Poolbeg Pharma kicks off POLB001 Phase 2a trial with specialist partner

American Resources Corp CEO Mark Jensen joined Steve Darling to announce a major capacity expansion at its Noblesville, Indiana critical mineral refining facility, operated through its subsidiary ReElement Technologies. The expansion increases the site’s footprint by 141%, bringing it to more than 16,500 square feet and providing near-term refining capacity of over 200 metric tons per year of ultra-pure separated defense elements and rare earth oxides. Jensen explained that this investment significantly enhances ReElement’s ability to deliver critical minerals essential to the defense and advanced technology sectors. Among the materials targeted for production are yttrium, germanium, gadolinium, gallium, terbium, samarium, dysprosium, and antimony — all of which are designated as vital to U.S. national security and high-performance applications. The Noblesville facility now stands as a key near-term supplier while the company’s larger-scale Marion Supersite continues to advance toward commissioning. As part of this expansion, ReElement recently installed nine additional separation columns, alongside critical equipment such as its state-of-the-art ICP-MS machine, ensuring the facility can consistently produce materials of 99.999% purity at commercial scale. Notably, the company has managed to execute this expansion while maintaining uninterrupted daily operations, demonstrating its operational efficiency and scalability. Meanwhile, at the Marion Supersite, ReElement has either ordered, identified, or begun installing more than 60% of the equipment required for the site’s initial contracted growth phase. Once operational, Marion will provide large-scale refining capacity across multiple critical materials, including magnet-grade rare earths, battery metals, antimony, and additional defense elements. Jensen emphasized that the Noblesville expansion is an important step in strengthening the United States’ domestic critical minerals supply chain. By scaling up both near-term and long-term refining capacity, ReElement is positioning itself as a cornerstone provider of sustainable, onshore solutions for defense, clean energy, and advanced manufacturing markets. #proactiveinvestors #americanresourcescorporation #nasdaq #arec #SustainableMining, #MineralRefining, #RecyclingInnovation, #CriticalMinerals, #RareEarthRecycling, #EVRecycling, #BatteryRecycling, #princialminerals #adamjohnson #RareEarths #EWasteRecycling #ReElement #CriticalMinerals #SustainableTech #MagnetRecycling #TechInnovation #GreenSupplyChain #ElectrifiedMaterials

B HODL PLC (AQSE:HODL) CEO Freddie New and CFO David Boylan talked with Proactive about the company's listing on the Aquis Exchange and its strategy as a Bitcoin treasury and services business. New explained that B HODL aims to take advantage of both Bitcoin’s store of value and its potential as a medium of exchange. New said: “What really, really excites me about B Hodl PLC is not simply the treasury… it's that opportunity to show what Bitcoin can do.” New outlined the company’s ambition to generate revenue from Bitcoin through operational strategies like providing liquidity to the Lightning Network. Boylan also emphasised transparency as a cornerstone of the company’s investor approach. “Bitcoin is still scary to people… we’re basically staking our reputations and service behind Bitcoin,” he said. B HODL plans to provide accessible data and reporting to help demystify Bitcoin for investors. New discussed the company's strong management team, which includes experience from CoinCorner, PayPal, Baillie Gifford, and other financial services and crypto institutions. He also noted that while the business is listed and fully compliant with UK regulations, many of its operational activities remain outside the scope of traditional regulation. Boylan added that the company will track traditional treasury metrics like NAV and Bitcoin yield, while also highlighting new KPIs tied to Bitcoin utility and revenue generation. For more interviews like this, visit Proactive’s YouTube channel. Don’t forget to like this video, subscribe to the channel, and enable notifications for future content. #Bitcoin #BHodl #CryptoTreasury #LightningNetwork #CryptoInvesting #BitcoinRevenue #BitcoinUK #AquisListing #CryptoTransparency #DigitalAssets

