#474: Why PAIN Lingers After Healing: Nervous System Secrets, Neuroplasticity Hacks & The Future of Injury Rehab | With Garrett Salpeter

📍 Good news! My original Instagram is back! Please follow my original account at https://www.instagram.com/nathalieniddam/ and also my backup account at https://www.instagram.com/longevitywithnat/. Today, I’m joined by the innovative Garrett Salpeter, an engineer-turned-neuroscience trailblazer and the founder of NeuFit. In this episode, Garrett Salpeter reveals how a college hockey injury—and a near miss with surgery—catapulted him into the world of neurology and direct current stimulation. His personal story of healing, curiosity, and relentless pursuit of understanding the nervous system will change how you think about pain, movement, and recovery. Episode Timestamps: Welcome and episode introduction ... 00:00:00 From hockey injury to neuroscience ... 00:06:08 Central role of the nervous system in healing ... 00:08:33 Viewing the body through an electrical lens ... 00:12:29 The nervous system as health regulator ... 00:17:41 Why chronic stress impedes recovery ... 00:20:47 Brain-driven movement limitations post-injury ... 00:22:16 Neuroplasticity and chronic pain ... 00:26:05 Role of fear and exposure therapy in rehab ... 00:31:13 Direct current tech for nervous system recalibration ... 00:39:39 NeuFit method vs. standard physiotherapy ... 00:43:04 Why imaging and pain don’t always align ... 00:45:48 Threat bucket model for pain and stress ... 00:46:43 Neurological diversity in cases with identical injuries ... 00:48:52 What makes Neubie different from TENS ... 00:51:11 Direct current clinical outcomes ... 00:54:10 Pain relief, function, and confidence—NeuFit’s impact ... 00:57:08 Contraindications and safety for NeuFit ... 00:58:34 Evidence, muscle building, and clinical studies ... 01:00:29 Neurological adaptability and aging ... 01:02:05 Movement, balance, and “use it or lose it” ... 01:06:50 Myths about pain, aging, and the nervous system ... 01:14:50 Our Amazing Sponsors: Ozlo Sleepbuds 2 Sleepbuds 2- use smart sound engineering and sleep detection to help you stay in deeper, more stable sleep all night. Create your ideal sleep environment anywhere: go to ozlosleep.com/nat and use code NAT for $20 off Sleepbuds 2. Quantum Upgrade – A 24/7 quantum energy streaming service designed to support energy, focus, sleep, recovery, and a more balanced nervous system, backed by placebo-controlled research showing measurable improvements in stress-related brain activity and heart rate variability. Try it free for 15 days with no credit card required at QuantumUpgrade.io and use code NAT15.  C.A.R.E. Mitochondrial MoisturizerYoung Goose – An upgraded cellular skincare formula featuring Methylene Blue and Liposomal Creatine to support mitochondrial function, skin barrier health, and resilient, hydrated skin. Click HERE and use code NAT10 to save on C.A.R.E. Mitochondrial Moisturizer. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Original Instagram Backup Instagram Dr. Bill Lawrence Episode

📍 Good news! My original Instagram is back! Please follow my original account at https://www.instagram.com/nathalieniddam/ and also my backup account at https://www.instagram.com/longevitywithnat/. Today, I’m joined by Dr. Rafael Gonzalez, a longtime leader in regenerative medicine whose work spans everything from spinal cord injuries to cutting-edge immune modulation and stem cell therapies. Dr. Gonzalez takes us through his journey from studying secondary degeneration in the nervous system to diving deep into what actually drives healthy aging—and what most people get wrong about immune decline, senescent cells, and the promise (and pitfalls) of regenerative interventions. Offer: Mention this podcast and get 10% off any cell therapy at www.rehealth.com Episode Timestamps: Podcast intro and overview of immune system in aging ... 00:00:00 Spinal cord injury, inflammation, and immune response ... 00:05:00 Why immune modulation matters more than cell replacement ... 00:09:02 Personal/lifestyle factors affecting immune recovery ... 00:12:20 Daily variation in NK cells; diet’s immediate immune impact ... 