#829: James Nestor — Breathing Protocols to Reboot Your Health, Fix Your Sleep, and Boost Performance

Boyd Varty is the founder of Track Your Life, which offers a limited number of premium retreats in South Africa’s bushveld, and author of one of my favorite books, The Lion Tracker’s Guide to Life. As a fourth-generation custodian of Londolozi Game Reserve, Boyd grew up with lions, leopards, snakes, and elephants and has spent his life in apprenticeship to the natural world. He is also the host of the Track Your Life podcast.This episode is brought to you by:Our Place’s Titanium Always Pan® Pro using nonstick technology that’s coating-free and made without PFAS, otherwise known as “Forever Chemicals”: https://fromourplace.com/tim (use code TIM at checkout) Gusto simple and easy payroll, HR, and benefits platform used by 400,000+ businesses: https://gusto.com/tim (three months free)Wealthfront high-yield cash account: https://Wealthfront.com/Tim (new clients get 3.75% base APY from program banks + additional 0.65% boost for 3 months on your uninvested cash (max $150k balance). Terms apply. The Cash Account offered by Wealthfront Brokerage LLC (“WFB”) member FINRA/SIPC, not a bank. The base APY as of 9/26/25 is representative, can change, and requires no minimum. Tim Ferriss, a non-client, receives compensation from WFB for advertising and holds a non-controlling equity interest in the corporate parent of WFB.  Experiences will vary. Outcomes not guaranteed. Instant withdrawals may be limited by your receiving firm and other factors. Investment advisory services provided by Wealthfront Advisers LLC, an SEC-registered investment adviser. Securities investments: not bank deposits, bank-guaranteed or FDIC-insured, and may lose value.)*Timestamps:[00:00:00] Start.[00:01:59] Boyd returns.[00:03:14] Elite firefighting unit: Boyd’s French Foreign Legionnaire predecessor.[00:04:27] The paper mache lion incident and Lucky’s dramatic exit.[00:08:07] Firefighting drill disaster: When 50/50 failed spectacularly.[00:09:58] Leadership lesson: Bringing energy down when chaos climbs.[00:11:52] Story hunting and the natural world as meaning machine.[00:17:16] Uncle JV: Wildlife filmmaker with a dangerous drama meter.[00:19:10] Camera bearing adventures: Elephants, hyenas, and the red mist.[00:22:30] Zambia expeditions: Crocodiles, dead elephants, and shovel oars.[00:25:48] Orienting toward safety: Building capability versus childhood overwhelm.[00:29:11] Wilderness retreat lessons: Wordlessness and natural state.[00:31:40] The Londolozi time war: Tech detox and parasympathetic shifts.[00:39:49] Mystical animal encounters: Lions, southern boubous, and synchronicity.[00:43:11] Re-enchantment: Nature’s desire to help us heal.[00:45:25] Following non-rational energy and forays into wordlessness.[00:52:31] Diana Chapman’s Whole-Body Yes and avoiding the simmering six.[00:58:04] Toby Pheasant and the great black mamba escape.[01:06:09] Training for persistence hunting using Bushman Great Dance wisdom.[01:09:23] The desert as storehouse: Abundance psychology in action.[01:11:23] Persistence hunt mechanics: Heat, time, and the animal’s energy transfer.[01:15:04] Running into ceremony: 47 degrees and letting the body know.[01:21:31] The kudu gives itself: Profound respect at the edge of survival.[01:27:22] Seeking the wild man: Access to the full spectrum of presence.[01:29:20] Context and discernment: Armor in cities, openness in wild spaces.[01:34:55] Men need men: Collective exploration around the fire.[01:37:40] Relationship as practice: Moving from romantic myth to active work.[01:40:15] Dick jokes and raft building: The indirect work that does heavy lifting.[01:45:43] Lunch the baboon: Hand lotion, bloody handprints, and royal delays.[01:55:43] Living amongst the animals: Warthog intelligence and leopard relationships.[01:57:27] Parting thoughts.