Josh Duhamel on Nootropics, Peptides, and Testosterone at 53 : 1537

**Visit https://www.gatlan.com/ and use cod ‘DAVE’ to unlock a free consultation!**At 53, Josh Duhamel says he feels better than he did in his 30s. Host Dave Asprey sits down with actor and Gatlan Health founder Josh Duhamel to talk testosterone, peptides, nootropics, brain health, fatherhood, and what it takes to stay strong as you age. Josh shares why he started TRT in his early 40s, what changed once he began tracking his hormones, and why he decided to build a health company around hormone optimization. They also discuss injectable testosterone, GLP-1s, peptide quality, hair loss treatments, stem cells, and the importance of medical guidance when experimenting with longevity tools. The conversation also gets into cognitive performance, including Josh's past struggles with forgetting lines, his interest in nootropics, and Dave's experience with Modafinil and Aniracetam. Josh explains why having a newborn and a toddler at 53 has made longevity more personal, while Dave and Josh explore the connection between physical health, spirituality, breathwork, psychedelics, and mental performance. This is essential listening for anyone interested in testosterone, TRT, peptides, nootropics, brain health, GLP-1s, healthy aging, fatherhood, hormone optimization, and longevity. You'll Learn: Why Josh started testosterone therapy in his early 40s How TRT changed his energy, strength, joints, and motivation Why testosterone levels should be individualized How injectable, oral, and topical testosterone differ Why peptide sourcing matters How GLP-1s can affect muscle and body composition What Josh has tried for hair loss Why brain performance became a major concern for him Which nootropics come up for memory, focus, and mental stamina Why becoming a father later in life changed how Josh thinks about longevity How breathwork, psychedelics, and spirituality fit into the conversation Thank you to our sponsors!      - Omni-Biotic | Discover your formula at OmnibioticLife.com. Take 20% off your first order with code ASPREY. - MOD | Visit mod.com for a consultation and get 10% off your first order plus free shipping with promo code DAVE. - Timeline | Visit timeline.com/dave and get up to 20% off when you subscribe and save. - Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Josh Duhamel, Gatlan Health, testosterone therapy, TRT, low testosterone, hormone optimization, injectable testosterone, testosterone cream, oral testosterone, peptides, peptide therapy, GLP-1, healthy aging, longevity, nootropics, Modafinil, Aniracetam, Dihexa, brain health, cognitive performance, hair loss, stem cells, fatherhood, men over 50, energy, muscle, strength, bloodwork, hormone testing, psychedelics, breathwork, spirituality Resources:    • Visit https://www.gatlan.com/ and use cod ‘DAVE’ to unlock a free consultation • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/   • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.    • Danger Coffee: https://dangercoffee.com/discount/davetube • My Daily Supplements: SuppGrade Labs (15% Off)     • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)     Timestamps:  00:00 – Trailer 01:15 – Intro 07:16 – Alcohol & Hangover Hacks 13:24 – Spirituality & Health 19:36 – Hormone Therapy for Women 24:45 – Inside Gatlan's Model 30:35 – Potty Training Secrets 38:39 – North Dakota & Fargo 43:57 – Hollywood's Beauty Secrets 50:19 – Acting Career & Longevity See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Carolina Reis de Oliveira on Reversing Skin Age, Menopause, GLP-1 Skin, and the Science of Senescent Cells Your skin is likely biologically older than you are, but new research suggests some of that aging may be reversible. **For Dave’s listeners only, visit oneskin.co/Dave  for exclusive early access to the OS-01 Face Rich Cream!**Host Dave Asprey sits down with Carolina Reis de Oliveira, PhD, CEO and co-founder of OneSkin. Carolina holds a PhD in stem cell biology and tissue engineering, is a co-inventor of five patents, and has co-authored numerous scientific publications. She and her team are studying skin longevity by targeting one of the central drivers of aging: the accumulation of senescent cells.  