Digestive enzymes for IBS: Do they actually work?

You may have seen Bryan Johnson talking about autoimmune gastritis (AIG), but what is it actually, and what does the research say? In this episode of The Gut Show, we're digging into autoimmune gastritis, including what happens in the stomach, symptoms, pernicious anemia, and what treatment actually looks like. We'll also take a closer look at some of the claims being shared online and separate what's backed by research from what might be getting a little ahead of the science. If Bryan Johnson's story has you wondering about AIG or questioning whether you should be worried about it, this episode will help you understand what we actually know.   Mentioned in this episode:  MASTER Method Membership What's your poop personality?   Thank you to our partner: If you're dealing with GI issues like IBS, SIBO, EoE, IBD, or IMO, you may have heard of the elemental diet. mBIOTA Elemental is a clinically proven, short-term liquid nutrition protocol that provides essential nutrients in their simplest forms, allowing much of the GI tract to rest and reset. It's a nutrition-based alternative to antibiotics for managing GI conditions. Developed by a patient and her doctors to improve the patient experience — without sacrificing effectiveness. Learn more at mBIOTA.com and save 15% on the two-week protocol with code GUTSHOW15.   Connect with Erin Judge, RD:  Instagram TikTok Work with Erin FREE symptom tracker  

Colon cancer rates are rising, especially among younger adults….but before you let that statistic stress you out, listen to this episode to learn what you actually need to know! In this episode of The Gut Show, I'm joined by Dr. Leybelis Padilla to talk about what we know about colon cancer, what may increase your risk, symptoms to pay attention to, and the different screening options available, including the misinformation surrounding them. In this episode, we cover: Introducing Dr. Leybelis Padilla [2:44] What is colon cancer? [4:00] What causes polyps? [6:19] Family history [8:13] Why are the numbers rising? [11:13] Can fiber be protective? [15:33] Signs of colon cancer [18:28] Colonoscopies and other options [26:23] Misinformation [29:17] Is colonoscopy prep harmful? [36:36] How to work with Dr. Leybelis Padilla [47:28]   Mentioned in this episode: MASTER Method Membership What's your poop personality?   About our guest: Dr. Leybelis Padilla, MD, FACG, is more than a physician—she's a force of transformation in the world of health and high performance. As a Gastroenterologist and Lifestyle Medicine physician, she has redefined what it means to heal from within. She founded Unlocking GI, an evidence-based telemedicine practice that utilizes her 4M framework—Medicine, Meals, Mindset, and Movement—delivering personalized and sustainable micro habits that unlock vitality, improve digestive health, and elevate overall well-being. But her mission doesn't stop at medicine. She's also the co-founder of Game Beyond the Game, where alongside her husband, Prince, they curate luxury events designed to help organizations transform their company mindset. Whether she's guiding patients or world-class achievers, Dr. Leybelis is on a mission to turn obstacles into opportunities and unlock limitless potential.   Connect with Dr. Leybelis Padilla: Website Instagram TikTok YouTube Email: [email protected]   Thank you to our partner: If you're dealing with GI issues like IBS, SIBO, EoE, IBD, or IMO, you may have heard of the elemental diet. mBIOTA Elemental is a clinically proven, short-term liquid nutrition protocol that provides essential nutrients in their simplest forms, allowing much of the GI tract to rest and reset. It's a nutrition-based alternative to antibiotics for managing GI conditions. Developed by a patient and her doctors to improve the patient experience — without sacrificing effectiveness. Learn more at mBIOTA.com and save 15% on the two-week protocol with code GUTSHOW15.   Connect with Erin Judge, RD:  Instagram TikTok Work with Erin FREE symptom tracker    

