TWiV 1341: Phage breaks and COVID origins

TWiV explains research that reveals dual activity of a phage-encoded lysin that modulates infection dynamics in a mycobacteriophage, and refutes a proposed link between the SARS-CoV-2 furin cleavage site and mouse-adapted MERS-coronavirus MA30. Hosts: Vincent Racaniello, Kathy Spindler, Angela Mingarelli, and Jolene Ramsey Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Positions in Rosenfeld Lab (email) Dual activity of phage-encoded lysin (mBio) Furin cleavage site and SARS-CoV-2 origins (PNAS) Theories on SARS-CoV-2 origins (CR Biol) Timestamps by Jolene Ramsey. Thanks! Picks of the Week Angela – Pigeons. An underappreciated animal. Superparamagnetic macrophages, cancer detectors, mirror mark test Kathy – Wednesday’s APOD and Graphene Jolene – Microbial Puppet Masters science exhibit, 3D-models linked in their paper Vincent – Beyond Inheritance by Roxanne Khamsi (TWiEVO 126) Listener Pick Lana – The Episodic Table of Elements Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected] Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Daniel Griffin and Vincent Racaniello debate if Senator Mitch McConnell’s recent hospitalization is due to post-polio syndrome or just old age, how air quality from Maine to Chicago has been affected by the Ontario wild fires, new screwworm, Legionnaires and cyclosporasis cases, the Ebola outbreak in the Congo and development of a novel vaccine and antiviral, before Dr. Griffin deep dives into the measles outbreak, recent statistics on RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, how to access and pay for Paxlovid, where to go for answers about long COVID-19, long term effects of COVID-19 immune dysfunction including ocular and gut and contacting your federal government representative to stop the assault on science and biomedical research. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Statement From Senator Mitch McConnell (Mitch McConnell US Senator for Kentucky) Polio(NY Department of Health: Polio) Global polio vaccination (CDC) For Some Survivors, Polio Casts a Long Shadow (GAVI) Former Republican Senate Majority Leader Mitch McConnell hospitalized (NPR) Hundreds of thousands of Americans live with the long-term effects of polio (CIDRAP) Child Care, Schools, Camps: Outdoor Air Quality Health Recommendations Based on Air Quality Index (NY City of Health: air quality) Current Air Quality (AirNow) Domestically Acquired Cyclosporiasis Cases in Multiple U.S. States, 2026 (CDC: Health Alert Network) How helpful is not up to date? CDC: cyclosporiasis Top 10 Cyclospora questions (Katelyn Jetelina: your local epidemiologist) Cyclospora, wildfire smoke, and another Legionella outbreak (Marisa Donnelly: your local epidemiologist in New York) Cyclospora keeps climbing, a bad West Nile season, truck spraying, and good news (Katelyn Jetelina and Marisa Donnelly: your local epidemiologists) Infectious Disease Outbreaks (Michigan: Health & Human Services) Cyclospora cases up dramatically in New York (Outbreak News Today) Cyclospora Infection (Cyclosporiasis) (NYC Health) Legionnaires’ Disease (NYC Health) New York officials find Legionella in 76 cooling towers as cases hit 63 (CIDRAP) Dashboard SCREWWORM.Gov (USDA: Animal and Plant Health Inspection Service) CDC Activates Emergency Operations Center for New World Screwworm Response (CDC Newroom) Ebola dashboard (ebola.fyi) EBOLA:The Democratic Republic of the Congo, 2026 (WHO) Bundibugyo virus disease outbreak Democratic Republic of the Congo (WHO: Democratic Republic of Congo) Ebola Outbreak: Current Situation (CDC:Ebola) Why the fastest-growing Ebola outbreak in history is becoming more challenging (AP News) Oxford begins first human trial of Bundibugyo Ebola vaccine (Reuters) Gilead launches Ebola antiviral trial in DR Congo as cases near 2,000 (CIDRAP) Information for Travelers Returning from Ebola-Affected Areas (CDC: Ebola) Wastewater for measles (WasterWater Scan) Measles cases and outbreaks (CDC Rubeola) Big outbreak, bright lights…Measles Dashboard (South Carolina Department of Public Health) Utah measles outbreak response (Utah Department of Health and Human Services) UtahMeasles Dashboard (Utah Department of Health and Human Services) Measles (VDH: Virginia Department of Health) Tracking Measles Cases in the U.S. (Johns Hopkins) Measles vaccine recommendations from NYP (jpg) Weekly measles and rubella monitoring (Government of Canada) Measles (WHO) Get the FACTS about measles (NY State Department of Health) Measles (CDC Measles (Rubeola)) Measles vaccine (CDC Measles (Rubeola)) Presumptive evidence of measles immunity (CDC) Contraindications and precautions to measles vaccination (CDC) Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) Deaths following vaccination: what does the evidence show (Vaccine) Influenza: Waste water scan for 11 pathogens (WastewaterSCan) US respiratory virus activity (CDC Respiratory Illnesses) Respiratory virus activity levels (CDC Respiratory Illnesses) Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA) WHO updates all 3 viral strains to be included in fall flu shots (CIDRAP) FDA vaccine advisers recommend adding subclade K to fall shots (CIDRAP) Weekly surveillance report: cliff notes (CDC FluView) OPTION 2: XOFLUZA $50 Cash Pay Option(xofluza) RSV: Waste water scan for 11 pathogens (WastewaterSCan) Respiratory Diseases (Yale School of Public Health) USrespiratory virus activity (CDC Respiratory Illnesses) RSV-Network (CDC Respiratory Syncytial virus Infection) Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) Respiratory Diseases (Yale School of Public Health) Waste water scan for 11 pathogens (WastewaterSCan) COVID-19 deaths (CDC) Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) COVID-19 national and regional trends (CDC) COVID-19 variant tracker (CDC) SARS-CoV-2 genomes galore (Nextstrain) Where to get pemgarda (Pemgarda) EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) Infusion center (Prime Fusions) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Drug interaction checker (University of Liverpool) Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) Understanding Coverage Options (PAXCESS) Infectious Disease Society guidelines for treatment and management (ID Society) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What to do when sick with a respiratory virus (CDC) Managing healthcare staffing shortages (CDC) Anticoagulationguidelines (hematology.org) Daniel Griffin’s evidence based medical practices for long COVID (OFID) Long COVID hotline (Columbia : Columbia University Irving Medical Center) The answers: Long COVID Long-term ocular symptoms following COVID-19 linked to immune dysregulation, dysautonomia and peripheral neuropathy (Nature Communications) Vagal cholinergic denervationof the gastric mucosa in Long-COVID-19: in vivo evidence of structural autonomic dysfunction (International Journal of Infectious Diseases) Reaching out to US house representative Letters read on TWiV 1340 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene Ramsey. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected] Content in this podcast should not be construed as medical advice.

