The Science Behind Memory - Dr. Charan Ranganath : 1152

Today on The Human Upgrade, Dr. Anurag Singh, a renowned expert in muscle biology and aging, shares his expertise on the impact of GLP-1 agonists like Ozempic and Wegovy on weight loss, muscle health, and aging. In this episode, you'll learn about the science behind these popular drugs, their potential benefits, and the risks involved. Discover how you can maintain muscle mass while losing weight, enhance your mitochondrial function for better health, and what the future holds for medical treatments in weight management. Gain expert insights into making smart choices for your long-term health and wellness, whether you're considering these treatments or just curious about new health technologies. Timestamped Highlights: (00:00:00) Introduction to GLP-1 agonists and their popularity in weight loss. (00:01:40) Guest introduction: Dr. Anurag Singh's expertise and background. (00:02:50) Dr. Singh discusses the primary functions and uses of GLP-1 drugs. (00:06:23) The significant muscle loss associated with GLP-1 drug use. (00:10:01) Addressing common misconceptions and concerns about GLP-1 agonists. (00:15:34) How GLP-1 agonists affect mitochondrial function and overall metabolism. (00:20:30) Comparing the effects of fasting to GLP-1 drugs on weight loss and muscle preservation. (00:28:43) New testing methods for mitochondrial function and their implications. (00:35:00) Potential future directions in GLP-1 treatment and muscle preservation strategies. (00:41:48) The concept of 'Ozempic face' and its effects on personal appearance and self-esteem. (00:50:04) Discussion on 'Urolithin A' and its role in mitochondrial health and muscle strength. (01:04:02) Predictions for the next innovations in weight loss and muscle health treatments. Resources: Vitamin Dake | www.VitaminDAKE.com Dave Asprey’s Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Follow Dave on Instagram: @Dave.Asprey Follow The Human Upgrade: @TheHumanUpgradePodcast Want to join The Human Upgrade Podcast Live? Join Our Upgrade Collective: https://www.ourupgradecollective.com/ Sponsors: STEMREGEN | Go to www.STEMREGEN.CO/DAVE for 20% Off Timeline Nutrition | Go to www.TimelineNutrition.com/Dave for an exclusive discount.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today's episode focuses on Cancer with a true expert, Mark Lintern. You'll learn about the surprising links between infections, inflammation, and our body's powerhouses - the mitochondria. This is a chance to arm yourself with cutting-edge theories that could change the way we treat cancer. Simple changes in treatment perspectives might be the key to unlocking new ways to tackle cancer and by the end of this episode, you'll have a fresh arsenal of knowledge to rethink cancer's causes and solutions. This is an eye-opening discussion that promises to transform the way we approach this formidable disease. Timestamp Highlights: (00:00:01) Introduction to a new theory about cancer (00:01:08) The interplay between mitochondrial dysfunction and genetic factors (00:02:08) Evaluating cancer from a citizen scientist's perspective (00:03:15) Challenging mainstream cancer narratives with personal research (00:07:49) How biases affect cancer research and therapy development (00:09:40) Exploring the Warburg effect in cancer metabolism (00:23:05) Investigating pathogens as a potential trigger for the Warburg effect (00:27:18) Fungal connections to chronic disease and cancer (00:35:32) How pathogens and inflammation contribute to cancer's growth (00:37:37) Importance of addressing inflammation and fungal infections in cancer (00:43:32) Estrogen's role in cancer promotion (00:47:10) The connection between methyl deficiency and cancer (00:49:17) Metformin's dual role in blood sugar regulation and antifungal activity (00:50:01) Wrapping up the conversation with final insights  Sponsors: ARRC LED | For More Information Visit www.ARRCLED.COM EnVy | Upgrade your sleep and skin health now at www.enVyPillow.com, use code DAVE10 at checkout.  Resources:  https://www.cellsuppression.com/ Help Mark advance his research: https://www.gofundme.com/f/help-mark-lintern-advance-cancer-treatment Website - www.cellsuppression.com Book - The Cancer Resolution Follow Yes To Life: @YesToLifeCharity Donate to Yes To Life: https://yestolife.org.uk/ Dave Asprey’s Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Follow Dave on Instagram: @Dave.Asprey Follow The Human Upgrade: @TheHumanUpgradePodcast Moldy Movie: www.MoldyMovie.com Want to join The Human Upgrade Podcast Live? Join Our Upgrade Collective: https://www.ourupgradecollective.com/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Get ready for a journey that takes you beyond the pain of heartbreak and into a world where loss transforms into growth with science journalist Florence Williams, who shares her personal triumph over the heartbreak of divorce, which inspired her to write a book on the subject. This episode sheds light on how heartbreak reshapes our bodies and minds. You'll gain valuable tactics