00:13:07 Connecting immune health to neurodegeneration and aging ... 00:16:25 From stem cell replacement hype to signaling reality ... 00:18:12 Importance of extracellular matrix in longevity ... 00:19:37 Key immune biomarkers for healthy aging ... 00:22:00 NK cells’ role in clearing senescent cells ... 00:31:25 Diet, lifestyle, and exercise as immune foundations ... 00:36:14 Senolytics, exosomes, and evidence gaps ... 00:40:29 Risks in unregulated cell and exosome therapies ... 00:59:29 ReStem, umbilical cord cells, and clinical progress ... 00:52:07 Advice for evaluating international regenerative clinics ... 01:14:58 Hope, hype, or here now: rapid-fire therapy assessment ... 01:21:47 Where to find Dr. Gonzalez and episode close ... 01:24:30 Our Amazing Sponsors: LongeFera by Regenerive - A precision-formulated ashwagandha supplement that isolates four key bioactive compounds to support a healthy stress response, cognitive function, balanced inflammation, and cellular longevity—without the fillers and inconsistent extracts found in many products. Head to regenerive.co and use code NAT25 for 25% off your order. Mitopure Gummies by Timeline – Supports healthier cellular energy, muscle strength, recovery, and healthy aging with clinically proven Urolithin A—without artificial sweeteners, colors, flavors, or unnecessary fillers. Head to timeline.com/NAT20 to get Mitopure starting at just $99 and save an additional 20% on your order. Just Thrive 90-Day Probiotic – A spore-based probiotic that survives stomach acid to arrive 100% alive in your gut, supporting better digestion, nutrient absorption, immunity, and less bloating. Start your first 90-day subscription today and you'll get a FREE 90-day supply of Digestive Bitters (a $90 value) to help optimize digestion and support healthy appetite regulation. Click HERE to learn more. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Original Instagram Backup Instagram Dr. Bill Lawrence Episode

📍 Good news! My original Instagram is back! Please follow my original account at https://www.instagram.com/nathalieniddam/ and also my backup account at https://www.instagram.com/longevitywithnat/. Today, I’m joined once again by neuroscientist Siobhan Mitchell for a conversation that will totally reframe how you think about creatine. Siobhan is here to break down why this simple supplement might actually be one of the most powerful and underappreciated tools for longevity, brain health, and overall resilience as we age. So, if you’re curious about practical ways to close the energy gap as you get older, this episode will give you the science, the real-world tips, and the inspiration to look at creatine in a brand new light. Head to MitoQ.com/nat and use code NAT10 to try it for yourself. Episode Timestamps: Welcome and podcast introduction ... 00:00:00 Creatine’s impact on brain and muscle energy ... 00:00:40 Creatine myths, bro culture, and broader benefits ... 00:01:30 Mitochondrial health, aging, and the Countdown initiative ... 00:02:19 Declining creatine intake with age and in women ... 00:09:40 Preventative power of creatine for muscle and mitochondria ... 00:14:05 Creatine’s role in fall risk, injury, and recovery ... 00:15:11 How to dose and titrate creatine ... 00:17:39 Benefits for older adults and cognitive health ... 00:18:49 Creatine and cognition: sleep deprivation, stress, mood ... 00:25:10 Special recommendations for menopausal and pregnant women ... 00:29:33 Choline, citicoline, and neuromuscular support ... 00:50:23 AKG, L-carnitine, and synergy for mitochondrial function ... 00:57:16 Study insights and future directions ... 01:00:46 Dosing, prepping, and best practices for creatine ... 01:10:31 Quickfire round and episode wrap up ... 