Unpacking Longevity and Cellular Health: A Conversation with Dr. Jon Brudvig - Part Two

Carly Taylor will help you discover how shifting from threat mode to challenge mode can change the way you handle stress.See omnystudio.com/listener for privacy information.

Here is the second part of my conversation with biochemist Jon Brudvig to delve into the fascinating world of longevity and contemporary health interventions. We tackle topics ranging from SGLT2 inhibitors and their unexpected benefits to the controversial nature of microplastics in our environment. This dialogue is a treasure trove for anyone interested in the intersections of health, science, and longevity. What You'll Learn: Exploring SGLT2 Inhibitors: Discover the multifaceted benefits of SGLT2 inhibitors, originally diabetes drugs, for heart, kidney, and possibly cognitive health. Metformin: A Mixed Bag: Get an overview of the metformin debate, examining its potential benefits and the contentious nature of the research. Fasting Fundamentals: Gain insights into intermittent fasting, its impact on metabolism, potential benefits, and the critical role of resistance training to mitigate muscle loss. Microplastics: An Underestimated Threat: Learn about the insidious presence of microplastics in human tissues and their potential health repercussions. Potential Interventions: Hear about experimental approaches to reducing microplastics in the body, including the potential role of sulforaphane. Key Takeaways: SGLT2 inhibitors: These drugs have shown promising longevity benefits beyond their initial purpose for diabetes management. Metformin's Controversy: While some data suggests potential longevity benefits, criticism exists regarding its exercise interference and study methodologies. The Role of Fasting: Intermittent fasting can be beneficial, particularly for metabolic health, but must be carefully balanced with nutritional needs and physical activity. Microplastics Concern: Ubiquitous in the environment, microplastics are potentially linked to inflammation and adverse health outcomes, necessitating further research and interventions. Self-Experimentation: Personal health experiments, like those done by Jon Brudvig, highlight the importance of understanding one’s own biology in response to health interventions. Resources: Connect with Dr. Jon Brudvig for more insights into longevity and health: LinkedIn: Jon Brudvig  Substack: https://jonbrudvig.substack.com/   Support the Podcast: If you found this episode valuable, please consider subscribing to our podcast and leaving a review. Your feedback helps us continue bringing important conversations like these to a wider audience. Whether you're driven by personal health challenges or broader scientific curiosity, this conversation provides a unique peek into the current and future possibilities of living healthier, longer lives. Share this with individuals passionate about health and longevity, and join the ongoing dialogue to advance our understanding and well-being. 00:12 Understanding SGLT2 Inhibitors 02:51 Mendelian Randomization and SGLT2 Inhibitors 06:24 Benefits and Mechanisms of SGLT2 Inhibitors 09:47 Discussion on Metformin 14:36 Intermittent Fasting and Ketone Supplements 17:46 Fasting, Autophagy, and Muscle Health 22:38 Exploring Glycine and N-Acetyl Cysteine 24:48 Microplastics: A Growing Concern 26:25 The Impact of Microplastics on Health 31:54 Self-Experimentation with Sulforaphane 38:33 Final Thoughts and Future Work          See omnystudio.com/listener for privacy information.

Protect your heart and arteries with this one powerful nutrient. In this episode, we dive into fascinating new research showing how omega-3 fatty acids like DHA can stabilize arterial plaque and dampen inflammation - reducing your risk of heart attacks and strokes. Timestamps:- 00:45 - How arterial plaque buildup causes inflammation and instability - 02:30 - Study on DHA's effects on plaque inflammation - 04:15 - How DHA reduces immune cell invasion and inflammation - 06:00 - DHA encourages immune cells to leave plaque- 07:30 - How much DHA we should be taking Key Takeaways:- Unstable arterial plaque prone to rupture causes most heart attacks/strokes- DHA reduces inflammatory immune cell invasion into plaque - DHA dampens inflammation by reducing NF-kB activation- Recommendations on supplements Don't miss this fascinating deep dive into using omega-3s like DHA for heart and artery health. Tune in now to protect yourself against cardiovascular disease!See omnystudio.com/listener for privacy information.

