Better Sex podcast

380: [Soapbox] The potential for MDMA in coupes work

4/9/2026
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Sex therapist Jess Zimmerman shares what she’s learning from a 30-hour training on guiding people who choose to use MDMA (Ecstasy/Molly), emphasizing she is not endorsing illegal substance use and is focused on the research and potential pending FDA approval. She describes MAPS’s Phase 3 clinical trials using an MDMA-assisted protocol for severe, treatment-resistant PTSD, noting results where about two-thirds of participants no longer meet PTSD diagnostic criteria, though the FDA has requested more long-term safety data and has not approved it yet. Jessa explains proposed mechanisms such as increased serotonin, dopamine, and oxytocin and reduced fear/defensiveness, and discusses why this could be promising for couples therapy by enabling deeper, less reactive conversations and breakthroughs, supported by integration sessions. She invites listeners to follow her work via www.heartweaveforcouples.com.


00:00 Show Intro

00:47 Soapbox Topic MDMA

01:09 Training And Disclaimer

01:46 MAPS Research Update

02:24 PTSD Protocol Results

03:01 FDA Status And Concerns

03:43 Why Couples Could Benefit

04:47 Therapy Breakthrough Potential

06:03 Heart Weave And Next Steps

06:50 Outro And Credits

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