Can digestive enzymes help with IBS symptoms? What about enzymes that target specific FODMAPs? In this episode of The Gut Show, we're talking with Jocelyn Wells from FODZYME about digestive enzymes and their role in breaking down FODMAPs. We'll explore what digestive enzymes are, how they work, and how targeted enzyme therapy may help with digestion and IBS symptoms. We'll take a closer look at enzymes designed to target specific FODMAPs, discuss whether using an enzyme supplement means you're actually deficient in that enzyme, and whether enzyme therapy can be effective when it doesn't target every FODMAP group. If you're a clinician wanting FODZYME samples and resources for your practice, you can request them here.    In this episode, we cover: Behind the scenes [1:53] Today's guest [3:35] What are enzymes? [4:39] What are the different types of enzymes? [6:14] If an enzyme works, does that mean you are deficient? [10:59] Targeted enzyme therapy [17:57] Specific enzymes for the different FODMAPs [22:07] Inulinase [23:40] How do these enzymes work? [28:24] Is it a bad thing to not have that fermentation process? [31:18] Does it actually work if it doesn't target all of the groups? [34:31] Can we bypass this and just put these microbes in the gut? [40:28] Access to dietitian team [43:42] Have your provider request free samples for their office [47:32] What's coming up this season [50:05]   Mentioned in this episode: What's your poop personality? MASTER Method Membership Clinicians can request free FODZYME samples for patients at providers.fodzyme.com/hcp-sample-request Customers can save 20% off your first FODZYME subscription order at fodzyme.com/foodfreedom   About our guest: Jocelyn Wells, MS, RDN, CSDH, is a Registered Dietitian specializing in gastrointestinal nutrition. She holds a BA from Duke University and an MS in Clinical Nutrition from New York University. She currently leads clinical strategy and partnerships at FODZYME, a digestive enzyme for FODMAP intolerance, where she oversees HCP education, clinical research, sales, nutrition communications, and professional collaborations. Her work focuses on advancing evidence-based nutrition care to improve patient outcomes and quality of life.   Thank you to our partner: If you're dealing with GI issues like IBS, SIBO, EoE, IBD, or IMO, you may have heard of the elemental diet. mBIOTA Elemental is a clinically proven, short-term liquid nutrition protocol that provides essential nutrients in their simplest forms, allowing much of the GI tract to rest and reset. It's a nutrition-based alternative to antibiotics for managing GI conditions. Developed by a patient and her doctors to improve the patient experience — without sacrificing effectiveness. Learn more at mBIOTA.com and save 15% on the two-week protocol with code GUTSHOW15.   Connect with Erin Judge, RD:  Instagram TikTok Work with Erin FREE symptom tracker  

What do Ehlers-Danlos syndrome and hypermobility have to do with IBS? A lot more than you might think.   In this episode, Rebecca Mass-Krajewski, Hypermobility & Ehlers-Danlos expert and I break down how connective tissue differences can impact the entire body—from digestion and motility to pain, sensitivity, and even the pelvic floor.   If you've ever felt like your symptoms don't quite "fit the box," this conversation will help connect the dots.   About our guest: Rebecca Mass-Krajewski, RN, MSN, FNP-BC, is a Hypermobility & Ehlers-Danlos expert, medical detective, and founder of The EDS Clinic. She specializes in the complex trifecta of Hypermobile Ehlers-Danlos Syndrome (hEDS), POTS, and Mast Cell Activation Syndrome (MCAS), uncovering overlooked drivers like autoimmune dysfunction, nervous system dysregulation, and gut imbalance Through her clinical work and speaking, Rebecca integrates the science of neuroplasticity, recognizing how the brain and autonomic nervous system can amplify pain, inflammation, and dysautonomia when stuck in chronic threat patterns. She leads a community where she troubleshoots complex cases live, giving members direct access to her clinical reasoning and real-time problem-solving. Rebecca is redefining what's possible for patients who have been dismissed or misdiagnosed while equipping practitioners nationwide to confidently unravel hypermobility-related challenges and deliver transformational care. Learn more + download your FREE Guide: How to Talk So Your Doctor Listens at www.theEDSclinic.com.    Thank you to our partners: @fodzyme is the world's first enzyme supplement specialized to target FODMAPs.   When sprinkled on or mixed with high-FODMAP meals, FODZYME's novel patent-pending enzyme blend breaks down fructan, GOS and lactose before they can trigger bloating, gas and other digestive issues.    With FODZYME, enjoy garlic, onion, wheat, brussels sprouts, beans, dairy and more — worry free! Discover the power of FODZYME's digestive enzyme blend and eat the foods you love and miss.   Visit fodzyme.com and save 20% off your first order with code THEGUTSHOW. One use per customer.   @mbiotaelemental is the next generation of the elemental diet. Developed with leading gastroenterologists and food scientists, it's the first formula that's both clinically effective AND genuinely easy to drink.   If you're looking for an option to support SIBO or your gut, mBIOTA Elemental may be one to consider. Learn more at mbiota.com and save 20% on their two-week protocol with code GUTIVATE.   @imodifyhealth is the leader in evidence-based, medically-tailored meal delivery offering Monash Certified low FODMAP, Gluten free, and Mediterranean meals - expertly crafted to help you achieve better symptom control AND improve overall health.    The best part? They make it easy by doing all prep work for you. Simply choose the meals you want, stock your fridge or freezer when meals arrive at your door, then heat and enjoy when you're ready. Delicious meals. Less stress. Complete peace of mind.   Check out modifyhealth.com and save 35% off your first order plus free shipping across the US with code: THEGUTSHOW.   Mentioned in this episode: MASTER Method Membership FREE IBS Warrior Summit Take the quiz: What's your poop personality?