*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Frank Miller is regarded as one of the most influential and awarded creators. He began his career in comics in the late 1970s, first gaining notoriety as the artist, and later writer, of Daredevil for Marvel Comics. Next, came the science-fiction samurai drama Ronin, followed by the groundbreaking Batman: The Dark Knight Returns and Batman: Year One with artist David Mazzuchelli. Following these seminal works, Miller fulfilled a lifelong dream by doing an all-out crime series, Sin City, which spawned two blockbuster films that he co-directed with Robert Rodriguez. Miller’s multi-award-winning graphic novel 300 was also adapted into a highly successful film by Zack Snyder. His upcoming memoir, Push the Wall: My Life, Writing, Drawing, and the Art of Storytelling, is now available for pre-order.This episode is brought to you by: Eight Sleep Pod Cover 5 sleeping solution for dynamic cooling and heating: EightSleep.com/Tim (use code TIM to get $350 off your very own Pod 5 Ultra.)Shopify global commerce platform, providing tools to start, grow, market, and manage a retail business: https://shopify.com/tim (one-dollar-per-month trial period)AG1 all-in-one nutritional supplement: DrinkAG1.com/Tim (1-year supply of Vitamin D (and 5 free AG1 travel packs) with your first subscription purchase.)Timestamps:[00:00:00] Start.[00:02:14] Aristotle’s definition of happiness: Devotion to excellence.[00:03:02] Tools of the trade: Blackwing pencils, India ink, liquid frisket.[00:04:45] Sin City‘s physical creation at “twice up” size.[00:08:06] The toothbrush spatter technique.[00:09:24] Channeling impatience, anger, and violence into dramatic creative work.[00:10:33] What Jack Kirby knew about making comics competitive with cinema’s spectacle.[00:11:56] Will Eisner and The Spirit‘s influence on the US market where writer-artist duality is rare.[00:13:33] How Jack Kirby blasted apart the panel grid (and a young Frank’s mind).[00:15:49] Push the wall and defy the code.[00:19:54] The ruthless mentorship of Neal Adams.[00:24:57] The genesis of the Elektra amd Daredevil “soap opera.”[00:27:56] Story structure: Start late, end early.[00:29:10] Trusting the muse over rigid methodology.[00:31:15] European invasion: Moebius and Forbidden Planet.[00:32:52] Japanese influence: Lone Wolf and Cub‘s impact.[00:34:30] Cultural differences in depicting violence and motion.[00:36:38] Ronin: Shameless imitation and rebirth.[00:37:28] How does Frank know if something is working (or not working)?[00:39:27] The critical reception of Ronin as a “broken nose.”[00:42:37] The ruthless structure of The Dark Knight Returns.[00:43:40] Mutual elevation with “smartest fan” Alan Moore.[00:48:26] Robert Rodriguez: Angel of goodwill and generosity.[00:49:28] Sin City film: Co-directing and the Director’s Guild sacrifice.[00:50:31] Working as a “two-headed beast” with Rodriguez.[00:55:27] Favorite films.[00:58:19] Books and ancient history inspiring 300.[00:59:00] Hollywood lessons: The importance of working with the right people.[01:01:13] The partnership and guidance of Silenn Thomas.[01:02:01] The clarity and creative rejuvenation of getting sober from alcohol.[01:04:48] Advice for aspiring comic artists: Story, story, story.[01:06:20] Learning to draw: Bridgman and Loomis books.[01:08:07] Perspective as a mathematical trick and lie.[01:11:00] Dick Giordano’s advice: Lay in blacks first.[01:13:52] Sin City workflow innovation: Batch processing stages.[01:15:48] Dark Horse Comics and creative freedom.[01:17:29] Economy of line work and elegant minimalism.[01:20:46] On collaborating with Bill Sienkiewicz on Elektra.[01:25:20] Billboard wisdom: “Ask every question,” and “Why?”[01:27:08] Challenging pathological conformity.[01:27:39] Parting thoughts and where to find Frank’s work.*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Richard H. Thaler is the 2017 recipient of the Nobel Memorial Prize in Economic Sciences for his contributions to behavioral economics and the Charles R. Walgreen Distinguished Service Professor of Behavioral Science and Economics at the University of Chicago Booth School of Business. He is the New York Times bestselling co-author of Nudge: Improving Decisions About Health, Wealth, and Happiness and the author of Misbehaving: The Making of Behavioral Economics. His new book is The Winner's Curse: Behavioral Economics Anomalies, Then and Now. My co-host for this conversation is Nick Kokonas. Nick is an entrepreneur, investor, and author best known as the co-founder of The Alinea Group (sold in 2024) and the reservation platform Tock, which is now owned by American Express.This episode is brought to you by:Seed's DS-01® Daily Synbiotic broad spectrum 24-strain probiotic + prebiotic: https://Seed.com/Tim (Use code 25TIM for 25% off your first month's supply)ExpressVPN high-speed, secure, and anonymous VPN service: https://www.expressvpn.com/tim (get 4 months free on their annual plans)AG1 all-in-one nutritional supplement: https://DrinkAG1.com/Tim (1-year supply of Vitamin D plus 5 free AG1 travel packs with your first subscription purchase.)Timestamps:[00:00:00] Start.