the-art results on public video benchmarks and remains highly competitive on general image-based tasks (Figure 1). Furthermore, we develop and release the \textbf{KC-MMBench}, a new benchmark tailored for real-world short-video scenarios, where Keye-VL shows a significant advantage.

🤗 Upvotes: 61 | cs.CV Authors: Nan Chen, Mengqi Huang, Yihao Meng, Zhendong Mao Title: LongAnimation: Long Animation Generation with Dynamic Global-Local Memory Arxiv: http://arxiv.org/abs/2507.01945v1 Abstract: Animation colorization is a crucial part of real animation industry production. Long animation colorization has high labor costs. Therefore, automated long animation colorization based on the video generation model has significant research value. Existing studies are limited to short-term colorization. These studies adopt a local paradigm, fusing overlapping features to achieve smooth transitions between local segments. However, the local paradigm neglects global information, failing to maintain long-term color consistency. In this study, we argue that ideal long-term color consistency can be achieved through a dynamic global-local paradigm, i.e., dynamically extracting global color-consistent features relevant to the current generation. Specifically, we propose LongAnimation, a novel framework, which mainly includes a SketchDiT, a Dynamic Global-Local Memory (DGLM), and a Color Consistency Reward. The SketchDiT captures hybrid reference features to support the DGLM module. The DGLM module employs a long video understanding model to dynamically compress global historical features and adaptively fuse them with the current generation features. To refine the color consistency, we introduce a Color Consistency Reward. During inference, we propose a color consistency fusion to smooth the video segment transition. Extensive experiments on both short-term (14 frames) and long-term (average 500 frames) animations show the effectiveness of LongAnimation in maintaining short-term and long-term color consistency for open-domain animation colorization task. The code can be found at https://cn-makers.github.io/long_animation_web/.

🤗 Upvotes: 35 | cs.CV, cs.AI Authors: Boyuan Sun, Modi Jin, Bowen Yin, Qibin Hou Title: Depth Anything at Any Condition Arxiv: http://arxiv.org/abs/2507.01634v1 Abstract: We present Depth Anything at Any Condition (DepthAnything-AC), a foundation monocular depth estimation (MDE) model capable of handling diverse environmental conditions. Previous foundation MDE models achieve impressive performance across general scenes but not perform well in complex open-world environments that involve challenging conditions, such as illumination variations, adverse weather, and sensor-induced distortions. To overcome the challenges of data scarcity and the inability of generating high-quality pseudo-labels from corrupted images, we propose an unsupervised consistency regularization finetuning paradigm that requires only a relatively small amount of unlabeled data. Furthermore, we propose the Spatial Distance Constraint to explicitly enforce the model to learn patch-level relative relationships, resulting in clearer semantic boundaries and more accurate details. Experimental results demonstrate the zero-shot capabilities of DepthAnything-AC across diverse benchmarks, including real-world adverse weather benchmarks, synthetic corruption benchmarks, and general benchmarks. Project Page: https://ghost233lism.github.io/depthanything-AC-page Code: https://github.com/HVision-NKU/DepthAnythingAC

🤗 Upvotes: 24 | cs.RO Authors: Yifan Zhong, Fengshuo Bai, Shaofei Cai, Xuchuan Huang, Zhang Chen, Xiaowei Zhang, Yuanfei Wang, Shaoyang Guo, Tianrui Guan, Ka Nam Lui, Zhiquan Qi, Yitao Liang, Yuanpei Chen, Yaodong Yang Title: A Survey on Vision-Language-Action Models: An Action Tokenization Perspective Arxiv: http://arxiv.org/abs/2507.01925v1 Abstract: The remarkable advancements of vision and language foundation models in multimodal understanding, reasoning, and generation has sparked growing efforts to extend such intelligence to the physical world, fueling the flourishing of vision-language-action (VLA) models. Despite seemingly diverse approaches, we observe that current VLA models can be unified under a single framework: vision and language inputs are processed by a series of VLA modules, producing a chain of \textit{action tokens} that progressively encode more grounded and actionable information, ultimately generating executable actions. We further determine that the primary design choice distinguishing VLA models lies in how action tokens are formulated, which can be categorized into language description, code, affordance, trajectory, goal state, latent representation, raw action, and reasoning. However, there remains a lack of comprehensive understanding regarding action tokens, significantly impeding effective VLA development and obscuring future directions. Therefore, this survey aims to categorize and interpret existing VLA research through the lens of action tokenization, distill the strengths and limitations of each token type, and identify areas for improvement. Through this systematic review and analysis, we offer a synthesized outlook on the broader evolution of VLA models, highlight underexplored yet promising directions, and contribute guidance for future research, hoping to bring the field closer to general-purpose intelligence.