Tom Ksiazek, a world-renowned virus expert with 40 years of experience on the front lines of some of the worst outbreaks the world has ever seen, joins TWiV to discuss his career, ebolaviruses in general, and the current outbreak of Bundibugyo ebolavirus in Africa. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Guest: Tom Ksiazek Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Positions in Rosenfeld Lab (email) Fred Murphy passes (pdf) CJ Peters passes (pdf) Tom Ksiazek on TWiV 583 Letters read on TWiV 1339 Timestamps by Jolene Ramsey. Thanks! Picks of the Week Brianne – APoD July 7: Dragons of Ara Rich – The Iconic Bass Riff That NOBODY Can Play; Riff (Wiki) see “Riff-Driven” Vincent – The song that made Carlos Santana a rock legend Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected] Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Daniel Griffin and Vincent Racaniello are dismayed over the military deaths due to the voluntary influenza vaccination policy, FDA’s first vaccine recommendations since 2023, the efficacy of influenza vaccines, new screwworm, Legionnaires and cyclosporiasis cases, the Ebola outbreak in the DRC and Uganda and before Dr. Griffin deep dives into the measles outbreak, recent statistics on RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, how to access and pay for Paxlovid, publication of the blocked COVID-19 vaccine findings, where to go for answers about long COVID-19, use of antivirals in children with COVID-19, severe West Nile disease and contacting your federal government representative to stop the assault on science and biomedical research. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode A1C Keon Talik McDaniel (Bexar Memorial) Hegseth: Flu Vaccine Optional (US Department of War) Air Force trainee in San Antonio, Texas, died from flu(CIDRAP) Key FDA committee unanimously recommends its first vaccine since 2023(NPR) Efficacy and Safety of an mRNA Seasonal Influenza Vaccine in Adults (NEJM) Influenza Vaccine Effectiveness Against Pediatric Death in the United States: 2016–2025 (Pediatrics) Dashboard SCREWWORM.Gov (USDA: Animal and Plant Health Inspection Service) CDC Activates Emergency Operations Center for New World Screwworm Response (CDC Newroom) Upper East Side Legionnaires’ Outbreak Source Remains Unknown (Bloomberg) Outbreak of diarrhea-causing parasite grows to more than 1,000 cases (AP) Cyclosporiasis outbreak in Michigan exceeds 1,000 cases (WOODTV+) Ebola deaths top 500 as DR Congo health workers threaten to strike (CIDRAP) Ebola deaths in Congo top 500 as health workers threaten to strike (AP) Ebola dashboard (ebola.fyi)  EBOLA:The Democratic Republic of the Congo, 2026 (WHO) Bundibugyo virus disease outbreak Democratic Republic of the Congo (WHO: Democratic Republic of Congo) Ebola Outbreak: Current Situation (CDC:Ebola) Wastewater for measles (WasterWater Scan) Measles cases and outbreaks (CDC Rubeola) Big outbreak, bright lights…Measles Dashboard (South Carolina Department of Public Health) Utah measles outbreak response (Utah Department of Health and Human Services) Utah Measles Dashboard (Utah Department of Health and Human Services) Measles (VDH: Virginia Department of Health) Tracking Measles Cases in the U.S. (Johns Hopkins) Measles vaccine recommendations from NYP (jpg) Weekly measles and rubella monitoring (Government of Canada) Measles (WHO) Get the FACTS about measles (NY State Department of Health) Measles (CDC Measles (Rubeola)) Measles vaccine (CDC Measles (Rubeola)) Presumptive evidence of measles immunity (CDC) Contraindications and precautions to measles vaccination (CDC) Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) Deaths following vaccination: what does the evidence show (Vaccine) Influenza: Waste water scan for 11 pathogens (WastewaterSCan) USrespiratory virus activity (CDC Respiratory Illnesses) Respiratory virus activity levels (CDC Respiratory Illnesses) Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA) WHO updates all 3 viral strains to be included in fall flu shots (CIDRAP) FDA vaccine advisers recommend adding subclade K to fall shots(CIDRAP) Weekly surveillance report: cliff notes (CDC FluView) OPTION 2: XOFLUZA $50 Cash Pay Option (xofluza) RSV: Waste water scan for 11 pathogens (WastewaterSCan) Respiratory Diseases (Yale School of Public Health) USrespiratory virus activity (CDC Respiratory Illnesses) RSV-Network (CDC Respiratory Syncytial virus Infection) Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) Respiratory Diseases (Yale School of Public Health) Waste water scan for 11 pathogens (WastewaterSCan) COVID-19 deaths (CDC) Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) COVID-19 national and regional trends (CDC) COVID-19 variant tracker (CDC) SARS-CoV-2 genomes galore (Nextstrain) Where to get pemgarda (Pemgarda) EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD) Infusion center (Prime Fusions) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Nirmatrelvir/Ritonavir for the Treatment of COVID-19 in Children Aged 6 Years and Older (Pediatrics) Drug interaction checker (University of Liverpool) Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) Understanding Coverage Options (PAXCESS) Infectious Disease Society guidelines for treatment and management (ID Society) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What to do when sick with a respiratory virus (CDC) Managing healthcare staffing shortages (CDC) Anticoagulation guidelines (hematology.org) Daniel Griffin’s evidence based medical practices for long COVID (OFID) Long COVID hotline (Columbia : Columbia University Irving Medical Center) The answers: Long COVID Efficacy and safety of rivaroxaban, colchicine, and famotidine–loratadine with specialist supportive clinical care for fatigue in patients with post-COVID-19 condition in the UK: a multisite, open-label, randomised controlled trial (LANCET: Infectious Diseases) Long-term Sequelae Associated With Severe West Nile Virus Disease in Maricopa County, Arizona, 2021 (OFID) Reaching out to US house representative Letters read on TWiV 1338 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene Ramsey. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected] Content in this podcast should not be construed as medical advice.

