Tiziana Reports PET data sees reduced neuroinflammation in patient treated with Intranasal Therapy

American Rare Earths CEO Chris Gibbs joined Steve Darling from Proactive to announce new assay results from the company’s ongoing mapping and channel sampling program at the Cowboy State Mine area of the Halleck Creek Rare Earths Project in Wyoming. The results further confirm the project's potential to become a major U.S.-based source of critical minerals. Gibbs shared that a total of 106 channel samples were collected across the Red Mountain area, a key target within the Halleck Creek project. Assay results revealed elevated levels of rare earth mineralization, with one standout sample grading 1.37% Total Rare Earth Oxide (TREO). Across the Red Mountain Pluton — the rare earth-bearing lithology — TREO grades ranged from 711 parts per million (ppm) to 13,651 ppm, with an average of 3,661 ppm. Notably, the company reported that magnet rare earth oxides, which are essential for high-performance magnets used in electric vehicles and wind turbines, account for approximately 28% of the total rare earth content. Heavy rare earth oxides, which are typically rarer and more valuable, represent about 13%. Fifteen of the collected samples exceeded 4,500 ppm TREO, further underscoring the presence of elevated-grade zones within the Red Mountain system. The company is currently incorporating the new channel sampling data into an updated geological model and mineral resource estimate for the CSM area. These updates will inform the ongoing mine planning process and play a key role in the upcoming Pre-Feasibility Study, which remains on track for completion in late 2025. #proactiveinvestors #americanrareearthslimited #asx #arr #otcqx #arrnf #adr #amrry #wyomingrareinc #AmericanRareEarths #HalleckCreek #CowboyStateMine #CriticalMinerals #Neodymium #Praseodymium #Yttrium #Dysprosium #MiningUpdate #PFS #ChannelSampling #ProactiveInvestors

Hive Digital Technologies Executive Chairman Frank Holmes joined Steve Darling from Proactive to highlight the company’s latest achievements in scaling its Bitcoin mining operations. The update comes on the heels of Hive’s successful acquisition of Bitfarms’ Yguazú assets in Paraguay and the energization of the site's initial 100 MW phase. Hive has now surpassed a significant milestone, reporting a global Bitcoin mining hashrate of 7.3 Exahash per second (EH/s). This represents a 10% increase over last month’s peak hashrate of 6.6 EH/s. The growth is primarily driven by the energization of the new hydro-powered facility in Paraguay, where Hive has deployed a blend of its proprietary BUZZ Miners and cutting-edge Bitmain S21+ air-cooled units. The company is rapidly accelerating the deployment of new ASIC miners, currently adding approximately 1 EH/s of capacity each month. With additional hardware deliveries expected, Hive anticipates increasing this pace to 1 EH/s every two weeks. Construction is also advancing at the company’s Valenzuela site, further contributing to Hive’s aggressive expansion strategy. By the end of May, Hive expects to have more than 20,000 mining machines operational at the Yguazú facility. The company remains on schedule to reach its Phase 1 target of 11.5 EH/s by June 2025, positioning itself as a major player in the global Bitcoin mining industry. #proactiveinvestors #hivedigitaltechnologieslet #tsxv #hive #nasdaq #hive #CryptoMining #GreenEnergy #BitcoinMining #ParaguayMining #DataCenter #Exahash #S21Miners #DigitalAssets #ProactiveInvestors

Synchronoss Technologies CEO Jeff Miller spoke with Steve Darling from Proactive to announce strong first-quarter 2025 results, marked by growth in cloud subscribers, improved margins, and high recurring revenue. The company reported $42.2 million in revenue, slightly down from $43 million a year earlier due to the expiration of a customer contract. However, recurring revenue rose to 93.1% of the total, up from 91.1%. Income from operations more than doubled to $8.2 million, while adjusted EBITDA grew 17% to $12.7 million, achieving a 30.2% margin. Synchronoss also completed a $200 million refinancing through a new four-year loan with TP Birch Grove, allowing it to retire $73.6 million in debt and fund the redemption of $121.4 million in senior notes. The company reaffirmed its full-year 2025 guidance, projecting revenue between $170 million and $180 million, adjusted EBITDA of $52 million to $56 million, and free cash flow of $11 million to $16 million, excluding a pending $28 million U.S. federal tax refund. #proactiveinvestors #synchronosstechnologiesinc #nasdaq #sncr #cloud #CloudRevenue #Q12025Results #JeffMiller #RecurringRevenue #TechEarnings #VerizonCloud #ATandTCloud #InvestorUpdates #TPBirchGrove #SoftwareGrowth #Refinancing