Poolbeg Pharma PLC (AIM:POLB, OTC:POLBF) CEO Jeremy Skillington and principal scientist Liam Tremble talked with Proactive's Stephen Gunnion about the company’s upcoming Phase 2a trial for POLB001. Tremble explained that Poolbeg has partnered with Accelerating Clinical Trials (ACT) in the UK to conduct the study, which will be led by Dr Emma Searle at the University of Manchester and the NHS Christie Foundation Trust. The Christie is one of Europe’s largest cancer centres, treating more than 60,000 patients annually, and will act as the lead site. Tremble emphasised, “We’ve been really fortunate and feel quite blessed that we found a massive amount of interest in participating on this trial.” The trial will be a single-arm, open-label Phase 2a study involving approximately 30 patients. With sufficient supply of both POLB001 and the required bispecific antibody, Poolbeg expects to generate data throughout 2026, with a focus on safety and efficacy. Skillington noted the wider potential for POLB001 in cancer immunotherapy. He said that reducing cytokine release syndrome could allow treatments to move beyond specialist centres into community hospitals. “We feel POLB001 can do that,” he added, describing the market opportunity as greater than $10 billion. He also highlighted that the company holds FDA orphan drug designation for POLB001 and has a cash runway into 2027, positioning Poolbeg to achieve multiple milestones and advance partnering discussions. For more interviews and updates, visit Proactive’s YouTube channel. Don’t forget to like this video, subscribe to the channel, and enable notifications for future content. #PoolbegPharma #POLB001 #CancerResearch #Immunotherapy #ClinicalTrials #Biotech #Oncology #BloodCancer #PharmaNews #DrugDevelopment

Arecor Therapeutics PLC (AIM:AREC) CEO Sarah Howell talked with Proactive's Stephen Gunnion about the company’s strategic updates, including a key partnership with Sequel Med Tech and a new royalty financing agreement with Ligand Pharmaceuticals. Howell explained that Arecor has partnered with Sequel, a US-based insulin pump device company, to advance its lead program AT278, described as “the only ultra-concentrated, ultra-rapid acting insulin in development.” Together, the companies will co-develop AT278 in combination with Sequel’s twiist automated insulin delivery system, with phase 2 clinical trial preparations already underway. Each party has committed up to $1.3 million to fund development, with trial readiness targeted for 2026. Discussing the rationale for the partnership, Howell said Sequel “really bring innovation to the table, significant experience in terms of patient need, the market and also clearly commercialisation.” She noted the potential for AT278 and the Twist system to extend insulin pump wear times and support future miniaturisation, expanding access for people with diabetes. In addition, Arecor announced a royalty financing deal with Ligand Pharmaceuticals, securing up to $11 million in non-dilutive funding linked to partnered products using its Arestat technology. Howell said this extends the company’s cash runway into the first half of 2027, while supporting development of AT278 and its oral peptide delivery platform. For more interviews and updates, visit Proactive’s YouTube channel. Don’t forget to like this video, subscribe to the channel, and enable notifications for future content. #ArecorTherapeutics #AT278 #DiabetesCare #InsulinPump #SequelMedTech #TwistSystem #DiabetesTechnology #BiotechNews #PharmaUpdates #ClinicalTrials

Gunnison Copper Corp SVP and CFO Craig Hallworth joined Steve Darling from Proactive to announce a major operational milestone for the company — the first commercial sales of pure copper cathode from its fully operational Johnson Camp Mine (JCM) in southeast Arizona. The mine, which has the capacity to produce up to 25 million pounds of copper cathode annually, has now transitioned into revenue generation following successful commissioning. Hallworth reported that on September 15, Gunnison completed its inaugural copper sales, delivering a total of 225,371 pounds of finished copper cathode. The copper was sold at an average realized price of US$4.64 per pound, generating gross proceeds of approximately US$1.05 million. These sales represent the first “Made-in-America” copper cathode from JCM delivered directly into domestic markets, marking a significant contribution to strengthening the U.S. copper supply chain. Looking ahead, Gunnison Copper expects to begin production using Nuton’s innovative bio-leaching technology later this year. Nuton, a venture of Rio Tinto, has selected JCM as the first commercial-scale deployment site for this breakthrough technology, which is designed to deliver improved recovery rates while reducing environmental impact. Production at Johnson Camp Mine officially began during the final week of August 2025, ahead of schedule and with an exemplary health and safety record. The mine’s output is entirely U.S.-produced, directly supporting critical industries tied to energy independence, advanced manufacturing, clean technology, and national defense. Hallworth emphasized that this milestone is not only a key achievement for Gunnison Copper but also a significant development for domestic copper production, as the company continues to build value while contributing to America’s strategic resource independence. #proactiveinvestors #gunnisoncoppercorp #tsx #gcu #otcqb #gcumf #CopperMining #USMining #CopperProject #CopperMining #GunnisonCopper #NutonTechnology #USMining #CriticalMinerals #CopperProduction #MiningStocks #NaturalResources #ElectricEconomy #CopperPrices #FreeCashFlow #JohnsonCampMine