[00:02:33] First principles: What is economics, really?[00:04:18] The “max” assumption and agents as optimizers.[00:06:41] Rationality in models: Solving problems like an economist would.[00:07:29] “Meh” vs “Max” — shortcuts instead of optimization.[00:08:06] Selfishness, fairness, and self-control in economic models.[00:10:08] Milton Friedman’s “as if” defense.[00:12:36] The cashew nuts story: Origin of behavioral economics.[00:14:02] Removing choice and status quo bias.[00:17:31] The case for Americans needing forced savings.[00:19:34] Academic resistance: Psychologists laughing at economic theory.[00:24:37] Loss aversion: Disease cure experiment.[00:27:04] Endowment effect: Coffee mug experiment.[00:29:45] Restaurant reservations and the power of deposits.[00:31:05] Fairness research: Snow shovels and blizzards.[00:32:50] Uber surge pricing and the 9/11 thought experiment.[00:34:37] Behavioral economics in one sentence.[00:35:00] Nudges: 401(k) auto-enrollment case study.[00:37:46] The fly in the urinal and nudge durability.[00:39:07] Lakeshore Drive lines: Making safety easy.[00:41:30] Choice architecture: Good nudges vs. malicious nudges.[00:42:40] Online gambling and Robinhood’s gamification.[00:45:51] Lessons learned from teaching decision-making for 40 years.[00:46:52] Winner’s curse: The jar of coins demonstration.[00:49:04] ARCO engineers discover the winner’s curse in oil bidding.[00:50:11] Writing papers as competitive strategy.[00:52:31] Amos Tversky’s note: People learn through stories.[00:53:44] Overconfidence: Amazon River and CFO predictions.[00:55:59] NFL draft: 53% success rate (barely better than coin flips).[00:57:12] Trading down in the draft as optimal strategy.[00:59:26] Applying behavioral insights to daily habits.[01:01:04] The law of one price and restaurant deposit resistance.[01:02:39] Being a chef doesn’t automatically make you a good businessperson.[01:03:33] Sports analytics: The three-point shot revolution.[01:04:29] Michael Jordan vs Steve Kerr: 50% three-point shooting.[01:05:56] Finding $20 bills on the street.[01:06:35] Mental accounting: Money in jeans feels like a windfall.[01:07:50] Obama stimulus: Lump sum vs. spread out payments — why does it matter?[01:09:58] Airline baggage fees: “There’s a guy who owns that.”[01:11:43] Sunk cost fallacy: The dessert we don’t need.[01:12:37] Nick’s $500 wine example and building Tock on sunk costs.[01:14:41] Richard’s daughter and the baseball/concert tickets experiment.[01:16:05] Temptation bundling: Using cognitive biases for self-improvement.[01:19:06] Big data and natural experiments in the real world.[01:19:50] Mental accounting in action: Premium gas during the financial crisis.[01:22:34] Amazon’s hundred-PhD economics department.[01:23:48] The pragmatic reason Richard invented behavioral economics.[01:25:47] Strategy: Corrupt the youth, not change old minds.[01:27:06] The behavioral economics summer camp running since 1994.[01:28:12] The “Anomalies” column in Journal of Economic Perspectives.[01:29:44] Citations matter: Writing articles people can understand.[01:30:31] Availability bias: Homicides vs. suicides.[01:31:47] Kahneman and Tversky: The reason for everything.[01:33:11] Systematic bias vs. random errors.[01:34:08] Amos’ dinner trap: Everyone you know is dumb, except your models.[01:37:19] Michael Lewis’ The Undoing Project.[01:38:11] Daniel Kahneman’s assisted suicide decision as peak-end rule applied to life itself.[01:45:11] What keeps Richard going?[01:46:44] Why the updated version of The Winner’s Curse should appeal to economists and everyday humans.[01:49:58] Parting thoughts.*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

James Nestor is a science journalist and the author of the international bestseller Breath: The New Science of a Lost Art, with more than three million copies sold in 44 languages.This episode is brought to you by:Helix Sleep premium mattresses: https://HelixSleep.com/Tim (27% off all mattress orders)Momentous high-quality creatine for cognitive and muscular support: https://livemomentous.com/Tim (Code TIM for up to 35% off.)AG1 all-in-one nutritional supplement: https://DrinkAG1.com/Tim (1-year supply of Vitamin D plus 5 free AG1 travel packs with your first subscription purchase.)Timestamps:[00:00:00] Start.[00:01:37] Why I waited years to interview James about Breath.[00:02:35] Maurice Daubard: The mysterious 90-year-old who preceded Wim Hof.[00:05:01] Tummo breathing: Ancient Bon Buddhist heat generation.