Standard Uranium Vice President of Exploration Sean Hillacre joined Steve Darling from Proactive to announce two key developments as it continues to advance its uranium exploration efforts in Canada’s Athabasca Basin. The company has signed a definitive property option agreement with Vital Battery Metals Inc., granting Vital the right to earn a 75% interest in the 12,265-hectare Corvo Project in the eastern Athabasca Basin. The project includes over 29 kilometres of exploration strike length across three northeast-southwest magnetic low trends, coincident with electromagnetic (EM) conductors and structural fault zones — key geological features for uranium targeting. Historic drill holes TL-79-3 and TL-79-5 returned uranium intercepts of 0.057% U₃O₈ over 3.5 metres and 0.065% U₃O₈ over 0.1 metres, respectively. Additionally, the Manhattan Showing on the property reported surface values of 59,800 ppm uranium. A recent high-resolution geophysical survey has enhanced target resolution, providing a solid foundation for future drilling. Standard Uranium has also completed a detailed ground gravity survey over the Wishbone, McNie, and Armbruster South targets at its 48,443-acre Sun Dog Project, located near Uranium City on the northern margin of the Athabasca Basin. The survey, combined with existing geophysical data, has outlined several high-priority drill targets. Drilling at the previously untested Wishbone target during the 2024 program returned anomalous uranium from all eight drill holes. Further gravity anomalies and favorable structures at McNie, Armbruster South, and Spring Dome offer additional kilometres of untested potential for high-grade, basement-hosted uranium mineralization. Standard Uranium’s exploration strategy continues to focus on advancing de-risked, high-impact drill targets across a growing portfolio of highly prospective projects in the world’s premier uranium district. #proactiveinvestors #standarduraniumltd #tsxv #stnd #otcqb #sttdf #mining #uranium #sundogproject #StandardUranium #BatteryMetals #AthabascaBasin #CorvoProject #SunDogProject #JuniorMining #MiningNews #CriticalMinerals #ProactiveInvestors

Tiziana Life Sciences CEO Ivor Elrifi joined Steve Darling from Proactive to share news the company has announced promising PET scan results from a patient with moderate Alzheimer’s disease treated for three months with intranasal foralumab under an expanded access program. The scan revealed a significant reduction in microglial activation, a key marker of neuroinflammation linked to Alzheimer’s progression. This outcome represents a major milestone for the company’s intranasal foralumab program. With no approved therapies for moderate Alzheimer’s disease, Tiziana sees foralumab—a fully human anti-CD3 monoclonal antibody—as a potential treatment option, both as a monotherapy and in combination with amyloid-targeting therapies. Foralumab has shown the ability to induce regulatory T cells (Tregs) that migrate to the brain and suppress neuroinflammation. These effects have been validated in preclinical models and in patients with secondary progressive multiple sclerosis, supporting further clinical development in neurodegenerative conditions. The company is set to begin a Phase 2 randomized, placebo-controlled trial in June 2025 involving mild Alzheimer’s patients. Data from this trial are expected by the end of 2025. The aim is to determine if reducing neuroinflammation translates into improved quality of life. #proactiveinvestors #tizianalifescienceslts #nasdaq #tlsa #newceo #ivorelrifi #Foralumab #AlzheimersResearch #Neuroinflammation #BiotechNews #PETscan #ClinicalTrials #AlzheimersTreatment #PharmaUpdates #HealthcareInnovation

