RRSP02 The state of Life Sciences, pt 2 - How AI relates to human life and longevity with Dr. Alex Zhavoronkov Insilico Medicine

Life sciences are at a critical inflection point, where scientific innovation, regulatory demands, and patient expectations converge with advances in data and artificial intelligence, positioning IT as a central driver of faster and more effective drug discovery and clinical development.This week, Dave and Rob continue with part 2 off the Life Sciences mini-series with Dr. Alex Zhavoronkov founder and CEO of Insilico Medicine to exploring how drug discovery and clinical development can become faster and more effective, and the role of AI in that process.  TLDR00:40 – Introduction01:00 – Hang out: Kill Bill Vol. 1 & 2 03:07 – Dig in: Life Sciences mini-series, Part 2 06:43 – Conversation with Dr Alex Zhavoronkov 42:12 – The future of AI in drug discovery and a new paradigm for pharma GuestDr. Alex Zhavoronkov: https://www.linkedin.com/in/zhavoronkov/ HostsDave Chapman:  https://www.linkedin.com/in/chapmandr/Esmee van de Giessen:  https://www.linkedin.com/in/esmeevandegiessen/Rob Kernahan:  https://www.linkedin.com/in/rob-kernahan/ ProductionMarcel van der Burg:  https://www.linkedin.com/in/marcel-vd-burg/Dave Chapman:  https://www.linkedin.com/in/chapmandr/ SoundBen Corbett:  https://www.linkedin.com/in/ben-corbett-3b6a11135/Louis Corbett:   https://www.linkedin.com/in/louis-corbett-087250264/ 'Realities Remixed' is an original podcast from Capgemini

Innovation isn’t about funding, it’s about how organisations are built and led. Progress comes from cutting bureaucracy, empowering mission-led teams, and asking the right questions to unlock bold breakthroughs. This week, Dave, Esmee and Rob are joined again by André Loesekrug-Pietri, Chair and Scientific Director of the Joint European Disruptive Initiative (JEDI, Europe’s ARPA) to explore how Europe can turn moonshot ambitions into reality by building the right people, culture and operating models for future-shaping organisations. TLDR00:41 – Introduction01:14 – Hang out: Esmee returns and the missing API has been found!05:14 – Dig in: Staying in step with global innovation12:57 – Conversation with André Loesekrug-Pietri1:02:26 – Roland Garros tennis, and unlocking creative energy GuestAndre Loeskrug-Petri: https://www.linkedin.com/in/andrepietri/X: @eurojediwww.jedi.foundation HostsDave Chapman:  https://www.linkedin.com/in/chapmandr/Esmee van de Giessen:  https://www.linkedin.com/in/esmeevandegiessen/Rob Kernahan:  https://www.linkedin.com/in/rob-kernahan/ ProductionMarcel van der Burg:  https://www.linkedin.com/in/marcel-vd-burg/Dave Chapman:  https://www.linkedin.com/in/chapmandr/ SoundBen Corbett:  https://www.linkedin.com/in/ben-corbett-3b6a11135/Louis Corbett:   https://www.linkedin.com/in/louis-corbett-087250264/ 'Realities Remixed' is an original podcast from Capgemini

Realities Remixed, formerly known as Cloud Realities, launches a new season exploring the intersection of people, culture, industry and tech.Life sciences are at a turning point, where scientific innovation, regulatory pressure, and patient expectations collide with unprecedented advances in data, AI, and digital platforms. IT is no longer a supporting function but a critical driver of how therapies are discovered, developed, scaled, and delivered safely and at speed.This week, Dave and Rob kick off the Life Sciences mini‑series with Thorsten Rall, Global Industry Lead for Life Sciences at Capgemini, to exploring the current state of the sector, the key themes shaping the episodes ahead, and what it takes to drive better patient outcomes. TLDR00:30 – Introduction to Life Sciences and co‑host Thorsten Rall04:37 – Hang‑out: Navigating Waterloo Station07:50 – Deep dive with Thorsten Rall into the Life Sciences landscape28:03 - What are the main challenges in the sector and main themes45:31 – BBQ season is starting HostsDave Chapman:  https://www.linkedin.com/in/chapmandr/Esmee van de Giessen:  https://www.linkedin.com/in/esmeevandegiessen/Rob Kernahan:  https://www.linkedin.com/in/rob-kernahan/with co-host Thorsten Rall: https://www.linkedin.com/in/thorsten-alexander-rall-b232185/ ProductionMarcel van der Burg:  https://www.linkedin.com/in/marcel-vd-burg/Dave Chapman:  https://www.linkedin.com/in/chapmandr/ SoundBen Corbett:  https://www.linkedin.com/in/ben-corbett-3b6a11135/Louis Corbett:   https://www.linkedin.com/in/louis-corbett-087250264/ 'Realities Remixed' is an original podcast from Capgemini

