DIME Trial: New study finds a ketogenic diet may help some with severe depression

Setbacks are a natural part of any journey, and mental health recovery is no exception. In this video, Dr. Matt Bernstein shares a powerful perspective on why downturns aren’t failures, but opportunities to learn, adapt, and build resilience.Rather than viewing setbacks as something to fear or avoid, Dr. Bernstein explains how adopting a growth mindset can transform the way we respond to challenges. With the right preparation and support, moments of struggle can become key turning points in long-term recovery.In this video, you’ll learn:Why setbacks are normal in any recovery journeyHow to reframe “failures” as opportunities for growthThe importance of identifying early warning signsHow to build a personal plan for navigating downturnsWhy support systems and connection are critical during difficult timesHow tools like mindfulness and structured planning can help you regain momentumDr. Bernstein also discusses practical strategies like creating a Wellness Recovery Action Plan, leveraging your support network, and even planning ahead for more serious crises with tools like a healthcare proxy.If you’re navigating mental health challenges or supporting someone who is, this conversation offers practical tools and a more compassionate framework for the journey.💡Learn more about navigating setbacks on the mental health journey in our detailed article: How to Bounce Back from Challenges and Setbacks.🔎 Have questions about how to apply metabolic therapies effectively? Submit them at metabolicmind.org/questions to be featured in a future Metabolic Mailbag episode.#MetabolicMind #KetogenicTherapy #MetabolicPsychiatryExpert Featured:Dr. Matt Bernsteinhttps://accordmh.com/http://linkedin.com/in/matthew-bernstein-md-5743338Free CME Clinician Trainings:Are you a clinician who would like to learn more about the science behind these therapies and how to implement them in practice? Earn CME with our growing library of courses from some of the top experts in the field including Dr. Chris Palmer, Dr. Georgia Ede, Dr. Matthew Bernstein, Dr. Mariela Glandt, Dr. Deanna Kelly, Dr. Julie Milder, Dr. Zoltan Sarnyai, and Dr. Bret Scher with more coming soon.Our courses have been made FREE by grants from Baszucki Group, so we can spread these powerful therapies as widely as possible. Earn CME/CNE credits: https://www.metabolicmind.org/for-clinicians/trainings-courses/?utm_medium=organic-social&utm_source=youtube&utm_campaign=cme-ytFollow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.

Can a ketogenic diet improve mental health?This week marks a significant moment for metabolic psychiatry and ketogenic therapy for serious mental illness.A New York Times piece highlighted early research from Stanford University, The Ohio State University, and the University of Edinburgh—alongside stories from individuals who have shared their lived experience here on Metabolic Mind.This kind of visibility matters. It reflects years of work by researchers and clinicians like Drs. Chris Palmer, Shebani Sethi, and Iain Campbell, research funded by Baszucki Group, advocates like Jan Baszucki, as well as the many people who have been willing to share their personal stories.Lived experience alone isn’t enough. Early data alone isn’t enough. But together, they point to something that must be tested, confirmed — or challenged — through high-quality science. That’s why we are excited about several RCTs currently completed or underway around the world.We need to continue efforts to advance education, public awareness and research on a scale that will require public funding. That’s how medicine moves forward. And that’s the exciting work ahead.📰 Read the full article here: https://nyti.ms/4sj2WZDHear more from our founder Jan Baszucki, calling for further investments in research and clinical care, and sharing her family’s story highlighting how after a decade of illness, ketogenic therapy sent her son's bipolar I disorder symptoms into remission and has kept him there since 2021.🔗 Read Jan’s op-ed: https://bit.ly/4dpkU7Z🔎 Have questions about how to apply metabolic therapies effectively? Submit them at metabolicmind.org/questions to be featured in a future Metabolic Mailbag episode.Expert Featured:Dr. Bret ScherBaszucki Group Medical Directorhttps://x.com/bschermdResources Mentioned:NYT Article: Can the Keto Diet Really Improve Mental Health?https://nyti.ms/4sj2WZDFoundational Clinical Trials Pagehttps://www.metabolicmind.org/resources/science/clinical-trials/Maya Schumer’s THINK+SMART Profile:https://www.metabolicmind.org/thinksmart/explore-strategies/maya-schumer/Lewis Anstee’s THINK+SMART Profile:https://www.metabolicmind.org/thinksmart/explore-strategies/lewis-anstee/Lived Experience Stories & Strategieshttps://www.metabolicmind.org/thinksmart/explore-strategies/Free CME Clinician Trainings:Are you a clinician who would like to learn more about the science behind these therapies and how to implement them in practice? Earn CME with our growing library of courses from some of the top experts in the field including Dr. Chris Palmer, Dr. Georgia Ede, Dr. Matthew Bernstein, Dr. Mariela Glandt, Dr. Deanna Kelly, Dr. Julie Milder, Dr. Zoltan Sarnyai, and Dr. Bret Scher with more coming soon.Our courses have been made FREE by grants from Baszucki Group, so we can spread these powerful therapies as widely as possible. Earn CME/CNE credits: https://www.metabolicmind.org/for-clinicians/trainings-courses/?utm_medium=organic-social&utm_source=youtube&utm_campaign=cme-ytFollow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.