This week Carly explores the power of glimmers—those tiny moments that calm your nervous system and begin to shift you out of stress. Learn how to spot them, why they matter, and how becoming a glimmer hunter can change the way you experience everyday life.See omnystudio.com/listener for privacy information.

In a fascinating and insightful discussion, I sat down with Dr. Jon Brudvig, a medical scientist and expert in neuroscience and drug development. Together, we explored the science of aging, the critical role of cellular recycling, and the practical steps anyone can take to improve their healthspan. Jon Brudvig shared his journey from rare disease research to longevity science, offering actionable insights into how our daily choices impact the aging process. Such a good conversation, I have split it into two parts. What You'll Learn: The Cellular Foundation of Aging:Discover how Dr. Brudvig’s research into lysosomal storage diseases led him to understand the universal decline in cellular recycling (autophagy and lysosomal function) as a key driver of aging. Autophagy Explained:Learn why autophagy—the body’s process of breaking down and recycling damaged cellular components—is essential for health, and how modern lifestyles can disrupt this natural cycle. The Fundamentals of Longevity:Understand why exercise, diet, sleep, vitamin D, omega-3s, and real-life social connections are the true building blocks of a long and healthy life. Mouse Models and Human Longevity:Gain perspective on the limitations of animal studies in longevity research, and why findings in mice don’t always translate directly to humans. The mTOR Pathway and Protein Intake:Explore the debate around the mTOR pathway, protein consumption, and how balancing periods of growth and rest may be the key to optimal aging. Healthspan vs. Lifespan:Reflect on the difference between living longer and living better, and why increasing your years of good health (healthspan) is a more realistic and valuable goal than chasing extreme longevity.   Key Takeaways: Aging is cellular: The decline in lysosomal and autophagy function is a core driver of aging and disease. Autophagy matters: Fasting, exercise, and periodic stressors help trigger the body’s natural recycling processes. Master the basics: Exercise, a balanced diet, quality sleep, and strong social ties are the most effective longevity interventions. Be cautious with quick fixes: Not all supplements or drugs that work in mice will work in humans—focus on proven fundamentals first. Balance is key: Intermittent activation of growth pathways (like mTOR) through meals and exercise, balanced with periods of rest, supports healthy aging. Protein quality counts: Mix your protein sources and prioritise whole foods for optimal health outcomes. Connect with Dr. Jon Brudvig for more insights into longevity and health: LinkedIn: Jon Brudvig  Substack: https://jonbrudvig.substack.com/   00:53 Dr. Brudvig’s Background and PhD Focus01:22 Gene Therapy and Lysosomal Storage Diseases02:45 Connecting Rare Diseases to Aging03:10 Lysosomal Function and Aging03:40 Professional Work in Drug Development04:01 The Link Between Professional and Personal Interests04:22 The Role of Lysosomes in Autophagy04:40 What is Autophagy?04:54 Why Autophagy Matters for Cellular Health05:07 The Recycling Analogy: Cells as Master Recyclers05:26 Evolutionary Importance of Autophagy06:14 Autophagy, Fasting, and Modern Lifestyles07:07 The Impact of Modern Comfort on Health07:28 Social Media, Longevity, and Biohacks08:00 The Interventions Testing Program Explained08:42 Mouse Studies and Their Limitations09:32 The Importance of Fundamentals: Exercise, Diet, Sleep10:22 Omega-3s and Social Networks for Longevity11:00 The Hallmarks of Aging11:40 Homeostasis and the Aging Process12:20 Healthspan vs. Lifespan: Which Matters More?13:07 The Two Camps in Longevity Science13:51 Promising Interventions: SGLT2 Inhibitors and Rapamycin14:45 Rapamycin: Hype, Dosing, and Human Application15:53 mTOR Pathway, Protein Intake, and Longevity17:00 Balancing mTOR Activation and Autophagy18:00 Practical Protein Advice: Whey, Collagen, and Plant-Based Sources18:45 Final Thoughts: Eat Real Food and Mix Protein Sources  See omnystudio.com/listener for privacy information.