01:15:52 Our Amazing Sponsors: Countdown Insiders by Countdown — Join a community helping fund groundbreaking mitochondrial research while receiving exclusive events, science briefings, partner perks, and a voice in what Countdown does next. Get your first month free with code NATHALIE at joincountdown.org/membership. Nature's Marvels Bioregulators by Profound Health - Natural bioregulators designed to support your body's own cellular communication and healthy aging, with targeted formulas for everything from brain and immune health to sleep and vitality. Visit https://profound-health.com/?Aff=Longevity15 and use code NAT15 for 15% off your first order. Grass-Fed Whey by Puori - A third-party tested, grass-fed whey protein delivering 21g of protein per serving, with every batch tested for over 200 contaminants and results available via a QR code for complete transparency. Head to puori.com/NAT and use code NAT to get 32% off your first subscription order, plus a free premium shaker bottle. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Original Instagram Backup Instagram Dr. Bill Lawrence Episode

Today, I’m joined by Steve Scott, an entrepreneur, researcher, and author of The Carbonated Body, who is on a mission to change the way we think about carbon dioxide—and trust me, it’s not just a waste gas. In this episode, Steve makes a compelling case for why CO2 is vital for better energy, resilient mitochondria, and improved recovery, and explains how we’ve misunderstood its role in human health for far too long. Visit https://carbogenetics.com/?ref=NAT and use NAT to get $500 off the CO2inhaler! Episode Timestamps: Introduction to Longevity Podcast and CO2 focus ... 00:00:00 CO2’s misunderstood role in health ... 00:01:44 Host’s personal CO2 inhalation experience ... 00:02:24 Healthy aging and MitoBlue ... 00:03:35 Welcoming the guest and origins ... 00:06:16 CO2 as a vital pH buffer ... 00:08:49 What drew Steve Scott to CO2 ... 00:10:13 The Bohr effect and oxygen delivery ... 00:22:40 History and science of CO2 therapy ... 00:25:06 Evolution of CO2 therapies and devices ... 00:26:28 Transdermal CO2, mitochondria, and angiogenesis ... 00:33:23 CO2’s impact on skin and recovery ... 00:42:57 Combining CO2 with sauna for bone and health ... 00:44:44 Cautions, surprises, and brain health potential ... 00:48:46 CO2’s place in longevity and health routines ... 00:53:00 Recommendations, myths, and breathing tips ... 00:55:07 Where to find Steve Scott and special offer ... 01:00:05 Our Amazing Sponsors: MitoBlue by Wizard Sciences – A longevity-focused formula that combines pharmaceutical-grade methylene blue with NMN, PQQ, fisetin, and apigenin to support healthy mitochondria, cellular renewal, and healthy aging. Learn more HERE and use code NAT15 for 15% off. Electrolyze by BEAM Minerals - Electrolyze is a plant-based fulvic mineral formula that delivers a full spectrum of highly bioavailable trace minerals and electrolytes to support hydration, nutrient delivery, and cellular energy. Head to beamminerals.com/NAT20, use code NAT20, and get 20% off your first order. Vita Zero-Age Exosomes by Vitali Skincare — a regenerative “stacking” formula with exosomes, GHK-Cu, niacinamide, and glutathione designed to support your skin at a cellular level rather than just the surface; go to www.vitaliskincare.com/?ref=Nat20 and use code NAT20 for 20% off. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Original Instagram Backup Instagram Dr. Bill Lawrence Episode

Together, we dive into one of the biggest topics of our time—microplastics. With fresh research showing a 74% reduction in blood microplastics in just one month, Heather Hutchens and Dr. Debra Kimless from Pure BioHealth open up about what that means for our health, our pets, and how we think about longevity. In this eye-opening conversation, we break down how microplastics don’t just clutter our environment—they infiltrate our bodies, disrupt cellular energy, drive chronic inflammation, and even pass through to future generations. We also get real about the hidden sources of plastic exposure all around us, including the products we think are “healthy,” and why our companion animals may be the environmental sentinels we’ve been ignoring. Visit https://purebiohealth.com/discount/NAT20 Use code NAT20 for 20% off the total order value. *Customers may use the code more than once. Offer ends Dec 31, 2026. Episode Timestamps: Introduction and podcast mission ... 00:00:00 Plastic pollution: environmental vs. personal health ... 