They break down why skin loses its ability to hold water as you age, and why that process can accelerate dramatically during perimenopause and menopause. Carolina explains the skin's "brick and mortar" barrier system, how declining estrogen affects collagen, ceramides, cholesterol, hyaluronic acid, and elastin, and why simply sealing moisture into your skin with occlusive products does not solve the underlying biology. They also explore why GLP-1 users can experience loose or sagging skin after rapid weight loss and what may help preserve skin structure over time. Carolina reveals how her team screened hundreds of peptides to develop OS-01, a senomorphic peptide designed to reduce the damaging signals produced by senescent "zombie" cells while supporting healthier skin function. In their research, OS-01 reduced markers of cellular senescence and inflammation, increased collagen production, and was associated with a 2.5-year reduction in measured biological skin age. She also explains why more peptides are not necessarily better, why some GHK-Cu formulations may fail to perform, and why peptide stability, concentration, delivery, and formulation matter. The conversation also covers why the skin around your eyes may biologically age decades faster than your cheeks, whether topical collagen really works, why cholesterol is essential for a healthy skin barrier, how over-moisturizing and "slugging" can backfire, and how damaged skin may contribute to systemic inflammation. Carolina also shares clinical data on OneSkin's new OS-01 Rich moisturizer, including improvements in hydration, firmness, fine lines, wrinkles, collagen, hyaluronic acid, and elastin. This is essential listening for anyone serious about skin longevity, anti-aging, menopause, GLP-1 weight loss, collagen, senescent cells, peptides, biological age testing, inflammation, hydration, hair and skin health, and maintaining younger-looking skin as you age. You'll Learn: -Why menopause can rapidly accelerate dry, thin, and crepey skin -How your skin's natural barrier holds water and why it breaks down with age -Why GLP-1 weight loss can make loose and sagging skin more noticeable -How senescent "zombie" cells accelerate inflammation and collagen loss -How OS-01 was associated with a 2.5-year reduction in biological skin age -Why skin around your eyes may be biologically much older than skin on your cheeks -Why topical collagen is different from collagen amino acids and collagen-producing signals -How cholesterol, ceramides, fatty acids, and hyaluronic acid support skin hydration -Why some GHK-Cu peptide products may not perform as expected -How over-moisturizing, face masks, Vaseline, and "slugging" can disrupt the skin barrier -How scientists measure the biological age of skin with epigenetic clocks -Why healthier skin may help lower inflammation throughout the body  Thank you to our sponsors!      - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh - Calroy | Go to calroy.com/dave for your discount. - Puori | Use code DAVE at puori.com/DAVE to get 32% off your first Puori CP1 Pure Collagen order when you start a subscription. You save more than $26. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Carolina Reis de Oliveira, OneSkin, OS-01, skin longevity, skin biological age, skin age reversal, senescent cells, zombie cells, menopause skin, perimenopause skin, GLP-1 weight loss, loose skin, crepey skin, skin hydration, skin barrier, collagen production, hyaluronic acid, elastin, ceramides, cholesterol skin, GHK-Cu, copper peptide, peptides, epigenetic skin clock, MoClock, fine lines, wrinkles, skin firmness, slugging, topical collagen Resources:    • OneSkin | Get Early Access To OS-01 Rich Cream: oneskin.co/Dave   • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/   • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.    • Danger Coffee: https://dangercoffee.com/discount/davetube • My Daily Supplements: SuppGrade Labs (15% Off)     • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)     Timestamps:  00:00 — Trailer 01:33 — Meet Carolina & OneSkin 04:31 — Skin Hydration Decline 11:46 — How the Peptide Hydrates Skin 18:20 — Zombie Cells Explained 23:32 — Discovering Peptide OS-01 32:44 — Measuring Biological Skin Age 39:00 — Skincare Philosophy for Men 43:32 — Body Lotion & Inflammation 50:09 — New Rich Cream Data See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Try TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/discount/davetubeTry Suppgrade Labs: https://shopsuppgradelabs.com/Try Longevity Gummies: https://www.timeline.com/partners/dave-aspreyThis video walks you through the complete biological timeline of a 36-hour sugar fast, from insulin dropping and liver glycogen draining to fat burning, ketone production, lower inflammation, and sharper mental clarity. You’ll see how quickly your metabolism can start switching back to the fuel system it was built to use.Thank you to our sponsors!Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thighBrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power BundleiRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE00:00 – Sugar's Deadly Toll01:31 – Insulin's Hidden Damage02:52 – The Glycogen Reserve04:12 – Liver Fuel Runs Low05:29 – Reversing Insulin Resistance07:30 – Brain's Fuel Problem07:53 – Ketones: Backup Fuel09:24 – The Hormonal Reset10:46 – Visible Physical ChangesConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Sea Squirt Plasmalogens Show Brain And Aging Benefits In Old Mice Aged mice given purified plasmalogen supplements showed better memory performance, healthier synaptic structure, lower neuroinflammation, and increased signaling tied to neurite growth and synapse development, with treated mice even growing thicker, darker, glossier hair. Plasmalogens are specialized lipids concentrated in cell membranes and the brain that tend to decline with age and neurodegenerative disease, making them an intriguing target for cognitive longevity. Host Dave Asprey breaks down why membrane composition matters for brain signaling, mitochondrial function, and inflammation, while stressing that this remains mouse research from 2022 and does not mean eating sea squirts or taking an unproven plasmalogen supplement will reproduce the same effects in humans. Sources: https://www.sciencedaily.com/releases/2026/09/260902234518.htm https://doi.org/10.3389/fmolb.2022.815320 ~~ Apple Watch Series 12 Adds More HRV Data, Readiness Scoring, And Health Age Apple Watch Series 12 pushes deeper into health tracking with heart rate measurements every five seconds, substantially more frequent HRV sampling, a new daily Readiness score, and a Longevity section in the Health app featuring Health Age. Apple is also expanding its health ecosystem with daytime vitals, movement assessments, menopause tracking, and Quest Diagnostics lab ordering for more than fifty biomarkers. Host Dave Asprey explains why higher-frequency wearable data can become useful for spotting changes in stress, recovery, sleep, and illness, but warns against letting algorithmic scores override your own baseline, symptoms, and real-world performance. Source: https://www.apple.com/newsroom/2026/09/introducing-apple-watch-series-12-with-the-all-new-health-sensing-system/ ~~ FDA Moves To Accelerate Botanical Drug Development The FDA has opened a formal request for input on how to accelerate botanical drug development, including better clinical trial designs, stronger quality standards, improved standardization of complex plant mixtures, and expanded use of real-world evidence. The agency is also working with the European Medicines Agency on regulatory considerations for herbal and botanical medicines, potentially creating a clearer path for standardized plant-derived therapies to move beyond vague supplement claims and into more rigorous clinical testing. Host Dave Asprey breaks down why this could strengthen the evidence behind compounds like berberine, saffron, medicinal mushrooms, and flavanols, while also warning that more pharmaceutical-style regulation could increase costs and reduce access. Source: https://www.healthmanagement.com/insights/weekly-roundup-v2/september-9-2026/ ~~ Persistent Adolescent Cannabis Use Linked To Long-Term IQ And Cognitive Decline A long-running New Zealand birth cohort found that people with persistent cannabis dependence beginning in adolescence showed significant cognitive decline by age thirty-eight, including losses in IQ, memory, processing speed, attention, and executive function. The most persistent users showed an average decline of roughly eight IQ points, while adult-onset users did not show the same pattern, pointing toward adolescence as a potentially important developmental vulnerability window. Host Dave Asprey explains why this 2012 observational study cannot prove cannabis caused every cognitive change, but argues that dose, frequency, age of exposure, and brain development all matter when evaluating cannabis for performance, health, or therapeutic use. Source: https://pmc.ncbi.nlm.nih.gov/articles/PMC3479587/ ~~ Pterostilbene Helps Mouse Muscle Cells Burn More Fat Through PPAR-Delta Researchers testing pterostilbene, a polyphenol found in blueberries and grapes, found that it reduced intracellular fat accumulation and increased fatty acid oxidation in cultured mouse muscle cells. Rather than directly activating PPAR-delta, pterostilbene appeared to slow its breakdown, leaving more of the protein available to regulate genes involved in fat metabolism and potentially offering a new mechanistic target for myosteatosis and metabolic dysfunction. Host Dave Asprey explains why the PPAR-delta mechanism is interesting for metabolic health, but draws a clear line between promising cell research and human outcomes, emphasizing that resistance training, walking, muscle mass, and mitochondrial health still have far stronger evidence than taking blueberry extracts to reduce muscle fat. Sources: https://www.sciencedaily.com/releases/2026/09/260903064219.htm https://doi.org/10.1016/j.fbio.2026.109519 https://www.reddit.com/r/Biohackers/comments/1w8flq4/compound_in_blueberries_may_help_muscle_cells/ ~~ This episode is designed for biohackers, longevity enthusiasts, and high-performance listeners who want emerging research on brain aging, wearables, botanical medicine, cannabis, metabolic health, and supplements translated into what matters for human biology. Host Dave Asprey separates promising mechanisms from premature hype and explains how to evaluate new health research through the lens of evidence quality, dose, biological context, and measurable outcomes. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: plasmalogens aging, plasmalogens brain health, sea squirt plasmalogens, cognitive longevity, neuroinflammation, synaptic health, Apple Watch Series 12, Apple Watch HRV, Apple Watch Readiness score, Apple Health Age, biological age tracking, wearable health data, Quest Diagnostics Apple Health, FDA botanical drugs, botanical medicine regulation, standardized botanical extracts, berberine research, medicinal mushrooms, cannabis IQ decline, adolescent cannabis brain development, cannabis cognitive decline, marijuana memory, pterostilbene fat metabolism, pterostilbene PPAR delta, blueberries metabolism, intramuscular fat, myosteatosis, metabolic flexibility, longevity news 2026, biohacking news 2026 Thank you to our sponsors!  - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh - Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount. - iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE Resources:   • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  • Danger Coffee: https://dangercoffee.com/discount/dave15   • My Daily Supplements: SuppGrade Labs (15% Off)   • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)   • Dave Asprey’s BEYOND Conference: https://beyondconference.com   • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated  • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com   Timestamps: 00:00 – Intro 00:24 – Sea Squirt Anti-Aging Lipids 01:39 – Apple Watch Series 12 03:38 – FDA Botanical Drug Push 05:25 – Cannabis & Brain Health 06:47 – Blueberry Fat Metabolism 08:33 – Takeaway See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Dr. Karan Rajan on Fiber Fermentation, Sodium Myths, and What Your Poop Reveals About Disease Risk Your poop is more predictive than almost any other health signal, and you are flushing that data away every single day without a second look. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Karan Rajan, a practicing NHS gastrointestinal surgeon, best-selling author, and Chief Science Officer at Throne, who has built a following of over 12 million people by making gut science accessible and actionable. He has spent his career removing colon cancers, treating digestive disease, and now studies how gut bacteria drive nearly every system in the body, from hormone metabolism to brain optimization. They break down why fibermaxxing can backfire without the right mix of fast, medium, and slow fermenting fibers, and why generic "eat more fiber" advice ignores what your gut bacteria actually need. The conversation covers protein absorption limits and how much your body can really use, the truth about saturated fat and metabolism, and why the sodium-to-potassium ratio matters more than sodium alone. They also dig into fasting and the gut's natural cleaning cycle, the estrobolome and testobolome and their role in hormone balance and longevity, and how AI is starting to reshape personalized health data, supplements, and functional medicine. Dr. Rajan shares some of the strangest objects he has surgically removed from patients, and explains what your poop's color, shape, and consistency reveal about liver function, inflammation, and disease risk long before symptoms show up anywhere else. This is essential listening for anyone serious about biohacking, gut health, human performance, longevity, mitochondria function, nootropics, ketosis, carnivore and fiber-based diets, sleep optimization, anti-aging, and hacking your metabolism from the inside out. You'll Learn: Why fibermaxxing can cause bloating instead of better gut health The real difference between fast, medium, and slow fermenting fibers How much protein your gut can actually absorb and digest Why low sodium may be more dangerous than high sodium for most people How fasting triggers your gut's natural cleaning cycle, the migrating motor complex What your poop's color and consistency can reveal about liver and metabolic health How gut bacteria influence hormone metabolism through the estrobolome and testobolome Where AI and functional medicine are headed in personalized gut health tracking  Thank you to our sponsors!      - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thigh - Download Dave’s Free Peptide Guide at daveasprey.com/peptide-guide. - Caldera + Lab | Go to calroy.com/dave for the research, a discount, and a 45-day money back guarantee. - Kenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Karan Rajan, gut surgeon, fibermaxxing, gut microbiome, Bristol stool chart, poop health, Throne, fermentation geography, soluble fiber, insoluble fiber, prebiotics, inulin, oxalates, estrobolome, testobolome, migrating motor complex, sodium potassium ratio, saturated fat, ghee, collagen, protein absorption, keto, carnivore, fasting, gut bacteria, flatulence science  Resources:   • Dr. Karan's Newsletter: https://drkaran.kit.com • Learn more about Throne - https://www.thronescience.com/• Check Out Dr. Karan’s YouTube: https://www.youtube.com/c/DrKaran • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.   • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off)    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)    Timestamps:  00:00 – Trailer 00:55 – Meet Dr. Karan Rajan 04:04 – Kellogg's History & Farts 11:53 – Throne Poop Tracking 19:35 – Poop Colors & Wild Stories 28:02 – Worst Foods & Saturated Fat 36:26 – Fiber Fermentation Geography 46:57 – Sodium & Salt Myths 59:03 – Keto, Carnivore & Fasting 01:04:45 – AI, Misinformation & Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Try TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/discount/davetubeTry Suppgrade Labs: https://shopsuppgradelabs.com/Try Longevity Gummies: https://www.timeline.com/partners/dave-aspreyMost people fail to lose weight because they have a metabolic block nobody told them about. In this video, I’ve shared the three golden rules for losing 50 pounds fast, and why everything you've been told about weight loss is working directly against you. You'll also learn:Why insulin resistance creates a metabolic block that locks your fat cells shut, no matter how hard you diet The overlooked reason constant snacking keeps insulin elevated all day, and why that alone can stall your fat loss Why most of your hunger isn't real hunger at all, and how conditioned cravings trick your body into eating when it doesn't need to The simple environmental shift that beats willpower every time, and why redesigning your kitchen matters more than any diet ruleThank you to our sponsors!PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off.Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade.iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE00:00 – Intro00:24 – The Metabolic Block02:21 – Rule 1: Cut Processed Food03:46 – Rule 2: Fasting Matters05:29 – Two Types of Hunger06:34 – How Fasting Works07:11 – Rule 3: Environment Design08:32 – Redesign Your KitchenConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Raw Garlic "Ultimate Biohack" Trend Faces Scientific Scrutiny Raw garlic has gone viral as a morning ritual, with fans crushing a clove, mixing it with honey, and crediting it with everything from lower cholesterol and better insulin sensitivity to cleared acne, eliminated brain fog, and colds cured within 24 hours. The biochemistry behind the trend is real: garlic contains no allicin until it's crushed or chopped, which mixes an enzyme with a sulfur compound to form the active compound, and letting it sit for ten to fifteen minutes before cooking preserves more of that activity. Host Dave Asprey separates what the human data actually supports, modest blood pressure and cholesterol effects, real antimicrobial properties, and a genuine bleeding-risk caution for anyone on blood thinners, from the unproven parasite-cleanse and brain fog claims driving the trend online, drawing on his own EEG tracking to challenge the cognitive benefit narrative directly. Sources: https://nypost.com/2026/09/01/health/is-garlic-the-ultimate-biohack/ https://holisticheartcenters.com/new-cholesterol-guidelines-2026/ ~~ HEPA Air Filtration Linked To Measurable Brain Function Improvements In One Month A new study found that older adults using true HEPA filtration to reduce indoor fine particulate matter saw small but measurable cognitive improvements after just one month, adding to a growing body of evidence connecting air pollution exposure to neuroinflammation and long-term cognitive decline. Host Dave Asprey breaks down why clean air belongs in the biohacking conversation alongside supplements and training protocols, and why the World Health Organization's decision to list air pollution as a modifiable dementia risk factor is a bigger deal than it sounds. Sources: https://www.sciencedaily.com/releases/2026/08/260830000016.htm https://health.yahoo.com/conditions/neurological/dementia/articles/7-dementia-risk-factors-revealed-110006268.html ~~ Egg Yolk-Derived Peptides Show Neuroprotective Effects Against Oxidative Stress New research on phosphopeptides isolated from egg yolk phosvitin found that the compounds reduced reactive oxygen species, improved antioxidant defense markers, and increased neuron survival in cells exposed to oxidative stress in the lab. Host Dave Asprey connects this early but promising finding to his long-standing case for the whole egg, yolk included, as one of the most nutrient-dense foods available, and flags what would need to happen next for this to