Mice, neuroscience and the debate around "curing" autism

It's been almost 30 years since a narrow vote in the 1995 referendum ended the last threat to Canadian unity. And while it's not as though there hasn't been idle talk since then from angry provinces and their citizens, there's never again been a serious question of a province seceding from Canada...But history repeats, and as the 30th anniversary of the 1995 vote looms, a look at the underlying political conditions reveals some striking similarities—particularly if as expected the Conservatives decimate the Liberals in the next federal election. So is this idle speculation? Or is this a likely scenario that, amid all the political turmoil in Ottawa and around the world, nobody is paying enough attention to?GUEST: Gerald Butts, vice chair of the Eurasia group and Director of the World Wildlife Fund; former Principal Secretary to Prime Minister Justin Trudeau and former Ontario Premier Dalton McGuinty, writing about Quebec secession for The Walrus We love feedback at The Big Story, as well as suggestions for future episodes. You can find us:Through email at [email protected] Or by calling 416-935-5935 and leaving us a voicemailOr @thebigstoryfpn on Twitter

This week, with all of the wrappers and candy scattered around after Halloween, we're revisiting a episode from 2023 about Toronto's so-called trash bandits. Enjoy!  --------------------------------------------------------One hundred years ago, raccoons were so rare in Toronto, that a mysterious creature rummaging in a garbage bin warranted a newspaper report. Today, raccoons are basically the city's mascot—literally, the creatures are on all sorts of Toronto memorabilia. The war Toronto waged on raccoons spanned decades, with no end of amusing skirmishes. But it's abundantly clear that it's over. The raccoons won, the people lost, and now we just try to protect our garbage and hope the mess isn't too bad. This is how Toronto became the raccoon capital of the world—gradually, then suddenly.GUEST: Amy Dempsey, senior writer, The Toronto Star We love feedback at The Big Story, as well as suggestions for future episodes. You can find us:Through email at [email protected] Or by calling 416-935-5935 and leaving us a voicemailOr @thebigstoryfpn on Twitter

This episode first aired on October 31, 2024 over at In This Economy?!, our sister show at the Frequency Podcast Network. The show helps Canadians understand the systems behind their money problems so they can make informed decisions about their personal finances. If you like what you hear, please consider giving us a follow! Many of us, at one point or another, have thought about changing banks. But with those thoughts comes a little uncertainty. How much time will it take? How much money will it cost? Will it impact my borrowing power? Today we tackle everything you need to know about switching banks, so you can understand your options and make a sound decision. GUEST: Rubina Ahmed-Haq, personal finance expert and multimedia journalist. We love feedback at The Big Story, as well as suggestions for future episodes. You can find us:Through email at [email protected] Or by calling 416-935-5935 and leaving us a voicemailOr @thebigstoryfpn on Twitter

Two weeks from today, Taylor Swift will land in Toronto for the first of six shows in the city on the Eras Tour's Canadian leg. In December she'll play three more shows in Vancouver. And when the Eras Tour comes to a city, it makes its presence felt in the form of hundreds of millions of dollars, tens of thousands of fans, security challenges, snarled traffic, price gouging and more.So what happens when Swift lands in Canada? What should we expect? And exactly how did a teenage country singer out of Nashville become, quite literally, bigger than the Beatles? How did Taylor Swift take over the entire music industry? And will she ever give it back?GUEST: Rob Sheffield,  American music journalist, author of Heartbreak is the National Anthem: How Taylor Swift Reinvented Pop Music We love feedback at The Big Story, as well as suggestions for future episodes. You can find us:Through email at [email protected] Or by calling 416-935-5935 and leaving us a voicemailOr @thebigstoryfpn on Twitter

In 2002, Ryan James Wedding was a member of Team Canada at the Salt Lake City Olympics. Today, if you know where he is, the police will pay you $50,000. In the 22 years in between, he's alleged to have been a part of everything from trafficking and distribution thousands of kilos of cocaine to a series of contract killings in Ontario. How did an Olympic athlete come to this? It's a story police and reporters and still trying to untangle...GUEST: Calvi Leon, reporter, The Toronto Star We love feedback at The Big Story, as well as suggestions for future episodes. You can find us:Through email at [email protected] Or by calling 416-935-5935 and leaving us a voicemailOr @thebigstoryfpn on Twitter

