Preserving muscle mass with antiobesity medications, investigating the relationship between sensor-detected hypoglycemia and patient-reported hypoglycemia, and more!

Welcome to episode no. 27 (December 2024) of Diabetes Care “On Air”—a new and different way to bring the research published in Diabetes Care to life. Join co-hosts Alice Cheng, MD, FRCPC, and Michael Rickels, MD, MS, as they discuss the latest and greatest content in the December 2024 issue of Diabetes Care and beyond. 0:40 2024 was a big year for diabetes research. With the year coming to a close, Mike and Alice discuss the highlights, including studies on the automated use of insulin during pregnancy and the arrival of weekly basal insulin. 2:00 Alice is joined by Fida Bacha, pediatric endocrinologist, professor of pediatrics at Baylor College of Medicine in Houston, Texas to discuss her study, “Pathophysiology and Treatment of Prediabetes and Type 2 Diabetes in Youth.” The article is available for free at doi.org/10.2337/dci24-0029. 19:40 Mike dives into a study entitled “Consensus Considerations and Good Practice Points for Use of Continuous Glucose Monitoring Systems in Hospital Settings.” He is joined by authors Julie Shaw, head of the Division of Biochemistry and associate professor at the Department of Pathology and Laboratory Medicine at the University of Ottawa, Jane Seley, clinical assistant professor of medicine at Weill Cornell Medicine, and Rebecca Longo, an assistant professor of medicine at the University of Massachusetts campus in Burlington. The article is available for free at doi.org/10.2337/dci24-0073. 39:20 In a special segment, Alice interviews the artist behind this month’s Diabetes Care cover. Hannah Wesley is a dentist, epidemiologist, and public health scientist at the Madras Diabetes Research Foundation in Chennai, India. Wesley’s artist profile is available for free at doi.org/10.2337/dci24-0088. 46:15 In the “Diabetes Care Rapid Exchange,” Alice and Mike wrap up the episode by reviewing several interesting articles in the December 2024 issue of Diabetes Care. Studies highlighted in this segment include: Berlanda et al. Impact of Syringe and Needle Reuse on the Clinical Outcomes of Patients With Type 2 Diabetes: A 12-Week Randomized Clinical Trial doi.org/10.2337/dc24-0157 Sun et al. Association of Insulin Resistance With Cardiovascular Disease and All-Cause Mortality in Type 1 Diabetes: Systematic Review and Meta-analysis doi.org/10.2337/dc24-0475 Lee et al. Efficacy and Feasibility of Intradialytic Plantar Electrical Stimulation in Patients With Diabetes: A Randomized Double-Blind Controlled Trial doi.org/10.2337/dc24-0928 Chaput et al. Sleep Irregularity and the Incidence of Type 2 Diabetes: A Device-Based Prospective Study in Adults doi.org/10.2337/dc24-1208 Gao et al. A Systematic Review and Meta-analysis on the Safety and Efficacy of Sodium–Glucose Cotransporter 2 Inhibitor Use in Hospitalized Patients doi.org/10.2337/dc24-0946 Renard et al. Efficacy and Safety of a Tubeless AID System Compared With Pump Therapy With CGM in the Treatment of Type 1 Diabetes in Adults With Suboptimal Glycemia: A Randomized, Parallel-Group Clinical Trial doi.org/10.2337/dc24-1550 To learn more about Diabetes Care, please visit diabetesjournals.org/care. Interested in submitting cover art to the journal? Please visit https://diabetesjournals.org/care/pages/submit_a_cover_image.