Can the ketogenic diet help improve symptoms for individuals living with treatment-resistant depression?In this conversation, Dr. Bret Scher sits down with Dr. Megan Kirk Chang, a senior researcher in metabolic psychiatry at the University of Oxford and a co-author of the recently published DIME trial.This study represents the first randomized clinical trial to evaluate a ketogenic diet in adults with treatment-resistant depression.Participants were assigned to either a ketogenic diet or a plant-rich comparison diet for six weeks to assess whether dietary intervention could influence depressive symptoms. Both groups experienced meaningful improvements in depression scores, with the ketogenic diet slightly outperforming the control group at 6 weeks.While the difference between groups did not reach the threshold for statistical significance, the findings suggest a positive signal that warrants further investigation.In this interview, Dr. Kirk Chang reflects on:The strengths of the study and where she sees opportunity for improvement.What the modest difference between diets might meanWhy early pilot trials are designed to detect signals rather than definitive answersWhat the study revealed about adherence, cravings, and behavioral factorsHow these results will inform larger and longer clinical trials now being plannedAs Dr. Kirk Chang explains, this six-week pilot trial was designed as proof-of-concept research to determine whether there is enough signal to justify larger studies in metabolic psychiatry.At Metabolic Mind, we view studies like this as an important step in a growing scientific effort to understand how metabolism and nutrition may influence serious mental illness. Each new study contributes to the evolving evidence base that will help researchers determine who may benefit, why, and under what conditions.🔗 To learn more about the available evidence for ketogenic therapy in depression and our top resources, visit our Depression Topic Page: https://www.metabolicmind.org/resources/topics/keto-for-depression/🔎 Have questions about how to apply metabolic therapies effectively? Submit them at metabolicmind.org/questions to be featured in a future Metabolic Mailbag episode.Expert Featured:Dr. Megan Kirk Chang, PhDSenior Researcher, Department of Psychiatry, University of Oxfordhttps://x.com/DrMegKirkChanghttps://www.linkedin.com/in/megankirkchang/Resources Mentioned:A Ketogenic Diet for Treatment-Resistant Depression: A Randomized Clinical Trialhttps://doi.org/10.1001/jamapsychiatry.2025.4431Free CME Clinician Trainings:Are you a clinician who would like to learn more about the science behind these therapies and how to implement them in practice? Earn CME with our growing library of courses from some of the top experts in the field including Dr. Chris Palmer, Dr. Georgia Ede, Dr. Matthew Bernstein, Dr. Mariela Glandt, Dr. Deanna Kelly, Dr. Julie Milder, Dr. Zoltan Sarnyai, and Dr. Bret Scher with more coming soon.Our courses have been made FREE by grants from Baszucki Group, so we can spread these powerful therapies as widely as possible. Earn CME/CNE credits: https://www.metabolicmind.org/for-clinicians/trainings-courses/?utm_medium=organic-social&utm_source=youtube&utm_campaign=cme-ytFollow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.