00:06:31 Human and canine studies on microplastic reduction ... 00:09:28 Motivations behind this mission ... 00:11:03 Heather’s personal environmental awakening ... 00:14:17 Frustrations with current medical training ... 00:18:44 Purpose of "Poisoned by Convenience" ... 00:21:10 Microplastics’ impact on aging and beauty span ... 00:22:17 Surprises in everyday plastic exposure ... 00:24:34 Companion animals as sentinels for toxins ... 00:29:02 Canine study results ... 00:30:31 First published human study design and results ... 00:35:01 Research barriers and study limitations ... 00:37:43 Next steps in scientific research ... 00:40:23 Product info, safety, and patent status ... 00:47:53 Microplastics’ link to fertility and future health ... 00:50:24 Reducing exposure and practical action steps ... 00:59:39 Hidden plastic sources in health routines ... 01:01:30 Empowerment, hope, and closing reflections ... 01:03:44 Our Amazing Sponsors: MitoQ Hormonal Metabolic Control – A targeted formula designed to support women through the hormonal and metabolic shifts of perimenopause and menopause, featuring S-Equol for healthy estrogen signaling, B. breve to support the gut-hormone connection, and chromium to help maintain healthy blood sugar balance. Head to MitoQ.com/nat and use code NAT10 to try it for yourself. Wolverine by LVLUP Health – A peptide-based formula designed to support recovery, tissue repair, and musculoskeletal health, helping your body bounce back from workouts and everyday wear and tear. Head to lvluphealth.com and use code NAT for 15% off your order. Magnesium Breakthrough Advanced 10 by BIOptimizers - A comprehensive magnesium formula with 10 bioavailable forms, active vitamin B6, and ionic trace minerals designed to support sleep, relaxation, recovery, stress, and metabolic health. Head to bioptimizers.com/bionat and use code BIONAT for 15% off, exclusive bonuses, and free shipping on select orders. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Original Instagram Backup Instagram Dr. Bill Lawrence Episode

📍 Good news! My original Instagram is back! Please follow my original account at https://www.instagram.com/nathalieniddam/ and also my backup account at https://www.instagram.com/longevitywithnat/. Today, I’m joined by Wade Lightheart, a true thought leader in the world of biohacking and co-founder of BiOptimizers. Wade has spent decades diving deep into the science of longevity—questioning what really moves the needle for our long-term health, and challenging some of the biggest assumptions in the wellness industry. Head to bioptimizers.com/bionat and use code BIONAT for 15% off your order! Episode Timestamps: Welcome and introduction ... 00:00:00 Hydration as the key limit in longevity ... 00:06:35 Pitfalls of the modern hydration and electrolyte industry ... 00:07:41 Sodium vs. potassium: optimizing hydration ... 00:10:15 Personal hydration protocol and fasting ... 00:12:24 Longevity obsession: accumulation vs. optimization ... 00:13:45 The deep fear of death behind longevity pursuits ... 00:17:37 Spiritual and societal costs of radical life extension ... 00:20:54 Quality vs. quantity of life discussion ... 00:23:58 Magnesium’s foundational role and innovations ... 00:29:55 EMF, magnesium, and modern deficiencies ... 00:37:33 Electrolyte breakthroughs and the potassium shift ... 00:46:18 Trace minerals, humic/fulvic acid, and synergy ... 00:53:34 Habits and environments draining magnesium ... 00:57:34 Chronic stress, social support, and resilience ... 00:59:07 High-risk groups for mineral depletion ... 01:04:27 “Normal aging” and missed mineral issues ... 01:07:51 AI, data, and mineral science ... 01:16:06 Our Amazing Sponsors: Qualia NAD+ by Qualia Life – Clinically proven to increase NAD+ levels by an average of 67% in just four weeks, Qualia NAD+ uses three highly bioavailable precursors to support cellular energy, mental clarity, metabolism, and healthy aging. Visit qualialife.com/nathalie and use code NATHALIE at checkout to save 15%. C.A.R.E. Mitochondrial MoisturizerYoung Goose – An upgraded cellular skincare formula featuring Methylene Blue and Liposomal Creatine to support mitochondrial function, skin barrier health, and resilient, hydrated skin. Click HERE and use code NAT10 to save on C.A.R.E. Mitochondrial Moisturizer. Mitopure Gummies by Timeline – Supports healthier cellular energy, muscle strength, recovery, and healthy aging with clinically proven Urolithin A—without artificial sweeteners, colors, flavors, or unnecessary fillers. Head to timeline.com/NAT20 to get Mitopure starting at just $99 and save an additional 20% on your order. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Original Instagram Backup Instagram Dr. Bill Lawrence Episode