[00:08:13] James’ personal breathwork practice and the Wim Hof method (with warnings).[00:09:25] How breathwork cured James’ chronic respiratory issues.[00:11:46] Sudarshan Kriya: The weekend workshop that changed everything.[00:16:56] My nine-minute breath hold experiment (hyperbaric chamber edition).[00:18:57] Post-book revelations and angry doctors’ offices.[00:20:41] The ADHD-breathing connection: A controversial Venn diagram.[00:22:00] DIY breathing assessments for kids.[00:25:55] Mouth tape: From hostage situations to sleep optimization.[00:28:48] James’ seven-year mouth taping commitment.[00:31:14] CO2 levels: Your LEED-certified hotel is suffocating you.[00:36:50] Monitoring CO2 with the Aranet4 and building a CO2 database.[00:39:51] James’ travel kit: Red lights, granny packs, and a Soviet-era PEMF device.[00:51:59] In Weirdville, eyes sing The Body Electric.[00:52:58] The supplements included in David’s granny packs.[00:54:16] Natto vs. nattokinase.[00:56:18] Athletes and breathing: The BOLT score explained.[01:03:25] LeBron James’ alternate nostril breathing and diaphragmatic dysfunction.[01:04:47] Inspiratory muscle training and the back soreness warning.[01:08:47] The Relaxator: An adult breathing pacifier for focus.[01:12:54] San Francisco Writers Grotto and the trustafarian invasion.[01:16:10] Writer’s block: A convenient excuse for hobbyists.[01:19:04] Cutting the corporate cord: James’ visceral “I quit” moment.[01:23:25] The freediving story that launched a book deal.[01:25:41] Deep‘s disappointing launch and publisher betrayal.[01:28:10] Breath: From 290,000 words to 85,000 in a house in the woods.[01:31:51] Finding the skeleton: The Stanford experiment as through-line.[01:35:44] Prayer and coherent breathing: The 5.5-second secret.[01:38:44] James’ critique of breathwork culture and barriers to entry.[01:41:07] Sleep optimization: SnoreLab, side sleeping, and incline bed therapy.[01:44:56] Parting thoughts and where to find James and free breathing protocols.*Show notes for this episode: https://tim.blog/2025/09/30/james-nestor-breath/For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

David Senra is the host of the Founders podcast. For the past nine years, David has intensely studied the life and work of hundreds of history’s greatest entrepreneurs. His new podcast, David Senra, showcases conversations with the best-of-the-best living founders and extreme winners.This episode is brought to you by:Cresset family office services for CEOs, founders, and entrepreneursOur Place’s Titanium Always Pan® Pro using nonstick technology that’s coating-free and made without PFAS, otherwise known as “Forever Chemicals”AG1 all-in-one nutritional supplementTimestamps:[00:00:00] Who is David Senra?[00:01:11] Brad Jacobs: Roll-up king and positive-driven billionaire founder.[00:02:26] Rare positive archetypes: Ed Thorp, Sol Price, Brunello Cucinelli.[00:06:04] Michael Dell as another exception; fear of failure and motivation.[00:06:47] Negative self-talk, excellence, and its ripple effects.[00:08:26] Jensen Huang story: “Why do you suck so much?”[00:08:54] Inspiration from Dan Carlin’s Hardcore History.[00:10:00] Derek Sivers: unconventional, philosophical entrepreneur.[00:11:04] Learning equals behavior change, not memorization.[00:11:48] Jeremy Giffon insight: biographies as substitute mentors.[00:12:37] Reading biographies as one-sided conversations.[00:13:16] The chain of influence.[00:14:09] Podcasting as “relationships at scale.”[00:14:28] Coping with trauma and breaking cycles.[00:20:18] Note-taking process: books, Post-its, ruler, Readwise.[00:29:27] OCD tendencies and love of doing things the hard way.[00:31:04] Comparing our reading/re-reading workflows.[00:35:04] A family falling out and the randomness of student housing.[00:38:58] David’s introduction to my work during his MySpace-era college years.[00:40:07] Podcasting influences: Jocko Willink, Kevin Rose’s Elon Musk interview.[00:44:14] Five-and-a-half years of obscurity before breakthrough.[00:46:50] Graphtreon and experiments with subscription models.[00:49:25] Patrick O’Shaughnessy’s endorsement sparks growth.[00:51:23] Sam Hinkie and Patrick connections fuel momentum.[00:52:19] Transition to ads and joining Patrick’s network.[00:55:17] Edwin Land: patron saint of founders and Steve Jobs’ influence.[00:57:02] Lessons from Sam Zell, Jay Pritzker, and William Zeckendorf.[00:58:48] Need a generous, well-connected person? You can’t go wrong with Rick Gerson.