632: The science of skin aging & how to slow it down | Saranya Wyles, M.D., Ph.D.

“Skin is our most visible biomarker of how we're aging on the inside,” explains Saranya Wyles, M.D., Ph.D.  Wyles, a dermatologist, regenerative medicine scientist, and the director of the Regenerative Dermatology & Skin Longevity Lab at the Mayo Clinic, joins us today to unpack how the skin reflects systemic aging and the emerging therapies shaping the future of regenerative dermatology. - The skin’s connection to longevity (~3:45) - Markers of skin aging (~5:20) - Senescent cells & systemic aging (~6:35) - 5 pillars of skinspan (~8:25) - How to eat for better skin (~10:20) - The role of exercise (~12:30) - The best topicals (~13:55) - Sunscreen & morning sunlight exposure (~17:05) - What are peptides (~20:20)  - Lasers & longevity (~25:20) - Procedures to be mindful of (~32:40) - Underrated skin habits (~33:35) - The future of skin longevity (~35:15) - Cognitive function & skin health (~39:50) - Hair loss (~42:30) Referenced in the episode:  - Follow Wyles on Instagram (@drwyles.derm) - Check out her research (https://pubmed.ncbi.nlm.nih.gov/?term=saranya+wyles)   - The Baltimore Longitudinal Study of Aging (https://www.nia.nih.gov/research/labs/blsa/about)  - Participate in the Skin Aging And Longevity Understanding Database (SALUD) (https://www.mayo.edu/research/clinical-trials/cls-20578108) We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: [email protected]. Learn more about your ad choices. Visit megaphone.fm/adchoices

Here’s the story of some scientists in the 1980s who tried to cause heart disease in rabbits. Instead, they stumbled upon a discovery so surprising it challenged everything we thought we knew about cardiovascular health—and may hold a powerful lesson for human longevity. This story isn’t just about rabbits. It’s about us. - How we eat. - Who we eat with. - And how guilt, stress, love, and presence shape the way our bodies respond to food. Emerging science shows that eating in a relaxed, connected state activates the parasympathetic nervous system—supporting digestion, blood sugar balance, and heart health. In other words: how you eat may matter as much as what you eat. Link to the actual study Chapters 00:00 – The mysterious rabbit experiment 01:35 – A result that made no sense 02:30 – The detail researchers almost missed 04:00 – What this teaches us about eating & stress 05:00 – Why love may protect the heart 🎙️ This new format episode, hosted by founder and co-CEO Jason Wachob, is from the mindbodygreen podcast, where science meets meaning—and small shifts lead to big health changes. If this story resonated with you: 👍 Like this video 💬 Share your thoughts in the comments 🔔 Subscribe for more science-backed stories on longevity, nutrition, and whole-body health Read more here: https://www.mindbodygreen.com/ Shop our supplements: https://shop.mindbodygreen.com/ Join 1M+ subscribers on their journey towards strong and healthy: https://www.mindbodygreen.com/newsletters  Follow us:  Instagram: @mindbodygreen   TikTok: @mindbodygreen Learn more about your ad choices. Visit megaphone.fm/adchoices

“Most women are doing too much cardio and not enough resistance training,” explains Jaime Seeman, M.D.  Seeman, a board-certified Obstetrician-Gynecologist and member of mindbodygreen’s scientific board of advisors, joins us today to dive deep into how women can support muscle, hormones, and metabolic health across every decade of life. - Dr. Seeman’s morning routine (~3:40) - How to do fasting the right way (~6:35) - How to eat for body recomposition (~8:30) - Balancing macros (~11:00) - Optimizing your nutrition (~15:55) - Wearables, macros, & hormones (~17:55) - Nutrition & exercise for your 20s (~19:00) - Health advice for your 30s (~20:55) - Jaime’s personal experience postpartum (~25:25) - Seeman’s prescription for training (~27:10) - How to make the most of your training (~28:30) - Health in your 40s & 50s (~32:00) - Understanding the nuance with HRT (~34:00) - Seeman’s favorite supplement, creatine (~38:00) - Her hot takes (~41:30) Referenced in the episode:  - Follow Dr. Seeman on Instagram (@doctorfitandfabulous) - Check out her website (https://www.doctorfitandfabulous.com/)  - Listen to her podcast The Fit and Fabulous Podcast (https://podcasts.apple.com/us/podcast/the-fit-and-fabulous-podcast/id1575100757)  - Watch her TEDx Talk (https://www.youtube.com/watch?v=dJIw-hljICY)  - Listen to her previous episode (Muscle, metabolism, & mindset for women | Jamie Seeman, M.D.)   We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: [email protected]. Learn more about your ad choices. Visit megaphone.fm/adchoices