📍 Good news! My original Instagram is back! Please follow my original account at https://www.instagram.com/nathalieniddam/ and also my backup account at https://www.instagram.com/longevitywithnat/. Today, I’m joined by Scott Hickle, former SpaceX engineer and the innovative co-founder of Throne Science (use code LISTENTOYOURGUT for $50 off) —the company on a mission to transform your toilet into a powerful tool for understanding your health. In our conversation, Scott shares how a casual poker night conversation turned into a game-changing pursuit to unlock the health secrets hidden in our daily bathroom routines, (we’re talking about your poop and pee) and why gut health has long been a blind spot for those tracking every other health metric. If you’ve ever wondered what your “waste” can reveal about your wellness—or how small, data-driven changes can make a serious difference for your energy, longevity, and even self-knowledge—this episode is full of surprising insights and practical strategies you won’t hear anywhere else. OFFER: Click Here and use code LISTENTOYOURGUT for $50 off! Episode Timestamps: Welcome and podcast introduction ... 00:00:00 Rise of colorectal cancer in younger adults & urgency of early detection ... 00:10:06 Barriers to gut health - why stool testing is underutilized ... 00:07:19 Signs and symptoms to watch for in bowel habits ... 00:12:51 Why younger people are missed by current screening ... 00:14:27 Role of environmental and dietary factors in rising colorectal cancer rates ... 00:16:37 History of ultra-processed food and military diet impact on long-term gut health ... 00:17:26 Throne device explained—features, privacy, and user experience ... 00:20:18 How Throne uses AI and app coaching to help users identify gut health triggers ... 00:21:25 Tracking bathroom habits and the health implications of toilet time ... 00:27:26 Throne’s founder story, going from a poker table joke to a serious mission ... 00:30:34 Lessons from first product prototypes and the evolution to a user-friendly design ... 00:38:34 Gut health basics: hydration, fiber, meal timing, & tracking patterns ... 00:44:03 Unique challenges of IBS and Throne’s data-driven approach ... 00:51:36 Vision for Throne’s future: early cancer detection and global impact ... 01:00:11 Quickfire Q&A on gut health habits, trends, and important symptoms ... 01:01:31 Where to learn more about Throne and the closing offer ... 01:04:07 Our Amazing Sponsors: Ozlo Sleepbuds 2 Sleepbuds 2- use smart sound engineering and sleep detection to help you stay in deeper, more stable sleep all night. Create your ideal sleep environment anywhere: go to ozlosleep.com/nat and use code NAT for $20 off Sleepbuds 2. Vita Zero-Age Exosomes by Vitali Skincare — a regenerative “stacking” formula with exosomes, GHK-Cu, niacinamide, and glutathione designed to support your skin at a cellular level rather than just the surface; go to www.vitaliskincare.com/?ref=Nat20 and use code NAT20 for 20% off. Wolverine by LVLUP Health – A peptide-based formula designed to support recovery, tissue repair, and musculoskeletal health, helping your body bounce back from workouts and everyday wear and tear. Head to lvluphealth.com and use code NAT for 15% off your order. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Original Instagram Backup Instagram Dr. Bill Lawrence Episode

