Immunic CMO on Celiac Disease Awareness Month, potential of IMU-856

Synchronoss Technologies CEO Jeff Miller spoke with Steve Darling from Proactive to announce strong first-quarter 2025 results, marked by growth in cloud subscribers, improved margins, and high recurring revenue. The company reported $42.2 million in revenue, slightly down from $43 million a year earlier due to the expiration of a customer contract. However, recurring revenue rose to 93.1% of the total, up from 91.1%. Income from operations more than doubled to $8.2 million, while adjusted EBITDA grew 17% to $12.7 million, achieving a 30.2% margin. Synchronoss also completed a $200 million refinancing through a new four-year loan with TP Birch Grove, allowing it to retire $73.6 million in debt and fund the redemption of $121.4 million in senior notes. The company reaffirmed its full-year 2025 guidance, projecting revenue between $170 million and $180 million, adjusted EBITDA of $52 million to $56 million, and free cash flow of $11 million to $16 million, excluding a pending $28 million U.S. federal tax refund. #proactiveinvestors #synchronosstechnologiesinc #nasdaq #sncr #cloud #CloudRevenue #Q12025Results #JeffMiller #RecurringRevenue #TechEarnings #VerizonCloud #ATandTCloud #InvestorUpdates #TPBirchGrove #SoftwareGrowth #Refinancing

Standard Uranium Vice President of Exploration Sean Hillacre joined Steve Darling from Proactive to announce two key developments as it continues to advance its uranium exploration efforts in Canada’s Athabasca Basin. The company has signed a definitive property option agreement with Vital Battery Metals Inc., granting Vital the right to earn a 75% interest in the 12,265-hectare Corvo Project in the eastern Athabasca Basin. The project includes over 29 kilometres of exploration strike length across three northeast-southwest magnetic low trends, coincident with electromagnetic (EM) conductors and structural fault zones — key geological features for uranium targeting. Historic drill holes TL-79-3 and TL-79-5 returned uranium intercepts of 0.057% U₃O₈ over 3.5 metres and 0.065% U₃O₈ over 0.1 metres, respectively. Additionally, the Manhattan Showing on the property reported surface values of 59,800 ppm uranium. A recent high-resolution geophysical survey has enhanced target resolution, providing a solid foundation for future drilling. Standard Uranium has also completed a detailed ground gravity survey over the Wishbone, McNie, and Armbruster South targets at its 48,443-acre Sun Dog Project, located near Uranium City on the northern margin of the Athabasca Basin. The survey, combined with existing geophysical data, has outlined several high-priority drill targets. Drilling at the previously untested Wishbone target during the 2024 program returned anomalous uranium from all eight drill holes. Further gravity anomalies and favorable structures at McNie, Armbruster South, and Spring Dome offer additional kilometres of untested potential for high-grade, basement-hosted uranium mineralization. Standard Uranium’s exploration strategy continues to focus on advancing de-risked, high-impact drill targets across a growing portfolio of highly prospective projects in the world’s premier uranium district. #proactiveinvestors #standarduraniumltd #tsxv #stnd #otcqb #sttdf #mining #uranium #sundogproject #StandardUranium #BatteryMetals #AthabascaBasin #CorvoProject #SunDogProject #JuniorMining #MiningNews #CriticalMinerals #ProactiveInvestors

Tiziana Life Sciences CEO Ivor Elrifi joined Steve Darling from Proactive to share news the company has announced promising PET scan results from a patient with moderate Alzheimer’s disease treated for three months with intranasal foralumab under an expanded access program. The scan revealed a significant reduction in microglial activation, a key marker of neuroinflammation linked to Alzheimer’s progression. This outcome represents a major milestone for the company’s intranasal foralumab program. With no approved therapies for moderate Alzheimer’s disease, Tiziana sees foralumab—a fully human anti-CD3 monoclonal antibody—as a potential treatment option, both as a monotherapy and in combination with amyloid-targeting therapies. Foralumab has shown the ability to induce regulatory T cells (Tregs) that migrate to the brain and suppress neuroinflammation. These effects have been validated in preclinical models and in patients with secondary progressive multiple sclerosis, supporting further clinical development in neurodegenerative conditions. The company is set to begin a Phase 2 randomized, placebo-controlled trial in June 2025 involving mild Alzheimer’s patients. Data from this trial are expected by the end of 2025. The aim is to determine if reducing neuroinflammation translates into improved quality of life. #proactiveinvestors #tizianalifescienceslts #nasdaq #tlsa #newceo #ivorelrifi #Foralumab #AlzheimersResearch #Neuroinflammation #BiotechNews #PETscan #ClinicalTrials #AlzheimersTreatment #PharmaUpdates #HealthcareInnovation