A new meta-analysis just dropped, and once again, saturated fat takes center stage. But does the data actually support the decades-long warnings we've heard about saturated fat and heart disease? Not exactly.In this video, Dr. Bret Scher dives deep into a recent study published in the Annals of Internal Medicine that reviewed randomized controlled trials on saturated fat intake and health outcomes.Despite the headlines and abstract language hinting at risk, a closer look at the data reveals no statistically significant increase in heart attacks, strokes, or early death, even with modest increases in LDL.So why the disconnect between what the data shows and what the authors claim? Dr. Scher breaks it down and explores the nuances often missing from the conversation about saturated fat, including context like food quality, carbohydrate intake, metabolic health, and lifestyle factors that make a big difference.🔍 Key Topics Covered:What this new meta-analysis actually found (vs. what it claimed)The persistent bias in nutrition science and reportingWhy LDL isn’t the whole storyHow dietary context, like carbs, processing, and lifestyle, matters more than saturated fat aloneWhy focusing on whole dietary patterns is essential for metabolic healthDr. Scher says it best, “If the medical and dietetic institutions are so certain that saturated fat is harmful, why are there so many studies that fail to reach meaningful conclusions?”To learn more about ketogenic therapy and heart disease, check out our Is Keto Safe Topic Page for more content from cardiologist Dr. Bret Scher breaking down keto, dietary fat, saturated fat, LDL, and more.https://www.metabolicmind.org/resources/topics/is-keto-safe/🔎 Have questions about how to apply metabolic therapies effectively? Submit them at metabolicmind.org/questions to be featured in a future Metabolic Mailbag episode.Expert Featured:Dr. Bret ScherBaszucki Group Medical Directorhttps://x.com/bschermdResources Mentioned:Effect of Interventions Aimed at Reducing or Modifying Saturated Fat Intake on Cholesterol, Mortality, and Major Cardiovascular Events: A Risk Stratified Systematic Review of Randomized Trialshttps://doi.org/10.7326/ANNALS-25-02229Free CME Clinician Trainings:Are you a clinician who would like to learn more about the science behind these therapies and how to implement them in practice? Earn CME with our growing library of courses from some of the top experts in the field including Dr. Chris Palmer, Dr. Georgia Ede, Dr. Matthew Bernstein and Dr. Bret Scher with more coming soon.Our courses have been made FREE by grants from Baszucki Group, so we can spread these powerful therapies as widely as possible. Earn CME/CNE credits: https://www.metabolicmind.org/for-clinicians/trainings-courses/?utm_medium=organic-social&utm_source=youtube&utm_campaign=cme-ytFollow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.

You may have seen headlines or social media posts claiming that ketones increase the risk of heart attacks and that this proves ketogenic diets are dangerous for heart health. But when you actually examine the study behind those claims, the data tell a very different story.In this video, Dr. Bret Scher takes a closer look at a recent paper published in the Journal of the American Heart Association that analyzed circulating ketone levels in participants from the UK Biobank. The study has been widely shared online as evidence against ketogenic diets. The issue? The participants weren’t following a ketogenic diet at all.Instead, researchers measured very small baseline ketone levels in a general population that was consuming around 250 grams of carbohydrates per day, that’s far from the levels associated with nutritional ketosis.In this video, you’ll learn:Why this study was not a ketogenic diet studyThe difference between association and causation in epidemiologyWhy the measured ketone levels were far below nutritional ketosisHow metabolic stress, illness, or diabetes can raise ketone levels independently of dietWhy these findings don’t tell us anything about ketogenic dietsUnderstanding the context behind nutrition research is critical. Misinterpreting observational data can easily lead to misleading headlines and unnecessary confusion about diet and health.💡If you want to learn more about the science behind ketogenic metabolic therapy, visit metabolicmind.org for research, resources, and expert insights.👍 If you found this helpful, like and subscribe for more evidence-based discussions about metabolic health and mental health.🔎 Have questions about how to apply metabolic therapies effectively? Submit them at metabolicmind.org/questions to be featured in a future Metabolic Mailbag episode.#MetabolicMind #KetogenicTherapy #FoodAsMedicineExpert Featured:Dr. Bret ScherBaszucki Group Medical Directorhttps://x.com/bschermdResources Mentioned:Circulating Ketone Bodies and Incident Cardiovascular Outcomes and Mortality: Insights From the UK Biobankhttps://www.ahajournals.org/doi/10.1161/JAHA.125.042582Free CME Clinician Trainings:Are you a clinician who would like to learn more about the science behind these therapies and how to implement them in practice? Earn CME with our growing library of courses from some of the top experts in the field including Dr. Chris Palmer, Dr. Georgia Ede, Dr. Matthew Bernstein, Dr. Mariela Glandt, Dr. Deanna Kelly, Dr. Julie Milder, Dr. Zoltan Sarnyai, and Dr. Bret Scher with more coming soon.Our courses have been made FREE by grants from Baszucki Group, so we can spread these powerful therapies as widely as possible. Earn CME/CNE credits: https://www.metabolicmind.org/for-clinicians/trainings-courses/?utm_medium=organic-social&utm_source=youtube&utm_campaign=cme-ytFollow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.

