Let's Talk About The Duffy Null Variant

In this milestone handover episode of Let’s Talk About SACT, outgoing host Michal reflects on three and a half years and 50 episodes at the helm as he prepares to step down from host and step into his new role as BOPA Vice President. He passes the microphone to incoming host Eoin Tabb, Chief II Pharmacist for Clinical Cancer Services at University Hospital Waterford and host of the Irish Haematology Oncology Podcast.

In this episode, we are joined by Melanie Dalby. We talk about publishing manuscripts. We discuss how to develop a publishable idea, study design and statistics, choosing the right journal, writing a manuscript, and navigating submission and peer review. Melanie also shares practical advice for pharmacy professionals looking to publish their work, including some of the common pitfalls to avoid and tips for first-time authors.

Disclaimer: The views and opinions expressed during this episode are those of the individual speakers and are shared in their personal capacity. They do not necessarily reflect the views, positions, or policies of the companies with which the speakers are affiliated. In this episode we are joined by Poonam Dhokia, Dolapo Sanni and Zsofia Nemeth. We explore the pharmaceutical industry from the perspective of working across medical affairs, clinical research and strategic roles. We discuss how the industry is structured, the importance of medical–commercial separation, clinical trials, the role of Medical Science Liaisons, and how collaboration between the NHS and pharmaceutical companies can improve research, service development and ultimately patient care. Along the way, we challenge common misconceptions about working in pharma and share practical advice for healthcare professionals on building effective, ethical partnerships with industry.

In this episode we are joined by Nikita Ponda. We discuss the pharmacist role in a melanoma charity, we discuss TrialFinder, developments in melanoma and much more.

In this episode we are joined by Dani Binnington, founder of Menopause and Cancer (https://menopauseandcancer.org/). We discuss Dani's journey as a cancer patient going through menopause, guidance and best practice. Link for Non-hormonal-based treatments for menopausal symptoms guidance: https://thebms.org.uk/wp-content/uploads/2025/11/04-BMS-ConsensusStatement-Non-hormonal-based-treatments-for-menopausal-symptoms-NOV2025-C.pdf

In this episode we are joined by Alice Tew and Meera Desai. We discuss the history of the immunotherapy group, how and why it was established and how its work has evolved. We explore key projects including improving equity of access to second-line agents, the development of immunotherapy monographs, upcoming priorities for the group and much more.

In this episode we are joined by Alia Nizam. We discuss the Cancer Research UK Consent Form Project. We explore how and why the project was developed, what's involved in creating consent forms and much more.

In this episode we are joined by Andrew Hantel, Stephen Hibbs and Lauren Merz. We discuss the Duffy Null variant. Specifically what it is, the history, clinical impact and much more.

In this episode we are joined by Hana, also known as @pharmadrama on Instagram. Hana is a hospital pharmacist based in the UK who creates content about pharmacy practice, especially in the field of cancer care. We discuss online cancer misinformation, how to tackle it and much more.

In this episode we are joined by Suzanne Frank. We discuss Inavo120 (Inavolisib-Based Therapy in PIK3CA-Mutated Advanced Breast Cancer) study. We discuss the relevance of the data and how it might change practice going forward. This study is available to read at https://www.nejm.org/doi/full/10.1056/NEJMoa2404625 and the update at https://ascopubs.org/doi/10.1200/JCO.2024.42.16_suppl.1003