The Evolutionary Epic: Crash Course Big History #5

We’ve already learned the basics of carbonyl chemistry and talked about how we can synthesize aldehydes and ketones, but there’s still so much more to learn, like the role carbonyl groups play in reactions involving sedatives! In this episode of Crash Course Organic Chemistry we’re diving deeper into aldehydes and ketones by focusing on addition reactions of oxygen and nitrogen based nucleophiles. We’ll cover hydrates, acetals and hemiacetals, imines and enamines, and more!Episode Sources:io9. 2020. This Is The Drug In The Rolling Stones' Song "Mother's Little Helper". [online] Available at: https://io9.gizmodo.com/this-is-the-drug-in-the-rolling-stones-song-mothers-li-1693032181 Bionity.com. 2020. Mickey_Finn_(Drugs). [online] Available at: https://www.bionity.com/en/encyclopedia/Mickey_Finn_%28drugs%29.html#The_Chicago_bartender_Michael_.22Mickey.22_Finn Chm.bris.ac.uk. 2020. Ninhydrin - Molecule Of The Month - April 2018. [online] Available at: http://www.chm.bris.ac.uk/motm/ninhydrin/ninhydrinh.htmEwan, H.S., Iyer, K., Hyun, S.H., Wleklinski, M., Cooks, R.G. and Thompson, D.H., 2017. Multistep flow synthesis of diazepam guided by droplet-accelerated reaction screening with mechanistic insights from rapid mass spectrometry analysis. Organic Process Research & Development, 21(10), pp.1566-1570.Series Sources:Brown, W. H., Iverson, B. L., Ansyln, E. V., Foote, C., Organic Chemistry; 8th ed.; Cengage Learning, Boston, 2018.Bruice, P. Y., Organic Chemistry, 7th ed.; Pearson Education, Inc., United States, 2014.Clayden, J., Greeves, N., Warren., S., Organic Chemistry, 2nd ed.; Oxford University Press, New York, 2012.Jones Jr., M.; Fleming, S. A., Organic Chemistry, 5th ed.; W. W. Norton & Company, New York, 2014. Klein., D., Organic Chemistry; 1st ed.; John Wiley & Sons, United States, 2012.Louden M., Organic Chemistry; 5th ed.; Roberts and Company Publishers, Colorado, 2009.McMurry, J., Organic Chemistry, 9th ed.; Cengage Learning, Boston, 2016.Smith, J. G., Organic chemistry; 6th ed.; McGraw-Hill Education, New York, 2020.Wade., L. G., Organic Chemistry; 8th ed.; Pearson Education, Inc., United States, 2013.***Watch our videos and review your learning with the Crash Course App! Download here for Apple Devices: https://apple.co/3d4eyZoDownload here for Android Devices: https://bit.ly/2SrDulJCrash Course is on Patreon! You can support us directly by signing up at http://www.patreon.com/crashcourseThanks to the following patrons for their generous monthly contributions that help keep Crash Course free for everyone forever:Vincent, Emilee Murphy, Michael Wang, Jordan willis, Krystle Young, Michael Dowling, Alexis B, Rene Duedam, Burt Humburg, Aziz, Nick, DAVID MORTON HUDSON, Perry Joyce, Scott Harrison, Mark & Susan Billian, Junrong Eric Zhu, Alan Bridgeman, Rachel Creager, Jennifer Smith, Matt Curls, Tim Kwist, Jonathan Zbikowski, Jennifer Killen, Sarah & Nathan Catchings, Brandon Westmoreland, team dorsey, Trevin Beattie, Divonne Holmes à Court, Eric Koslow, Indika Siriwardena, Khaled El Shalakany, Shawn Arnold, Siobhán, Ken Penttinen, Nathan Taylor, William McGraw, Andrei Krishkevich, Sam Ferguson, Eric Prestemon, Jirat, TheDaemonCatJr, Wai Jack Sin, Ian Dundore, Jason A Saslow, Justin, Jessica Wode, Mark, Caleb Weeks__Want to find Crash Course elsewhere on the internet?Facebook - http://www.facebook.com/YouTubeCrashCourseTwitter - http://www.twitter.com/TheCrashCourseTumblr - http://thecrashcourse.tumblr.com Support Crash Course on Patreon: http://patreon.com/crashcourseCC Kids: http://www.youtube.com/crashcoursekids Learn more about your ad choices. Visit megaphone.fm/adchoices

