Comparative Effectiveness of Tocilizumab vs Rituximab in Rheumatoid Arthritis-Associated Interstitial Lung Disease: An Emulated Target Trial

James Cheng Chung Wei, MD, PhD, and Po-Cheng Shih, MD, join CHEST® Journal Podcast Moderator Alice Gallo De Moraes, MD, FCCP, to discuss their research into the comparative effectiveness and safety of tocilizumab and rituximab in patients with rheumatoid arthritis-associated interstitial lung disease.   DOI: 10.1016/j.chest.2025.09.009 Disclaimer: The purpose of this activity is to expand the reach of CHEST content through awareness, critique, and discussion. All articles have undergone peer review for methodologic rigor and audience relevance. Any views asserted are those of the speakers and are not endorsed by CHEST. Listeners should be aware that speakers’ opinions may vary and are advised to read the full corresponding journal article(s) for complete context. This content should not be used as a basis for medical advice or treatment, nor should it substitute the judgment used by clinicians in the practice of evidence-based medicine.  

CHEST February 2026, Volume 169, Issue 2       CHEST® journal's Editor in Chief Peter Mazzone, MD, MPH, FCCP, highlights key research published in the journal CHEST February 2026 issue, including an examination of the association between culture conversion and mortality in patients with Mycobacterium abscessus complex pulmonary disease, an investigation of the comparative effectiveness of tocilizumab vs rituximab in rheumatoid arthritis-associated interstitial lung disease, and more.     Moderator:    Peter Mazzone, MD, MPH, FCCP

Hemang Yadav, MBBS, joins CHEST® Journal Podcast Moderator Alice Gallo De Moraes, MD, FCCP, to discuss his research into the magnitude and determinants of diffusing capacity for carbon monoxide intersession variability in routine clinical practice and evidence-based thresholds that can guide interpretation of serial measurements. DOI: 10.1016/j.chest.2025.09.006 Disclaimer: The purpose of this activity is to expand the reach of CHEST content through awareness, critique, and discussion. All articles have undergone peer review for methodologic rigor and audience relevance. Any views asserted are those of the speakers and are not endorsed by CHEST. Listeners should be aware that speakers’ opinions may vary and are advised to read the full corresponding journal article(s) for complete context. This content should not be used as a basis for medical advice or treatment, nor should it substitute the judgment used by clinicians in the practice of evidence-based medicine.  

Karen J. Wernli, PhD, joins CHEST® Journal Podcast Moderator Gretchen Winter, MD, to discuss her research into additional health communication to improve patient knowledge of lung cancer screening timeliness.  DOI: 10.1016/j.chest.2025.07.4111 Disclaimer: The purpose of this activity is to expand the reach of CHEST content through awareness, critique, and discussion. All articles have undergone peer review for methodologic rigor and audience relevance. Any views asserted are those of the speakers and are not endorsed by CHEST. Listeners should be aware that speakers’ opinions may vary and are advised to read the full corresponding journal article(s) for complete context. This content should not be used as a basis for medical advice or treatment, nor should it substitute the judgment used by clinicians in the practice of evidence-based medicine.       Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under Award Number R01CA262015. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. 

Originally aired: January 28, 2026   Avraham Z. Cooper, MD, joins CHEST® Journal Podcast Moderator Abhishek Bhardwaj, MD, to discuss his Exhalations article, “The Mountain,” and explore his relationship with his late father, a physician with a photographic memory, and how his complicated relationship with his father’s legacy has inspired him to become the physician that he is today. This episode is part of a new series exploring articles published in the journal's Humanities section.   Moderator:  Abhishek Bhardwaj, MD 

Bettia Celestin, MD, and Francois Haddad, MD, join CHEST® Journal Podcast Moderator Matt Siuba, DO, MS, to discuss their research into the reliability of a fully automated deep learning workflow in echocardiography when assessing pulmonary hypertension.  DOI: 10.1016/j.chest.2025.06.052 Disclaimer: The purpose of this activity is to expand the reach of CHEST content through awareness, critique, and discussion. All articles have undergone peer review for methodologic rigor and audience relevance. Any views asserted are those of the speakers and are not endorsed by CHEST. Listeners should be aware that speakers’ opinions may vary and are advised to read the full corresponding journal article(s) for complete context. This content should not be used as a basis for medical advice or treatment, nor should it substitute the judgment used by clinicians in the practice of evidence-based medicine. 

CHEST January 2026, Volume 169, Issue 1       CHEST® journal's Editor in Chief Peter Mazzone, MD, MPH, FCCP, highlights key research published in the journal CHEST January 2026 issue, including an exploration of intermittent asthma and risk of severe exacerbation in children, an examination of the use of ceftriaxone to prevent early-onset pneumonia in patients following out-of-hospital cardiac arrest, and more.       Moderator:    Peter Mazzone, MD, MPH, FCCP

CHEST December 2025, Volume 168, Issue 6       CHEST® journal's Editor in Chief Peter Mazzone, MD, MPH, FCCP, highlights key research published in the journal CHEST December 2025 issue, including an exploration of the relationship between inflammation and mucociliary clearance in chronic respiratory conditions, an investigation into the association of hypoxic burden with major cardiovascular events, and more.       Moderator:    Peter Mazzone, MD, MPH, FCCP

Kristen R. Mathias, MD, MHS, joins CHEST® Journal Podcast Moderator Gretchen Winter, MD, to discuss her research into the ways patients with sarcoidosis describe their experiences with the disease, how they are impacted by uncertainty around sarcoidosis management, and the challenges they face in receiving care.   DOI: 10.1016/j.chest.2025.06.025 Disclaimer: The purpose of this activity is to expand the reach of CHEST content through awareness, critique, and discussion. All articles have undergone peer review for methodologic rigor and audience relevance. Any views asserted are those of the speakers and are not endorsed by CHEST. Listeners should be aware that speakers’ opinions may vary and are advised to read the full corresponding journal article(s) for complete context. This content should not be used as a basis for medical advice or treatment, nor should it substitute the judgment used by clinicians in the practice of evidence-based medicine. 

Gina M. Piscitello, MD, and Katrina E. Hauschildt, PhD, BCPA, join CHEST® Journal Podcast Moderator Gretchen Winter, MD, to discuss their research into the ways that and extent to which hospital policies influence clinician approaches to decisions to withhold or withdraw life-sustaining treatment among patients admitted to an ICU.  DOI: 10.1016/j.chest.2025.06.036 Disclaimer: The purpose of this activity is to expand the reach of CHEST content through awareness, critique, and discussion. All articles have undergone peer review for methodologic rigor and audience relevance. Any views asserted are those of the speakers and are not endorsed by CHEST. Listeners should be aware that speakers’ opinions may vary and are advised to read the full corresponding journal article(s) for complete context. This content should not be used as a basis for medical advice or treatment, nor should it substitute the judgment used by clinicians in the practice of evidence-based medicine.