32. Why Has There Been So Little Progress on Alzheimer’s Disease?

One possibility: a leading hypothesis pursued by researchers (and funders) was built on science that now appears to be fraudulent. Stephen Dubner speaks with the scientist and the journalist who blew the whistle.   SOURCES: Charles Piller, investigative journalist for Science, author of Doctored. Matthew Schrag, associate professor of neurology at Vanderbilt University Medical Center.   RESOURCES: Doctored: Fraud, Arrogance, and Tragedy in the Quest to Cure Alzheimer's, by Charles Piller (2025). "The brain makes a lot of waste. Now scientists think they know where it goes," by Jon Hamilton (NPR, 2024). "The history of Alzheimer’s disease," by Lisa Kiani and Richard Hodson (Nature, 2024).   EXTRAS: "Can Marty Makary Fix the F.D.A.?" by Freakonomics Radio (2026). "Are You Ready for the Elder Swell?" by Freakonomics Radio (2025). Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Just beneath the surface of the global economy, there is a hidden layer of dealmakers for whom war, chaos, and sanctions can be a great business opportunity. In this updated episode from 2025, journalists Javier Blas and Jack Farchy help us shine a light on the shadowy realm of commodity traders.   SOURCES: Javier Blas, opinion columnist at Bloomberg News. Jack Farchy, energy and commodities senior reporter at Bloomberg News. RESOURCES: The World For Sale: Money, Power, and the Traders Who Barter the Earth's Resources, by Javier Blas and Jack Farchy (2021) The King of Oil: The Secret Lives of Marc Rich, by Daniel Ammann (2010). EXTRAS: "How the Supermarket Helped America Win the Cold War (Update)" by Freakonomics Radio (2024). "The First Great American Industry," by Freakonomics Radio (2023). Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

... of bad reviews, meager financing, or artificial intelligence. But he is worried that the world is full of sloppy thinkers who mistake facts for the truth.   SOURCES: Werner Herzog, writer, filmmaker, and actor.   RESOURCES: The Future of Truth, by Werner Herzog (2025). Every Man for Himself and God Against All: A Memoir, by Werner Herzog (2023).   EXTRAS: "When Did We All Start Watching Documentaries?" by Freakonomics Radio (2025). "Werner Herzog Thinks His Films Are a Distraction," by People I (Mostly) Admire (2023). Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