TWiV explains research that reveals an an alternative evolutionary path of antiviral signalling in a sea anemone, and how a bacterial symbiont and a plant virus enhance insect fitness by inducing physical defenses against fungal parasites. Hosts: Vincent Racaniello, Alan Dove, and Rich Condit Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Positions in Rosenfeld Lab (email) Springer-Nature retracted two papers by Max Planck, probably with a bot (Science) Alternative evolutionary path of antiviral signalling in sea anemone (Nat Ecol Evol) Bacterial symbiont and plant virus protect whitefly against fungal parasites (PNAS) Letters read on TWiV 1337 Timestamps by Jolene Ramsey. Thanks! Picks of the Week Rich – The Mercy of Gods by James S. A. Corey; Livesuit by James S. A. Corey Alan – Climate.us, run by former NOAA scientists after Trump gutted their agency’s climate site Vincent – A Chemically Defined Synthetic Cell Capable of Growth and Replication Listener Pick Lana – The Episodic Table of Elements Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected] Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Daniel Griffin and Vincent Racaniello lament about the new ACIP charter, how administration of the HPV vaccine has eliminated cervical cancer deaths in young women, the global economic burden of infectious disease, restoring trust in vaccinology, new screwworm cases, the Ebola outbreak in the Congo and Uganda and need for preparedness, before Dr. Griffin deep dives into the measles outbreak, recent statistics RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, how to access and pay for Paxlovid, publication of the blocked COVID-19 vaccine findings, where to go for answers about long COVID-19, and contacting your federal government representative to stop the assault on science and biomedical research. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode New ACIP charter broadens criteria for members, calls for review of alternatives to vaccines (STAT News) ACIP Charter (CDC: Advisory Committee on Immunization Practices) HPV vaccination eliminated cervical cancer deaths in young UK women in recent years, study suggests (CIDRAP) Cervical cancer mortality trends following HPV vaccination in England, 2001–24: an analysis of population-based mortality data (LANCET) Dashboard SCREWWORM.Gov (USDA: Animal and Plant Health Inspection Service) CDC Activates Emergency Operations Center for New World Screwworm Response (CDC Newroom) Ebola dashboard (ebola.fyi) EBOLA:The Democratic Republic of the Congo, 2026 (WHO) Bundibugyo virus disease outbreak Democratic Republic of the Congo (WHO: Democratic Republic of Congo) Ebola Outbreak: Current Situation (CDC:Ebola) Size of the 2026 Ebola outbreak and risk of cross-border spillover from Bundibugyo virus in Ituri Province, DR Congo, and its implications for preparedness: a recalibrated stochastic modelling study (LANCET Infectious Diseases) US CDC raises Ebola outbreak response to highest level (Reuters) Construction of US-backed Ebola quarantine unit in Kenya is stopped (CIDRAP) ASPR Supports Global Ebola Response While Strengthening U.S. Preparedness (Administration for Strategic Preparedness & Response) Wastewater for measles (WasterWater Scan) Measles cases and outbreaks (CDC Rubeola) Big outbreak, bright lights…Measles Dashboard (South Carolina Department of Public