Realities Remixed, formerly known as Cloud Realities, launches a new season exploring the intersection of people, culture, industry and tech.Today’s most pressing challenges arise from the collision of rapid technological change with deepening economic inequality, weakening democratic systems, geopolitical instability and accelerating climate pressure, leaving world leaders wrestling with how to govern and solve these deeply interconnected crises.This week, Dave, Esmee and Rob are joined by Dex Hunter-Torricke, Founder & President The Center for Tomorrow to explore how tech can solve world macro issues. TLDR00:33 – Introduction00:40 – Hang out: The Boys on Amazon Prime final episode (spoilers) 06:02 – Dig in: How to solve world macro issues? 07:45 – Conversation with Dex Hunter-Torricke 44:52 – Writing a book and meeting world leaders GuestDex Hunter-Torricke: https://www.linkedin.com/in/dextb/https://www.centerfortomorrow.com/ HostsDave Chapman:  https://www.linkedin.com/in/chapmandr/Esmee van de Giessen:  https://www.linkedin.com/in/esmeevandegiessen/Rob Kernahan:  https://www.linkedin.com/in/rob-kernahan/ ProductionMarcel van der Burg:  https://www.linkedin.com/in/marcel-vd-burg/Dave Chapman:  https://www.linkedin.com/in/chapmandr/ SoundBen Corbett:  https://www.linkedin.com/in/ben-corbett-3b6a11135/Louis Corbett:   https://www.linkedin.com/in/louis-corbett-087250264/ 'Realities Remixed' is an original podcast from Capgemini

Starting an AI company is all about spotting a real problem and using AI to solve it in a smarter, faster way than what’s out there today. It’s less about having the perfect idea and more about starting focused, learning fast, and building something people actually want.This week, Dave, Esmee, and Rob are joined by Gijs van de Nieuwegiessen and Tijn van Daelen, founders of One Horizon AI, to explore what it really takes to start and build an AI‑native company TLDR00:32 – Introduction00:55 – Hang out: Why Dutch names can be a real tongue-twister02:00 – Dig in: Exploring how an AI-native culture fits with human-to-human interaction13:35 – Deep dive with Gijs van de Nieuwegiessen and Tijn van Daelen1:01:54 – Following AI: Bloopers, reflections, and field hockey with the kids GuestGijs van de Nieuwegiessen: https://www.linkedin.com/in/nieuwegiessen/Tijn van Daelen: https://www.linkedin.com/in/tijn-van-daelen-495986131/Open source repo: https://github.com/onehorizonai/ink HostsDave Chapman:  https://www.linkedin.com/in/chapmandr/Esmee van de Giessen:  https://www.linkedin.com/in/esmeevandegiessen/Rob Kernahan:  https://www.linkedin.com/in/rob-kernahan/ ProductionMarcel van der Burg:  https://www.linkedin.com/in/marcel-vd-burg/Dave Chapman:  https://www.linkedin.com/in/chapmandr/ SoundBen Corbett:  https://www.linkedin.com/in/ben-corbett-3b6a11135/Louis Corbett:   https://www.linkedin.com/in/louis-corbett-087250264/ 'Realities Remixed' is an original podcast from Capgemini

Open Source is giving AI a real boost, making it easier and faster for organisations to build and experiment with new ideas. As adoption grows, these open ecosystems are helping businesses move quicker, stay flexible, and unlock value with more confidence.This week, Dave, Esmee, and Rob are joined by Richard Harmon, VP & Global Head of Financial Services at Red Hat to explore how Open Source is shaping AI, from mainframes to Kubernetes, and from regulation and sovereignty to a future of AI agents writing code. TLDR00:25 – Introduction00:52 – Hangout: Deep democracy training and “what instrument are you?”03:19 – Dig in: Open‑source culture and AI, do they complement each other?10:02 – Conversation with Richard Harmon51:12 – Sitting in the chair and trying to keep up with AI GuestRichard Harmon: https://www.linkedin.com/in/richardlaurenharmon/ HostsDave Chapman:  https://www.linkedin.com/in/chapmandr/Esmee van de Giessen:  https://www.linkedin.com/in/esmeevandegiessen/Rob Kernahan:  https://www.linkedin.com/in/rob-kernahan/ ProductionMarcel van der Burg:  https://www.linkedin.com/in/marcel-vd-burg/Dave Chapman:  https://www.linkedin.com/in/chapmandr/ SoundBen Corbett:  https://www.linkedin.com/in/ben-corbett-3b6a11135/Louis Corbett:   https://www.linkedin.com/in/louis-corbett-087250264/ 'Realities Remixed' is an original podcast from Capgemini

The SaaSpocalypse marks the end of traditional CRM with manual data entry, rigid interfaces, and seat‑based software no longer make sense in an AI‑driven world. Success now depends on outcome‑focused plumbing: intelligent orchestration that delivers results, not screens.This week, Dave, Esmee, and Rob are joined by Hannah Datz, Americas Vice President of CRM at ServiceNow, to unpack the major announcements from ServiceNow Knowledge 2026 in Las Vegas and explore how AI is accelerating the SaaSpocalypse and driving a fundamental shift in the future of CRM. TLDR00:34 – Introduction 00:54 – Hang out: Happy Password Day and emerging threats 06:46 – Conversation with Hannah Datz 57:20 – From tennis excitement to the best burger ever GuestHannah Datz: https://www.linkedin.com/in/hannahdatz/ HostsDave Chapman:  https://www.linkedin.com/in/chapmandr/Esmee van de Giessen:  https://www.linkedin.com/in/esmeevandegiessen/Rob Kernahan:  https://www.linkedin.com/in/rob-kernahan/ ProductionMarcel van der Burg:  https://www.linkedin.com/in/marcel-vd-burg/Dave Chapman:  https://www.linkedin.com/in/chapmandr/ SoundBen Corbett:  https://www.linkedin.com/in/ben-corbett-3b6a11135/Louis Corbett:   https://www.linkedin.com/in/louis-corbett-087250264/ 'Realities Remixed' is an original podcast from Capgemini