Equinox Gold Vice President of Investor Relations Rhylin Bailie joined Steve Darling from Proactive to provide insight into the company’s recent strategic moves, including its transformative merger with Calibre Mining and continued development of key mining operations across the Americas. Founded in late 2017, Equinox Gold was built on a bold vision: to become a one million-ounce-per-year gold producer. Bailie remarked that the timing was fortuitous, as the company’s growth strategy coincided with a strong upswing in gold prices. Today, Equinox operates six active mines located in Canada, the United States, Brazil, and Mexico, steadily progressing toward its ambitious production goal. A major step toward achieving that target is the newly announced merger with Calibre Mining, a transaction Bailie described as “a significant milestone” in Equinox’s evolution. The deal brings together two world-class gold projects: Equinox’s Greenstone mine in Ontario and Calibre’s Valentine mine in Newfoundland. Both assets are characterized by long mine lives, low operating costs, and substantial production potential. Once the merger is finalized—expected by the end of Q2 2025—the combined entity will become the second-largest gold producer based in Canada. The Greenstone and Valentine mines alone are projected to contribute nearly 600,000 ounces of annual production, putting Equinox much closer to its long-term output target. Bailie noted that both mines are expected to be fully operational by early 2026. In the meantime, Equinox is focusing on scaling up operations, controlling costs, and maximizing cash flow, capitalizing on sustained strength in gold prices. With a strong asset base, robust market conditions, and a strategic merger underway, Equinox Gold is positioning itself as a leading force in the North American gold mining sector. #proactiveinvestors #equinoxgoldcorp #tsx #eqx #nyseamerican #eqx #CalibreMining #GoldStocks #GoldMining #GreenstoneMine #ValentineMine #MiningMerger #GoldInvesting #CanadaMining #ProactiveInvestors

Supernova Metals CEO Mason Granger joined Steve Darling from Proactive to discuss has appointment as Chief Executive Officer. Granger brings over two decades of capital markets experience, with a background in portfolio management of public and private oil and gas assets. He is a five-time recipient of the Brendan Wood International TopGun Investment Mind award and has earned a Canadian Lipper Fund Award. Granger is also recognized for his leadership in ESG, sustainability, and energy transition. In conjunction with his appointment, Supernova has entered into a non-binding letter of intent with Orogen Corp. to evaluate the potential acquisition of an additional 36% equity interest in WestOil Limited. WestOil, a private company based in the Republic of Seychelles, holds a 70% operating interest in Block 2712A, offshore Namibia in the highly prospective Orange Basin. Supernova, through its subsidiary NamLith Resources Corp., currently owns a 12.5% interest in WestOil. The proposed transaction would increase the company’s stake to 48.5%. This strategic move positions Supernova to significantly enhance its exposure to one of the world’s most active offshore exploration regions. #proactiveinvestors #supernovametalscorp #cse #supr #NamibiaOil #OilExploration #EnergyInvesting #OffshoreDrilling #OrangeBasin #MasonGranger #OilAndGas #3DSeismic #JuniorExplorers #ResourceStocks

