“Just So Grateful.” Artemis II Crew & Eli Lilly’s New GLP-1 Pill 4/30/26

Home from space, the crew of the Artemis II stops by the Squawk set. Commander Reid Wiseman, Pilot Victor Glover, and Mission Specialists Christina Koch and Jeremy Hansen discuss their brave journey around the moon, the newest frontiers, the emotional and physical toll of takeoff and reentry, and handling snafus–like smoke alarms and toilet troubles–while in space. Eli Lilly CEO David Ricks discusses the drugmaker’s big financial quarter in an exclusive interview. He shares the first prescription numbers of Lilly’s newest GLP-1 pill, Foundayo, as well as how it differs from Zepbound and Novo Nordisk’s Wegovy. Plus, Anthropic is in talks to raise funds at a $900B valuation, the Saudi Public Investment Fund will stop funding the LIV Golf League, and Jerome Powell will remain on the Fed’s Board of Governors after his time as Chairman ends.    Steve Liesman - 3:17 Angelica Peebles & David Ricks - 17:12 Artemis II Crew - 32:06   In this episode: Artemis Crew, @NASAArtemis Steve Liesman, @steveliesman Angelica Peebles, @angelicapeebles Joe Kernen, @JoeSquawk Andrew Ross Sorkin, @andrewrsorkin Cameron Costa, @CameronCostaNY Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Today is likely Jay Powell’s final FOMC meeting as Federal Reserve Chair, with Kevin Warsh expected to be sworn in as his successor. Carlyle Group co-founder and co-chairman David Rubenstein discusses the Fed’s two-day policy meeting and Powell’s legacy leading the central bank. Then, a heated debate over a potential federal rescue of Spirit Airlines: Association of Flight Attendants international president Sara Nelson and Advancing American Freedom senior fellow Joel Griffith break down the pros and cons of a $500 million bailout. Plus, Elon Musk continues his testimony in the high-profile trial against OpenAI CEO Sam Altman, and CNBC’s Dan Murphy reports on the UAE’s departure from OPEC.    Dan Murphy - 06:35 David Rubenstein - 16:00 Sara Nelson & Joel Griffith - 30:32   In this episode: David Rubenstein, @DM_Rubenstein Sara Nelson, @FlyingWithSara Joel Griffith, @JoelGriffith Becky Quick, @BeckyQuick Joe Kernen, @JoeSquawk Andrew Ross Sorkin, @andrewrsorkin Cameron Costa, @CameronCostaNY Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The United Arab Emirates has announced that it will leave OPEC, effective May 1. CNBC’s Brian Sullivan breaks down the role that the UAE has played in the group since joining in the 1960s. In business, a WSJ report reveals that OpenAI missed internal growth targets. The news comes as SpaceX, Anthropic, and OpenAI consider IPOs; three new debuts, each with enormous demand, mean the AI race is now also a race for public capital. This weekend, Formula 1 heads to Miami. Mercedes team principal and CEO Toto Wolff discusses F1’s regulation evolution and his team’s star driver: the youngest Championship leader ever, Kimi Antonelli. Plus, CNBC’s Sharon Epperson discusses the importance of financial transparency in families and the real costs of skipping financial conversations with your kids.    Toto Wolff - 17:14 Sharon Epperson - 27:48 In this episode: Brian Sullivan, @SullyCNBC Sharon Epperson, @sharon_epperson Becky Quick, @BeckyQuick Joe Kernen, @JoeSquawk Andrew Ross Sorkin, @andrewrsorkin Cameron Costa, @CameronCostaNY Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

It took years for actress Selma Blair to find the role of a lifetime – and joy – in a shocking diagnosis. Discovering in her 40s that decades of health concerns and misunderstandings were the result of multiple sclerosis, Blair transformed her diagnosis into action. Around 1 million Americans are known to have the auto-immune disease MS, which can impact the brain and spinal cord, as well as the body’s ability to communicate.     The “Legally Blonde” and “Cruel Intentions” actress is an advocate for fellow MS patients and she is speaking up for anyone traveling the difficult path of finding medical answers, care and possible treatment.  In this episode of "The Path," Selma Blair takes CNBCs Becky Quick into her inspiring and empathetic journey of self-acceptance.    Join us in advancing awareness and understanding of rare diseases. Visit CNBC.com/Cures to access clips, resources, or to sign up for our weekly newsletter.  Follow Becky Quick on X: @BeckyQuick Please share your thoughts or rare disease story in the comments, and join us on The Path. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

After gunshots interrupted the White House Correspondents’ Dinner on Saturday, attendees including CNBC’s Joe Kernen and Eamon Javers recount the evening’s turn. Attorney for the Southern District of New York Jay Clayton was also in the room, close enough to the President to be swept off with the Secret Service. Clayton considers the public’s and media’s role in amplifying hate, and then he discusses the legal proceedings of the week, starting with the feud between Sam Altman and Elon Musk over OpenAI’s founding mission as a nonprofit. Plus, CNBC’s Dan Murphy is in Dubai with the latest on Iran, and the Senate Banking Committee is scheduled to vote on Kevin Warsh’s Fed Chair nomination this week.    Eamon Javers        2:30 Dan Murphy     14:57 Steve Liesman    17:13 Jay Clayton      23:08    In this episode: Eamon Javers, @EamonJavers Dan Murphy, @dan_murphy Steve Liesman, @steveliesman Becky Quick, @BeckyQuick Joe Kernen, @JoeSquawk Andrew Ross Sorkin, @andrewrsorkin Katie Kramer, @Kramer_Katie Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