[01:03:04] Edwin Land’s philosophies: Differentiation and doing to excess.[01:04:30] Entrepreneurial archetypes and conflicting advice.[01:06:00] Daniel Ek as an alternative founder archetype and mentor.[01:10:59] Further founder archetypes and contrasts.[01:13:41] What is an anti-business billionaire?[01:19:55] Advice from “shark” Michael Ovitz about the value of truth in one’s inner circle.[01:22:30] The hands-on approach of practical founders who live for the love of their business.[01:23:28] Doing one thing relentlessly.[01:23:51] “This can’t be my life” as a powerful motivator.[01:26:57] Low introspection as a common trait among founders — and its implications about human nature.[01:30:15] Robert Caro: The only writer David believes should be allowed to write thousand-page biographies.[01:32:40] James Dyson’s persistence vs. the risk of blind stubbornness.[01:34:22] Todd Graves (Raising Cane’s) as an example of relentless focus on one idea.[01:35:41] Separating fact from fiction in biographies/histories.[01:41:55] Considering trainable vs. non-trainable attributes in potential role models.[01:46:11] Perusing Charlie Munger’s library.[01:49:35] Dealmaking lessons on Eddie Lampert’s superyacht.[01:55:34] The smartest person David knows.[01:56:55] David’s obsessive craftsman approach to podcast creation.[01:58:51] Why David decided to begin a second podcast.[02:01:21] The economics of trust.[02:03:40] The benefits of cultivating a purposeful aloofness about current events.[02:07:11] Using the pulpit of publicity for good, not evil.[02:09:57] New show frequency/dynamic and how David plans to balance the burden of running two shows.[02:13:30] Teamwork with essence of turtle.[02:15:40] Adapting the Rockefeller “secret allies” strategy to podcasting.[02:17:56] Chris Hutchins: The mad scientist of podcasting?[02:18:30] Working with Rob Mohr and Andrew Huberman of SciComm.[02:20:54] Why David focuses on 24-hour cycles over long-term planning.[02:24:54] Does David worry the extra workload will disrupt his lifestyle?[02:30:18] What makes one potential guest more interesting to David than another?[02:34:34] Making an impact vs. happiness.[02:36:32] Playing the status game when your heart’s not in it is for suckers.[02:44:23] Travel observations and the rarity of truly unique experiences.[02:46:26] Books as philosophical operating systems.[02:48:39] Parting thoughts.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Pablos Holman is a hacker and inventor and the author of Deep Future: Creating Technology that Matters, the indispensable guide to deep tech. Previously, Pablos worked on spaceships at Blue Origin and helped build The Intellectual Ventures Lab to invent a wide variety of breakthroughs. Pablos also hosts the Deep Future Podcast and is managing partner at Deep Future.This episode is brought to you by:Cresset prestigious family office for CEOs, founders, and entrepreneurs: https://cressetcapital.com/timMaui Nui Venison​, delicious, nutrient-dense, and responsible red meat: https://mauinuivenison.com/lp/timAG1 all-in-one nutritional supplement: https://drinkag1.com/timTimestamps:[00:00:00] Start.[00:02:12] The first time I witnessed Pablos’ digital sleight of hand.[00:04:33] How did Pablos become what he considers to be a hacker?[00:08:04] The off-label mindset that makes a good hacker (like Samy Kamkar) great.[00:17:07] The magic of Rodney Mullen.[00:20:28] How Eric Johanson and Pablos gave life to adorable password thief Hackerbot.[00:23:44] Hacker self-defense and the zero-click exploit market.[00:27:11] International pockets of hacker density.[00:30:13] Conventions where modern hackers congregate.[00:30:48] Why, in geopolitics, technology is a game lost by the non-players.[00:33:05] The case to rally behind new nuclear power.[00:36:54] Sequencing priorities so the US can remain technologically competitive.[00:44:49] Evaluating risk and reward in deep tech investment.[00:50:40] Shoring up the shape of shipping.[00:56:59] How Pablos gained his name and famous frames.[00:58:48] Pablos is a possible-ist.[00:59:45] What makes Pablos an attractive hire for the world’s richest people?[01:02:06] From Silicon Valley to Seattle: the Blue Origin origin story.[01:08:55] Why Pablos prevails over his M-dash peers.[01:11:41] Zero Effect and WarGames: The only movies that matter?[01:15:58] A major security malfunction exploited by Major Malfunction.[01:18:30] The enigmatic Neal Stephenson.[01:19:38] Long-form lessons gleaned from Jeff Bezos and the Blue Origin mission.