Immunic Inc chief medical officer Dr Andreas Muehler talked with Proactive's Stephen Gunnion about new developments in celiac disease research during Celiac Disease Awareness Month. He emphasized the seriousness of the autoimmune condition, noting it is often misdiagnosed due to vague symptoms. “Celiac disease is a really important disease with significant consequences for patients,” Muehler said, citing malnutrition, infertility, and even malignancy risks as complications. The emotional and social toll of the condition, he added, is also substantial, with many patients facing isolation due to dietary restrictions. Muehler discussed Immunic's investigational drug IMU-856, which targets the SIRT-6 protein to regenerate intestinal lining and strengthen gut barrier function. Early results from a Phase 1b trial involving 43 patients indicated improvements across multiple measures: bowel histology, disease symptoms, biomarkers, and micronutrient absorption. At the recent DDW conference, Immunic presented data showing IMU-856's efficacy even in patients with severe intestinal damage. Additionally, the drug's absorption was not hindered by pre-existing gut damage, an encouraging sign for future use. Muehler also noted the drug’s impact on GLP-1 hormone levels, aligning with emerging gastrointestinal treatment trends. Visit Proactive's YouTube channel for more videos, and don't forget to give the video a like, subscribe to the channel and enable notifications for future content. #CeliacDisease #ImmunicInc #IMU856 #AutoimmuneDisorders #GutHealth #BiotechNews #DDW2025 #CeliacTreatment #Epigenetics #GLP1 #MedicalResearch

Sona Nanotech CEO David Regan joined Steve Darling from Proactive to announce a groundbreaking Research Agreement with BioVaxys Technology Corp. aimed at developing a novel class of cancer therapeutics. The collaboration unites two innovative technologies: BioVaxys’ Immune Educating Platform (DPX) and Sona’s Targeted Hyperthermia Therapy (THT), powered by proprietary gold nanorod technology. Sona’s THT is an advanced photothermal cancer therapy that uses near-infrared light to generate localized heat within solid tumors. This thermal energy is delivered through Sona’s biocompatible gold nanorods, which not only destroy tumor cells but also stimulate a strong immune response—a crucial factor in combating cancer recurrence. The research will explore how BioVaxys’ DPX platform, known for priming the innate immune system, can further enhance this immune response when used in tandem with THT. “The potential synergy between these two technologies could significantly accelerate the immune system’s ability to recognize and attack tumors,” said Regan. One area of focus is the use of DPX to deliver tumor-specific neoantigens—unique proteins that emerge after cancer cell mutations and are absent from healthy tissues. Since THT can induce these mutations and neoantigen expression, pairing it with DPX could dramatically improve immune system targeting and treatment efficacy. Essentially, THT triggers changes in tumor cells, and DPX packages those changes for the immune system to attack. The research initiative is supported by the Giacomantonio Immuno-Oncology Research Group, which will fund the preclinical studies. Both companies will contribute their core technologies to the collaboration. Any new therapeutic candidate developed will be jointly owned and prosecuted by BioVaxys and Sona, with a commercialization agreement planned ahead of a potential Phase 1 clinical trial. #proactiveinvestors #sonananotechinc #cse #sona #otcqb #snanf #CancerResearch #MelanomaTreatment #BioVaxys #DPXTechnology #ClinicalTrials #TargetedTherapy #GoldNanorods #OncologyInnovation #ProactiveInvestors

FireFly Metals Ltd managing director Steve Parsons talked with Proactive about the company’s ongoing drilling success at the Green Bay Copper-Gold Project in Newfoundland, Canada. FireFly has reported strong extensional drilling results that intersect mineralisation more than 200 metres beyond the current Mineral Resource Estimate. The Green Bay Project currently hosts a Measured and Indicated Mineral Resource of 24.4 million tonnes at 1.9% copper equivalent (CuEq), with an additional 34.5 million tonnes at 2.0% CuEq classified as Inferred. Drilling is targeting growth through multiple fronts, including a 35,000-metre resource extension program and a further 35,000 metres for infill drilling to convert Inferred resources. Significant new intercepts include 25.8 metres at 5.1% CuEq and 12.4 metres at 6.8% CuEq. Drilling from the 805 Level continues to deliver high-grade hits across both VMS and Footwall Zone (FWZ) styles of mineralisation. Underground drilling continues with five rigs active, and a sixth underground rig is arriving in late May. A Down Hole Electromagnetic (DHEM) anomaly over 700 metres beyond current drill extents is also being tested, presenting further exploration potential. “We are about to add a seventh rig because we have so many opportunities to pursue,” Parsons said. “There are very few projects which could justify such an aggressive drilling campaign.” Visit Proactive’s YouTube channel for more videos, and don’t forget to give the video a like, subscribe to the channel, and enable notifications for future content. #FireFlyMetals #CopperExploration #GoldMining #GreenBayProject #NewfoundlandMining #DrillingResults #MineralResource #MingMine #MiningUpdates #ResourceExpansion #VMS #ExplorationNews #JuniorMining