“It is more dangerous to your health not to have muscle mass than to have excess body fat,” explains Rocío Salas-Whalen, M.D. Salas-Whalen, a board-certified Endocrinologist, Obesity Medicine specialist, and widely recognized as one of the earliest adopters of GLP-1 therapies in the United States, joins us today to explain how GLP-1s work, who truly benefits, and the crucial steps you need to take to protect your metabolism along the way. - How to know if GLP-1s are right for you (~4:00) - Are there longevity benefits of GLP-1s? (~5:10) - Types of body composition profiles (~7:00) - How to protect your muscle mass on GLP-1s (~8:50) - Protein recommendations (~12:00) - Common mistakes (~13:00) - Conversations to have with your provider (~14:25) - Getting off GLP-1s (~18:05) - The most important steps to build muscle (~19:30) - HRT + GLP-1s (~21:30) - Who should not take GLP-1s (~25:05) - The importance of lifestyle (~27:55) - The internal gains of GLP-1s (~29:45) - The mindset needed for long-term success (~31:35) - GLP-1s for minors? (~37:55) - The future of this space (~42:00) Referenced in the episode:  - Follow Salas-Whalen on Instagram (@drsalaswhalen)  - Pick up her book, Weightless (https://weightlessthebook.com/)   - Work with her (https://www.nyendocrinology.com/home)  - Liraglutide in mild to moderate Alzheimer’s disease (https://www.nature.com/articles/s41591-025-04106-7)  We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: [email protected]. Learn more about your ad choices. Visit megaphone.fm/adchoices

“There are hundreds, maybe thousands, of drug repurposing opportunities just waiting to be uncovered,” explains David Fajgenbaum, M.D.  David Fajgenbaum, M.D., physician-scientist, bestselling author of Chasing My Cure, co-founder of Every Cure, and leader in the global push for drug repurposing, joins us today to explain why the cures of tomorrow may already be on pharmacy shelves today—and how his team is racing to uncover them. - From college athlete to ICU (~3:15) - Finding a cure (~7:20) - Hope needs to drive action (~9:45) - Repurposing drugs (~11:10) - Use cases of generic drugs (~13:30) - Lithium for bipolar & Alzheimer’s (~16:00) - Lidocaine & breast cancer (~17:25) - GLP-1 for longevity benefits (~19:20) - Increasing awareness in the healthcare system (~20:10) - The 3 main hurdles for repurposing drugs (~22:00) - Opportunities in the space (~23:10) - 14 advanced repurpose treatments (~28:00) - The power of AI (~32:50) - Using AI for personalized medicine (~34:30) - AI for treatment options (~37:45) - Common drugs with big potential (~41:00) - The future of healthcare & drug discovery (~44:50) - How you can help (~49:30) Referenced in the episode:  - Follow Fajgenbaum on Instagram (@dfajgenbaum)  - Check out his website (https://davidfajgenbaum.com/)  - Listen to his previous episode on the mbg podcast  (https://podcasts.apple.com/us/podcast/life-lessons-from-a-doctor-who-almost-died-from/id1246494475?i=1000470061486) - Pick up his book, Chasing My Cure (https://www.amazon.com/Chasing-My-Cure-Doctors-Action/dp/1524799637/)  - Listen to his TED Talk (https://www.youtube.com/watch?v=sb34MfJjurc)   - Learn more about Every Cure (https://everycure.org/) We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: [email protected]. Learn more about your ad choices. Visit megaphone.fm/adchoices