Welcome to episode no. 26 (November 2024) of Diabetes Care “On Air”—a new and different way to bring the research published in Diabetes Care to life. Join co-hosts Alice Cheng, MD, FRCPC, and Michael Rickels, MD, MS, as they discuss the latest and greatest content in the November 2024 issue of Diabetes Care and beyond. 0:40 In the spirit of Thanksgiving, Alice and Mike begin with a special offer from the ADA for new and renewing members: a 15% discount on a 1- or 2-year membership. Go to professional.diabetes.org/membership, create your account, fill out the application, and use the discount code ‘FALL24’ at checkout. Act fast because this offer expires November 30, 2024! 3:00 In a Diabetes Care “On Air” first, Michael interviews not a clinician, but a lawyer. Anthony May, a law partner at Brown, Goldstein, and Levy, LLP in Baltimore, MD, is the senior author of “Diabetes and Driving: A Statement of the American Diabetes Association.” This statement provides an overview of existing licensing rules for people with diabetes in the U.S., addresses the factors that affect driving ability, identifies general guidelines for assessing driver fitness and determining appropriately tailored licensing restrictions, and provides practical guidance for health care professionals regarding clinical interventions and education for people with diabetes. This review is available for free at doi.org/10.2337/dci24-0068. 16:15 Amy is joined by Dr. Daniel J. Drucker, endocrinologist and professor of medicine at the Lunenfeld-Tanenbaum Research Institute, Mt. Sinai Hospital, University of Toronto, and one of Time Magazine’s 100 most influential people of 2024. They discuss his review, “Efficacy and Safety of GLP-1 Medicines for Type 2 Diabetes and Obesity.” This article is available for free at doi.org/10.2337/dci24-0003. 30:45 In the “Diabetes Care Rapid Exchange,” Alice and Mike wrap up the episode by reviewing several interesting articles in the October 2024 issue of Diabetes Care. Studies highlighted in this segment include: Retnakaran et al. A Glycemic Threshold Above Which the Improvement of β-Cell Function and Glycemia in Response to Insulin Therapy Is Amplified in Early Type 2 Diabetes: The Reversal of Glucotoxicity doi.org/10.2337/dc24-1375 Yang et al. Maternal Glycemia During Pregnancy and Child Lung Function: A Prospective Cohort Study doi.org/10.2337/dc24-0865 Lim et al. Utilizing Continuous Glucose Monitoring for Early Detection of Gestational Diabetes and Pregnancy Outcomes in an Asian Population doi.org/10.2337/dc24-0944 Agarwal et al. The Supporting Emerging Adults With Diabetes (SEAD) Program: An Adult-Based Real-World Clinical Model That Improves Hospitalizations, Diabetes Technology Uptake, and Glycemic Outcomes in Underserved Young Adults With Type 1 Diabetes doi.org/10.2337/dc24-1346 Beunen et al. Advanced Hybrid Closed-Loop Therapy Compared With Standard Insulin Therapy Intrapartum and Early Postpartum in Women With Type 1 Diabetes: A Secondary Observational Analysis From the CRISTAL Randomized Controlled Trial doi.org/10.2337/dc24-1320 Htoo et al. Health Care Utilization and Costs Associated With Empagliflozin in Older Adults With Type 2 Diabetes doi.org/10.2337/dc24-0270 To learn more about Diabetes Care, please visit diabetesjournals.org/care. Interested in submitting cover art to the journal? Please visit https://diabetesjournals.org/care/pages/submit_a_cover_image.    

Welcome to episode no. 25 (October 2024) of Diabetes Care “On Air”—a new and different way to bring the research published in Diabetes Care to life. Join co-hosts Alice Cheng, MD, FRCPC, and Michael Rickels, MD, MS, as they discuss the latest and greatest content in the October 2024 issue of Diabetes Care and beyond.  0:40 Alice and Mike ring in Fall with a special offer from the ADA for new and renewing members: a 15% discount on a 1- or 2-year membership. Go to professional.diabetes.org/membership, create your account, fill out the application, and use the discount code ‘FALL24’ at checkout. Act fast because this offer expires November 30, 2024!  