Can you reverse fatty liver disease with a ketogenic diet?Fatty liver disease is now one of the fastest-growing liver conditions in the world, affecting roughly 30% of adults and an increasing number of children. And in many cases, it’s driven by metabolic dysfunction and insulin resistance.In this conversation, Dr. Bret Scher speaks with Dr. Amy Goss (University of Alabama at Birmingham) and Dr. Karen Jerome-Zapadka (Trajectory Health Partners) about the growing epidemic of metabolic dysfunction–associated steatotic liver disease (MASLD) and why carbohydrate restriction and ketogenic nutrition may be powerful tools for addressing it.In this interview, you’ll learn:What MASLD (formerly NAFLD) is and why it’s becoming so commonHow insulin resistance and excess carbohydrates contribute to fatty liverNew research showing how carbohydrate restriction can reduce liver fatWhy ketogenic and low-carb diets may improve liver metabolism beyond weight lossThe clinical experience of reversing fatty liver through metabolic therapyWhy lifestyle approaches often receive less attention than medicationsDr. Amy Goss and her team at the University of Alabama at Birmingham are currently conducting a large NIH-funded clinical trial investigating how carbohydrate restriction affects liver fat and insulin sensitivity in adolescents with fatty liver disease.At the same time, Dr. Karen Jerome-Zapadka is applying these metabolic principles in clinical practice at Trajectory Health Partners, helping patients reverse steatotic liver disease through carbohydrate reduction and comprehensive metabolic care. Together, their research and real-world clinical experience are helping advance a deeper understanding of how targeting metabolic dysfunction may transform the way fatty liver disease is treated.Curious about the safety of ketogenic therapy? Visit our Is Keto Safe topic page to see all of our top content on the topic: https://www.metabolicmind.org/resources/topics/is-keto-safe/🔎 Have questions about how to apply metabolic therapies effectively? Submit them at metabolicmind.org/questions to be featured in a future Metabolic Mailbag episode.#MetabolicMind #KetogenicTherapy #MASLD #FattyLiverExpert Featured:Dr. Amy Miskimon Gosshttps://www.instagram.com/dr.amygoss/www.linkedin.comDr. Karen Jerome-ZapadkaTrajectoryhp.cominstagram.com/kzapadkahttps://www.linkedin.com/in/karen-jerome-zapadka-md-dabom-mhp-581b22113/Free CME Clinician Trainings:Are you a clinician who would like to learn more about the science behind these therapies and how to implement them in practice? Earn CME with our growing library of courses from some of the top experts in the field including Dr. Chris Palmer, Dr. Georgia Ede, Dr. Matthew Bernstein, Dr. Mariela Glandt, Dr. Deanna Kelly, Dr. Julie Milder, Dr. Zoltan Sarnyai, and Dr. Bret Scher with more coming soon.Our courses have been made FREE by grants from Baszucki Group, so we can spread these powerful therapies as widely as possible. Earn CME/CNE credits: https://www.metabolicmind.org/for-clinicians/trainings-courses/?utm_medium=organic-social&utm_source=youtube&utm_campaign=cme-ytFollow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.

A new meta-analysis of 174 randomized controlled trials on “carbohydrate-restricted diets” found consistent benefits for body composition, blood pressure, inflammation, and more. But instead of highlighting the metabolic benefits, most of the headlines focused almost entirely on a small bump in LDL.In this video, Dr. Bret Scher breaks down why that reaction misses the point and how biases in nutrition reporting are holding back real progress in improving metabolic health.📌In this video, you’ll learn:How the authors classified “carbohydrate-restricted diets”The many health benefits associated with restricting carbohydratesWhat impact low carbohydrate diets had on LDL levelsWhether or not we should sound the alarm on LDL increasesThe double standard in how we talk about diet vs. diabetes drugs that may produce increases in LDLWhat matters more than LDL alone when assessing metabolic riskWhether you're a patient or a practitioner, it’s essential to look beyond sensational headlines and focus on the full body of evidence, especially when it comes to nutrition and cardiovascular risk. Clear and balanced conversations are more important than ever if we want to turn the tide on metabolic disease.🔎 Have questions about how to apply metabolic therapies effectively? Submit them at metabolicmind.org/questions to be featured in a future Metabolic Mailbag episode.👉 Subscribe to Metabolic Mind to stay up-to-date on the latest in metabolic psychiatry, low-carb nutrition, and brain health: https://www.youtube.com/@metabolicmind.#MetabolicMind #KetogenicTherapy #MetabolicDiseaseExpert Featured:Dr. Bret ScherBaszucki Group Medical Directorhttps://x.com/bschermdResources Mentioned:Effects of carbohydrate-restricted diets and macronutrient replacements on cardiovascular health and body composition in adults: a meta-analysis of randomized trialshttps://doi.org/10.1016/j.ajcnut.2025.09.012Free CME Clinician Trainings:Are you a clinician who would like to learn more about the science behind these therapies and how to implement them in practice? Earn CME with our growing library of courses from some of the top experts in the field including Dr. Chris Palmer, Dr. Georgia Ede, Dr. Matthew Bernstein and Dr. Bret Scher with more coming soon.Our courses have been made FREE by grants from Baszucki Group, so we can spread these powerful therapies as widely as possible. Earn CME/CNE credits: https://www.metabolicmind.org/for-clinicians/trainings-courses/?utm_medium=organic-social&utm_source=youtube&utm_campaign=cme-ytFollow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.

