Briefing Chat: New narcolepsy drug could unlock host of novel brain therapies

In this episode:00:46 Human brain-organoids transplanted into mice missing their cortexNature: Human brain cells transplanted into mice in ‘most extensive’ integration ever13:51 Research HighlightsNature: Ruins of ancient Asian city show engineering prowess and organizationNature: Distant sensors announced a fearsome tsunami’s birth16:16 Paper2Agent: the AI tool that lets researchers talk to papersNature: AI tool turns any paper into an ‘agent’ that can collaborate and answer complex queriesSubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.

Nature staff discuss an AI tool that can assess the impact of nine billion mutations — plus, how the Bunsen burner’s reputation for sterilization may be based on tradition alone.00:21 Deepmind’s new tool helps scientists find the impact of mutationsNature: DeepMind’s new genome ‘atlas’ charts effects of all nine billion human gene mutations07:10 Bacteria can still contaminate plates near to active Bunsen burnersNature: Bunsen burners’ reputation for sterilizing workplaces flames out Subscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.

In this episode:00:46 How telephone teaching could boost education during school shutdownsNature: Pick up the phone! Phone calls with tutors keep kids learning when schools shut down11:42 Research HighlightsNature: Super-precise optical clocks in four nations tick in harmonyNature: These greenhouse-gas sources have trotters and snouts14:15 Why atlases might need an updateNature: Hello Equal Earth: what the UN’s new world map will changeSubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.

In this episode:00:21 Our picks of this year’s Ig Nobel prizesNature: Buried underpants and a new definition of kissing win 2026 Ig Nobel prizes07:47 Massive xenon experiment detects tantalizing hint of dark matterNature: Is this the first glimpse of dark matter? Data point excites physicistsSubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.

Scientists are amassing evidence that unrepaired or poorly repaired DNA damage underlies many of the hallmarks of ageing. This has led to research into whether boosting DNA repair can keep people healthy for longer.This is an audio version of our Feature: Could mending damaged DNA prolong life? Hosted on Acast. See acast.com/privacy for more information.

In this episode:00:18 Researchers celebrate Dolly Parton's contributions to scienceNature: Dolly Parton dies aged 80 — researchers celebrate her contributions to science08:40 Phase III trial of melanoma vaccine shows promiseNature: Moderna cancer vaccine stops melanoma returning: what’s next for personalized treatments?Subscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.

Why extreme temperatures are expected to weaken ocean carbon sinks — plus, how mitochondrial injections could treat vision loss.00:46 The world’s oceans reach a record temperatureNature: Ocean temperatures set to break all-time record: what’s next?10:05 Research HighlightsNature: Astronaut vest cuts radiation exposure in halfNature: Earth-shaking thunder probes underground geology12:54 How mitochondrial injections could treat vision lossNature: Patient’s own mitochondria injected into eyes in attempt to restore vision​​​​​​​Subscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.

Nature staff discuss how an FDA-approved drug for narcolepsy could have promise beyond the condition, and the longest-lived human brain organoids yet.00:28 The promise of a new narcolepsy drugNature: First-of-its-kind narcolepsy drug opens door to new therapies for the brain05:53 Human brain organoids kept alive for over five yearsNature: Human organoids that mimic brain development grown for years in lab​​​​​​​Subscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.

Star orbiting close to Sagittarius A* could reveal its spin — plus, how exoskeletons might change the way humans move.00:46 The star that could reveal a black hole’s spinResearch article: Dayem et al.13:23 Research HighlightsNature: ​​​​​​​Rattlesnakes’ own antivenom could protect humans tooNature: ​​​​​​​Shipping on rivers packs a surprisingly large climate punch15:40 Commercial exoskeletons are hitting the market — what now?Nature: ​​​​​​​Will you be wearing an exoskeleton in ten years? The tech that could change how we move​​​​​​​Subscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.

In this episode:00:29 What does Anthropic’s new watermark mean for research?Nature: Can Anthropic’s invisible watermarks curb ‘AI slop’? Researchers remain sceptical10:57 Ticklishness is a distinct, specialized body sensation, research findsNature: Where are you ticklish? Researchers map the sensation across culturesSubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.