3:55 Alice interviews Dr. Bu B. Yeap, an endocrinologist and professor in the medical school at University of Western Australia in Perth, Australia. He is a corresponding author of “Incretin-Based Weight Loss Pharmacotherapy: Can Resistance Exercise Optimize Changes in Body Composition?” a narrative review which highlights the degree to which new antiobesity medications cause loss of lean mass, and the importance of resistance exercise in preserving muscle. The review is available at doi.org/10.2337/dci23-0100.  16:45 Mike welcomes Dr. Patrick Divilly, lead author of “Relationship Between Sensor-Detected Hypoglycemia and Patient-Reported Hypoglycemia in People With Type 1 and Insulin-Treated Type 2 Diabetes: The Hypo-METRICS Study.” This study is available at doi.org/10.2337/dc23-2332.  31:55 In the “Diabetes Care Rapid Exchange,” Alice and Mike wrap up the episode by reviewing several interesting articles in the October 2024 issue of Diabetes Care. Studies highlighted in this segment include:  Ye et al. Large-Scale Proteomics Improve Prediction of Chronic Kidney Disease in People With Diabetes. doi.org/10.2337/dc24-0290 Borel et al. Closed-Loop Insulin Therapy for People With Type 2 Diabetes Treated With an Insulin Pump: A 12-Week Multicenter, Open-Label Randomized, Controlled, Crossover Trial. doi.org/10.2337/dc24-0623  Atta et al. Associations of High BMI and Excessive Gestational Weight Gain With Pregnancy Outcomes in Women With Type 1 Diabetes: A Systematic Review and Meta-analysis doi.org/10.2337/dc24-0725  Yeh Lee et al. Empowering Hospitalized Patients With Diabetes: Implementation of a Hospital-wide CGM Policy With EHR-Integrated Validation for Dosing Insulin doi.org/10.2337/dc24-0626  Huang et al. Comprehensive Multiple Risk Factor Control in Type 2 Diabetes to Mitigate Heart Failure Risk: Insights From a Prospective Cohort Study doi.org/10.2337/dc24-0864  Dove et al. Diabetes, Prediabetes, and Brain Aging: The Role of Healthy Lifestyle https://doi.org/10.2337/dc24-0860  To learn more about Diabetes Care, please visit diabetesjournals.org/care. Interested in submitting cover art to the journal? Please visit https://diabetesjournals.org/care/pages/submit_a_cover_image.

Welcome to episode no. 24 (September 2024) of Diabetes Care “On Air”—a new and different way to bring the research published in Diabetes Care to life. Join co-hosts Alice Cheng, MD, FRCPC, and Michael Rickels, MD, MS, as they discuss the latest and greatest content in the September 2024 issue of Diabetes Care and beyond.  0:30 Alice and Mike begin by highlighting a special section of the September issue of Diabetes Care: the DCCT/EDIC 40th Anniversary Collection. This collection contains five original articles containing new research from DCCT/EDIC as well as a commentary and review on the history and importance of the DCCT/EDIC. This episode of Diabetes Care “On Air” features several of the researchers who have been involved in DCCT/EDIC as well as some of the individuals living with diabetes who have taken part in the studies. This article collection can be accessed at https://diabetesjournals.org/collection/2296/DCCT-EDIC-40th-Anniversary-Collection.  1:26: Alice kicks off the interviews by bringing on four individuals who she refers to as “very special guests”: Dr. Rose Gubitosi-Klug, Gayle Lorenzi, Pamela Curtin, and Bill King. Dr. Klug is the current chair of the DCCT/EDIC Research Group, and Gayle Lorenzi is the chair of the DCCT/EDIC Coordinators Committee and Community Health Project manager. Pamela Curtin and Bill King, as Alice says, “Represent arguably the most important people for this entire project.” They are individuals with diabetes who have participated in the study and have given their time, bodies, and minds to the pursuit of science and better care.  46:33: Mike talks to some of the authors of the five original articles of the DCCT/EDIC 40th anniversary collection that are featured in September’s issue: Drs. Barbara A. Blodi, Christine P. Limonte, Rodica Pop-Busui, and Naina Sinha Gregory. The articles can be accessed at https://diabetesjournals.org/collection/2296/DCCT-EDIC-40th-Anniversary-Collection.  