Aftermath Silver CEO Ralph Rushton joined Steve Darling from Proactive to provide an update on the company’s exploration strategy for its flagship Challacollo Silver-Gold Project, located in Region 1 of northern Chile. The property hosts a low-sulphidation epithermal Ag-Au vein system with a significant established silver resource, making it one of the more prospective undeveloped silver projects in the region. Rushton shared that Aftermath plans to initiate a 7–10 hole diamond core drilling program in Q4 2025, targeting up to 2,000 meters of total drilling. Previous drilling campaigns primarily focused on the Loló́n Vein, the principal structure on the property, which has been drilled to approximately 200 meters below surface. Importantly, the oxidation zone bottoms at around 200 meters, and beyond this depth the mineralized structures remain open and largely untested. Notably, gold and base metal grades have been observed to increase at depth, further enhancing the project’s exploration potential. The upcoming drilling campaign has three key objectives to expand the current resource by extending known veins down dip and along strike. Test additional veins—both historically identified but untested, as well as newly interpreted structures within Aftermath’s land package and twin select RC holes to collect supplementary geological and metallurgical data, strengthening the company’s understanding of orebody characteristics and potential processing options. Rushton emphasized that this program is designed to both de-risk the existing resource and unlock new exploration upside, positioning Challacollo as a cornerstone asset in Aftermath’s growing silver-gold portfolio. #proactiveinvestors #aftermathsilverltd #tsxv #aag #otcqx #aagff #mining #SilverMining, #BerenguelaProject, #Mining #Silver #Copper #Manganese #Peru #DrillingResults #BatteryMetals #ResourceModel #Investing

Algernon Pharmaceuticals CEO Christopher Moreau joined Steve Darling from Proactive to announce a major milestone in the company’s transition toward specialized healthcare services. Algernon has signed a definitive equipment purchase and financing agreement with Catalyst MedTech for four U.S. FDA-cleared Oncovision CareMiBrain brain-specific Positron Emission Tomography (PET) scanner systems. These systems will be deployed in Algernon’s first four planned neuroimaging medical clinics in the United States. The agreement, valued at over CAD $4 million, is a non-dilutive transaction and also includes provisions for Algernon to acquire an additional six scanner systems on an adjusted cost basis to support the establishment of future clinics. This marks an important step in scaling Algernon’s clinic network across North America. Moreau also highlighted that Algernon intends to rebrand as Algernon Health, a move that reflects the company’s strategic pivot into the Alzheimer’s Disease diagnostic market. The company’s neuroimaging clinics will be the first in the U.S. dedicated exclusively to brain-specific PET imaging, focusing on the early detection of Alzheimer’s Disease. In addition, the facilities will offer advanced PET imaging for other neurological conditions, including various forms of dementia, epilepsy, neuro-oncology, and movement disorders. Algernon plans to work closely with neurologists, geriatricians, primary care physicians, and other healthcare professionals to generate patient referrals and ensure its clinics are well-integrated into the broader medical ecosystem. The need for brain-specific imaging capacity in the U.S. is significant. While PET/CT scanners exist nationwide, the vast majority — 45% of which are located in hospitals — are prioritized for oncology and cardiology diagnostics, leaving limited availability for timely brain scans. This shortage is particularly pressing given the emerging demand for Alzheimer’s diagnostic tools and therapies. Each Alzheimer’s PET brain scan at Algernon’s planned clinics will cost approximately US$5,000, a service covered in the U.S. by private insurers, Medicare, and Medicaid. By establishing a dedicated network of clinics, Algernon aims to address this critical gap in diagnostic services and position itself at the forefront of the rapidly growing Alzheimer’s care market. #proactiveinvestors #algernonpharmaceuticalsinc #cse #agn #otcqb #agnpf #alzheimerdisease #demetia