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In this week's Mojo Monday, Carly Taylor delves into the intricacies of the nervous system through the lens of Polyvagal Theory, developed by Steven Porges and practically interpreted by Deb Dana. Carly explains the three distinct parts of the autonomic nervous system: the ventral vagal (calm and social engagement), sympathetic (fight or flight), and dorsal vagal (shutdown and collapse). She describes how we constantly move up and down this 'ladder' in response to various stimuli, and offers practical tips for regulating our nervous system. Carly emphasises the importance of understanding these states to better manage our responses and improve overall well-being.See omnystudio.com/listener for privacy information.

In an enlightening and intense discussion, I sat down with James Laughlin, a globally recognised high-performance coach and a seven-time world champion musician. Through our conversation, we explored the essence of peak performance, personal belief systems, and the integral role of habits in fostering success. James offered valuable insights into his journey and the mental and physical frameworks that cultivate true high performance.   What You'll Learn: The Foundation of High Performance: Understand James's perspective on how true peak performance is about exceeding norms while maintaining healthy relationships and well-being—not just relentlessly pursuing success at the cost of everything else. Radical Clarity: Learn why getting radically clear on your wants and needs is crucial in defining your path and avoiding distractions influenced by external pressures. Belief Systems and Their Impact: Discover how intrinsic and extrinsic motivations shape our drive and affect our outcomes, and why fostering strong, empowering beliefs is key. The Role of 'Meds' in Performance: James introduces the 'Meds' concept—mental training, exercise, diet, and sleep—as a holistic approach to supporting high performance and general well-being. The Pitfalls of Traditional Education: We discuss how conventional educational systems may not always support creative or high-performing individuals, emphasising the role parents play in filling the gap. The Dangers of Quick Fixes: James explains why there are no shortcuts to peak performance and how high achievers cultivate success through habits, not hustle or luck. Influencing Neurotransmitters Holistically: Explore how habits like meditation, cold therapy, and exercise naturally enhance motivation by regulating neurotransmitters. Motivation and Success: Understand why purpose, mastery, and autonomy, as identified by Daniel Pink, are vital to sustaining motivation and achieving long-term success.   Key Takeaways: High performance integrates personal wellness: James believes maintaining balance across all life's facets leads to sustainable success. Understand the 'why': Clarifying your motivations is critical in staying focused and aligned with your true goals. Intrinsic motivation carries greater longevity: Unlike rewards and recognition, personal fulfillment and passion drive deeper and more enduring engagement. Education needs flexibility: Traditional systems may stifle creative potential; external support can nurture expansive thinking. Slow and steady builds mastery: The discipline of practice, as highlighted through deliberate learning, is vital for true accomplishment. Holistic health habits matter: Simple practices like adequate sleep and proper nutrition form the bedrock of cognitive and physical performance.   Resources: Connect with James Laughlin for more insights into high performance and personal growth strategies: LinkedIn: James Laughlin Podcast: Lead on Purpose Website: jjlaughlin.com James' new book: Habits of High Performers   Support the Podcast: If you found this episode valuable, please consider subscribing to our podcast and leaving a review. Your feedback helps us continue bringing important conversations like these to a wider audience. Sharing this episode could help someone on their path to achieving high performance and personal fulfillment. 00:36 High Performance Coaching and Background 01:21 Relocation and Early Life Experiences 04:25 Realising Transferable Skills 06:30 Getting Radically Clear on Goals 12:25 Belief Systems and Their Impact 19:24 The Importance of Taking Your MEDS 26:47 Neurotransmitters and Peak Performance 30:36 Understanding Dopamine: Cheap vs. Earned 32:24 The Power of Delayed Gratification 34:12 Celebrating Small Wins 35:07 The Role of Journaling in Self-Development 36:38 Traditional Education vs. Peak Performance 38:17 Tall Poppy Syndrome Explained 41:59 The Myth of Quick Fixes and Instant Success 45:34 Visualisation and Deliberate Practice 51:44 Intrinsic vs. Extrinsic Motivation 58:03 Prioritising for High Performance  See omnystudio.com/listener for privacy information.