Bitwise Asset Management European head Bradley Duke talked with Proactive's Stephen Gunnion about the resurgence of Bitcoin to the $100,000 mark and the forces driving its momentum. Duke described the current environment as a "really bullish moment for Bitcoin", noting that the price has recovered steadily from recent lows of around $75,000. He attributed the surge to macroeconomic forces, particularly rising inflation expectations and growing scepticism toward the US dollar, describing the situation as part of a broader trend of “de-dollarisation”. He explained that aggressive US tariff policies are fuelling inflation expectations globally, pushing investors to consider alternative assets. Duke said, “We’ve seen that there’s a correlation to an increase in the price of Bitcoin if there’s a high expectation of inflation.” Duke also pointed to expanding corporate adoption of Bitcoin as a significant new development. He revealed that listed corporations had acquired over 101,000 bitcoins so far in 2025 — more than double the total new supply of Bitcoin this year. He noted that even US states have started to hold Bitcoin in their treasuries as part of strategic reserves, suggesting the shift from traditional assets to Bitcoin is accelerating. Visit Proactive's YouTube channel for more videos, and don't forget to give the video a like, subscribe to the channel, and enable notifications for future content. #Bitcoin #Cryptocurrency #DigitalAssets #BradleyDuke #Bitwise #BitcoinPrice #CorporateTreasuries #DeDollarization #InflationHedge #CryptoMarkets #ProactiveInvestors

Alvopetro Energy CEO Corey Ruttan joined Steve Darling from Proactive to share the company’s Q1 2025 earnings and operational highlights, revealing a robust start to the year driven by increased production in Brazil and new contributions from Canadian assets. The company reported a 41% year-over-year increase in first-quarter sales volumes, reflecting continued momentum in its core Brazilian natural gas operations. Field-estimated April sales volumes averaged 2,372 barrels of oil equivalent per day (boepd), including 13.5 million cubic feet per day (MMcfpd) of natural gas and 126 barrels per day (bopd) of condensate. Alvopetro’s Murucututu field remains a key driver of its Brazilian gas production, although Q1 volumes were partially impacted by downtime at the 183-A3 well. An intervention was successfully executed to isolate lower intervals and improve productivity. Looking ahead, the company has spud the 183-D4 well targeting the Caruaçu Formation, approximately 110 metres structurally updip of the 183-A3 well. A sidetrack operation is currently underway on the lower 680 metres of this new well. In parallel, the company has made notable progress in Canada. Two newly drilled wells with a 50% working interest came online in April, contributing approximately 90 bopd net to Alvopetro after initial clean-up. These additions bring the company’s total estimated April sales to 2,462 boepd. While this represents a 5% decrease compared to March, it marks a 1% increase over the Q1 average, indicating continued underlying strength. Ruttan also noted a positive development in pricing. As of May 1, Alvopetro’s natural gas price under its long-term agreement with Bahiagás has been adjusted to BRL2.08 per cubic metre, up 7% from the February price of BRL1.95/m³. This adjustment further strengthens the company’s revenue outlook for the remainder of the year. #proactiveinvestors #alvopetroenergyltd #tsxv #alv #otcqx #alvof #OilAndGas #BrazilNaturalGas #EnergyProduction #CEOInterview #Q32024 #ProactiveInvestors #CoreyRuttan #NaturalGas #BrazilEnergy #OilAndGas #EnergySector #ReservesUpdate #GasSales #ProactiveInvestors #2025Outlook