JOIN US FOR A FREE Webinar on a NEW and WAY more beneficial Ashwaganda supplement, join the trial and tell us how much your strength improved! Sept 02 at 7pm EST. Sign up here https://regenerive.co/pages/nat  Today, I’m diving solo into a topic that’s truly at the heart of everything I do: longevity—specifically, how to actually feel vibrant and strong as we age, not just rack up more years on the calendar. I break down the science behind aging, the real reasons why our repair systems start to slow down, and the practical ways we can take charge, starting right now. JOIN US FOR A FREE Webinar on Sept 02 at 7pm EST. Sign up here regenerive.co/nat  Want to try Longefera now? Head to regenerive.co and use code NAT25 for 25% off your order. Episode Timestamps: Intro to the Longevity Podcast and Host Natalie Nidum ... 00:00:00 Healthspan vs. lifespan: Why vitality matters ... 00:03:53 Key hallmarks of aging and their impacts ... 00:10:25 Dysbiosis and microbiome’s role in longevity ... 00:13:46 The Four Horsemen: Chronic disease and aging ... 00:15:17 Sirtuin genes and lifestyle interventions ... 00:16:23 LongeFera: Next-gen ashwagandha for healthy aging ... 00:29:32 Human trial results: Strength, endurance, balance, and brain health ... 00:36:01 Supplement safety and guidance ... 00:46:03 Join the LongeFera trial & free webinar ... 00:49:02 Our Amazing Sponsors: Stemregen - A daily formula designed to support your body’s natural repair systems by helping release your own stem cells into circulation, supporting recovery, resilience, and whole-body renewal at the source. Visit stemregen.co/NAT15 and use code NAT15.  Magnesium Breakthrough Advanced 10 by BIOptimizers - A comprehensive magnesium formula with 10 bioavailable forms, active vitamin B6, and ionic trace minerals designed to support sleep, relaxation, recovery, stress, and metabolic health. Head to bioptimizers.com/bionat and use code BIONAT for 15% off, exclusive bonuses, and free shipping on select orders. MitoBlue by Wizard Sciences – A longevity-focused formula that combines pharmaceutical-grade methylene blue with NMN, PQQ, fisetin, and apigenin to support healthy mitochondria, cellular renewal, and healthy aging. Learn more at wizardsciences.com and use code NAT15 for 15% off. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Original Instagram Backup Instagram Dr. Bill Lawrence Episode

📍 Good news! My original Instagram is back! Please follow my original account at https://www.instagram.com/nathalieniddam/ and also my backup account at https://www.instagram.com/longevitywithnat/. Today, I’m joined by the exceptional Dr. Laura James, a breast cancer specialist who has spent over two decades guiding women through conventional treatment and integrative care. In our conversation, Dr. James opens up about the real struggles women face beyond the diagnosis—everything from family dynamics and workplace challenges to the “unmentionables” like body image, sexuality, and grief. She shares how her personal journey with chronic illness shaped her unique approach to truly supporting the whole person, not just the disease. Episode Timestamps: Show introduction and podcast overview ... 00:00:00 Unspoken struggles and psychological impact of diagnosis ... 00:03:05 Building a strong support team and learning to ask for help ... 00:06:05 Dr. Laura James’ personal health journey ... 00:13:05 How cancer care has evolved: precision, openness, and team care ... 00:18:56 Nutrition, fasting, and conflicting dietary advice ... 00:29:01 Red and green flags in oncology care ... 00:36:02 Integrative vs. alternative cancer approaches ... 00:39:36 Access and perspectives on screening and prevention ... 00:43:13 Communication breakdowns in cancer care ... 00:46:43 Financial realities and high-yield ways to invest resources ... 00:54:07 Breast cancer as a feminist issue and self-care challenges ... 00:56:41 Resilience, growth, and balancing genetics vs. environment ... 01:03:20 Lifestyle factors, lab markers, and actionable prevention ... 01:15:14 Self-advocacy, decision-making, and family boundaries ... 01:20:20 Takeaways, resources, and outro ... 01:25:19 Our Amazing Sponsors: Nature's Marvels Bioregulators by Profound Health - Natural bioregulators designed to support your body's own cellular communication and healthy aging, with targeted formulas for everything from brain and immune health to sleep and vitality. Visit https://profound-health.com/?Aff=Longevity15 and use code NAT15 for 15% off your first order. C.A.R.E. Mitochondrial Moisturizer By Young Goose – An upgraded cellular skincare formula featuring Methylene Blue and Liposomal Creatine to support mitochondrial function, skin barrier health, and resilient, hydrated skin. Click HERE and use code NAT10 to save on C.A.R.E. Mitochondrial Moisturizer. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Original Instagram Backup Instagram Dr. Bill Lawrence Episode