[01:27:15] For solving the world’s problems, communities are crucial.[01:31:03] Newlab PSYOPS.[01:34:44] AI and the ripple effects of China’s engineering-minded vs. America’s attorney-heavy leadership.[01:48:20] Unearthing like-minded inventors and innovators.[01:50:42] How Pablos learned salsa dancing via aikido vs. my own tango experience.[02:08:27] Why you should invest or get involved in deep tech.[02:14:45] Clearing up fusion confusion.[02:21:17] Making progress happen is a team effort.[02:24:19] Parting thoughts.*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, Margaret Atwood, Mark Zuckerberg, Peter Thiel, Dr. Gabor Maté, Anne Lamott, Sarah Silverman, Dr. Andrew Huberman, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This episode is a solo Q&A session where I answer a bunch of questions. We covered a ton of ground, from personal health protocols to professional frameworks and creative projects. This episode is brought to you by:Eight Sleep Pod Cover 5 sleeping solution for dynamic cooling and heating: EightSleep.com/Tim (use code TIM to get $350 off your very own Pod 5 Ultra.)Monarch Money track, budget, plan, and do more with your money: MonarchMoney.com/Tim (50% off your first year at monarchmoney.com with code TIM)Shopify global commerce platform, providing tools to start, grow, market, and manage a retail business: https://shopify.com/tim (one-dollar-per-month trial period)Timestamps: [00:00:00] Start[00:06:00] Coyote retail distribution challenges and data gathering.[00:09:12] Elbow surgery recovery: sequencing, decongestion, Marc Pro device, peptides, BFR training.[00:16:14] California vs. Austin for builders, mechanical engineers, and tech startups.[00:19:06] Using AI for medical advice workflow (and cross-referencing with professionals).[00:23:51] Current supplement regimen and PAGG/AGG status.[00:31:54] California vs. Texas considerations for aspiring parents.[00:32:48] Saying "No" to good things for "Hell, yes" moments.[00:34:34] Philanthropy lessons learned since starting Saisei Foundation.[00:37:45] Something I've changed my mind about recently: intermittent fasting.[00:42:44] Precious items from childhood I still keep: D&D relics and marine biology books.[00:43:03] Bucket list hike: Glacier National Park.[00:43:42] How the catalytic chaos of publishing The 4-Hour Chef led to launching this podcast.[00:45:52] Bringing delight vs. sixth-gear, high-performance focus.[00:49:05] Thoughts on extended human fasting research from the Soviet era.[00:52:58] Most magical New Mexico experience: Mountain Cloud Zen Center meditation retreat.[00:53:22] Meta skills for the AI era: Hyper-adaptability and world-class learning.[00:54:01] The (real and ideal) future of CØCKPUNCH/Legends of Varlata.[00:59:47] Competitive chess training enhancement: glucose management, intermittent fasting, MCT oil.[01:06:31] Behind-the-scenes projects: Fusion, algae feed additives, meat alternatives.[01:08:32] Countries I wish I had visited earlier, and places I'd still like to see.[01:11:06] "Not yet" vs. "No" in early growth phases.[01:14:14] Post Coyote, do I have any future games in the works?[01:14:46] Over-ear vs. in-ear headphones for podcasting.[01:15:16] What's the uncrowded channel right now?[01:16:17] Recommendations for Dr. Mindy Pelz.[01:16:58] Robert Rodriguez and project juggling.[01:17:24] Fast neutron reactors and the Bugatti of ketones.[01:19:05] Extended family outings and Mahonk Mountain House.[01:20:31] NO BOOK meetup plans?[01:20:54] Parting thoughts.*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, Margaret Atwood, Mark Zuckerberg, Peter Thiel, Dr. Gabor Maté, Anne Lamott, Sarah Silverman, Dr. Andrew Huberman, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Dr. Dominic D’Agostino (@DominicDAgosti2) is a tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition.This episode is brought to you by: Helix Sleep premium mattresses: https://HelixSleep.com/Tim (27% off all mattress orders)Momentous high-quality creatine: https://livemomentous.com/tim (code TIM for up to 35% off)AG1 all-in-one nutritional supplement: https://DrinkAG1.com/Tim (1-year supply of Vitamin D plus 5 free AG1 travel packs)Timestamps:[00:00:00] Start.[00:14:43] Why I'm interested in ketogenic strategies for neurodegenerative prevention.[00:16:18] Mary and Steve Newport's ketone-linked temporary cognitive improvements.[00:18:18] A mechanisms overview for Alzheimer's/dementia.[00:21:25] The immune system as longevity's "fifth horseman" — and why metabolic control is key.