Health) Utah measles outbreak response (Utah Department of Health and Human Services) Utah Measles Dashboard (Utah Department of Health and Human Services) Measles (VDH: Virginia Department of Health) Tracking Measles Cases in the U.S. (Johns Hopkins) Measles vaccine recommendations from NYP (jpg) Weekly measles and rubella monitoring (Government of Canada) Measles (WHO) Get the FACTS about measles (NY State Department of Health) Measles (CDC Measles (Rubeola)) Measles vaccine (CDC Measles (Rubeola)) Contraindications and precautions to measles vaccination (CDC) Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) Deaths following vaccination: what does the evidence show (Vaccine) Influenza: Waste water scan for 11 pathogens (WastewaterSCan) US respiratory virus activity (CDC Respiratory Illnesses) Respiratory virus activity levels (CDC Respiratory Illnesses) Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA) WHO updates all 3 viral strains to be included in fall flu shots (CIDRAP) FDA vaccine advisers recommend adding subclade K to fall shots (CIDRAP) Weekly surveillance report: cliff notes (CDC FluView) US military requires flu vaccine for some after outbreak in Texas training center (Reuters) OPTION 2: XOFLUZA $50 Cash Pay Option (xofluza) RSV: Waste water scan for 11 pathogens (WastewaterSCan) Respiratory Diseases (Yale School of Public Health) USrespiratory virus activity (CDC Respiratory Illnesses) RSV-Network (CDC Respiratory Syncytial virus Infection) Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) Respiratory Diseases (Yale School of Public Health) Waste water scan for 11 pathogens (WastewaterSCan) COVID-19 deaths (CDC) Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) COVID-19 national and regional trends (CDC) COVID-19 variant tracker (CDC) SARS-CoV-2 genomes galore (Nextstrain) Where to get pemgarda (Pemgarda) EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) Infusion center (Prime Fusions) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Drug interaction checker (University of Liverpool) Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) Understanding Coverage Options (PAXCESS) Infectious Disease Society guidelines for treatment and management (ID Society) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What to do when sick with a respiratory virus (CDC) Managing healthcare staffing shortages (CDC) Anticoagulation guidelines (hematology.org) Daniel Griffin’s evidence based medical practices for long COVID (OFID) Long COVID hotline (Columbia : Columbia University Irving Medical Center) The answers: Long COVID Reaching out to US house representative Letters read on TWiV 1336 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene Ramsey. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected] Content in this podcast should not be construed as medical advice.

Vincent speaks with Karen Torghele about her recently published biography of polio vaccine pioneer Albert Sabin, the first ever written. Host: Vincent Racaniello Guest: Karen Torghele Subscribe (free): Apple Podcasts, RSS, email Links for this episode Karen Torghele’s website Purchase Albert Sabin by Karen Torghele (Bookshop or Amazon) My letters from Albert Sabin (virology blog) Become a patron of TWiV! Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected] Content in this podcast should not be construed as medical advice.

