S9 Ep1: Karl Deisseroth’s Big Idea: Decoding Brain Circuits to Understand the Human Mind

In this episode of the Big Idea series, Dean Lloyd Minor welcomes Eric Topol, MD, author of Super Agers: An Evidence-Based Approach to Longevity, for a conversation about why immune health may be more important than genetics in promoting healthy aging. They explore how lifestyle factors like sleep, diet, and exercise strengthen the body’s defenses, shaping longevity beyond our genes. They also discuss how emerging technologies, from wearable sensors to genetic risk tools, could make personalized prevention a reality for all. 

In an episode of his Big Idea series, Dean Lloyd Minor welcomes Stanford neuroscientist Karl Deisseroth, MD, PhD, for a conversation about how his groundbreaking research is reshaping our understanding of the brain and the experiences that define us as human. They delve into the origins of optogenetics — a revolutionary technology Deisseroth pioneered using light to map how the brain drives emotion and behavior — and they explore his vision for Stanford Medicine’s Human Neural Circuitry research program. Deisseroth also reflects on the beauty of scientific discovery, the role of humility in research, and how advances in brain science are opening new avenues for understanding and treating mental illness.

Dean Lloyd Minor welcomes Jeremy Kahn, award-winning journalist and AI Editor at Fortune, for a conversation about the transformative potential and societal risks of artificial intelligence. They discuss opportunities for AI to accelerate medical breakthroughs and personalize education, as well as the threat of overreliance on AI to critical thinking, writing, and social skills. They also explore how AI is reshaping jobs and business models, the role of regulation in balancing innovation with safety, and the geopolitical stakes as global competition in AI intensifies.

Dean Lloyd Minor welcomes Regina Dugan, CEO of Wellcome Leap, for a conversation about how to tackle complex global challenges through bold innovation. They discuss why emotional engagement is essential to achieving scientific progress, how high-risk, high-reward models can translate to health research, and the importance of addressing underfunded areas, such as women’s health. They also explore strategies for removing barriers to innovation and how redefining failure can lead to more meaningful progress.

Dean Lloyd Minor welcomes JPMorganChase Vice Chairman Peter Scher for a conversation about the evolving role of corporate responsibility and its intersection with business strategy. They discuss Scher’s leadership in JPMorganChase’s $200 million investment to revitalize the city of Detroit, as well as the firm’s work in other urban environments supporting business and growing communities. They also explore his work with Morgan Health, the firm’s business unit focused on improving the quality and delivery of employer-based health care, and how AI, data, and innovation are reshaping health care.

Dean Lloyd Minor welcomes Thrive Global CEO Arianna Huffington for a conversation about the connection between mental health and physical health and how tiny changes to behavior can have a profound impact. They discuss the transformative moment that led to Arianna’s pivot to wellness in 2016, and they explore the potential for AI to democratize personalized health coaching and make a meaningful difference across communities.

In a special episode recorded in front of a live audience, Dean Lloyd Minor welcomes Stanford’s legendary women’s basketball coach Tara VanDerveer for a discussion about her extraordinary 40-year career. They discuss the coaching philosophy that led her teams to three NCAA Championship titles and an Olympic gold medal, along with her approach to developing talent and fostering resilience. They also explore the art of making half-time adjustments, learning as a leader, and the future of women’s athletics.

Dean Lloyd Minor welcomes Daphne Koller, PhD, founder and CEO of insitro, for a conversation about AI’s potential to transform drug discovery. They discuss how machine learning algorithms can accelerate the drug design process, quickly identifying biological patterns and predicting outcomes. They also explore the challenges and opportunities of founding a startup in Silicon Valley, and how insitro’s collaborations with large pharmaceutical companies are advancing therapeutics for Amyotrophic lateral sclerosis (ALS) and other conditions.

Dean Lloyd Minor welcomes Dr. Karen DeSalvo, Google’s Chief Health Officer, for a conversation about how AI can help inform and advocate for patients while supporting clinicians and increasing access to care around the world. They discuss AI tools that Google has developed to accelerate diagnostics, particularly in lower-resource areas, and they explore the potential for AI to serve as a personal health assistant for patients. They also discuss Google’s strategy for providing accurate, meaningful health information to the general public, and the challenges and opportunities of integrating AI technologies into clinical care.

Dean Lloyd Minor welcomes Meena Seshamani, MD, PhD, director of the federal Center for Medicare at the Centers for Medicare & Medicaid Services, for a conversation about supporting holistic health care through the country’s government insurance program for seniors. They discuss Medicare’s role in advancing prescription drug affordability and the importance of family caregivers and community workers in helping seniors attain their optimal health. They also explore practical approaches Medicare has deployed to advance health equity, and discuss what needs to be done to ensure the program’s financial strength and viability for generations to come.