[00:22:04] How to measure ketones and GKI.[00:23:00] Fasting vs. ketogenic diet.[00:24:18] There's nothing fishy about sardine fasting.[00:28:32] My hiatal hernia discovery and increased cancer risk concerns.[00:30:04] HSCRP as a superior biomarker to LDL for cardiovascular risk.[00:31:57] Glucose tolerance testing revelations and CGM importance.[00:31:57] Upgrading the metabolic machinery through keto without getting bored.[00:42:07] What do do if you, like Dom and me, are among the 30% who suffer from cholesterol hyperabsorption.[00:43:42] Dom's day-to-day diet regimen.[00:45:56] How Dom optimizes his aging dogs with ketones, SARMs, and supplements.[00:51:30] Supplementing for sleep disruption while fasting.[00:55:41] Why Dom doesn't have misgivings about melatonin.[00:59:15] Shingles prevention through fasting protocols.[01:00:15] Immune system modulation: Innate vs. adaptive, vegan vs. ketogenic.[01:03:54] Dom at 50-something: Current meal timing and composition.[01:05:57] Blue zone observations: Greek and Sardinian longevity habits.[01:08:16] Ketogenic diet initiation tips: MCT, electrolytes, and fasted cardio.[01:15:18] Ketone metabolic therapy for cancer.[01:18:15] The metabolic psychiatry revolution.[01:22:10] The soothing effects of hyperbaric oxygen and ketosis on seizure sufferers.[01:28:27] Metformin vs. berberine.[01:31:43] The low-dose neuroprotective potential of GLP-1 drugs.[01:34:58] NAD research: MIB-626 and stabilized forms for mitochondrial health.[01:39:48] Idebenone, CoQ10, and the Deanna protocol for ALS.[01:42:05] Dom's supplement short list: CoQ10, creatine, ketones, vitamin D, melatonin.[01:44:43] KetoNutrition.org, Metabolic Health Summit, Audacious Nutrition, veteran-focused research protocols, and other parting thoughts.*Show notes for this episode: https://tim.blog/2025/09/03/dr-dominic-dagostino-all-things-ketones/For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Kevin J. Tracey, MD is president and CEO of the Feinstein Institutes for Medical Research at Northwell Health, a pioneer of vagus nerve research and author of the recent book, The Great Nerve: The New Science of the Vagus Nerve and How to Harness Its Healing Reflexes. This episode is brought to you by:Eight Sleep Pod Cover 5 sleeping solution for dynamic cooling and heating: EightSleep.com/Tim (use code TIM to get $350 off your very own Pod 5 Ultra.)AG1 all-in-one nutritional supplement: https://DrinkAG1.com/Tim (1-year supply of Vitamin D plus 5 free AG1 travel packs with your first subscription purchase.)Wealthfront high-yield cash account: https://Wealthfront.com/Tim (Start earning 3.75% Annual Percentage Yield (APY) from program banks on your short-term cash until you’re ready to invest. And when new clients open an account, they can get an extra fifty-dollar bonus with a deposit of five hundred dollars or more.) Terms & Conditions apply. The APY on cash deposits as of 09/26/25 is representative, subject to change, and requires no minimum. Tim Ferriss receives cash compensation from Wealthfront Brokerage LLC for advertising and holds a non-controlling equity interest in the corporate parent of Wealthfront Brokerage. See full disclosures here.Timestamps:00:00 Tim’s intro: why he dismissed vagus-nerve hype06:34 What the vagus nerve actually is, plus common myths11:31 Breaking news: FDA approval for SetPoint’s RA implant + Kelly Owens’s turnaround21:11 Inflammation 101: when healing turns harmful31:37 Bioelectronic medicine: from lab insight to real devices55:26 TNF, IL-1, and IL-6: immune drivers and what VNS modulates56:06 Exercise & recovery: vagal signals, IL-6, and adaptation56:30 Cold exposure & breathwork: sympathetic spike, parasympathetic payoff59:04 Chronic inflammation today: prevalence, diagnostics, and uncertainty59:53 Autoimmunity: genes, environment, infections01:01:08 Stress hormones, personality traits, and metabolic fallout01:05:41 VNS tech landscape: implants, focused ultrasound, and what’s just TENS01:11:14 Ear maps, revisited: the real science behind auricular stimulation01:27:52 Ulf Andersson: auricular TENS, famotidine, and a depression turnaround01:36:48 Depression & inflammation: where VNS helps (and where it doesn’t)01:41:38 Body-brain loop: how inflammation signals ride the vagus nerve01:42:56 Why VNS can lift mood: a working theory01:43:22 Ulf’s setup: electrode placement and twice-daily routine01:44:37 Acupuncture, fertility, and plausible vagal links01:47:23 Chronic pain