Are you shrinking yourself to stay safe? Staying in the shadow of someone? Holding back ideas, keeping quiet, or silencing your voice so you don’t rock the boat? That’s what playing small looks like — and it comes at a cost. In this week’s Mojo Monday, Carly Taylor shares why staying in the comfort zone feels safe in the short term but creates a gap between who you are and who you’re capable of being. She reflects on her own experience of dipping in and out of “smallness,” and the choice to step into the unknown instead of retreating. This isn’t about arrogance or ego — it’s about showing up as your full self, unapologetically, and being willing to take risks when it matters.  See omnystudio.com/listener for privacy information.

In this enlightening discussion, I sit down with Tim Jack Adams, the founder of Green X7, to explore the concept of personal well-being and the metaphorical "battery" that reflects our life's energy and purpose. Tim shares his compelling journey from a dive master to a wellness expert, motivated by personal tragedies and a passion for nature. They delve into the practical steps and philosophical shifts necessary to lead a life that is both fulfilling and sustainable. What You'll Learn: The Importance of Purpose: Discover why defining the 'why' behind your actions is crucial for long-term well-being and satisfaction. Personal Battery Concept: Learn how to gauge your life’s energy with Tim Jack Adams' personal battery check – a simple tool to measure well-being across eight areas of life. Practical Interventions for Well-being: Gain insights into 'Green X7', a framework combining movement, connection, and nature to boost mental and physical health. The Role of Ego: Understand how ego can be a barrier to true happiness and why letting go of materialistic pursuits can lead to a more meaningful life. Addressing Loneliness: Examine the critical impact of relationships and belonging on subjective well-being and overall life satisfaction. Empowerment Through Simplicity: Explore how small, intentional actions can lead to significant improvements in mental health.   Key Takeaways: Understanding and living your purpose can redirect your life towards a path of genuine happiness and fulfillment. Wellness isn't just about relaxation; it’s about active recovery that rejuvenates both body and mind. Simplifying life by living within your means can provide the freedom and time necessary to pursue passions and family connections. Embracing vulnerability and sharing personal struggles can improve emotional health and build stronger relationships. Regular assessment of your well-being can proactively prevent burnout and sustain energy levels. Community and connection are vital for mental health; engaging with nature and others can significantly enhance well-being. Resources: Explore Green X7's comprehensive wellness tools on their website. Stay connected with Tim Jack Adams for more insights into fostering sustainable well-being and leadership. If you find these insights valuable, consider sharing this post to inspire and support others in their journey of personal growth and fulfillment. Instagram:Greenx7 Tim's Book: Energised Support the Podcast: If you found this episode valuable, please consider subscribing to our podcast and leaving a review. Your feedback helps us continue bringing important conversations like these to a wider audience.   00:48 Tim's Early Adventures and Career Beginnings 03:12 Tragic Loss and Emotional Awakening 04:11 The Birth of Water Sports Guru 04:34 Discovering the Power of Nature 06:02 The Concept of Personal Battery 07:38 Childhood and Emotional Resilience 09:48 The Importance of Wellbeing 14:20 Living Within Your Means 16:53 The Problem with Modern Life 19:05 The Benefits of Earthing 25:11 Finding Purpose and Recharging Your Battery 30:35 The Role of Money in Happiness 31:13 Living Within Your Means 32:07 The Importance of Purpose 32:28 Ego and Financial Decisions 33:29 Balancing Work and Personal Life 34:20 The Cost of Overworking 36:13 Quality of Relationships and Wellbeing 37:42 Men and Loneliness 39:04 Challenges Faced by Middle-Aged Men 40:33 The Importance of Talking About Problems 44:03 Teaching the Next Generation 44:40 Creating Value, Meaning, and Belonging 47:30 The Green X Seven Framework 51:58 Advice for Single Parents 52:15 The Power of Small IntentionsSee omnystudio.com/listener for privacy information.