Equinox Gold Vice President of Investor Relations Rhylin Bailie joined Steve Darling from Proactive to provide insight into the company’s recent strategic moves, including its transformative merger with Calibre Mining and continued development of key mining operations across the Americas. Founded in late 2017, Equinox Gold was built on a bold vision: to become a one million-ounce-per-year gold producer. Bailie remarked that the timing was fortuitous, as the company’s growth strategy coincided with a strong upswing in gold prices. Today, Equinox operates six active mines located in Canada, the United States, Brazil, and Mexico, steadily progressing toward its ambitious production goal. A major step toward achieving that target is the newly announced merger with Calibre Mining, a transaction Bailie described as “a significant milestone” in Equinox’s evolution. The deal brings together two world-class gold projects: Equinox’s Greenstone mine in Ontario and Calibre’s Valentine mine in Newfoundland. Both assets are characterized by long mine lives, low operating costs, and substantial production potential. Once the merger is finalized—expected by the end of Q2 2025—the combined entity will become the second-largest gold producer based in Canada. The Greenstone and Valentine mines alone are projected to contribute nearly 600,000 ounces of annual production, putting Equinox much closer to its long-term output target. Bailie noted that both mines are expected to be fully operational by early 2026. In the meantime, Equinox is focusing on scaling up operations, controlling costs, and maximizing cash flow, capitalizing on sustained strength in gold prices. With a strong asset base, robust market conditions, and a strategic merger underway, Equinox Gold is positioning itself as a leading force in the North American gold mining sector. #proactiveinvestors #equinoxgoldcorp #tsx #eqx #nyseamerican #eqx #CalibreMining #GoldStocks #GoldMining #GreenstoneMine #ValentineMine #MiningMerger #GoldInvesting #CanadaMining #ProactiveInvestors

Supernova Metals CEO Mason Granger joined Steve Darling from Proactive to discuss has appointment as Chief Executive Officer. Granger brings over two decades of capital markets experience, with a background in portfolio management of public and private oil and gas assets. He is a five-time recipient of the Brendan Wood International TopGun Investment Mind award and has earned a Canadian Lipper Fund Award. Granger is also recognized for his leadership in ESG, sustainability, and energy transition. In conjunction with his appointment, Supernova has entered into a non-binding letter of intent with Orogen Corp. to evaluate the potential acquisition of an additional 36% equity interest in WestOil Limited. WestOil, a private company based in the Republic of Seychelles, holds a 70% operating interest in Block 2712A, offshore Namibia in the highly prospective Orange Basin. Supernova, through its subsidiary NamLith Resources Corp., currently owns a 12.5% interest in WestOil. The proposed transaction would increase the company’s stake to 48.5%. This strategic move positions Supernova to significantly enhance its exposure to one of the world’s most active offshore exploration regions. #proactiveinvestors #supernovametalscorp #cse #supr #NamibiaOil #OilExploration #EnergyInvesting #OffshoreDrilling #OrangeBasin #MasonGranger #OilAndGas #3DSeismic #JuniorExplorers #ResourceStocks

Immunic Inc chief medical officer Dr Andreas Muehler talked with Proactive's Stephen Gunnion about new developments in celiac disease research during Celiac Disease Awareness Month. He emphasized the seriousness of the autoimmune condition, noting it is often misdiagnosed due to vague symptoms. “Celiac disease is a really important disease with significant consequences for patients,” Muehler said, citing malnutrition, infertility, and even malignancy risks as complications. The emotional and social toll of the condition, he added, is also substantial, with many patients facing isolation due to dietary restrictions. Muehler discussed Immunic's investigational drug IMU-856, which targets the SIRT-6 protein to regenerate intestinal lining and strengthen gut barrier function. Early results from a Phase 1b trial involving 43 patients indicated improvements across multiple measures: bowel histology, disease symptoms, biomarkers, and micronutrient absorption. At the recent DDW conference, Immunic presented data showing IMU-856's efficacy even in patients with severe intestinal damage. Additionally, the drug's absorption was not hindered by pre-existing gut damage, an encouraging sign for future use. Muehler also noted the drug’s impact on GLP-1 hormone levels, aligning with emerging gastrointestinal treatment trends. Visit Proactive's YouTube channel for more videos, and don't forget to give the video a like, subscribe to the channel and enable notifications for future content. #CeliacDisease #ImmunicInc #IMU856 #AutoimmuneDisorders #GutHealth #BiotechNews #DDW2025 #CeliacTreatment #Epigenetics #GLP1 #MedicalResearch