1:22:03: In the “Diabetes Care Rapid Exchange,” Alice and Mike wrap up the episode by reviewing several interesting articles in the September 2024 issue of Diabetes Care. Studies highlighted in this segment include: Yland et al. Perinatal Outcomes Associated With Metformin Use During Pregnancy in Women With Pregestational Type 2 Diabetes Mellitus. https://doi.org/10.2337/dc23-2056     Feig et al. Long-term Neurobehavioral and Metabolic Outcomes in Offspring of Mothers With Diabetes During Pregnancy: A Large, Population-Based Cohort Study in Ontario, Canada. https://doi.org/10.2337/dc24-0108       Bjornstad et al. Dulaglutide and Glomerular Hyperfiltration, Proteinuria, and Albuminuria in Youth With Type 2 Diabetes: Post Hoc Analysis of the AWARD-PEDS Study. https://doi.org/10.2337/dc24-0322      Johansson et al. Rational Pharmacotherapy in Type 2 Diabetes: Danish Data From 2002 to 2020 on Mortality, Diabetes-Related Outcomes, Adverse Events, and Medication Expenses. https://doi.org/10.2337/dc24-0619     Bismuth et al. Sustained 3-Year Improvement of Glucose Control With Hybrid Closed Loop in Children With Type 1 Diabetes While Going Through Puberty. https://doi.org/10.2337/dc24-0916 Kianersi et al. Association Between Accelerometer-Measured Irregular Sleep Duration and Type 2 Diabetes Risk: A Prospective Cohort Study in the UK Biobank. https://doi.org/10.2337/dc24-0213        To learn more about Diabetes Care, please visit diabetesjournals.org/care. Interested in submitting cover art to the journal? Please visit https://diabetesjournals.org/care/pages/submit_a_cover_image.

Welcome to a very special, all-new episode (no. 23) of Diabetes Care “On Air.” While this podcast usually focuses exclusively on the research published in each month’s issue of Diabetes Care, this unique episode focuses on the incredible scholarly content of the 84th Scientific Sessions, which took place 21–24 June in Orlando, FL. Diabetes Care “On Air” co-hosts Alice Cheng, MD, FRCPC, and Michael Rickels, MD, MS, hosted a panel discussion with Kirk Habegger, PhD, Darleen Sandoval, PhD, and Kevin Williams, PhD, who co-host DiabetesBio, as well as Neil Skolnik, MD, co-host of Diabetes Core Update and Diabetes Day by Day. This episode is being released on three of our professional podcasts: Diabetes Care “On Air,” DiabetesBio, and Diabetes Core Update. This special episode is supported by an independent educational grant from Bayer.  This wide-ranging discussion begins with introductions and brief descriptions of the various podcasts, and then the panelists highlight their favorite sessions and events from the 84th Scientific Sessions---the new, high-impact research presented at the meeting, implications for future research, and clinical considerations and take-aways---across the “bench-to-bedside” spectrum of biomedical research, clinical research, and treatment advances. (Please note that anyone who registered for the event can still access the recorded content at ada2024.org until August 26.)    To learn more about Diabetes Care, please visit diabetesjournals.org/care. Interested in submitting cover art to the journal? Please visit https://diabetesjournals.org/care/pages/submit_a_cover_image.

Welcome to episode no. 22 (August 2024) of Diabetes Care “On Air”—a new and different way to bring the research published in Diabetes Care to life. Join co-hosts Alice Cheng, MD, FRCPC, and Michael Rickels, MD, MS, as they discuss the latest and greatest content in the August 2024 issue of Diabetes Care.  0:42 Alice opens the show by reminding listeners that August 26 is the last day to access the online sessions from the 84th Scientific Sessions, which took place 21–24 June in Orlando, FL. Anyone who has registered can access the content at ada2024.org, so don’t forget to check it out! 1:26: Mike hosts the first interview of the episode, with Dr. Anastasia Albanese-O’Neill and Dr. Linda A. DiMeglio, corresponding author and last author, respectively, of “Consensus Guidance for Monitoring Individuals With Islet Autoantibody–Positive Pre-Stage 3 Type 1 Diabetes.” This consensus report is an editor-selected feature article appearing in the August 2024 issue and is openly accessible at https://doi.org/10.2337/dci24-0042. 28:37: Alice’s initial guest is Dr. Guillermo E. Umpierrez, first author of “Hyperglycemic Crises in Adults With Diabetes: A Consensus Report.” This consensus report is also an editor-selected feature article in the August 2024 issue and is openly accessible at https://doi.org/10.2337/dci24-0032. 