translate into a usable protocol. Source: https://www.news-medical.net/news/20260827/Egg-yolk-peptides-protect-brain-cells-from-oxidative-stress.aspx ~~ Heat Stroke Survivors Face Elevated Cardiovascular Risk Years Later, Research Shows A closer look at heat stroke recovery reveals it's rarely a one-day event. Survivors of classic heat stroke had three and a half times the rate of ischemic heart disease twelve years later compared to matched controls, along with elevated long-term risk of kidney disease and lingering heat intolerance, fatigue, and dizziness. Host Dave Asprey draws the line between the controlled heat stress he uses deliberately in sauna and hyperthermic conditioning and the uncontrolled, uncooled heat exposure that leaves this kind of lasting cardiovascular damage, and what that distinction means for how to think about any stressor. Source: https://www.latimes.com/science/story/2026-09-01/even-people-who-appear-to-recover-from-heatstroke-may-face-health-issues-later ~~ Long-Term Melatonin Use Linked To Nearly Double Heart Failure Risk In Large Cohort Study A cohort study of over 130,000 adults with chronic insomnia found that those who used melatonin for a year or more had nearly double the rate of heart failure and all-cause mortality compared to non-users, along with a three and a half times higher rate of heart failure hospitalization. Host Dave Asprey walks through why this is observational data, not proof of causation, and why he's stayed a low-dose, occasional melatonin user for years rather than a nightly one, plus what the real underlying driver of chronic insomnia might be for listeners still relying on it every night. Source: https://www.sciencedaily.com/releases/2026/08/260829035228.htm ~~ This episode is designed for biohackers, longevity enthusiasts, and high-performance listeners who want the latest research on nutrition, air quality, brain health, heat stress, and sleep translated into what actually matters for your biology right now. Host Dave Asprey connects viral trends, clinical data, and decades of context into practical frameworks for taking control of your own health decisions. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: raw garlic biohack, allicin formation, garlic blood pressure, aged garlic extract, garlic cholesterol, HEPA air purifier brain health, PM2.5 cognitive decline, air pollution dementia risk, egg yolk phosvitin peptides, oxidative stress neuroprotection, egg yolk nutrition, heat stroke cardiovascular risk, heat stroke recovery, hyperthermic conditioning, sauna protocol, melatonin heart failure risk, chronic insomnia, sleep hygiene, circadian rhythm, biohacking news 2026 Thank you to our sponsors!  Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.comKenetik | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount.iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVEResources:   • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.  • Danger Coffee: https://dangercoffee.com/discount/dave15   • My Daily Supplements: SuppGrade Labs (15% Off)   • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com   Timestamps: 00:00 – Intro 00:19 – Garlic & Brain Fog 02:06 – HEPA Filtration & Cognition 03:20 – Egg Yolk Peptides04:16 – Heat Stroke05:22 – Melatonin06:54 - WrapupSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Jenny McCarthy on Reversing Autism, Healing Mold Toxicity, and the Biohacking Protocol Big Pharma Doesn't Want You to Know Back with another long one! Autism, mold poisoning, and cognitive decline share more root causes than most doctors admit, and this episode hands you the biohacking playbook to reverse all three. Want to try Jenny's makeup and skincare line? Visit https://bit.ly/Formless-Beauty and use code DAVE to unlock a discount. Host Dave Asprey sits down with Jenny McCarthy Wahlberg, a New York Times bestselling author, actress, comedian, and 14-season judge on The Masked Singer who became one of the most trusted voices in the autism community after her son's regression following a vaccine reaction. She documented his recovery in books including Louder Than Words and Healing and Preventing Autism, founded the vegan, cruelty-free beauty brand Formless Beauty, and now develops unscripted television, documentaries, and podcasts with her husband Donnie Wahlberg through their Work Baby Productions banner under a first look deal with Lionsgate. Dave and Jenny trace her son's autism diagnosis back to a vaccine reaction and walk through the biohacking protocol that helped him recover, including candida detox, activated charcoal binders, collagen and hypermobility support, and hacking his gut with a low toxin diet that removed wheat and dairy. They connect autism to mitochondria energy collapse and neuroinflammation, and explain how nootropics like modafinil restore focus without the crash of stimulants. The conversation