The FDA has approved Regeneron’s gene therapy for a rare form of inherited deafness, and it’s free for Americans. Regeneron CEO Leonard Schleifer discusses the breakthrough treatment, drug pricing, AI’s role in medical innovation, and what breakthroughs might come next. Co-chair of the President’s Council of Advisors on Science and Technology David Sacks was one of the original executives at PayPal, alongside Elon Musk and Peter Thiel. As an AI and crypto advisor to President Trump, the All In Podcast co-host is helping shape AI regulation and policy in the United States. He comments on the government’s complicated relationship with Anthropic and the ongoing feud between Elon Musk and Sam Altman. Plus, a U.S. soldier was arrested for his winning Polymarket bet on the capture of Venezuelan leader Nicolás Maduro, and Intel reported a blowout quarter.   David Sacks - 17:43 Leonard Schleifer - 29:21   In this episode: Becky Quick, @BeckyQuick Joe Kernen, @JoeSquawk Andrew Ross Sorkin, @andrewrsorkin Katie Kramer, @Kramer_Katie Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Nasdaq CEO Adena Friedman discusses the exchange’s latest financial results, the IPO pipeline–including SpaceX’s potential listing–and the 23 hours a day, 5 days a week U.S. equity trading coming in December.CNBC’s Steve Liesman shares the results of the latest CNBC All-America Economic Survey: 40% of people nationwide approve of the President’s overall job performance. Amid surging fuel prices and the Iran war, President Trump’s net approval rating fell 10 points to -18, the lowest ever measured for his two terms.  Plus, Arkansas Governor Sarah Huckabee Sanders discusses the President’s approval ratings and his handling of the war in Iran.   Steve Liesman - 2:44 Adena Friedman - 12:57 Gov. Sarah Huckabee Sanders - 30:41   In this episode: Sarah Huckabee Sanders, @SarahHuckabee Steve Liesman, @steveliesman Becky Quick, @BeckyQuick Joe Kernen, @JoeSquawk Andrew Ross Sorkin, @andrewrsorkin Cameron Costa, @CameronCostaNY Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

United Airlines CEO Scott Kirby discusses his company’s latest financial report and responds to President Trump’s comments on a potential United-American merger. Plus, an executive order on medical treatments for serious mental health issues bumped psychedelics stocks higher. Psychedelics investor and founder Christian Angermayer explains the industry’s opportunity for mental health–and for investors.  Dan Murphy Scott Kirby & Phil LeBeau - 15:13 Christian Angermayer - 30:21   In this episode: Christian Angermayer, @C_Angermayer Dan Murphy, @dan_murphy Phil LeBeau, @Lebeaucarnews Becky Quick, @BeckyQuick Joe Kernen, @JoeSquawk Andrew Ross Sorkin, @andrewrsorkin Katie Kramer, @Kramer_Katie Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In an extended interview, President Donald Trump discusses negotiations with Iran, the U.S. alliance with Israel, and the future of America’s presence in the region. The President also weighs in on inflation, the White House’s relationship with Anthropic, and the possibility of consolidation in the airline industry. Plus, Steve Liesman reports on Kevin Warsh’s Fed chair confirmation hearing, and both President Trump and Warren Buffett address the biggest corporate headline of the day: Apple CEO Tim Cook, handing over the reins to John Ternus in September.    President Trump - 17:45   In this episode: President Donald Trump, @realDonaldTrump MacKenzie Sigalos, @KenzieSigalos Steve Liesman, @steveliesman Becky Quick, @BeckyQuick Joe Kernen, @JoeSquawk Andrew Ross Sorkin, @andrewrsorkin Cameron Costa, @CameronCostaNY Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

As concerns mount regarding the health of the private credit ecosystem, Oaktree Capital Management co-chairman Howard Marks offers perspective–and some investing advice–when it comes to private lending. Former FDA Commissioner Dr. Scott Gottlieb discusses Eli Lilly’s deal to expand its cancer treatment pipeline as well as President Trump’s executive order on therapeutic psychedelics. Plus, Kevin Warsh’s Fed Chair nomination hearing is this week, and Anthropic’s Mythos is at work within the NSA, despite being blacklisted by the US government.    Steve Liesman          14:36 Howard Marks             23:54 Dr. Scott Gottlieb          41:27   In this episode: Steve Liesman, @steveliesman Andrew Ross Sorkin, @andrewrsorkin Becky Quick, @BeckyQuick Joe Kernen, @JoeSquawk Katie Kramer,  @Kramer_Katie Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.