TWiV explains research showing how temperate phages enhance bacterial host fitness via RNA-guided flagellar remodelling, and that IgA antibody is necessary and sufficient to prevent norovirus infection in mice. Hosts: Vincent Racaniello, Rich Condit, Brianne Barker, and Jolene Ramsey Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Positions in Rosenfeld Lab (email) Fred Murphy passes away (X) US has lost its hold on measles elimination (CIDRAP) What’s in the genetic code of America’s measles outbreaks (ProPublica) Did Pete Hegseth single-handedly raise the R₀ of flu? (Inside Medicine) Fred Murphy’s Virus Images and Foundations of Virology (UTMB) Temperate phages and RNA-guided flagellar remodelling (Nat Micro) Eukaryotic RNA guided system (Nature) IgA prevents norovirus infection in mice (Sci Transl Med) Craig Wilen’s letter to TWiV (TWiV 492) Timestamps by Jolene Ramsey. Thanks! Picks of the Week Brianne – APod June 26: Milky Way Urban Style Rich – Your birth order affects your future, but not for the reason you think; Dr. McCoy Jolene – Bakteriopolis paper and site Vincent – The Claude Shutdown Is a Total Sh*tshow Listener Pick Martin – Ancient text charred by Vesuvius read for first time in 2,000 years Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected] Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Daniel Griffin and Vincent Racaniello discuss the global economic burden of infectious disease, restoring trust in vaccinology, the Legionnaires outbreak in Harlem, new screwworm cases, the Ebola outbreak in the Congo and Uganda and an import case into France, end of the hantavirus outbreak before Dr. Griffin deep dives into the measles outbreak, recent statistics RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, outbreak of measles in Cook County Illionis in 2025, loss of measles elimination in the US, how to access and pay for Paxlovid, publication of the blocked COVID-19 vaccine findings, where to go for answers about long COVID-19, and contacting your federal government representative to stop the assault on science and biomedical research. Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Health and economic burdens of emerging infectious diseases in the USA, US territories and globally (BMJ Journal of Global Health) Meeting People Where They Are: Scientist-Creators Delivering Trusted Health Information on Social Media and Beyond (The Evidence Collective) Vaccine Integrity Project, The Evidence Collective announce projects to improve vaccine policy, restore trust (CIDRAP) Outbreak of Legionnaires’ Disease Associated with Cooling Tower Systems in Central Harlem (NEJM Evidence) Dashboard SCREWWORM.Gov (USDA: Animal and Plant Health Inspection Service) CDC Activates Emergency Operations Center for New World Screwworm Response (CDC Newroom) Ebola dashboard (ebola.fyi)  EBOLA:The Democratic Republic of the Congo, 2026 (WHO) Bundibugyo virus disease outbreak Democratic Republic of the Congo (WHO: Democratic Republic of Congo) Ebola Outbreak: Current Situation (CDC:Ebola) France confirms first Ebola case (BBC) Hantavirusdashboard (Hantavirus.up) Hantavirus on board with Prof. VincentRacaniello (microbeTV) Health agencies signal end of quarantine period for cruise-linked Andes virus outbreak (DG:Alerts) HHS Successfully Concludes Hantavirus Response Effort; Monitoring Ends with No Positive U.S. Case (US: HHS) Wastewater for measles (WasterWater Scan) Measles cases and outbreaks (CDC Rubeola) Big outbreak, bright lights…Measles Dashboard (South Carolina Department of Public Health) Utah measles outbreak response (Utah Department of Health and Human Services) UtahMeasles Dashboard (Utah Department of Health and Human Services) US measles cases continue to climb, especially in Virginia (CIDRAP) Measles (VDH: Virginia Department of Health) Tracking Measles Cases in the U.S. (Johns Hopkins) Measles vaccine recommendations from NYP (jpg) Weekly measles and rubella monitoring (Government of Canada) Measles (WHO) Get the FACTS about measles (NY State Department of Health) Measles(CDC Measles (Rubeola)) Measles vaccine (CDC Measles (Rubeola)) Presumptive evidence of measles immunity (CDC) Contraindications and precautions to measles vaccination (CDC) Measles (CDC Measles (Rubeola)) Measles (CDC: Measles Rubeola) Adverse events associated with childhood