“If you really want to be strong and you want to do strength training, you need to eat carbohydrates,” explains Ana Kausel, M.D.  Ana Kausel, M.D., a board-certified endocrinologist and women’s health expert, joins us today to share how women can build metabolic strength from the inside out—through muscle, nutrition, hormones, and lifestyle. - Her experience gaining 9 lbs of muscle (~3:40) - GLP-1 dosage (~6:10) - The importance of lifestyle on GLP-1s (~6:45) - Her approach to training (~11:00) - Balancing fat & protein (~14:15) - Increasing protein intake (~17:00) - The role of carbs (~17:30) - Improving metabolic health (~19:00) - Creatine & taurine (~21:00) - Testing female hormones (~22:15) - Symptoms vs. lab work (~23:45) - HRT: Compounding vs. bioidentical (~27:40) - Her take on DHEA (~28:45) - Testosterone levels (~31:15) - Use cases of GLP-1s (~35:55) - Her nutrition philosophy (~37:20) - Are NAD supplements worth it? (~47:25) - The importance of calcium (~48:00) Referenced in the episode:  - Follow Kausel on Instagram (@dranakausel)  - Check out her YouTube (https://www.youtube.com/@DraAnaKausel)  - Work with her (https://anzarahealth.com/)  This podcast was made in partnership with Gaia Herbs. Your path to stress support starts now.* Visit gaiaherbs.com and use promo code MBGPod to get 20% off. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: [email protected]. Learn more about your ad choices. Visit megaphone.fm/adchoices

“Muscle is built in recovery.  It's not built in the workout,” explains Shannon Ritchey, P.T., DPT.  Ritchey, Doctor of Physical Therapy, personal trainer, and the founder of Evlo Fitness, joins us today to share how you can train smarter—not harder—to build strength, protect your body, and finally see results that last. - Workout less & get better results (~4:15) - The effects of overtraining (~7:35) - The problem with group fitness classes (~9:20) - How to structure your week of workouts (~11:50) - Cardio & strength training (~15:05) - Superset training (~18:30) - You need to lift to failure (~19:30) - How to know if you need to lift heavier (~20:40) - The importance of form (~24:15) - Building muscle postpartum (~27:25)  - The power of intentional training (~29:30) - How to dial in nutrition (~30:30) - The role of cardio (~32:50) - Muscle & metabolic health (~36:30) - Beyond the scale (~40:00) - Training your pelvic floor (~42:55) - A new perspective on training during perimenopause (~45:15) Referenced in the episode:  - Follow Ritchey on Instagram (@dr.shannon.dpt)  - Check out her company, Evlo Fitness (https://evlofitness.com/)   - Follow Evlo Fitness on Instagram (@evlofitness)  - Listen to her podcast, The Dr. Shannon Show  This podcast was made in partnership with Gaia Herbs. Your path to stress support starts now.* Visit gaiaherbs.com and use promo code MBGPod to get 20% off. This episode of The mindbodygreen Podcast is sponsored by Spring Sleep.  eXciteOSA is an FDA-cleared daytime therapy device that helps to reduce snoring and treat a root cause of mild sleep apnea. Visit https://spectrumsleep.sjv.io/c/309912/3060225/35996 to learn more or get started. eXciteOSA is an FDA-cleared, prescription-only device for mild obstructive sleep apnea and snoring. Consult your doctor to see if it’s right for you. Individual results may vary. Learn more, including risks and benefits, at https://spectrumsleep.sjv.io/c/309912/3060225/35996 We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: [email protected]. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Learn more about your ad choices. Visit megaphone.fm/adchoices