Are there real contraindications to a ketogenic diet? Yes, but they’re far rarer than many people think. So who shouldn’t do keto?In this video, Dr. Bret Scher breaks down the difference between absolute and relative contraindications to ketogenic therapy. While rare inborn metabolic disorders and certain acute illnesses are true absolute contraindications, most commonly cited concerns, including type 1 or type 2 diabetes, heart disease, serious mental illness, high cholesterol, and even pregnancy are listed as relative contraindications, which really means, “use caution and work with an experienced clinician.”Watch to learn who should avoid ketogenic therapy, who may benefit, and why clinical guidance makes all the difference.👉To learn more about the safety and efficacy of ketogenic therapy, check out our “Is Keto Safe?” topic page: https://www.metabolicmind.org/resources/topics/is-keto-safe/🔎 Have questions about how to apply metabolic therapies effectively? Submit them at metabolicmind.org/questions to be featured in a future Metabolic Mailbag episode.#MetabolicMind #KetogenicTherapy #FoodAsMedicineExpert Featured:Dr. Bret ScherBaszucki Group Medical Directorhttps://x.com/bschermdResources Mentioned:Clinician Directorieshttps://www.metabolicmind.org/peers-families/get-help/Can a Keto Diet Cause Hypomania, and How Can It Be Avoided?https://www.youtube.com/watch?v=F11ZBvCjVNkFree CME Clinician Trainings:Are you a clinician who would like to learn more about the science behind these therapies and how to implement them in practice? Earn CME with our growing library of courses from some of the top experts in the field including Dr. Chris Palmer, Dr. Georgia Ede, Dr. Matthew Bernstein, Dr. Mariela Glandt, Dr. Deanna Kelly, Dr. Julie Milder, Dr. Zoltan Sarnyai, and Dr. Bret Scher with more coming soon.Our courses have been made FREE by grants from Baszucki Group, so we can spread these powerful therapies as widely as possible. Earn CME/CNE credits: https://www.metabolicmind.org/for-clinicians/trainings-courses/?utm_medium=organic-social&utm_source=youtube&utm_campaign=cme-ytFollow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.