For 50 years, the healthcare industry has been trying (and failing) to harness the power of artificial intelligence. It may finally be ready for prime time. What will this mean for human doctors — and the rest of us? (Part four of “The Freakonomics Radio Guide to Getting Better.”) SOURCES:Bob Wachter, professor, chair of the department of medicine at the University of California, San Francisco.Pierre Elias, cardiologist, assistant professor of biomedical informatics at Columbia University, medical director for artificial intelligence at NewYork-Presbyterian Hospital. RESOURCES:A Giant Leap: How AI Is Transforming Healthcare and What That Means for Our Future, by Bob Wachter (2026)."Epic Systems (MyChart)," by Acquired (2025)."Detecting structural heart disease from electrocardiograms using AI," by Pierre Elias and Timothy Poterucha (Nature, 2025)."What Are the Risks of Sharing Medical Records With ChatGPT?" by Maggie Astor (New York Times, 2025)."Will Generative Artificial Intelligence Deliver on Its Promise in Health Care?" by Bob Wachter and Erik Brynjolfsson (JAMA, 2023).The Digital Doctor: Hope, Hype, and Harm at the Dawn of Medicine’s Computer Age, by Bob Wachter (2015). EXTRAS:"The Doctor Won’t See You Now," by Freakonomics Radio (2025)."How to Stop Worrying and Love the Robot Apocalypse (Update)," by Freakonomics Radio (2024). Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Zeke Emanuel (a physician, medical ethicist, and policy wonk) has some different ideas for how to lead a healthy and meaningful life. It starts with ice cream. (Part three of “The Freakonomics Radio Guide to Getting Better.”) SOURCES:Zeke Emanuel, oncologist, bioethicist, professor at the University of Pennsylvania. RESOURCES:Eat Your Ice Cream: Six Simple Rules for a Long and Healthy Life, by Zeke Emanuel (2026)."Nutrition Science’s Most Preposterous Result," by David Merritt Johns (The Atlantic, 2023). EXTRAS:"Is Ozempic as Magical as It Sounds?" by Freakonomics Radio (2024)."The Suddenly Diplomatic Rahm Emanuel," by Freakonomics Radio (2023)."Ari Emanuel Is Never Indifferent," by Freakonomics Radio (2023)."What’s the “Best” Exercise?" by Freakonomics Radio (2014). Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In his new book “Breakneck,” Dan Wang argues that the U.S. has a lot to learn from China. He also says that “no two peoples are more alike.” We have questions. SOURCES:Dan Wang, research fellow at the Hoover Institution at Stanford University, author of Breakneck: China's Quest to Engineer the Future. RESOURCES:Breakneck: China's Quest to Engineer the Future, by Dan Wang (2025).The Anaconda in the Chandelier: Writings on China, by Perry Link (2025)."Is the U.S. Ready for the Next War?" by Dexter Filkins (The New Yorker, 2025)."How smartphones made Shenzhen China’s innovation capital," by Dan Wang (2016).How China Escaped the Poverty Trap, by Yuen Yuen Ang (2016).The Art of Not Being Governed, by Jame Scott (2009). EXTRAS:"The Engineering State and the Lawyerly Society: Dan Wang on his new book 'Breakneck,'" by the Sinica Podcast (2025)."Is the U.S. Really Less Corrupt Than China?" by Freakonomics Radio (2021). Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Just beneath the surface of the global economy, there is a hidden layer of dealmakers for whom war, chaos, and sanctions can be a great business opportunity. Javier Blas and Jack Farchy, the authors of The World for Sale, help us shine a light on the shadowy realm of commodity traders. SOURCES:Javier Blas, opinion columnist at Bloomberg News.Jack Farchy, energy and commodities senior reporter at Bloomberg News. RESOURCES:The World For Sale: Money, Power, and the Traders Who Barter the Earth's Resources, by Javier Blas and Jack Farchy (2021)The King of Oil: The Secret Lives of Marc Rich, by Daniel Ammann (2010). EXTRAS:"How the Supermarket Helped America Win the Cold War (Update)" by Freakonomics Radio (2024)."The First Great American Industry," by Freakonomics Radio (2023). Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Licensing began with medicine and law; now it extends to 20 percent of the U.S. workforce, including hair stylists and auctioneers. In a new book, the legal scholar Rebecca Allensworth calls licensing boards “a thicket of self-dealing and ineptitude” and says they keep bad workers in their jobs and good ones out — while failing to protect the public. SOURCES:Rebecca Allensworth, professor of law at Vanderbilt University. RESOURCES:"The Licensing Racket: How We Decide Who Is Allowed to Work, and Why It Goes Wrong" by Rebecca Allensworth (2025)."Licensed to Pill," by Rebecca Allensworth (The New York Review of Books, 2020)."Licensing Occupations: Ensuring Quality or Restricting Competition?" by Morris Kleiner (W.E. Upjohn Institute for Employment Research, 2006)."How Much of Barrier to Entry is Occupational Licensing?" by Peter Blair and Bobby Chung (British Journal of Industrial Relations, 2019). EXTRAS:"Is Ozempic as Magical as It Sounds?" by Freakonomics Radio (2024). Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Adam Moss was the best magazine editor of his generation. When he retired, he took up painting. But he wasn’t very good, and that made him sad. So he wrote a book about how creative people work— and, in the process, he made himself happy again. SOURCE:Adam Moss, magazine editor and author. RESOURCES:The Work of Art: How Something Comes from Nothing, by Adam Moss (2024)."Goodbye, New York. Adam Moss Is Leaving the Magazine He Has Edited for 15 Years," by Michael M. Grynbaum (The New York Times, 2019).Salt, Fat, Acid, Heat: Mastering the Elements of Good Cooking, by Samin Nosrat (2017). EXTRAS:"David Simon Is On Strike. Here’s Why," by People I (Mostly) Admire (2023)."Samin Nosrat Always Wanted to Be Famous," by Freakonomics Radio (2023)."What’s Wrong with Being a One-Hit Wonder?" by Freakonomics Radio (2023). Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

John J. Sullivan, a former State Department official and U.S. ambassador, says yes: “Our politicians aren’t leading — Republicans or Democrats.” He gives a firsthand account of a fateful Biden-Putin encounter, talks about his new book Midnight in Moscow, and predicts what a second Trump term means for Russia, Ukraine, China — and the U.S. SOURCES:John Sullivan, former U.S. Deputy Secretary of State and former U.S. Ambassador to Russia. RESOURCES:Midnight in Moscow: A Memoir from the Front Lines of Russia's War Against the West, by John Sullivan (2024)."The ‘Deathonomics’ Powering Russia’s War Machine," by Georgi Kantchev and Matthew Luxmoore (The Wall Street Journal, 2024).War, by Bob Woodward (2024)."On the Record: The U.S. Administration’s Actions on Russia," by Alina Polyakova and Filippos Letsas (Brookings, 2019)."Why Economic Sanctions Still Do Not Work," by Robert A. Pape (International Security, 1998). EXTRAS:"The Suddenly Diplomatic Rahm Emanuel," by Freakonomics Radio (2023). Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.