“If your brain is not healthy, you are much more likely to experience pain,” explains Daniel Amen, M.D.  Amen, a physician, double board-certified psychiatrist, award-winning researcher, and 20-time national bestselling author, joins us today to dive into the neuroscience behind brain health, emotional regulation, chronic pain, and supporting healthier minds across every age group. - The relationship between chronic pain & the brain (~4:30) - Defining an “unhealthy” brain (~5:40) - Emotional “red flags” for brain health (~10:00) - Jason’s experience with back pain (~17:50) - Managing your mind (~20:00) - Improving frontal lobe health (~22:15) - Recommendations for kids (~27:00) - The Doom Loop (~29:00) - A practice to manage your emotions (~33:10) - The impact of marijuana on the brain (~39:20) - Finding your triggers (~42:00) - Patient stories (~45:20) Referenced in the episode:  - Follow Amen on Instagram (@doc_amen) - Check out Amen Clinics (https://www.amenclinics.com/)  - Read his latest book, Change Your Brain, Change Your Pain (https://www.amazon.com/Change-Your-Brain-Pain-Emotional/dp/0063426706) We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: [email protected]. Learn more about your ad choices. Visit megaphone.fm/adchoices

“The spike protein from COVID is a true age accelerant,” explains Robin Rose, D.O. Rose, a double board-certified gastroenterologist, internal medicine specialist, and CEO of Terrain Health, joins us today to explain how lingering viral proteins from COVID can continue to affect the gut, brain, and immune system—and what we can do to identify and address their lasting impact. - What is Long COVID? (~2:00) - How to know if you have Long COVID (~3:45) - Which biomarkers can signal Long COVID (~7:05) - Asymptomatic presentations (~13:00) - The connection to neurodegenerative diseases (~18:50) - Why this is important for everyone (~21:50) - The impact of COVID on the body (~23:55) - How to detox from Long COVID (~28:15) - The impact on the gut (~38:00) - Conversations to have with your practitioner (39:45~) - The biomarkers to test (~41:50) - Final thoughts (~48:05)    Referenced in the episode:  - Follow Rose on Instagram (dr.robinrose) - Check out her clinic, Terrain Health (https://terrainhealth.org/)  We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: [email protected]. Learn more about your ad choices. Visit megaphone.fm/adchoices

“VO2 max is the best predictor of lifespan,” says Peter Attia, M.D. Peter Attia, M.D., physician, founder of Early Medical, and expert in the applied science of longevity, joins us today to break down the key levers for extending both lifespan and healthspan—from how to train for a higher VO2 max to the biomarkers that truly predict long-term health. - The most powerful habit for longevity (~6:15) - VO2 max (~8:55) - How to increase your VO2 max (~10:08) - Heart rate vs. perceived exertion (~12:35) - Attia’s strength training routine (~15:20) - 2 exercises Attia stopped doing (17:00) - Diminishing returns in terms of exercise (~19:55) - His take on wearables (~21:25) - Cardiovascular disease markers (~23:38) - Lowering ApoB (~25:35) - Pharmaceutical interventions for LDL & ApoB (~27:50) - Neuroinflammation markers (~37:25) - Perspectives on statins (~40:45) - The role of nutrition (~42:50) - Potential benefits of GLP-1s (~45:00) - Peptides (~47:50) - The power of exercise (~51:00) Referenced in the episode:  - Follow Attia on Instagram (@peterattiamd) - Listen to his podcast, The Peter Attia Drive  - Check out his website (https://peterattiamd.com/)  - Pick up his book, Outlive: The Science of Art & Longevity  - Take his class on MasterClass (https://www.masterclass.com/series/science-for-a-longer-better-life) - Watch the trailer for his class on MasterClass (youtube.com/watch?v=f_Mz095swls&feature=youtu.be)   We hope you enjoy this episode, and feel free to watch the full video on YouTube! Whether it's an article or podcast, we want to know what we can do to help here at mindbodygreen. Let us know at: [email protected]. Learn more about your ad choices. Visit megaphone.fm/adchoices