for emotional healing, understand the crucial role of touch in regaining trust, and see how therapeutic practices like EMDR and rituals can offer relief. For those on the mend or helping others heal, this discussion is packed with practical advice to help you transform the trials of heartbreak into a journey of empowerment. This episode provides clear steps to recover and emerge stronger from life's emotional challenges. Timestamp Highlights (00:02:26) Florence Williams’ Journey Through Divorce (00:07:42) Divorce as a Story of Inflammation (00:13:43) Rebuilding Connection Post-Heartbreak (00:18:02) Embracing Beauty and Awe in Healing (00:23:22) Therapeutic Use of Psychedelics in Overcoming Heartbreak (00:34:33) Reestablishing Trust After Betrayal (00:38:04) The Healing Power of Touch and Oxytocin (00:44:51) Safe Relationships and Self-Discovery Post-Divorce (00:50:33) Journaling as a Tool for Processing Emotions Sponsors ARMRA | Go to https://www.TryARMRA.com and use code Dave for 15% off BEAM Minerals | Go to www.Beam Minerals.com/Dave2024 for 20% off your first order. Resources Get your copy of ‘Heartbreak’ by Florence Williams: https://www.florencewilliams.com/books-2 Florence Williams website: https://www.florencewilliams.com/ Follow Florence Williams: @Florence999 Dave Asprey’s Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Follow Dave on Instagram: @Dave.Asprey Follow The Human Upgrade: @TheHumanUpgradePodcast See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Managing your stress effectively and building resilience just got easier with Dr. Aditi Nerurkar's guidance on The Human Upgrade. This episode tackles 'toxic resilience,' revealing its impacts on health and well-being. You'll gain insights into the HPA axis—the body's command center for stress response—and learn practical techniques to turn stress into a growth tool. Dr. Aditi introduces the 'Rule of Two,' a simple yet powerful approach to adapting to stress and shows how neuroplasticity can retrain your brain for better stress management. You'll also discover tips for setting digital boundaries, fostering gratitude, managing a full email inbox, and understanding the connections between stress management and longevity. It's all about taking actionable steps toward a more resilient, empowered life.Timestamp Highlights:(00:01:21) - The Pressures of the Pandemic and the Surge in Stress (00:02:08) - Introducing Dr. Aditi Nerurkar and Her Journey Through Burnout (00:05:06) - The Concept of 'Toxic Resilience' and Sustainable Stress Management (00:10:16) - The Physiological Responses to Stress and the HPA Axis (00:12:12) - Transforming Stress from Maladaptive to Adaptive (00:17:16) - The Importance of Understanding Personal Stress Thresholds (00:21:06) - Empowering Change and Managing Internal Alerts (00:25:15) - The 'Rule of Two' in Stress Adaptation (00:32:21) - The Role of Neuroplasticity in Resilience (00:37:13) - Combining Conventional Medicine with Stress Management Techniques (00:39:29) - How Dr. Nerurkar Achieves an 'Inbox Zero' Lifestyle (00:40:59) - The Connection Between Stress Management and Longevity Sponsors Pendulum | Get 20% off membership at https://pendulumlife.com with code Asprey20 Timeline Nutrition | Go to https://www.timeline.com/dave and get 10% off your first order.  Resources Get your copy of ‘The 5 Resets’ by Dr. Aditi Nerurkar Follow Dr. Aditi on Instagram: @draditinerurkar Dave Asprey’s Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Follow Dave on Instagram: @Dave.Asprey See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this special Asprey Archive episode you’ll learn that while yes, testosterone fuels energy and performance, it’s not the be-all and end-all solution for men’s health woes. A systems biology approach considers many other aspects and provides a broader perspective about what’s going on with you.This conversation features board-certified urologist Tracy Gapin, M.D. He joined us in 2022 for this episode to discuss new ways for men to improve their health and performance. He uses epigenetic coaching, hormones, peptide therapy, biometric monitoring, and unique nutrition and lifestyle interventions.In his book, “Male 2.0™: Cracking the Code to Limitless Health and Vitality,” he says medical school, residency training and even a two-decade career in urology and surgery specialties didn’t teach him how to get to root causes of men’s issues and solve them. He had a health crash of his own at 42. Since neither he nor his doctor had good answers, he went on a quest of discovery and change. He founded the Gapin Institute for High Performance Medicine and created the proprietary N1 Performance Health Program to go beyond conventional options.This conversation goes even further into what creates epigenetic signals that affect the function and expression of your genes. You’ll learn, too, that your mindset, stress and environment—and how you do or don’t control those things—have everything to do with your energy and focus. If you’re aiming for higher performance, Dr. Tracy suggests a trifecta that