
Neuroleptic Malignant Syndrome is a life threatening reaction to antipsychotic (neuroleptic) medication. In this video we look at the pathophysiology, symptoms, diagnosis, differentials (including serotoning syndrome) and treatment
PDFs available here: https://rhesusmedicine.com/pages/psychiatry
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Timestamps:
0:00 What is Neuroleptic Malignant Syndrome?
0:33 Typical vs Atypical Antipsychotics
1:37 Neuroleptic Malignant Syndrome Pathophysiology
2:32 Neuroleptic Malignant Syndrome Symptoms
3:39 Risk Factors
4:52 Neuroleptic Malignant Syndrome Diagnosis
6:00 Neuroleptic Malignant Syndrome Differential Diagnosis
6:14 Neuroleptic Malignant Syndrome Treatment
7:40 Neuroleptic Malignant Syndrome Complications
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References
- BMJ Best Practice, 2025. Neuroleptic malignant syndrome. [online] Available at: https://bestpractice.bmj.com/topics/en-gb/990.
- StatPearls, 2025. Neuroleptic Malignant Syndrome. [online] Available at: https://www.ncbi.nlm.nih.gov/books/NBK482282/.
- Wikipedia, 2025. Neuroleptic malignant syndrome. [online] Available at: https://en.wikipedia.org/wiki/Neuroleptic_malignant_syndrome.
- National Center for Biotechnology Information (NCBI), 2025. Introduction - First-Generation Versus Second-Generation Antipsychotics in Adults: Comparative Effectiveness. [online] Available at: https://www.ncbi.nlm.nih.gov/books/NBK107237/.
- MDedge Psychiatry, 2025. Identify neuroleptic malignant syndrome with FEVER. [online] Available at: https://www.mdedge.com/psychiatry/article/60368/identify-neuroleptic-malignant-syndrome-fever.
Disclaimer: Please remember this podcast and all content from Rhesus Medicine is for educational and entertainment purposes only and is not a guide to diagnose or to treat any form of condition. The content is not to be used to guide clinical practice and is not medical advice. Please consult a healthcare professional for medical advice.
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