52:19: In the “Diabetes Care Rapid Exchange,” Alice and Mike wrap up the episode by reviewing several interesting articles in the August 2024 issue of Diabetes Care. Studies highlighted in this segment include: Daultrey et al. What Is the Influence of HIV Serostatus on HbA1c? A Prospective Analysis Using Continuous Glucose Monitoring. https://doi.org/10.2337/dc24-0225  Durnwald et al. Continuous Glucose Monitoring Profiles in Pregnancies With and Without Gestational Diabetes Mellitus. https://doi.org/10.2337/dc23-2149 Ghalwash et al. Data-Driven Phenotyping of Presymptomatic Type 1 Diabetes Using Longitudinal Autoantibody Profiles. https://doi.org/10.2337/dc24-0198 Hessler et al. EMBARK: A Randomized, Controlled Trial Comparing Three Approaches to Reducing Diabetes Distress and Improving HbA1c in Adults With Type 1 Diabetes. https://doi.org/10.2337/dc23-2452 Kahn et al. Effect of Semaglutide on Regression and Progression of Glycemia in People With Overweight or Obesity but Without Diabetes in the SELECT Trial. https://doi.org/10.2337/dc24-0491 Lingvay et al. Semaglutide and Cardiovascular Outcomes by Baseline HbA1c and Change in HbA1c in People With Overweight or Obesity but Without Diabetes in SELECT. https://doi.org/10.2337/dc24-0764 Green et al. The Final Frontier in Diabetes Care: Implementing Research in Real-World Practice. https://doi.org/10.2337/dci24-0001 To learn more about Diabetes Care, please visit diabetesjournals.org/care. Interested in submitting cover art to the journal? Please visit https://diabetesjournals.org/care/pages/submit_a_cover_image.  

Welcome to episode no. 21 (July 2024) of Diabetes Care “On Air”—a new and different way to bring the research published in Diabetes Care to life. Join co-hosts Alice Cheng, MD, FRCPC, and Michael Rickels, MD, MS, as they discuss the latest and greatest content in the July 2024 issue of Diabetes Care.  0:42 Mike and Alice open the show by talking about the spectacularly successful 84th Scientific Sessions, which took place 21–24 June in Orlando, FL. Mike shares his enjoyment of various symposia on clinical trial results, scientific award lectures, and even the basic science sessions. Alice, chair of the planning committee for the Scientific Sessions, thanks her fellow members on the planning committee and describes her number one problem with the event: deciding which session to attend!  3:56: Alice begins the interview portion of the show by hosting Dr. David Sacks, lead author on the review “Point-of-Care HbA1c in Clinical Practice: Caveats and Considerations for Optimal Use.” This review is an editor-selected feature article appearing in the July 2024 issue and is openly accessible at https://doi.org/10.2337/dci23-0040.  18:53: Mike talks to Dr. Coco M. Fuhri Snethlage, first author of “Residual β-Cell Function Is Associated With Longer Time in Range in Individuals With Type 1 Diabetes.” This study is also an editor-selected feature article in the July 2024 issue and is openly accessible at https://doi.org/10.2337/dc23-0776.  28:47: In the “Diabetes Care Rapid Exchange,” Alice and Mike wrap up the episode by reviewing several interesting articles in the July 2024 issue of Diabetes Care. Studies highlighted in this segment include: Daniele et al. β-Cell Function, Incretin Effect, and Glucose Kinetics in Response to a Mixed Meal in Patients With Type 2 Diabetes Treated With Dapagliflozin Plus Saxagliptin. https://doi.org/10.2337/dc23-2051 Spaur et al. Association of Water Arsenic With Incident Diabetes in U.S. Adults: The Multi-Ethnic Study of Atherosclerosis and the Strong Heart Study. https://doi.org/10.2337/dc23-2231    Zhao et al. Hypoglycemic Response to Dorzagliatin in a Patient With GCK-MODY. https://doi.org/10.2337/dc23-2417     Fortmann et al. Medical Assistant Health Coaching for Type 2 Diabetes in Primary Care: Results From a Pragmatic Cluster Randomized Controlled Trial. https://doi.org/10.2337/dc23-2487  Bilal et al. Impaired Awareness of Hypoglycemia in Older Adults With Type 1 Diabetes: A Post Hoc Analysis of the WISDM Study. https://doi.org/10.2337/dc24-0201 Bratke et al. Ten Years of Improving Glycemic Control in Pediatric Diabetes Care: Data From the Norwegian Childhood Diabetes Registry. https://doi.org/10.2337/dc24-0086      To learn more about Diabetes Care, please visit diabetesjournals.org/care. Interested in submitting cover art to the journal? Please visit https://diabetesjournals.org/care/pages/submit_a_cover_image.  