makes sleep a priority, builds resilience to stress, and creates consistent behaviors with intention.Sponsors:EnVy | Go to https://www.envypillow.com/ and use code DAVE10 at checkout for an exclusive discount.Resources:Dave Asprey’s Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Website: Gapin Institute for High Performance MedicineInstagram: @DrTracyGapinInstagram: @Dave.AspreyYouTube: @DaveAspreyBPRSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In today’s episode you’ll explore the complexities of memory with Dr. Charan Ranganath, a top expert in cognitive neuroscience. This episode takes you through the fascinating ways our brains record, process, and utilize memories to navigate daily life and shape our futures. You’ll learn how memory impacts decision-making, the truth about common myths, and the role of groundbreaking research in our understanding of cognitive function. Dr. Ranganath shares insights from his book "Why We Remember," shedding light on the brain's ability to predict and prepare for what comes next. Whether you're a seasoned biohacker or just starting, this conversation offers valuable perspectives on the science of memory that will change how you think about your mind.Timestamp highlights (00:01:03) The Role of Memory in Shaping Our Reality (00:04:51) The Truth about Remembering and Forgetting (00:12:27) Psychedelics, Plasticity, and the Future of Memory Research (00:16:32) The Ethics of Memory Enhancement (00:21:10) Harnessing Memory for Predicting the Future (00:29:17) How Memory Evolves with Age (00:33:27) The Power of Pattern Recognition in Human Intelligence (00:38:34) Debunking Memory Myths with Dr. Ranganath (00:40:54) The Role of Diet and Lifestyle in Memory Preservation (00:50:18) What 'Spider Sense' Says About Our Predictive Brains (00:55:10) Building a Life of Meaningful Memories (00:59:42) How Long Would You Want to Live if Your Memory Stayed Intact? Sponsors Sunlighten | Head to Sunlighten.com/dave to save up to $600 STEMREGEN | Go to STEMREGEN.co/Dave for 20% off  Resources Get your copy of 'Why We Remember' by Dr. Charan Ranganath Dave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Follow Dr. Ranganath on Instagram: @TheMemoryDoc See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Join Dave Asprey for a fascinating discussion with Colleen Cutcliffe, Ph.D., on leveraging the power of GLP-1 for natural weight management and overall well-being. Discover how probiotics can naturally stimulate GLP-1 production in the body, helping reduce food cravings and maintain a healthy gut lining. We delve into the differences between pharmaceuticals and natural probiotics, the importance of GLP-1 for longevity, and practical tips for optimizing your microbiome health. Whether you're battling cravings or seeking to prevent diabetes and its associated risks, this episode sheds light on natural, effective strategies for a healthier life. Timestamp Highlights: (00:00:01) Introduction to GLP-1 and weight management (00:01:06) Colleen Cutcliffe, PhD, on natural ways to stimulate GLP-1 (00:04:41) The role of microbiome in regulating GLP-1 and cravings (00:16:00) The GLP-1 probiotic: benefits beyond weight loss (00:34:13) Dietary interventions to support GLP-1 probiotics (00:42:23) Personal experiences and results with GLP-1 probiotics (00:51:01) The different pendulum products and who should take them (00:59:23) How GLP-1 probiotics impact the gut lining and overall health (01:03:56) GLP-1 and its connection to longevity and disease prevention Sponsors: Pendulum | Get 20% off membership at https://pendulumlife.com with code Asprey20 ARMRA | Go to https://www.TryARMRA.com and use code Dave for 15% off ARRC LED | For More Information Visit ARRCLED.com Resources: Dave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books  Instagram: @Dave.Asprey Pendulum GLP-1 Probiotics: https://pendulumlife.com (Code: Asprey20 for 20% off) Instagram: @pendulumlifecoSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today you'll step inside the real world of fame with Ramon Hervey II, the mastermind manager behind iconic figures like Vanessa Williams, Bette Midler, and Richard Pryor. He is author of "The Fame Game: An Insider's Playbook for Earning Your 15 Minutes." With years of experience guiding celebrity journeys, Ramon dismantles the myths surrounding fame and success. In this episode, he shares invaluable insights on why pouring your heart into your work and letting excellence lead is more fulfilling and enduring than the pursuit of fame. Ramon, a Master of Media and public perception, brings a wealth of knowledge from his time shaping the narratives of household names. Get ready to redefine your ambitions and align your pursuits with the values that truly matter. You’ll step beyond the veneer of fame into a world where your achievements stand the test of time. (00:00:06) Introduction to the complexities of fame (00:01:06) Ramon's correction and insights into the unpredictability of fame (00:04:04) The statistical rarity of becoming famous (00:06:03) The truth behind fabricating