
#428: Poop, Peptides & The Power of Microbiome | The Secret Longevity Organ With Dr. Grace Liu
4/10/2026
0:00
1:24:57
Today, I'm joined by Dr. Grace Liu, often known as the “Gut Goddess,” a trailblazer in the world of microbiome science and founder of The Gut Institute. In this conversation, we take a bold dive into an often-overlooked pillar of longevity: your poop. That's right—Dr. Liu unpacks the fascinating and sometimes surprising science showing how gut health shapes everything from your immune system and brain to your lifespan itself.
Episode Timestamps:
Introduction to host ... 00:00:00
Dr. Grace Liu on the gut as a hallmark of aging ... 00:04:06
Peptides, FMT, and evidence for gut-driven regeneration ... 00:05:04
FMT safety, immune education, and the environmental “microdosing” effect ... 00:07:07
Links between gut aging, the immune system, and mental health ... 00:08:13
Diet, ancestry, and resistant starch for butyrate production ... 00:15:01
Ancestral diet, microbiome differences, and pitfalls of shortcuts ... 00:18:53
Fiber, polyphenols, and the key longevity bacteria ... 00:24:09
Gut markers, loss of diversity, and ABC species signature ... 00:25:15
Risks of overhyped probiotics, strep, and broad interventions ... 00:36:29
Peptides, bioregulators, and repairing the gut ... 01:12:01
Practical longevity: movement, daily habits & where to learn more ... 01:22:46
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