through an inflammation lens01:48:34 Neural “engrams”: how the brain can store inflammatory memories02:02:35 Cervical TENS vs. true VNS: mechanisms and open questions02:12:15 On stage with the Dalai Lama: blue energy and two vagus nerves02:16:55 Closing thoughts: self-care vs. medical devices, and what’s next*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, Margaret Atwood, Mark Zuckerberg, Peter Thiel, Dr. Gabor Maté, Anne Lamott, Sarah Silverman, Dr. Andrew Huberman, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Dr. Jeffrey Goldberg is Professor and Chair of Ophthalmology and Director of the Byers Eye Institute at Stanford University, a leading scientist in the development and degeneration of the visual system from eye to brain, and a practicing ophthalmologist and surgeon.This episode is brought to you by: Gamma AI design partner for effortless presentations, websites, social media posts, and more: https://gamma.app (Use code TIM at checkout for 30% off any plan.)Helix Sleep premium mattresses: https://HelixSleep.com/Tim (27% off on all mattress orders.)AG1 all-in-one nutritional supplement: https://DrinkAG1.com/Tim (1-year supply of Vitamin D plus 5 free AG1 travel packs with your first subscription purchase.)Timestamps:[00:00:00] Start.[00:05:30] How do you solve a problem like presbyopia?[00:08:34] The athletic benefits of training supranormal (better than 20/20) vision.[00:11:49] Indigenous eye drops and FDA-approved pilocarpine for presbyopia.[00:14:05] Understanding basic eye anatomy.[00:17:27] Exploring AREDS 2, CoQ10, ginkgo, vitamin B3, and other supplements for vision.[00:23:00] Visual training devices and psychedelic-prompted brain plasticity.[00:25:12] Thoughts on visual training effectiveness and motor action requirements.[00:28:29] Concussion rehabilitation and visual perception exercises.[00:32:36] Red light and violet light therapy for myopia and mitochondrial health.[00:36:07] Vision loss correlation with cognitive decline and depression.[00:39:36] Presbyopia progression and psychological dependence on readers.[00:41:15] Cognito Therapeutics headset for Alzheimer's treatment.[00:46:46] Glaucoma basics: neurodegenerative disease and risk factors.[00:48:53] Eye pressure variability and diurnal cycles.[00:50:02] Cannabis effects on eye pressure and compound isolation.[00:51:47] Stem cell research for vision restoration.[00:53:09] Anti-inflammatory effects and immune system role in eye diseases.[00:55:15] Gut microbiome connection to glaucoma in animal models.[00:58:43] Metabolic syndrome and GLP-1 receptor agonists.[01:00:50] Microbiome sharing and future therapeutic possibilities.[01:03:31] Dry eye treatment: preservative-free tears and serum drops.[01:08:43] Vision screening recommendations and UV protection.[01:11:22] Full-spectrum light benefits vs. UV exposure.[01:13:27] Paradigm shifts: irreversible vision loss becoming reversible.[01:17:18] Convergence of neuroscience advances and biotech investment.[01:21:58] Miraculous mitochondria: health, transplants, and three-parent babies.[01:26:24] My family history concerns and metabolic health screening.[01:29:26] Exercise's biggest gain: going from none to some.[01:33:03] Clinical trial participation resources and parting thoughts.*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferrissPast guests on The Tim Ferriss Show include Jerry Seinfeld, Hugh Jackman, Dr. Jane Goodall, LeBron James, Kevin Hart, Doris Kearns Goodwin, Jamie Foxx, Matthew McConaughey, Esther Perel, Elizabeth Gilbert, Terry Crews, Sia, Yuval Noah Harari, Malcolm Gladwell, Madeleine Albright, Cheryl Strayed, Jim Collins, Mary Karr, Maria Popova, Sam Harris, Michael Phelps, Bob Iger, Edward Norton, Arnold Schwarzenegger, Neil Strauss, Ken Burns, Maria Sharapova, Marc Andreessen, Neil Gaiman, Neil de Grasse Tyson, Jocko Willink, Daniel Ek, Kelly Slater, Dr. Peter Attia, Seth Godin, Howard Marks, Dr. Brené Brown, Eric Schmidt, Michael Lewis, Joe Gebbia, Michael Pollan, Dr. Jordan Peterson, Vince Vaughn, Brian Koppelman, Ramit Sethi, Dax Shepard, Tony Robbins, Jim Dethmer, Dan Harris, Ray Dalio, Naval Ravikant, Vitalik Buterin, Elizabeth Lesser, Amanda Palmer, Katie Haun, Sir Richard Branson, Chuck Palahniuk, Arianna Huffington, Reid Hoffman, Bill Burr, Whitney Cummings, Rick Rubin, Dr. Vivek Murthy, Darren Aronofsky, Margaret Atwood, Mark Zuckerberg, Peter Thiel, Dr. Gabor Maté, Anne Lamott, Sarah Silverman, Dr. Andrew Huberman, and many more.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.