Welcome to episode no. 20 (June 2024) of Diabetes Care “On Air”—a new and different way to bring the research published in Diabetes Care to life. Join co-hosts Alice Cheng, MD, FRCPC, and Michael Rickels, MD, MS, as they discuss the latest and greatest content in the June 2024 issue of Diabetes Care. 1:20 Alice and Mike begin by talking about some of the many great things that will happen at the ADA’s 84th Scientific Sessions, which will take place 21–24 June in Orlando, FL.  4:11: Mike kicks off the interviews by bringing on Drs. Jennifer L. Sherr and Jeremy Pettus, first and last authors, respectively, of “Severe Hypoglycemia and Impaired Awareness of Hypoglycemia Persist in People With Type 1 Diabetes Despite Use of Diabetes Technology: Results From a Cross-sectional Survey.” This study is an editor-selected feature article appearing in the June 2024 issue and is openly accessible at https://doi.org/10.2337/dc23-1765.  17:32: Alice interviews Dr. Elizabeth Selvin, author of a Perspectives in Care called “The Glucose Management Indicator: Time to Change Course?” This study is also an editor-selected feature article in the June 2024 issue and is openly accessible at https://doi.org/10.2337/dci23-0086.  30:45: In the “Diabetes Care Rapid Exchange,” Alice and Mike wrap up the episode by reviewing several interesting articles in the June 2024 issue of Diabetes Care. Studies highlighted in this segment include: Singh et al. Association of Continued Use of SGLT2 Inhibitors From the Ambulatory to Inpatient Setting With Hospital Outcomes in Patients With Diabetes: A Nationwide Cohort Study. https://doi.org/10.2337/dc23-1129    Voglová Hagerf et al. Accuracy and Feasibility of Real-time Continuous Glucose Monitoring in Critically Ill Patients After Abdominal Surgery and Solid Organ Transplantation. https://doi.org/10.2337/dc23-1663    Barmanray et al. The Specialist Treatment of Inpatients: Caring for Diabetes in Surgery (STOIC-D Surgery) Trial: A Randomized Controlled Trial of Early Intervention With an Electronic Specialist-Led Model of Diabetes Care. https://doi.org/10.2337/dc23-1905     Yang et al. Type 1 Diabetes Genetic Risk in 109,954 Veterans With Adult-Onset Diabetes: The Million Veteran Program (MVP). https://doi.org/10.2337/dc23-1927        Scheuer et al. Trends in Incidence of Hospitalization for Hypoglycemia and Diabetic Ketoacidosis in Individuals With Type 1 or Type 2 Diabetes With and Without Severe Mental Illness in Denmark From 1996 to 2020: A Nationwide Study. https://doi.org/10.2337/dc23-2394 Kwak et al. Time-to-Event Genome-Wide Association Study for Incident Cardiovascular Disease in People With Type 2 Diabetes. https://doi.org/10.2337/dc23-2274       To learn more about Diabetes Care, please visit diabetesjournals.org/care. Interested in submitting cover art to the journal? Please visit https://diabetesjournals.org/care/pages/submit_a_cover_image.