vaccines: evidence bearing on causality (NLM) Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America) Deaths following vaccination: what does the evidence show (Vaccine) Measles Outbreak in Cook County, Illinois, September–October 2025 (NEJM Evidence) CDC ‘transitioning away’ from diagnostic testing for measles, mumps (POLITICO PRO) CIDRAP Op-Ed: Call it what it is—the US has lost its hold on measles elimination (CIDRAP) Influenza: Waste water scan for 11 pathogens (WastewaterSCan) USrespiratory virus activity (CDC Respiratory Illnesses) Respiratory virus activity levels (CDC Respiratory Illnesses) Flu vaccine recommendations: Vaccines and Related Biological Products Advisory Committee March 12, 2026 Meeting Announcement (FDA) WHO updates all 3 viral strains to be included in fall flu shots (CIDRAP) FDA vaccine advisers recommend adding subclade K to fall shots (CIDRAP) Weekly surveillance report: clift notes (CDC FluView) US military requires flu vaccine for some after outbreak in Texas training center (Reuters) OPTION 2: XOFLUZA $50 Cash Pay Option (xofluza) RSV: Waste water scan for 11 pathogens (WastewaterSCan) Respiratory Diseases (Yale School of Public Health) USrespiratory virus activity (CDC Respiratory Illnesses) RSV-Network (CDC Respiratory Syncytial virus Infection) Vaccines for Adults (CDC: Respiratory Syncytial Virus Infection (RSV)) Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP) Respiratory Diseases (Yale School of Public Health) Waste water scan for 11 pathogens (WastewaterSCan) COVID-19 deaths (CDC) Respiratory Illnesses Data Channel (CDC: Respiratory Illnesses) COVID-19 national and regional trends (CDC) COVID-19 variant tracker (CDC) SARS-CoV-2 genomes galore (Nextstrain) CDC’s chief blocked a covid vaccine study. Now it’s in a top medical journal. (Washington Post) Interim Estimated Effectiveness of 2025-2026 COVID-19 Vaccines in Adults Using a Test-Negative Design (JAMA Network: OPEN) Where to get pemgarda (Pemgarda) EUAfor the pre-exposure prophylaxis of COVID-19 (INVIYD) Infusion center (Prime Fusions) CDC Quarantine guidelines (CDC) NIH COVID-19 treatment guidelines (NIH) Drug interaction checker (University of Liverpool) Help your eligible patients access PAXLOVID with the PAXCESS Patient Support Program (Pfizer Pro) Understanding Coverage Options (PAXCESS) Infectious Disease Society guidelines for treatment and management (ID Society) Molnupiravir safety and efficacy (JMV) Convalescent plasma recommendation for immunocompromised (ID Society) What to do when sick with a respiratory virus (CDC) Managing healthcare staffing shortages (CDC) Anticoagulationguidelines (hematology.org) Daniel Griffin’s evidence based medical practices for long COVID (OFID) Long COVID hotline (Columbia : Columbia University Irving Medical Center) The answers: Long COVID Reaching out to US house representative Letters read on TWiV 1334 Dr. Griffin’s COVID treatment summary (pdf) Timestamps by Jolene Ramsey. Thanks! Intro music is by Ronald Jenkees Send your questions for Dr. Griffin to [email protected] Content in this podcast should not be construed as medical advice.

TWiV explains research showing how HIV-1 signalling remodels nuclear pores to licence infection, and development of STING agonist nanoparticles to enable coordinated mucosal-systemic immunity for durable pan-β-coronavirus protection. Hosts: VVincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Positions in Rosenfeld Lab (email) Bundibugyo ebolavirus sitrep (WHO) Ebolavirus and Andes virus with John Dye (TWiV Special) Major research nonhuman primate supplier going out of business (Science) HIV-1 signalling remodels nuclear pores to licence infection (Nature) STING agonist nanoparticles enable mucosal-systemic immunity (Nature Nanoparticles) Timestamps by Jolene Ramsey. Thanks! Picks of the Week Brianne – Otherworldly music albums feature space weather data Rich – Evidence Mapping: Consolidating and summarising available evidence to support the demonstration of effectiveness of developmental vaccines, Australian Living Evidence Collaboration (ALEC) Alan – Holyoke dam fish elevator Vincent – 68 Quadrillion Underground Miles of Fungi Intro music is by Ronald Jenkees Send your virology questions and comments to [email protected] Content in this podcast should not be construed as medical advice.