moves into longevity and human performance strategies for adults, covering low dose Cialis for brain blood flow, DHEA and thyroid optimization for women over 35, peptide protocols including melanotan and Retatrutide, cyclical ketosis and fasting alternatives, and why hormone replacement therapy reverses aging instead of causing cancer. They dig into functional medicine tools for everyday life: electrolytes and salt for blood pressure and sleep optimization, blackout darkness for circadian repair, baking soda for metabolism and alkaline balance, and why Jenny trusts krill oil over fish oil for anti-aging support. Dave breaks down ibogaine and neuroplasticity for brain repair, defends his carnivore leaning diet, shares why Danger Coffee still starts his morning, and calls out AI chatbots for pushing censored health narratives. This is essential listening for anyone interested in biohacking, human performance, longevity, functional medicine, brain optimization, and building a smarter, not harder approach to supplements and long-term health. You'll Learn: How mold and candida trigger PANS and PANDAS, and why they mimic autism symptoms Why activated charcoal timing determines whether it works as a binder The link between collagen, hypermobility, and leaky gut in autism and long-term brain function How modafinil, nicotine, and Cialis support brain optimization, focus, and mitochondria function Why hormone replacement therapy and DHEA reverse aging in women after 35 The truth about ketosis supplements, structured water, and alkaline water myths How darkness, light exposure, and electrolytes rebuild sleep optimization and metabolism  Thank you to our sponsors!      - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount. - MOD | Visit https://mod.com/ for a consultation and get 10% off your first order plus free shipping with promo code DAVE. - KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off - Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thighs or top sirloins in every box for a year with free shipping always. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Jenny McCarthy Wahlberg, autism recovery, vaccine injury, biohacking, longevity, mitochondria, neuroinflammation, candida detox, mold toxicity, activated charcoal, hypermobility, collagen, modafinil, nootropics, human performance, hormone replacement therapy, DHEA, peptides, melanotan, ketosis, fasting, functional medicine, Danger Coffee, Smarter Not Harder, Dave Asprey, anti-aging, sleep optimization, brain optimization, metabolism, carnivore, ibogaine, neuroplasticity, supplements, PANS PANDAS Resources:   • Want To Try Jenny's Makeup And Skincare Sine? Visit https://bit.ly/Formless-Beauty and use code DAVE to unlock a discount. • Check Out Formless Beauty On YouTube: https://www.youtube.com/@formlessbeauty • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.   • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off)    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)    Timestamps:  00:00 – Trailer 01:20 – The Human Upgrade Starts 07:13 – Detoxing Candida: The Turnaround 15:00 – The Anti-Vaxxer Backlash 23:02 – The Many Flavors of Autism 29:36 – Powering Up the Autistic Brain 35:59 – The Bile & Binder Protocol 43:53 – Intuition, Trust & Integrity 53:40 – Building an Ethical Beauty Brand 58:34 – Sensory Sensitivities & Clean Living 01:04:00 – Modafinil: The Focus Drug 01:13:45 – Mold Illness, Memory & Brain Health 01:18:26 – Jenny McCarthy's Show Starts 01:22:45 – Dave's Mold Poisoning Story 01:31:04 – Nicotine, Ibogaine & Biohacking Extremes 01:38:33 – When Biohacking Goes Too Far 01:45:07 – Peptides, Hormones & Anti-Aging Hacks 01:52:24 – Hormone Replacement Therapy for Women See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The 3 "Longevity Drugs" That Fail the Data, and 4 Repurposed Ones Worth Considering  Back with another solo episode, this one on Big Pharma! Metformin, rapamycin, and statins are three of the most trusted names in longevity, and none of them hold up the way you've been told. This episode breaks down the human data behind the drugs everyone assumes are safe, and reveals four lesser-known repurposed pharmaceuticals that might do more for your metabolism, mitochondria, and lifespan. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR  Dave walks through why metformin blunts the muscle-building signal your body needs from exercise, why rapamycin's stunning mouse studies fell apart in the 2025 PEARL trial, and why statins help one person in a hundred while draining the CoQ10 your mitochondria depend on. Then he lays out the yes list: tadalafil for vascular and brain health, SGLT2 inhibitors for metabolic and kidney protection, acarbose for gut and longevity markers, and low dose naltrexone for calming an overactive immune system. Host Dave Asprey is the father of biohacking, founder of Danger Coffee and Smarter Not Harder, and a New York Times bestselling author who has spent decades studying human performance, functional medicine, and the science of not aging. As co-founder of Unlimited.Life, a concierge longevity practice that runs over $50,000 in lab work per client, he pulls back the curtain on what the data actually shows once you strip away the marketing. This is essential listening for anyone serious about biohacking, longevity, anti-aging, human performance, brain optimization, and hacking their own biology with real supplements and functional medicine tools instead of guesswork. You'll Learn: Why metformin can cancel out the muscle gains from resistance training and drain your B12 for years What the 2025 PEARL trial actually found when rapamycin was tested in healthy adults Why statins carry a 100-to-1 harm-to-benefit ratio and quietly starve your mitochondria of CoQ10 How tadalafil supports nitric oxide, vascular health, and neuroplasticity at low daily doses Why SGLT2 inhibitors trigger ketosis-like metabolic effects and protect kidney function How acarbose changes gut bacteria and shows some of the strongest longevity data in mouse studies How low dose naltrexone modulates the immune system and reduces neuroinflammation How to talk to your doctor about using these drugs off-label for longevity instead of disease treatment  Thank you to our sponsors!      - ALP | Go to alppouch.com, code DAVE for 10% off. - Timeline | Visit timeline.com/dave and get up to 20% off when you subscribe and save. - Kinetic | Instead of pushing your system harder, Kenetik feeds your brain the ketones it craves to fuel calm clarity and steady focus. Go to drinkkenetik.com/DAVE and use code DAVE for a discount. - Visit www.myvitalc.com/davesfav to unlock Dave’s discount Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Metformin, Rapamycin, Statins, Tadalafil, Cialis, SGLT2 inhibitors, Jardiance, Acarbose, low dose naltrexone, longevity drugs, anti-aging medication, repurposed pharmaceuticals, off-label drugs, mTOR inhibitor, AMPK, autophagy, endothelial dysfunction, CoQ10, insulin resistance, mitochondrial efficiency, senescent cells, nitric oxide, neuroinflammation, vascular health, PEARL trial, Unlimited.Life Resources:   • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/  • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.   • Danger Coffee: https://dangercoffee.com/discount/dave15? • My Daily Supplements: SuppGrade Labs (15% Off)    • Favorite Blue Light Blocking Glasses: TrueDark (15% Off)    • Dave Asprey’s BEYOND Conference: https://beyondconference.com    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated   • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/  • Upgrade Labs: https://upgradelabs.com      Timestamps:  00:00 – Trailer 01:01 – Intro 03:48 – Metformin 09:18 – Rapamycin 12:55 – Statins 17:28 – Statins & CoQ10 19:38 – Tadalafil 23:43 – SGLT2 Inhibitors 26:12 – Acarbose 28:40 – Low-Dose Naltrexone (LDN) 31:44 – Dosing & Recap See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Try TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/discount/davetubeTry Suppgrade Labs: https://shopsuppgradelabs.com/Try Longevity Gummies: https://www.timeline.com/partners/dave-aspreyThe most powerful energy compounds aren't in your local supplement store. They're sitting in Eastern European science, and Thai herbal medicine, completely ignored by an industry that only profits from what it can patent. In this video I break down 7 compounds that have transformed my energy, sharpened my focus, and kept my brain performing like it did decades ago. You'll also learn:Why sulbutiamine gets your dopamine receptors to work harder without the crash of regular stimulantsThe overlooked amino acid that keeps glutamate and glycine in balance, and why that balance decides how sharp your thinking feelsWhy a compound most people have never heard of protects your liver's biological age, and how that quietly determines your brain energyThe orally active peptide reshaping how your body produces its own hormones, and why it could replace the need for TRT in your late twenties or thirtiesThank you to our sponsors!Butcher Box | Go to ButcherBox.com/HUMANUPGRADE to get $20 off your first box, plus your choice of free ground beef for life, or free chicken thighs or top sirloins in every box for a year with free shipping always. Viome | Check it out at viome.com and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.iRestore | Unlock your best hair & skin with @iRestorelaser and HUGE savings on iRESTORE with code DAVE at irestore.com/DAVE00:00 – Intro 01:41 – Sulbutiamine03:00 – Sarcosine04:14 – Uridine05:08 – Thunbergia Laurifolia (Trumpet Vine)05:55 – The Muscle-Energy Connection06:38 – Dilucene08:08 – TUDCA09:06 – ACE 167Connect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.