Welcome to episode no. 19 (May 2024) of Diabetes Care “On Air”—a new and different way to bring the research published in Diabetes Care to life. Join co-hosts Alice Cheng, MD, FRCPC, and Michael Rickels, MD, MS, as they discuss the latest and greatest content in the May 2024 issue of Diabetes Care.  2:00: Alice gets things going by bringing on Valerie K. Sullivan, first author of “Plant-Based Dietary Patterns and Incident Diabetes in the Atherosclerosis Risk in Communities (ARIC) Study.” Dr. Sullivan and her colleagues examined the association between plant-based dietary patterns and diabetes in a sample of Black and White adults. This study is an editor-selected feature article appearing in the May 2024 issue and is openly accessible at https://doi.org/10.2337/dc23-2013.  17:35: Mike interviews Stephen I. Stone, lead author of “Atypical Diabetes: What Have We Learned and What Does the Future Hold?” Dr. Stone’s group investigated several forms of atypical diabetes and outlined genetic and clinical resources for examining patients with atypical diabetes.  This study is an editor-selected feature article appearing in the May 2024 issue and is openly accessible at https://doi.org/10.2337/dci23-0038.  35:55: Alice talks to the creator of the May issue cover art, Abby Gregg. A write-up of the artist by Benjamin Page is openly accessible at https://doi.org/10.2337/dci24-0027.  38:10: In the “Diabetes Care Rapid Exchange,” Alice and Mike wrap up the episode by reviewing several interesting articles in the May 2024 issue of Diabetes Care. Studies highlighted in this segment include: Zhao et al. LHLA Class II (DR, DQ, DP) Genes Were Separately Associated With the Progression From Seroconversion to Onset of Type 1 Diabetes Among Participants in Two Diabetes Prevention Trials (DPT-1 and TN07). https://doi.org/10.2337/dc23-1947  Sugimoto et al. Impact of Type 2 Diabetes and Glycated Hemoglobin Levels Within the Recommended Target Range on Mortality in Older Adults With Cognitive Impairment Receiving Care at a Memory Clinic: NCGG-STORIES. https://doi.org/10.2337/dc23-2324  Cahill et al. Haptoglobin Phenotype and Intensive Glycemic Control for Coronary Artery Disease Risk Reduction in People With Type 2 Diabetes: The ADVANCE Study. https://doi.org/10.2337/dc23-2165    Tan et al. Socioeconomic Deprivation and the Risk of Sight-Threatening Diabetic Retinopathy: A Population-Based Cohort Study in the U.K. https://doi.org/10.2337/dc23-1626  Sherr et al. Exploring Factors That Influence Postexercise Glycemia in Youth With Type 1 Diabetes in the Real World: The Type 1 Diabetes Exercise Initiative Pediatric (T1DEXIP) Study. https://doi.org/10.2337/dc23-2212    Sabag et al. Timing of Moderate to Vigorous Physical Activity, Mortality, Cardiovascular Disease, and Microvascular Disease in Adults With Obesity. https://doi.org/10.2337/dc23-2448     To learn more about Diabetes Care, please visit diabetesjournals.org/care. Interested in submitting cover art to the journal? Please visit https://diabetesjournals.org/care/pages/submit_a_cover_image.

Welcome to episode no. 18 (April 2024) of Diabetes Care “On Air”—a new and different way to bring the research published in Diabetes Care to life. Join co-hosts Alice Cheng, MD, FRCPC, and Michael Rickels, MD, MS, as they discuss the latest and greatest content in the April 2024 issue of Diabetes Care.  Notably, this episode is a more expansive journey than usual. Dive in at your own pace—segment by segment— or all at once. You can find time stamps for each segment in the notes below.  Mike and Alice begin the show by announcing that the April episode will be unlike any episode of Diabetes Care “On Air” that they’ve done. This month, they focus on a Special Collection of articles in the April issue of Diabetes Care. This collection features 10 articles from the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE) as well as a commentary on these articles. The full collection is openly accessible at https://diabetesjournals.org/collection/2066/Reports-from-the-GRADE-Study.   2:06: Mike and Alice begin the deep dive into the GRADE articles by bringing in David M. Nathan, chair of the steering committee for the GRADE study. They are then joined by Jennifer B. Green, a member of the GRADE Research Group and an associate editor of Diabetes Care.  9:56: After David M. Nathan and Jennifer B. Green give an overview and synopsis of the collection of GRADE articles, Alice brings in Matthew C. Riddle, former editor in chief of Diabetes Care and author of a commentary on the GRADE articles, to get his general impression of and insights into the GRADE collection. Dr. Riddle’s commentary on the GRADE collection is openly available at https://doi.org/10.2337/dci24-0008.  