fame in the entertainment industry (00:09:18) The importance of authenticity and integrity (00:21:54) Ramon's experience with the toxic side of fame (00:29:32) The gratitude for positive fan interactions (00:32:13) Ramon's advice for influencers on handling fame (00:41:19) How industries can shift and impact your fame (00:42:27) Dave's creation of the biohacking movement (00:48:41) The strategic management of public image and fame (00:52:10) The dangers of seeking fame for fame's sake (00:58:55) The misuse of fame and its consequences (01:07:13) The role of media and public perception (01:14:04) Ramon's take on fame as currency and liability (01:20:22) The Tenets of Fame - managing fame without destruction Sponsors: Timeline Nutrition | Go to https://www.timeline.com/dave and get 10% off your first order 40 Years of Zen | Go to https://www.40YearsOfZen.com/Dave for an exclusive offer.Resources: Dave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books Website: www.herveyandcompany.com IG - @trichemon FB - Ramon Hervey II Twitter: @coolramon See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today you’ll learn about female hormones: what they are, what they do, and what disrupts them. You’ll learn about the hormonal shifts that happen at different ages and life stages and get tips on how to balance hormones and make them work for you, not against you.This conversation features Anna Cabeca, D.O.. Dr. Anna is a Doctor of Osteopathy who’s triple-board certified in gynecology and obstetrics, integrative medicine, and anti-aging and regenerative medicine. She has additional certifications in functional medicine, sexual health, and bioidentical hormone replacement therapy. She joins this special preview episode to talk about female hormones. It’s her particular area of expertise and one of The Human Upgrade’s all-time Top 10 podcast topics. Today’s hormone discussion includes:How hormone disruptors go beyond stress to mold, and product and environmental toxinsHow estrogen levels change over timeWhat’s going on with progesterone, pregnenolone and DHEA, tooWhat happens to hormones during perimenopause and menopauseWhat’s causing brain fogWhat to know about bioidentical hormonesHow detoxing affects hormonesHow to keep your vaginal microbiome balancedHow “food as medicine” helps balance hormonesHow hormones influence longevityAnd much more!For the past 20 years, Dr. Anna's educated and helped women with their hormones through her private practice, books, online videos and articles. Learn more about her work with women’s hormone health:“MenuPause: Five Unique Eating Plans to Break Through Your Weight Loss Plateau and Improve Mood, Sleep, and Hot Flashes”“The Hormone Fix: Burn Fat Naturally, Boost Energy, and Stop Hot Flashes the Keto-Green™️ Way”“Keto-Green™️ 16”Sponsors:Quantum Upgrade | Go to https://quantumupgrade.io/dave for a 7-day Free TrailNeurohacker Senolytic | https://Neurohacker.com/Dave to get 15% off.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if you could catch cancer in its earliest stages, when it's most treatable—would you seize that chance? Our guest today is Dr. Josh Ofman, the president of GRAIL, and he's pioneering early cancer detection in a revolutionary new way. You'll discover the cutting-edge advances in multi-cancer early detection that are transforming the fight against this swift and silent killer. You'll also learn about the full potential of the GRAIL gallery test in your proactive health management. This technology is ushering in a new era in cancer care but also signals a paradigm shift in disease prevention. Learn why yearly screenings are your best strategy in the race against cancer. Prepare to dive deep into how the latest biotech innovations could significantly extend your life span!Timestamp Highlights (00:01:03) An Unsettling Trend in Cancer Proliferation  (00:04:51) Introducing Dr. Josh Ofman and the GRAIL Test  (00:12:27) The Revolutionary Approach of Multi-Cancer Early Detection  (00:16:32) The Shift to Biological Signals in Cancer Detection  (00:21:10) The Empowering Aspect of Knowing Your Cancer Status  (00:29:17) How GRAIL's Gallery Test Can Change the Paradigm of Cancer Treatment  (00:33:27) The Critical Nature of Annual Cancer Screening  (00:38:34) How Early Detection Affects Treatment Options and Survival  (00:40:54) The Future of GRAIL in Other Disease Pathways  (00:50:18) Combating Fear and Misconceptions Around Cancer  (00:55:10) The Impact of Socioeconomic Factors on Cancer Incidence  (00:59:42) The Pivotal Role of Data in Personalized Health Sponsors  ARRC LED | The perfect device for daily home use. For more information visit arrcled.com. Leela Quantum | Visit www.LeelaQ.com/Dave for 10% Off Resources  Dave Asprey’s NEW Book ‘Smarter Not Harder’: daveasprey.com/books  GRAIL Multi-Cancer Early Detection Test: Visit www.Galleri.com/Dave to see if you’re eligible for a $50 off limited-time online-only offer. GRAIL Research and Studies: grail.com/clinical-studies GRAIL on  Twitter: @GRAILbio See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.