Episode 95 - The similarities and differences between urticaria and mastocytosis

[This episode was recorded before 31 July 2024.] "Every chronic urticaria starts as acute urticaria, but not every acute urticaria becomes chronic." Associate Professor Dr Andaç Salman and Professor Marcus Maurer discuss causes of acute urticaria, how diagnosis and management can be improved, and UCARE’s research into drivers of “chronification”. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Additional resources for this episode: Acute and chronic urticaria diagnosis and management taking into account their differences; Acute urticaria – GA2LEN UCARE 2023 conference presentation and Project: CHAPEAU – GA2LEN UCARE Network Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria’ podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry. 

This episode was recorded before July 31, 2024. Professor Marcus Maurer and Dr Sigurd Broesby-Olsen discuss similarities and differences between urticaria and mastocytosis, two mast cell diseases. They then turn their attention to treatment, sharing their thoughts on ‘killing’ mast cells and the development of more targeted and less toxic therapies. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Additional resources for this episode: Mast cell silencing: A novel therapeutic approach for urticaria and other mast cell-mediated diseases; Mast cell–targeting therapies in mast cell activation syndromes; and Tyrosine kinase inhibitors for the treatment of indolent systemic mastocytosis: Are we there yet? Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria’ podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry. 

"We will only be able to cure this disease and treat it well if we know how it works." Back by popular demand, Dr Jörg Scheffel rejoins Professor Marcus Maurer to discuss the importance and intricacies of mast cell research in urticaria.” Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Additional resources for this episode: A novel approach for studying mast cell-driven disorders: Mast cells derived from induced pluripotent stem cells; and Isolation and Culture of Human Skin Mast Cells. Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria’ podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry. 

Dr Maryam Ali Al-Nesf joins Professor Marcus Maurer to discuss one of the big burdens of chronic urticaria: the "use, or should we say abuse, of cortisone" in chronic spontaneous urticaria. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Additional resources for this episode: Efficacy and safety of systemic corticosteroids for urticaria: A systematic review and meta-analysis of randomized clinical trials; and A patient charter for chronic urticaria. Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria’ podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry. Episode  100 will be held live on UDAY (1 October 2024, 14:30 CEST). Submit your questions in advance to [email protected]. Follow UCARE on Instagram to be notified of more information https://www.instagram.com/ga2len_acare_ucare/.

Professor Christian Vestergaard and Professor Marcus Maurer discuss the link between obesity and urticaria, including how obesity contributes to chronic inflammation and the importance of P4 medicine (preventive, predictive, personalised, participatory) in urticaria treatment.  Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Additional resources for this episode: High waist circumference rather than high body mass index may be a predictive risk factor for the longer disease duration of chronic spontaneous urticaria; and Risk of comorbidities in patients diagnosed with chronic urticaria: A nationwide registry-study. Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria’ podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry. Episode  100 will be held live on UDAY (1 October 2024, 14:30 CEST). Submit your questions in advance to [email protected]. Follow UCARE on Instagram to be notified of more information https://www.instagram.com/ga2len_acare_ucare/.

Professor Marcus Maurer and Professor Martin Metz reflect on the European Academy of Allergy and Clinical Immunology (EAACI) congress 2024, including novel treatments on the horizon, key takeaways and expectations for future meetings.  Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Additional resources for this episode: Remibrutinib demonstrates favourable safety profile and sustained efficacy in chronic spontaneous urticaria over 52 weeks; and European Medicines Agency approved indications for omalizumab biosimilar. Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria’ podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry. Episode  100 will be held live on UDAY (1 October 2024, 14:30 CEST). Submit your questions in advance to [email protected]. Follow UCARE on Instagram to be notified of more information https://www.instagram.com/ga2len_acare_ucare/.

Professor Marcus Maurer welcomes Dr Jörg Scheffel to discuss urticaria, including techniques used to interrogate mast cells and examine interstitial fluid, and a technique used to identify autoimmune-mediated forms of urticaria. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Additional resources for this episode: Chronic urticaria and the pathogenic role of mast cells; A novel approach for studying mast cell-driven disorders: Mast cells derived from induced pluripotent stem cells; Autoreactive IgE: Pathogenic role and therapeutic target in autoimmune diseases. Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria’ podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry. Episode  100 will be held live on UDAY (1 October 2024, 14:30 CEST). Submit your questions in advance to [email protected]. Follow UCARE on Instagram to be notified of more information https://www.instagram.com/ga2len_acare_ucare/.

Professor Elias Toubi joins Professor Marcus Maurer to discuss remission in urticaria, including its definition and possible risk factors for long disease duration. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Additional resources for this episode: Clinical and laboratory parameters in predicting chronic urticaria duration: A prospective study of 139 patients. Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria’ podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry.

Associate Professor Elena Borzova joins Professor Marcus Maurer to discuss exercise as a trigger for urticaria in some athletes, including the paradoxical protective effect of exercise in people with urticaria. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Additional resources for this episode: Exercise-induced urticaria: A rare case report; and Physical activity and mental health among patients with atopic dermatitis or chronic spontaneous urticaria: A cross-sectional study. Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria’ podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry.

Professor Marcus Maurer welcomes Dr Carolina Vera Ayala and Associate Professor Jonny Peter to discuss participation in clinical trials for urticaria, including patient concerns around placebo treatment. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here. Additional resources for this episode: What is clinical research and why is it done?  Access additional resources by signing up to Medthority and to be notified for future ‘All Things Urticaria’ podcast episodes! For more information about the UCARE/ACARE network and its activities, please visit: UCARE Website, UCARE LevelUp Program, ACARE Website, UCARE 4U Website, UDAY Website, CRUSE Control App and CURE Registry.