Sona Nanotech CEO David Regan joined Steve Darling from Proactive to announce a groundbreaking Research Agreement with BioVaxys Technology Corp. aimed at developing a novel class of cancer therapeutics. The collaboration unites two innovative technologies: BioVaxys’ Immune Educating Platform (DPX) and Sona’s Targeted Hyperthermia Therapy (THT), powered by proprietary gold nanorod technology. Sona’s THT is an advanced photothermal cancer therapy that uses near-infrared light to generate localized heat within solid tumors. This thermal energy is delivered through Sona’s biocompatible gold nanorods, which not only destroy tumor cells but also stimulate a strong immune response—a crucial factor in combating cancer recurrence. The research will explore how BioVaxys’ DPX platform, known for priming the innate immune system, can further enhance this immune response when used in tandem with THT. “The potential synergy between these two technologies could significantly accelerate the immune system’s ability to recognize and attack tumors,” said Regan. One area of focus is the use of DPX to deliver tumor-specific neoantigens—unique proteins that emerge after cancer cell mutations and are absent from healthy tissues. Since THT can induce these mutations and neoantigen expression, pairing it with DPX could dramatically improve immune system targeting and treatment efficacy. Essentially, THT triggers changes in tumor cells, and DPX packages those changes for the immune system to attack. The research initiative is supported by the Giacomantonio Immuno-Oncology Research Group, which will fund the preclinical studies. Both companies will contribute their core technologies to the collaboration. Any new therapeutic candidate developed will be jointly owned and prosecuted by BioVaxys and Sona, with a commercialization agreement planned ahead of a potential Phase 1 clinical trial. #proactiveinvestors #sonananotechinc #cse #sona #otcqb #snanf #CancerResearch #MelanomaTreatment #BioVaxys #DPXTechnology #ClinicalTrials #TargetedTherapy #GoldNanorods #OncologyInnovation #ProactiveInvestors

FireFly Metals Ltd managing director Steve Parsons talked with Proactive about the company’s ongoing drilling success at the Green Bay Copper-Gold Project in Newfoundland, Canada. FireFly has reported strong extensional drilling results that intersect mineralisation more than 200 metres beyond the current Mineral Resource Estimate. The Green Bay Project currently hosts a Measured and Indicated Mineral Resource of 24.4 million tonnes at 1.9% copper equivalent (CuEq), with an additional 34.5 million tonnes at 2.0% CuEq classified as Inferred. Drilling is targeting growth through multiple fronts, including a 35,000-metre resource extension program and a further 35,000 metres for infill drilling to convert Inferred resources. Significant new intercepts include 25.8 metres at 5.1% CuEq and 12.4 metres at 6.8% CuEq. Drilling from the 805 Level continues to deliver high-grade hits across both VMS and Footwall Zone (FWZ) styles of mineralisation. Underground drilling continues with five rigs active, and a sixth underground rig is arriving in late May. A Down Hole Electromagnetic (DHEM) anomaly over 700 metres beyond current drill extents is also being tested, presenting further exploration potential. “We are about to add a seventh rig because we have so many opportunities to pursue,” Parsons said. “There are very few projects which could justify such an aggressive drilling campaign.” Visit Proactive’s YouTube channel for more videos, and don’t forget to give the video a like, subscribe to the channel, and enable notifications for future content. #FireFlyMetals #CopperExploration #GoldMining #GreenBayProject #NewfoundlandMining #DrillingResults #MineralResource #MingMine #MiningUpdates #ResourceExpansion #VMS #ExplorationNews #JuniorMining