As the discussion continues, the speakers touch on each of the 10 articles of the Special Collection in the April issue of Diabetes Care. The following is a list of all the articles in the collection as well as the commentary, along with links to where these articles can be found (all are openly available).  Riddle. Individualizing treatment of type 2 diabetes after metformin: more insights from GRADE. https://doi.org/10.2337/dci24-0008  Gonzalez et al. Differential effects of type 2 diabetes treatment regimens on diabetes distress and depressive symptoms in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE). https://doi.org/10.2337/dc23-2459  Garvey et al. Association of baseline factors with glycemic outcomes in GRADE: a comparative effectiveness randomized clinical trial. https://doi.org/10.2337/dc23-1782  Banerji et al. Mortality in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE). https://doi.org/10.2337/dc23-1356  Cherrington et al. Does emotional distress predict worse glycemic control over time? Results from the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE). https://doi.org/10.2337/dc23-0642 Hoogendoorn et al. Emotional distress predicts reduced type 2 diabetes treatment adherence in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE). https://doi.org/10.2337/dc23-1401 Rasouli et al. Longitudinal effects of glucose-lowering medications on β-cell responses and insulin sensitivity in type 2 diabetes: the GRADE randomized clinical trial. https://doi.org/10.2337/dc23-1070 Kirkman et al. Comparative effects of randomized second-line therapy for type 2 diabetes on a composite outcome incorporating glycemic control, body weight, and hypoglycemia: an analysis of the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE). https://doi.org/10.2337/dc23-1332 Utzschneider et al. Impact of insulin sensitivity and β-cell function over time on glycemic outcomes in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE): differential treatment effects of dual therapy. https://doi.org/10.2337/dc23-1059 Cherrington et al. Impact of glucose-lowering medications on health-related quality of life in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE). https://doi.org/10.2337/dc23-1648 Hollander et al. The use of rescue insulin in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE). https://doi.org/10.2337/dc23-0516 42:50: Alice directs our attention to another kind of special article available in Diabetes Care, a Profile in Progress on none other than Dr. David M. Nathan. Alice chats with the author of the Profile, Deborah Wexler. Her piece, which Alice notes is “beautifully written,” is openly available at https://doi.org/10.2337/dci23-0095. 48:14: Mike and Alice are once again joined by David M. Nathan, this time for a discussion of his remarkable and extensive career as well as his dedication to advancing the understanding and treatment of diabetes.  1:10:00: In the “Diabetes Care Rapid Exchange,” Alice and Mike wrap up the episode by reviewing several interesting articles in the April 2024 issue of Diabetes Care. Studies highlighted in this segment include:  Birukov et al. Lifetime Duration of Breastfeeding and Cardiovascular Risk in Women With Type 2 Diabetes or a History of Gestational Diabetes: Findings From Two Large Prospective Cohorts. https://doi.org/10.2337/dc23-1494 Al Rifai et al. Epidemiology and Prognostic Implications of Coronary Artery Calcium in Asymptomatic Individuals With Prediabetes: A Multicohort Study. https://doi.org/10.2337/dc23-1864 Sattar et al. Cardiovascular and Kidney Risks in Individuals With Type 2 Diabetes: Contemporary Understanding With Greater Emphasis on Excess Adiposity. https://doi.org/10.2337/dci23-0041 Foss-Freitas et al. Efficacy and Safety of Glucagon-Like Peptide 1 Agonists in a Retrospective Study of Patients With Familial Partial Lipodystrophy. https://doi.org/10.2337/dc23-1614     Al-Sofiani et al. A Real-World Prospective Study of the Effectiveness and Safety of Automated Insulin Delivery Compared With Other Modalities of Type 1 Diabetes Treatment During Ramadan Intermittent Fasting. https://doi.org/10.2337/dc23-1968   Abdelgani et al. Empagliflozin Reduces Liver Fat in Individuals With and Without Diabetes. https://doi.org/10.2337/dc23-1646    To learn more about Diabetes Care, please visit diabetesjournals.org/care. Interested in submitting cover art to the journal? Please visit https://diabetesjournals.org/care/pages/submit_a_cover_image.