📍 Good news! My original Instagram is back! Please follow my original account at https://www.instagram.com/nathalieniddam/ and also my backup account at https://www.instagram.com/longevitywithnat/. Today, I’m joined by the incredible Dr. Nora Abdul-Hussein, a physician-scientist, medical geneticist, and one of the leading voices in the field of genomic medicine. In this episode, Dr. Abdul-Hussein and I dig into a huge question—why do two people taking the exact same GLP-1 medication have such wildly different results, from weight loss to side effect profiles? She shares her unique path from internal medicine to cutting-edge population genomics, and how her work at 23andMe is beginning to answer some of medicine’s toughest puzzles. Episode Timestamps: Introduction: podcast focus on genetics, peptides, and longevity ... 00:00:00 Dr. Nora Abdul-Hussein’s background and journey in genomic medicine ... 00:07:01 Prevention and population-scale genetics ... 00:08:06 Power of genetic insights for personal lifestyle choices ... 00:14:40 Barriers to adopting genetics in clinical practice ... 00:16:41 Pharmacogenomics and the move toward personalized prescribing ... 00:17:21 Launching a large-scale study on GLP-1 genetics ... 00:19:41 Discovery: GLP-1 receptor gene variants linked to weight loss and nausea ... 00:22:40 Risk calculators and personalized expectations for GLP-1s ... 00:27:26 Broader genomics: diet, exercise, and response variability ... 00:28:24 Avoiding genetic determinism and emphasizing holistic care ... 00:29:29 Findings for tirzepatide and the GIP receptor ... 00:34:20 Population differences and ancestry’s impact on results ... 00:38:07 Is genetic information ready for prime time in GLP-1 therapy? ... 00:41:12 Clinical implications beyond “calories in, calories out” ... 00:43:01 GLP-1s: potential for non-weight related conditions ... 00:44:48 Personalized medicine: integrating genomics with other data ... 00:51:02 Reducing shame and embracing genes as tools for prevention ... 01:00:02 Genomic information as an empowering health strategy ... 01:01:30 Study insights and validation: self-reporting and sample diversity ... 01:05:40 Protecting privacy and building trust in genomics ... 01:13:32 Final thoughts: embrace your genes and use the data for healthspan ... 01:20:10 Where to learn more and wrap-up ... 01:21:18 Our Amazing Sponsors: Mitopure Gummies by Timeline – Supports healthier cellular energy, muscle strength, recovery, and healthy aging with clinically proven Urolithin A—without artificial sweeteners, colors, flavors, or unnecessary fillers. Head to timeline.com/NAT20 to get Mitopure starting at just $99 and save an additional 20% on your order. Manukora Honey – A delicious real-food source of prebiotics, Manukora's high-MGO Manuka honey helps support your gut microbiome, digestion, and immune health with just one teaspoon a day. Head to MANUKORA.com/NAT to save up to 31% plus receive $25 worth of free gifts with the Starter Kit. Just Thrive 90-Day Probiotic – A spore-based probiotic that survives stomach acid to arrive 100% alive in your gut, supporting better digestion, nutrient absorption, immunity, and less bloating. Start your first 90-day subscription today and you'll get a FREE 90-day supply of Digestive Bitters (a $90 value) to help optimize digestion and support healthy appetite regulation. Click HERE to learn more. Nat's Links: YouTube Channel Join My Membership Community Sign up for My Newsletter Original Instagram Backup Instagram Dr. Bill Lawrence Episode