Today we wrap up our discussion of the media by talking about how the government interacts with and influences the content we see. Now it may be easy to assume that because we live in a free-market capitalist society, the only real regulation of the media is determined by the consumers, but this isn’t necessarily true. The government controls a number of factors including the potential for lawsuits, spectrum licensing, FCC fines, and has even tried to pass a bit of legislation. So we’ll talk about how all of these factors influence the media and end with a discussion of a pretty hotly debated topic these days - net neutrality. Produced in collaboration with PBS Digital Studios: http://youtube.com/pbsdigitalstudiosSupport is provided by Voqal: http://www.voqal.orgAll attributed images are licensed under Creative Commons by Attribution 4.0https://creativecommons.org/licenses/...Want to find Crash Course elsewhere on the internet?Facebook - http://www.facebook.com/YouTubeCrashC...Twitter - http://www.twitter.com/TheCrashCourseTumblr - http://thecrashcourse.tumblr.com Support Crash Course on Patreon: http://patreon.com/crashcourseCC Kids: http://www.youtube.com/crashcoursekids Learn more about your ad choices. Visit megaphone.fm/adchoices

In which John Green teaches you about railroads and some of the ways they changed the world, and how they were a sort of microcosm for the Industrial Revolution as a whole. Prior to the invention of steam-powered railroads, pretty much all locomotion had been muscle-powered. You either walked where you wanted to go or rode on an animal to get where you were going. The railroad changed human perception of time and space, making long-distance travel much faster and easier. Railroads also changed habits, including increasing reading. People needed some sort of distraction to ensure they didn't have to talk to other people on the train. Like any new technology, railroads also scared people. All kinds of fears surrounded rail travel, but over time, people got over them. And the quality of boiler manufacturing improved, so the trains exploded less often, which also made people feel safer. Crash Course is on Patreon! You can support us directly by signing up at http://www.patreon.com/crashcourseWant to find Crash Course elsewhere on the internet?Facebook - http://www.facebook.com/YouTubeCrashCourseTwitter - http://www.twitter.com/TheCrashCourseInstagram - https://www.instagram.com/thecrashcourse/CC Kids: http://www.youtube.com/crashcoursekids Learn more about your ad choices. Visit megaphone.fm/adchoices

In the previous episode we discussed what happens when we use electrophilic aromatic substitution to add a group to a benzene ring, but what happens when you try to add even more groups? Well, things get a little more complicated. In this episode of Crash Course Organic Chemistry, we’ll continue our exploration of EAS reactions by looking at electron donating groups and electron withdrawing groups on benzene, and how they affect what happens when we try to add new groups to the ring.Episode Sources:Hammond, G.S. and Douglas, K.J., 1959. Aromatic nitration. III. The ortho to para ratio in nitration of benzonitrile. Journal of the American Chemical Society, 81(5), pp.1184-1187.Series Sources:Brown, W. H., Iverson, B. L., Ansyln, E. V., Foote, C., Organic Chemistry; 8th ed.; Cengage Learning, Boston, 2018.Bruice, P. Y., Organic Chemistry, 7th ed.; Pearson Education, Inc., United States, 2014.Clayden, J., Greeves, N., Warren., S., Organic Chemistry, 2nd ed.; Oxford University Press, New York, 2012.Jones Jr., M.; Fleming, S. A., Organic Chemistry, 5th ed.; W. W. Norton & Company, New York, 2014. Klein., D., Organic Chemistry; 1st ed.; John Wiley & Sons, United States, 2012.Louden M., Organic Chemistry; 5th ed.; Roberts and Company Publishers, Colorado, 2009.McMurry, J., Organic Chemistry, 9th ed.; Cengage Learning, Boston, 2016.Smith, J. G., Organic chemistry; 6th ed.; McGraw-Hill Education, New York, 2020.Wade., L. G., Organic Chemistry; 8th ed.; Pearson Education, Inc., United States, 2013.***Watch our videos and review your learning with the Crash Course App! Download here for Apple Devices: https://apple.co/3d4eyZoDownload here for Android Devices: https://bit.ly/2SrDulJCrash Course is on Patreon! You can support us directly by signing up at http://www.patreon.com/crashcourseThanks to the following patrons for their generous monthly contributions that help keep Crash Course free for everyone forever:Shannon McCone, Amelia Ryczek, Ken Davidian, Brian Zachariah, Stephen Akuffo, Toni Miles, Oscar Pinto-Reyes, Erin Nicole, Steve Segreto, Michael M. Varughese, Kyle & Katherine Callahan, Laurel A Stevens, Vincent, Michael Wang, Stacey Gillespie, Jaime Willis, Krystle Young, Michael Dowling, Alexis B, Rene Duedam, Burt Humburg, Aziz, DAVID MORTON HUDSON, Perry Joyce, Scott Harrison, Mark & Susan Billian, Junrong Eric Zhu, Alan Bridgeman, Rachel Creager, Jennifer Smith, Matt Curls, Tim Kwist, Jonathan Zbikowski, Jennifer Killen, Sarah & Nathan Catchings, Brandon Westmoreland, team dorsey, Trevin Beattie, Divonne Holmes à Court, Eric Koslow, Jennifer Dineen, Indika Siriwardena, Khaled El Shalakany, Jason Rostoker, Shawn Arnold, Siobhán, Ken Penttinen, Nathan Taylor, William McGraw, Andrei Krishkevich, ThatAmericanClare, Rizwan Kassim, Sam Ferguson, Alex Hackman, Jirat, Katie Dean, neil matatall, TheDaemonCatJr, Wai Jack Sin, Ian Dundore, Matthew, Justin, Jessica Wode, Mark, Caleb Weeks__Want to find Crash Course elsewhere on the internet?Facebook - http://www.facebook.com/YouTubeCrashCourseTwitter - http://www.twitter.com/TheCrashCourseTumblr - http://thecrashcourse.tumblr.com Support Crash Course on Patreon: http://patreon.com/crashcourseCC Kids: http://www.youtube.com/crashcoursekids Learn more about your ad choices. Visit megaphone.fm/adchoices

So, "modern" is kind of a loaded term, but today we're going to talk about modern life in Europe, as it looked around the time the 19th century turned into the 20th. We'll look at what life was like in the rapidly growing urban centers of Europe, how developments in communication and information distribution influenced the way people saw their leaders and their neighbors, and how women began making strides toward equality in this era.Sources-Anderson, Harriet. Utopian Feminist: Women’s Movements in Fin-de-Siècle Vienna. New Haven: Yale University Press, 1992.-Hunt, Lynn. Making of the West: Peoples and Cultures. 6th ed. Boston: Bedford St. Martins, 2019.-Kent, Susan Kingsley. Sex and Suffrage in Britain, 1860-1914. Princeton: Princeton University Press, 1987.-Smith, Bonnie G. Women in World History, 1450 to the Present. London: Bloomsbury, 2019.Crash Course is on Patreon! You can support us directly by signing up at http://www.patreon.com/crashcourseThanks to the following patrons for their generous monthly contributions that help keep Crash Course free for everyone forever:Eric Prestemon, Sam Buck, Mark Brouwer, Efrain R. Pedroza, Matthew Curls, Indika Siriwardena, Avi Yashchin, Timothy J Kwist, Brian Thomas Gossett, Haixiang N/A Liu, Jonathan Zbikowski, Siobhan Sabino, Jennifer Killen, Nathan Catchings, Brandon Westmoreland, dorsey, Kenneth F Penttinen, Trevin Beattie, Erika & Alexa Saur, Justin Zingsheim, Jessica Wode, Tom Trval, Jason Saslow, Nathan Taylor, Khaled El Shalakany, SR Foxley, Yasenia Cruz, Eric Koslow, Caleb Weeks, Tim Curwick, DAVID NOE, Shawn Arnold, William McGraw, Andrei Krishkevich, Rachel Bright, Jirat, Ian Dundore--Want to find Crash Course elsewhere on the internet?Facebook - http://www.facebook.com/YouTubeCrashCourseTwitter - http://www.twitter.com/TheCrashCourseTumblr - http://thecrashcourse.tumblr.com Support Crash Course on Patreon: http://patreon.com/crashcourseCC Kids: http://www.youtube.com/crashcoursekids#crashcourse #history #europeanhistory Learn more about your ad choices. Visit megaphone.fm/adchoices

You might think a self regulating factory sounds pretty unbelievable, but that’s pretty much exactly how our bodies work! Our bodies are full of regulatory mechanisms that keep all the organic molecules we need to live in balance. In this episode of Crash Course Organic Chemistry, we’ll look at the building blocks that form these biological polymers, including carbohydrates, proteins, and DNA!Episode Sources:Garrett, R. H., & Grisham, C. M. (2016). Biochemistry. Cengage Learning.Appling, Dean R., Anthony-Cahill, Spencer J., Mathews, Christopher K.. (2016). Biochemistry: concepts and connections. Essex: Pearson.PDB IDs (available at https://www.rcsb.org/): • 1BNA, 6TNA, 3MQ7, 7BJK, 6EC0, 2D3H, 1UBQ, 1BBB, 3FGUSeries Sources:Brown, W. H., Iverson, B. L., Ansyln, E. V., Foote, C., Organic Chemistry; 8th ed.; Cengage Learning, Boston, 2018.Bruice, P. Y., Organic Chemistry, 7th ed.; Pearson Education, Inc., United States, 2014.Clayden, J., Greeves, N., Warren., S., Organic Chemistry, 2nd ed.; Oxford University Press, New York, 2012.Jones Jr., M.; Fleming, S. A., Organic Chemistry, 5th ed.; W. W. Norton & Company, New York, 2014. Klein., D., Organic Chemistry; 1st ed.; John Wiley & Sons, United States, 2012.Louden M., Organic Chemistry; 5th ed.; Roberts and Company Publishers, Colorado, 2009.McMurry, J., Organic Chemistry, 9th ed.; Cengage Learning, Boston, 2016.Smith, J. G., Organic chemistry; 6th ed.; McGraw-Hill Education, New York, 2020.Wade., L. G., Organic Chemistry; 8th ed.; Pearson Education, Inc., United States, 2013.***Watch our videos and review your learning with the Crash Course App! Download here for Apple Devices: https://apple.co/3d4eyZoDownload here for Android Devices: https://bit.ly/2SrDulJCrash Course is on Patreon! You can support us directly by signing up at http://www.patreon.com/crashcourseThanks to the following patrons for their generous monthly contributions that help keep Crash Course free for everyone forever:April Frazier, Dave Freeman, Hasan Jamal, DL Singfield, Lisa Owen, Jeremy Mysliwiec, Amelia Ryczek, Ken Davidian, Stephen Akuffo, Toni Miles, Steve Segreto, Michael M. Varughese, Kyle & Katherine Callahan, Laurel Stevens, Vincent, Michael Wang, Stacey Gillespie (Stacey J), Alexis B, Burt Humburg, Aziz Y, Shanta, DAVID MORTON HUDSON, Perry Joyce, Scott Harrison, Mark & Susan Billian, Junrong Eric Zhu, Rachel Creager, Breanna Bosso, Matt Curls, Tim Kwist, Jonathan Zbikowski, Jennifer Killen, Sarah & Nathan Catchings, team dorsey, Trevin Beattie, Divonne Holmes à Court, Eric Koslow, Jennifer Dineen, Indika Siriwardena, Khaled El Shalakany, Jason Rostoker, Shawn Arnold, Siobhán, Ken Penttinen, Nathan Taylor, Les Aker, ClareG, Rizwan Kassim, Sam Ferguson, Alex Hackman, Jirat, Katie Dean, Avi Yashchin, NileMatotle, Wai Jack Sin, Ian Dundore, Justin, Mark, Caleb Weeks__Want to find Crash Course elsewhere on the internet?Facebook - http://www.facebook.com/YouTubeCrashCourseTwitter - http://www.twitter.com/TheCrashCourseTumblr - http://thecrashcourse.tumblr.com Support Crash Course on Patreon: http://patreon.com/crashcourseCC Kids: http://www.youtube.com/crashcoursekids Learn more about your ad choices. Visit megaphone.fm/adchoices

In which John Green, Hank Green, and Emily Graslie teach you about evolution. So, in the last 3.8 billion years, life on Earth has evolved from single-celled prokaryotes to the dizzying array of life we have today. So how did all this happen? We'll talk about Darwin, evolution, natural selection, and how we got from there to here, and from then to now. Learn more here: http://www.bighistoryproject.comCrash Course is on Patreon! You can support us directly by signing up at http://www.patreon.com/crashcourseWant to find Crash Course elsewhere on the internet?Facebook - http://www.facebook.com/YouTubeCrashCourseTwitter - http://www.twitter.com/TheCrashCourseInstagram - https://www.instagram.com/thecrashcourse/CC Kids: http://www.youtube.com/crashcoursekids Learn more about your ad choices. Visit megaphone.fm/adchoices

This week on Crash Course Econ, Jacob and Adriene are talking about failure. Specifically, we're talking about market failures. When markets don't provide a good or service efficiently, that's a market failure. When markets fail, often governments step in to provide those services. Stuff like public education or military protection are good examples of market failures. So, what are some of the ways governments address, market failures? Well, it's funny you should ask, as we also talk about that in this episode. We'll get into taxes and subsidies and externalities and a bunch of other important stuff this week on Crash Course Econ.Crash Course is on Patreon! You can support us directly by signing up at http://www.patreon.com/crashcourseThanks to the following Patrons for their generous monthly contributions that help keep Crash Course free for everyone forever:Mark, Eric Kitchen, Jessica Wode, Jeffrey Thompson, Steve Marshall, Moritz Schmidt, Robert Kunz, Tim Curwick, Jason A Saslow, SR Foxley, Elliot Beter, Jacob Ash, Christian, Jan Schmid, Jirat, Christy Huddleston, Daniel Baulig, Chris Peters, Anna-Ester Volozh, Ian Dundore, Caleb Weeks--Want to find Crash Course elsewhere on the internet?Facebook - http://www.facebook.com/YouTubeCrashCourseTwitter - http://www.twitter.com/TheCrashCourseTumblr - http://thecrashcourse.tumblr.com Support Crash Course on Patreon: http://patreon.com/crashcourseCC Kids: http://www.youtube.com/crashcoursekids Learn more about your ad choices. Visit megaphone.fm/adchoices

Today we're going to learn about perhaps the best-known leader in the Civil Rights Era, Martin Luther King, Jr. From his rise to notoriety during the Montgomery Bus Boycott in 1955, his leadership of the Southern Christian Leadership Conference, the March on Washington in 1963, his work toward the Civil Rights and Voting Rights Acts of the mid-1960s, and his assassination in 1968, Dr. King is very broadly known. But maybe he isn't that well understood. Like many extremely famous people, Martin Luther King can sometimes be drawn as a bit of a flat character, and his ideas can be reduced to platitudes. Today we'll try to give you a fuller picture of the man and leader he was.Clint's book, How the Word is Passed is available now! https://bookshop.org/a/3859/9780316492935SOURCES:Rustin, “Montgomery Diary,” Liberation (April 1956): 7–10.D’Emilio, Lost Prophet, 2003.King to Edward P. Gotlieb, 18 March 1960, in Papers 5:390–391.Watch our videos and review your learning with the Crash Course App! Download here for Apple Devices: https://apple.co/3d4eyZoDownload here for Android Devices: https://bit.ly/2SrDulJCrash Course is on Patreon! You can support us directly by signing up at http://www.patreon.com/crashcourseThanks to the following patrons for their generous monthly contributions that help keep Crash Course free for everyone forever:April Frazier, Dave Freeman, Hasan Jamal, DL Singfield, Lisa Owen, Jeremy Mysliwiec, Amelia Ryczek, Ken Davidian, Stephen Akuffo, Toni Miles, Steve Segreto, Michael M. Varughese, Kyle & Katherine Callahan, Laurel Stevens, Vincent, Michael Wang, Stacey Gillespie (Stacey J), Alexis B, Burt Humburg, Aziz Y, Shanta, DAVID MORTON HUDSON, Perry Joyce, Scott Harrison, Mark & Susan Billian, Junrong Eric Zhu, Rachel Creager, Breanna Bosso, Matt Curls, Tim Kwist, Jonathan Zbikowski, Jennifer Killen, Sarah & Nathan Catchings, team dorsey, Trevin Beattie, Divonne Holmes à Court, Eric Koslow, Jennifer Dineen, Indika Siriwardena, Khaled El Shalakany, Jason Rostoker, Shawn Arnold, Siobhán, Ken Penttinen, Nathan Taylor, Les Aker, ClareG, Rizwan Kassim, Sam Ferguson, Alex Hackman, Jirat, Katie Dean, Avi Yashchin, NileMatotle, Wai Jack Sin, Ian Dundore, Justin, Mark, Caleb Weeks__Want to find Crash Course elsewhere on the internet?Facebook - http://www.facebook.com/YouTubeCrashCourseTwitter - http://www.twitter.com/TheCrashCourseTumblr - http://thecrashcourse.tumblr.com Support Crash Course on Patreon: http://patreon.com/crashcourseCC Kids: http://www.youtube.com/crashcoursekids Learn more about your ad choices. Visit megaphone.fm/adchoices

Do you know how Prozac works? Or lithium? Did you know that electroshock therapy is still a thing? There's a lot to know about biomedical treatments and how they work in tandem with psychotherapy or talk therapy. In this episode of Crash Course Psychology, Hank talks about how Biomedical Treatments have evolved and how they work with other therapies. If you are currently in need of help: http://www.mentalhealth.gov/get-help/ Want more videos about psychology? Check out our sister channel SciShow Psych at https://www.youtube.com/scishowpsych! --Chapters:Introduction: Does Psychotherapy Work? 00:00Client & Clinician Perceptions 01:19Treatment Outcome Research 2:19Effectiveness vs. Efficacy 3:10Which Therapies Work Best? 3:45Biomedical Therapies 4:42Classes of Psychotropic Drugs 5:09"Electro-Shock" or Electroconvulsive Therapy (ECT) 7:38Other Biomedical Therapies: rTMS & DBS 8:50Lifestyle Changes 9:25Review & Credits 10:09--Crash Course is on Patreon! You can support us directly by signing up at http://www.patreon.com/crashcourseWant to find Crash Course elsewhere on the internet?Facebook - http://www.facebook.com/YouTubeCrashCourseTwitter - http://www.twitter.com/TheCrashCourseInstagram - https://www.instagram.com/thecrashcourse/CC Kids: http://www.youtube.com/crashcoursekids Learn more about your ad choices. Visit megaphone.fm/adchoices