New Era Energy & Digital CEO Will Gray joined Steve Darling from Proactive to announce the successful completion of Phase One engineering for Texas Critical Data Centers LLC, the company’s flagship data center and power development project located in the heart of the Permian Basin of West Texas and southeastern New Mexico. TCDC is structured as a 50/50 joint venture between New Era and Sharon AI, Inc., combining expertise in energy infrastructure and artificial intelligence. Phase One engineering included a comprehensive series of environmental studies — all of which successfully passed review — along with detailed feasibility assessments for data center development and load studies to evaluate long-term energy requirements. Gray confirmed that the next step will be filing a large load interconnection application, a key milestone that will set the foundation for securing reliable energy delivery to the site. Based on the current project timeline, New Era anticipates that initial power delivery could begin as early as 2027. The TCDC campus is being designed to ultimately scale to 1 gigawatt of power capacity, positioning it as one of the largest AI-optimized data center complexes in North America. This ambitious design underscores the growing demand for next-generation data infrastructure capable of supporting artificial intelligence workloads, cloud computing, and high-performance computing applications. The project is further strengthened by previously announced partnerships that will establish behind-the-meter power islands, ensuring reliable energy delivery while maintaining compliance with Texas Senate Bill 6. This legislation, which directly affects large energy consumers like data centers on the Electric Reliability Council of Texas (ERCOT) grid, requires new operational models for balancing grid reliability with rising power demands. Gray emphasized that completing Phase One engineering validates the constructability and scalability of the TCDC project, providing a clear pathway toward developing a premier energy and data hub that will meet the needs of both AI-driven industries and broader digital infrastructure markets. #proactiveinvestors #neweraheliuminc #nasdaq #nuai #oil #gas #perimianbasin #HeliumProduction #NaturalGas #DataCenters #AIInfrastructure #PecosSlope #VerticalIntegration #EnergyMarkets #PermianBasin #Semiconductors #PowerGeneration #ProactiveInvestors

NEXE Innovations President Ash Guglani joined Steve Darling from Proactive to announce an exciting expansion of the company’s product portfolio, unveiling the launch of four new coffee SKUs in collaboration with a leading North American distributor specializing in office coffee services and retail channels. Since beginning this partnership in February 2025, NEXE has seen consistent customer engagement through recurring orders, underscoring strong market demand for its products. The first SKU in this launch is a seasonal pumpkin-flavored coffee pod, of which the company has already produced and distributed six pallets across U.S. and Canadian markets. Looking ahead, NEXE is actively developing three additional SKUs — decaf, vanilla, and bananas foster — which are expected to hit the market in the near term. These offerings are designed to cater to diverse consumer preferences while maintaining the company’s focus on high-quality, innovative coffee experiences. Beyond these initial launches, NEXE and its distribution partner plan to introduce at least ten more SKUs over the coming months. At the same time, the company is in advanced discussions with potential new partners to expand its distribution network, aiming to secure broader market access and reach more consumers across North America. NEXE remains dedicated to sustainable innovation, particularly in packaging and product development. Through strategic partnerships and environmentally conscious initiatives, the company continues to position itself as a forward-thinking leader in the coffee industry, blending quality, variety, and sustainability. #proactiveinvestors #nexeinnovationsinc #tsxv #nexe #otc #nexnf #Sustainability #CoffeePods #EcoFriendlyProducts #Manufacturing #PatentTechnology #StrategicPartnerships #AshGuglani #ProactiveInvestors #GreenTechnology

Resourcing Tomorrow divisional director Andrew Thake talked with Proactive's Stephen Gunnion about what makes this year’s event a pivotal moment for the global mining industry. Thake outlined how the conference brings together over 2,100 attendees, more than 175 mining companies, 500+ investors and representatives from over 40 governments. “We have really, really crucial conversations that set direction for the future of the industry,” he said. Key topics in 2025 include geopolitics, defence, and the impact of recent M&A activity, including the Anglo-Teck deal. Thake noted the return of commodity price strength, particularly in gold, as a driver for discussion. ESG and sustainability also remain on the agenda despite recent geopolitical pressures. Special focus sessions include keynote addresses from NATO, as well as unique panels featuring voices such as advertising executive Martin Sorrell. Roundtable discussions—under Chatham House rules—cover sensitive subjects including Ukraine’s reconstruction and deep-sea mining, with notable participants such as Dominic Raab and Geoffrey Pyatt. Technology Pitch Battles return to spotlight innovation, offering startups the chance to present solutions directly to miners and investors. The event also coincides with the inaugural London Mining Week, fostering wider collaboration through events like the Women in Mining Lounge and the Oxford Mining Club. Resourcing Tomorrow takes place from 2–4 December at the Business Design Centre in Islington, London. For more interviews like this, head to Proactive’s YouTube channel. Don’t forget to like this video, subscribe to our channel, and enable notifications so you never miss an update. #ResourcingTomorrow #MiningConference #AndrewThake #MiningInnovation #GeopoliticsAndMining #SustainableMining #MiningESG #MiningInvestment #TechnologyInMining #LondonMiningWeek #ProactiveInvestors