AI is only as strong as the data beneath it, and as it moves into the core of the enterprise, fragmented, duplicated, and poorly governed data is no longer hidden in the background, it’s amplified, exposed, and impossible to ignore.This week, Dave, Esmee, and Rob are joined by Edward Calvesbert, VP Product Management for IBM watsonx AI & Data Platform, to dig into the foundations of enterprise AI, from data silos and the SaaSpocalypse to lakehouse architectures and agent‑driven workflows. TLDR00:17 – Introduction 00:55 – Dig in: The big data unlock for AI14:02 – Conversation with Edward Calvesbert57:58 – Hiking Mount Rainier near Seattle GuestEdward Calvesbert: https://www.linkedin.com/in/ecalvesbert/ HostsDave Chapman:  https://www.linkedin.com/in/chapmandr/Esmee van de Giessen:  https://www.linkedin.com/in/esmeevandegiessen/Rob Kernahan:  https://www.linkedin.com/in/rob-kernahan/ ProductionMarcel van der Burg:  https://www.linkedin.com/in/marcel-vd-burg/Dave Chapman:  https://www.linkedin.com/in/chapmandr/ SoundBen Corbett:  https://www.linkedin.com/in/ben-corbett-3b6a11135/Louis Corbett:   https://www.linkedin.com/in/louis-corbett-087250264/ 'Realities Remixed' is an original podcast from Capgemini

Las Vegas, you’re officially on the record during Google Cloud Next 2026. The #RealitiesRemixed podcast team is back at GCN’26, recording live from the Strip, where bright lights collide with big ideas.This week, we’re swapping roulette wheels for real talk, hosting live conversations with Google leaders who are redefining what’s next across AI‑first enterprise transformation, agentic AI, data, sovereignty, security, and beyond.Expect sharp insights, bold opinions, and future‑shaping conversations, delivered straight from Las Vegas to your headphones. Dave, Rachel, and Rob discusse the highlights of Google Cloud Next 2026! TLDR00:24 – Introduction01:14 – Hang out: Progress from Google Cloud Next 2025 to Google Cloud Next 202608:15 – Dig in: Executive overview of this year’s key themes31:38 – Closing remarksHostsDave Chapman:   https://www.linkedin.com/in/chapmandr/Rachel Belmonte:  https://www.linkedin.com/in/rachel-belmonte-63550358/Rob Kernahan:   https://www.linkedin.com/in/rob-kernahan/ ProductionMarcel van der Burg:   https://www.linkedin.com/in/marcel-vd-burg/Dave Chapman:   https://www.linkedin.com/in/chapmandr/ SoundBen Corbett:   https://www.linkedin.com/in/ben-corbett-3b6a11135/Louis Corbett:    https://www.linkedin.com/in/louis-corbett-087250264/ 'Realities Remixed' is an original podcast from Capgemini

Las Vegas, you’re officially on the record during Google Cloud Next 2026. The #RealitiesRemixed podcast team is back at GCN’26, recording live from the Strip, where bright lights collide with big ideas.This week, we’re swapping roulette wheels for real talk, hosting live conversations with Google leaders who are redefining what’s next across AI‑first enterprise transformation, agentic AI, data, sovereignty, security, and beyond.Expect sharp insights, bold opinions, and future‑shaping conversations, delivered straight from Las Vegas to your headphones. Dave, Rachel, and Rob close out their conversation with Cliff Krimmel, Head of Customer Engineering for Banking at Google Cloud, diving into the changing stack and the rise of the agentic development platform. TLDR00:32 – Day 3 kicks off01:25 – Hang out: Travel-ready tips05:18 – Dig in: The Agentic Data Cloud09:00 – Conversation with Cliff Krimmel32:05 – Closing with burgers & hotdogs GuestCliff Krimmel: https://www.linkedin.com/in/ckrimmel/ HostsDave Chapman:   https://www.linkedin.com/in/chapmandr/Rachel Belmonte:  https://www.linkedin.com/in/rachel-belmonte-63550358/Rob Kernahan:   https://www.linkedin.com/in/rob-kernahan/ ProductionMarcel van der Burg:   https://www.linkedin.com/in/marcel-vd-burg/Dave Chapman:   https://www.linkedin.com/in/chapmandr/ SoundBen Corbett:   https://www.linkedin.com/in/ben-corbett-3b6a11135/Louis Corbett:    https://www.linkedin.com/in/louis-corbett-087250264/ 'Realities Remixed' is an original podcast from Capgemini