Ketogenic therapy for schizophrenia, bipolar disorder, and depression is gaining attention, but how can it be safely implemented into clinical practice?A newly published expert consensus provides practical recommendations to help clinicians thoughtfully apply ketogenic metabolic therapy (KMT) for serious mental illnesses.In this in-depth conversation, Dr. Matt Bernstein and Dr. Georgia Ede, both members of the expert committee, discuss how this Delphi consensus was developed, what it includes, and how it can be responsibly integrated into psychiatric practice.In this interview, they discuss:What a Delphi process is and why it was usedThe results of the Delphi process (33 consensus statements and 10 clinical recommendations)Who may be appropriate candidates for KMTAbsolute and relative contraindicationsRecommended laboratory screening and monitoringHow long a trial should last before assessing efficacyHow clinicians can personalize implementation safelyImportantly, the authors emphasize that ketogenic metabolic therapy is not a replacement for standard psychiatric treatment. Rather, it may be considered alongside first-line therapies, particularly for individuals who have not responded adequately, cannot tolerate medications, or are seeking additional options.Reflecting on the value of this work, Dr. Bernstein shares:“I would have loved to have read this six years ago when I was starting to think about implementing these types of practices. It would have given me confidence to charge forward… I probably would have been further along now than I am.”With randomized controlled trials ongoing and more research expected in the coming years, this consensus provides a thoughtful, experience-informed framework for clinicians who are seeing growing interest in metabolic approaches.If you are a clinician, we encourage you to read the full publication.If you are a patient or family member, consider sharing this interview and the paper with your care team to support an informed discussion about whether metabolic strategies may be appropriate in your individual case.As always, clinical decisions should be made in partnership with qualified healthcare professionals.📚 Read the Paper: Published in Frontiers in Nutrition: https://doi.org/10.3389/fnut.2026.1749406🔎 Have questions about how to apply metabolic therapies effectively? Submit them at metabolicmind.org/questions to be featured in a future Metabolic Mailbag episode.Expert Featured:Dr. Georgia EdeHarvard-Trained Psychiatristhttps://www.diagnosisdiet.com/Dr. Matthew BernsteinCEO of Accord: https://accordmh.com/https://www.linkedin.com/in/matthew-bernstein-5743338/Dr. Bret ScherBaszucki Group Medical Directorhttps://x.com/bschermdResources Mentioned:Awareness and Best Practices in using Ketogenic Therapy to Treat Serious Mental Illness: A Modified Delphi Consensushttps://doi.org/10.3389/fnut.2026.1749406Ketogenic Diets for Mental Health Clinician Training Coursehttps://www.diagnosisdiet.com/trainingFree CME Clinician Trainings:Are you a clinician who would like to learn more about the science behind these therapies and how to implement them in practice? Earn CME with our growing library of courses from some of the top experts in the field including Dr. Chris Palmer, Dr. Georgia Ede, Dr. Matthew Bernstein, Dr. Mariela Glandt, Dr. Deanna Kelly, Dr. Julie Milder, Dr. Zoltan Sarnyai, and Dr. Bret Scher with more coming soon.Our courses have been made FREE by grants from Baszucki Group, so we can spread these powerful therapies as widely as possible. Earn CME/CNE credits: https://www.metabolicmind.org/for-clinicians/trainings-courses/?utm_medium=organic-social&utm_source=youtube&utm_campaign=cme-ytFollow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.

Is a low-carb diet bad for your health? A recent New York Times article suggests so, but it leaves out critical context about ketogenic metabolic therapy and the role of metabolic health in chronic disease.In this video, Dr. Bret Scher explains why balanced reporting on low-carbohydrate and ketogenic diets truly matters, especially for people with insulin resistance, type 2 diabetes, PCOS, fatty liver disease, and many psychiatric conditions. Ketosis isn’t simply “eating fewer carbs.” It’s a distinct metabolic state that shifts the body’s primary fuel source and has documented therapeutic benefits in multiple conditions.In this video, you’ll learn:What nutritional ketosis actually is, and how it differs from general healthy eatingWhy, for some individuals, carb quantity matters just as much as carb qualityThe clinical evidence supporting ketogenic therapy for diabetes, PCOS, fatty liver, epilepsy, and mental healthWhile it’s true that not everyone needs to follow a low-carb or ketogenic diet, dismissing it without a clinical perspective does a disservice to the many who could benefit.💡Interested in learning more about the safety and efficacy of ketogenic therapy? Check out our “Is Keto Safe?” topic page:https://www.metabolicmind.org/resources/topics/is-keto-safe/🔎 Have questions about how to apply metabolic therapies effectively? Submit them at metabolicmind.org/questions to be featured in a future Metabolic Mailbag episode.#MetabolicMind #KetogenicTherapy #FoodAsMedicineExpert Featured:Dr. Bret ScherBaszucki Group Medical Directorhttps://x.com/bschermdFree CME Clinician Trainings:Are you a clinician who would like to learn more about the science behind these therapies and how to implement them in practice? Earn CME with our growing library of courses from some of the top experts in the field including Dr. Chris Palmer, Dr. Georgia Ede, Dr. Matthew Bernstein, Dr. Mariela Glandt, Dr. Deanna Kelly, Dr. Julie Milder, Dr. Zoltan Sarnyai, and Dr. Bret Scher with more coming soon.Our courses have been made FREE by grants from Baszucki Group, so we can spread these powerful therapies as widely as possible. Earn CME/CNE credits: https://www.metabolicmind.org/for-clinicians/trainings-courses/?utm_medium=organic-social&utm_source=youtube&utm_campaign=cme-ytFollow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry.Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them.Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications.