#32 Terpenes vs. Esters: Discovering Cannabis Compounds with Dr. Jordan Zager

We can read all of the scientific research studies in the world, but ultimately, we must learn to trust our own intuitive teacher when working with cannabis and plant medicines. Meagan Pilawski, a nurse and cannabis ceremony facilitator, shares her journey using cannabis to treat her own autoimmune disease, multiple sclerosis. In this episode, we discuss how cannabis and other psychedelic medicines can help us heal, not just by mitigating the symptoms of illness but also by guiding us to look at the root cause.  Meagan shares how she used her scientific training as well her intuition to design her own cannabis treatment regimen, how to intentionally use cannabis through ceremony, and how we can use plants and entheogens to help us heal.    Donate to our Indigogo Campaign for Season 5: https://www.indiegogo.com/projects/psychedelic-science-for-the-people-season-5/x/36089786#/

Microdosing psychedelics (i.e. taking a fraction of a dose of psilocybin or LSD) is gaining popularity as an alternative medicine for depression, anxiety, and ADHD. What are the benefits? Does it really work? And is it safe in the long term? Dr. Peter Grinspoon, a primary care physician and educator at Massachusetts General Hospital, shares his insight on some of the scientific studies about microdosing. We discuss the power of the placebo effect, the philosophy of ego annihilation, and the differences between microdosing and macro dosing. Finally, he gives some guidance on how to microdose safely if you choose to engage in this practice.   Donate to our Indigogo Campaign for Season 5: https://www.indiegogo.com/projects/psychedelic-science-for-the-people-season-5/x/36089786#/ Dr. Grinspoon's Article in Harvard Health: https://www.health.harvard.edu/blog/the-popularity-of-microdosing-of-psychedelics-what-does-the-science-say-202209192819 Studies Mentioned: https://www.nature.com/articles/s41398-022-02039-0 https://pubmed.ncbi.nlm.nih.gov/35773270/

Looking to taper off opiates or other pharmaceutical medications? Or seeking guidance on cannabis dosing? Colleen Higgins, a registered pharmacist and the author of The Cannabis Prescription: How to Use Medical Marijuana to Reduce or Replace Pharmaceutical Medications, is here to help. We talk about effective ways to use cannabis to reduce dependency on pharmaceutical medicine, as well as how patients can find their perfect dosing of THC, CBD, and CBN. Colleen discusses how cannabis can help patients suffering from chronic pain and shares how cannabis can slow the progression of inflammatory illnesses like Alzheimer’s and Parkinson’s. Colleen’s website and training modules: https://elevatethecannabisexperience.com/about/ Colleen’s Book https://www.amazon.com/Cannabis-Prescription-Marijuana-Pharmaceutical-Medications/dp/1734003448/ref=cm_cr_arp_d_product_top?ie=UTF8    

Thirty percent of patients with treatment-resistant depression attempt suicide at least once during their lifetime. Can a psychoactive tea brew from the Amazon help? Dr. Fernanda Palhano-Fontes, a neuroscientist and research engineer in Brazil, reveals the results of a randomized controlled trial examining the impact of Ayahuasca on suicidality. Dr. Fontes and her team have conducted a number of studies testing the effects of this Amazonian brew on humans using FMRI techniques. She explains exactly what is happening to the brain when someone takes Ayahuasca, discussing everything from the default mode network to Shannon entropy to neurotrophic factors. Finally, she shares why this medicine may be a lifesaver for people with treatment-resistant depression. Dr. Fontes' papers: https://scholar.google.com/citations?user=WmhroXIAAAAJ&hl=en Playlists during clinical trials: https://open.spotify.com/playlist/5wAyiC2RvBpbZUZeLMERza?si=cH5BAoSlROiTnQZ8TJRzFw   https://open.spotify.com/playlist/6sRsIxM4oNEpCPSFDQxAJB?si=eZVAiiMxSNmoOAs8cie9uA  

The Beatles, Steve Jobs, and Bob Dylan are just a few innovators who credited the hallucinogenic LSD (aka Lysergic acid diethylamide) for their creative breakthroughs. The lab results are catching up. Dr. Isabel Wießner led Brazil’s first double-blind, placebo-controlled study to test the effects of LSD on humans. In this episode, she reveals the effects of LSD on consciousness, thinking, creativity, and cognition. We discuss what differentiates an LSD session from being a blip of psychosis to a healing therapeutic experience, and she shares why LSD shows promise in treating conditions involving memory and language decline such as brain injury, stroke, or dementia.

Magic mushrooms or Lexapro? What about Magic Mushrooms + Lexapro? As psychedelics gain momentum as a potential treatment option for PTSD and depression, these questions are at the forefront. Dr. Ben Malcom, a clinical psychiatric pharmacist, shares the latest research on potential drug-drug-interactions between common psychiatric medications, such SSRIS, and psychedelics, like MDMA and psilocybin. We talk about serotonin sickness, risks associated with using isolated DMT, and best practices for using psychedelics safely and consciously. Dr. Malcom lives up to his name as the “Spirit Pharmacist,” and is a rare person who can explain exactly what is happening to our brain chemistry when we take psychedelics, while simultaneously honoring the profound spiritual shifts that these medicines can give us. Dr. Malcom’s Website: https://www.spiritpharmacist.com/    

Curious about cannabis sexual enhancement oils? Are CBD vaginal suppositories safe? Pam Miles and Dr. Cindy Orser, the visionaries behind Apothercare Advocacy and Research, share what they have learned from testing the safety and efficacy of over 30 intimate care products, some of which contain THC and CBD. We discuss how cannabis suppositories, sexual enhancement products, and washes and douches affect the vaginal microbiome. They offer some important warnings about these products and share promising (although not quite proven) research about the potential application of cannabis compounds, like CBD, to be used for various women’s health issues, like pelvic pain, candida, and Bacterial Vaginosis.   Episode Links: https://apothercare.com/about-us Study on Gut Microbiota: https://www.cell.com/current-biology/fulltext/S0960-9822(22)01750-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS096098222201750X%3Fshowall%3Dtrue#%20   List of drugs that contain SLS : https://www.drugs.com/inactive/sodium-lauryl-sulfate-124.

Oregon became the first state to decriminalize psilocybin in 2020 and many other states are expected to follow suit. Dr. Kevin Boehnke, a Research Investigator in the Department of Anesthesiology at the University of Michigan, shares his research on the therapeutic uses of cannabis for chronic pain and discusses his latest paper, “Applying Lessons from Cannabis to the Psychedelic Highway.”  As we look back on this past decade of cannabis legalization, what can we learn and how can we avoid repeating the same mistakes? We talk about whether the Western medical system is ready for psychedelics and he shares ideas for developing safety-oriented policies, collecting data systematically, and making this medicine accessible.  Leave us a review on Apple Podcasts* to win free CBD products from Millie! *(I say iTunes but I mean Apple Podcasts!) Here is how: https://agriculturalgenomics.org/podcast/How-to-Leave-a-Review.pdf Dr. Boehnke’s Article: “Applying Lessons From Cannabis to the Psychedelic Highway” https://pubmed.ncbi.nlm.nih.gov/36219016/ NYT Article: “Taking the Magic out of Magic Mushrooms”: https://www.nytimes.com/2022/07/15/opinion/hallucinations-psychedelics-depression.html  

Step aside, terpenes!  Dr. Jordan Zager, a biochemist and the founder of Dewey Scientific, shares some cutting-edge research about other volatile compounds found in cannabis. He explains that lesser-known compounds, such as esters, may be  responsible for the fruity flavor and aroma found in certain strains. Dr. Zager also shares what he learned from a research project comparing the chemotype data and the gene expression data of nine different commercial cannabis strains. Finally, he talks the latest breeding projects he is working on at Dewey Scientific.    Learn more about Dr. Zager’s work here: https://www.deweyscientific.com/  Want to enter our giveaway and win CBD Products from Millie? Here is how to leave a 5-star review on iTunes.   https://agriculturalgenomics.org/podcast/How-to-Leave-a-Review.pdf     

You’re probably already familiar with Delta-9 THC, which is the primary cannabinoid in the cannabis plant known for its psychoactive effects. But what’s going on with Delta-8 THC? In this episode, Dr. Eric Leas, from the University of California San Diego's School of Public Health, discusses the differences between Delta-9 and Delta-8 THC and a loophole in the Farm Bill that has led to a growing, unregulated market for Delta-8. We discuss the risks associated with this market and he shares some ideas on revisiting regulations at the federal and state level to protect consumers.  Links: Interview with Eric Streenstra, the founder of Vote Hemp: https://diagonventures.com/cannabis/hemp-versus-cannabis/ NYT article on Delta-8:  https://www.nytimes.com/2022/07/01/well/mind/delta-8-thc-marijuana.html Learn more about Dr. Eric Leas:  https://profiles.ucsd.edu/eric.leas