If anyone ever tries to tell you that your vote doesn't matter, you can tell them about this election. The final results of BC's vote took a week to calculate—and even then two ridings need judicial recounts. It was as close as an election can possibly be, and that means that the government it produces will be ... precarious, to say the least.So why was it so close? Where was the election ultimately decided? Will David Eby's NDP actually be able to form a government? If they do ... how long can it possibly last, and what could it actually get done?GUEST: Jen St. Denis, reporter, The Tyee We love feedback at The Big Story, as well as suggestions for future episodes. You can find us:Through email at [email protected] Or by calling 416-935-5935 and leaving us a voicemailOr @thebigstoryfpn on Twitter

One of the tools scientists have used in autism research has been lab mice, genetically engineered to display similar behavioural characteristics as some humans with autism. But the value of those experiments, has become the subject of fierce debate amongst neuroscientists.It's also that debate that gets at the heart of what we do and don't understand about autism: Should we be trying to "cure" it by identifying its genetic causes? How? What exactly would that look like in practice? Where should we be focusing our research efforts, and why? As you might imagine, none of those answers are easy, or without contention...GUEST: Celia Ford, PhD, neuroscience; Future Perfect fellow at Vox We love feedback at The Big Story, as well as suggestions for future episodes. You can find us:Through email at [email protected] Or by calling 416-935-5935 and leaving us a voicemailOr @thebigstoryfpn on Twitter

For our guest, it was a sandwich. For you it might be a box of cereal or a favourite candy bar. It doesn't matter what it is. What matters is that it makes you mad. There are plenty of signs that things are looking up in terms of affordability: Inflation is down and interest rates are declining fast—but somehow none of that is impacting how the economy makes Canadians feel.How has consumer rage becoming the defining issue of today's political landscape? If it brings down one federal government, what happens to the next one if things don't magically get cheaper? Why do we feel the price of a candy bar more than all the numbers that tell us things are getting better? And how are smart politicians channeling that rage?GUEST: Ira Wells, Toronto-based journalist writing in The Walrus We love feedback at The Big Story, as well as suggestions for future episodes. You can find us:Through email at [email protected] Or by calling 416-935-5935 and leaving us a voicemailOr @thebigstoryfpn on Twitter

This week, in honour of Halloween, we're revisiting an episode from 2023 about a quintessentially spooky topic: UFOs. Enjoy!  --------------------------------------------------------Right now, Canada is working on a process to improve our tracking and reporting of sightings of Unidentified Flying Objects. In late May, NASA and the US Department of Defence help a joint public meeting, where it was revealed that the Five Eyes—an alliance of intelligence agencies including the US and Canada—held a private forum about the sightings, which have included, specifically, metallic orbs seen all over the world.All of this could sounds like the opening of a blockbuster, or just a conspiracy theory. But it's neither. It's a serious attempt by some of the world's biggest military and intelligence agencies to figure out exactly what's going on in our skies, be it natural phenomena, secretive new aerospace technology or, yes, something out of this world...GUEST: Daniel Otis, freelance journalist reporting on UFOs We love feedback at The Big Story, as well as suggestions for future episodes. You can find us:Through email at [email protected] Or by calling 416-935-5935 and leaving us a voicemailOr @thebigstoryfpn on Twitter

This episode first aired on October 23, 2024 over at In This Economy?!, our sister show at the Frequency Podcast Network. The show helps Canadians understand the systems behind their money problems so they can make informed decisions about their personal finances. If you like what you hear, please consider giving us a follow! You may have seen recent headlines about Canada's economy adding 47,000 new jobs in September and full-time employment seeing the largest gain in two years. These numbers sound positive, but do they tell the full story? What does this mean for people currently looking for work? And how does it help, or hinder, those who are currently employed but hoping for a raise or promotion? We love feedback at The Big Story, as well as suggestions for future episodes. You can find us:Through email at [email protected] Or by calling 416-935-5935 and leaving us a voicemailOr @thebigstoryfpn on Twitter