What if your IBS symptoms aren't just about food… but about histamine?   In this episode of The Gut Show, we're unpacking one of the most talked-about (and misunderstood) connections in IBS.   We cover: What is histamine and is it a bad thing? What are mast cells? How can this affect IBS? What does research show? Can you test for histamine intolerance? Can a low FODMAP diet help?   Mentioned in this episode: FREE IBS Warrior Summit MASTER Method Membership Take the quiz: What's your poop personality? Mast Cells and MCAS with Dr. Zachary Spiritos   Thank you to our partners:   @mbiotaelemental is the next generation of the elemental diet. Developed with leading gastroenterologists and food scientists, it's the first formula that's both clinically effective AND genuinely easy to drink.   If you're looking for an option to support SIBO or your gut, mBIOTA Elemental may be one to consider. Learn more at mbiota.com and save 20% on their two-week protocol with code GUTIVATE.   @imodifyhealth is the leader in evidence-based, medically-tailored meal delivery offering Monash Certified low FODMAP, Gluten free, and Mediterranean meals - expertly crafted to help you achieve better symptom control AND improve overall health.    The best part? They make it easy by doing all prep work for you. Simply choose the meals you want, stock your fridge or freezer when meals arrive at your door, then heat and enjoy when you're ready. Delicious meals. Less stress. Complete peace of mind.   Check out modifyhealth.com and save 35% off your first order plus free shipping across the US with code: THEGUTSHOW.   @fodzyme is the world's first enzyme supplement specialized to target FODMAPs.   When sprinkled on or mixed with high-FODMAP meals, FODZYME's novel patent-pending enzyme blend breaks down fructan, GOS and lactose before they can trigger bloating, gas and other digestive issues.    With FODZYME, enjoy garlic, onion, wheat, brussels sprouts, beans, dairy and more — worry free! Discover the power of FODZYME's digestive enzyme blend and eat the foods you love and miss.   Visit fodzyme.com and save 20% off your first order with code THEGUTSHOW. One use per customer.

Weed and gut health...helpful or hype?   With cannabis possibly being reclassified federally, more people are asking whether THC or CBD can help digestive symptoms.   On this episode of The Gut Show, we're joined by @jordanshapiromd to talk about THC vs CBD, what the research shows, side effects and risks, and alternatives you can try.   Thank you to our partners:   @imodifyhealth is the leader in evidence-based, medically-tailored meal delivery offering Monash Certified low FODMAP, Gluten free, and Mediterranean meals - expertly crafted to help you achieve better symptom control AND improve overall health.    The best part? They make it easy by doing all prep work for you. Simply choose the meals you want, stock your fridge or freezer when meals arrive at your door, then heat and enjoy when you're ready. Delicious meals. Less stress. Complete peace of mind.   Check out modifyhealth.com and save 35% off your first order plus free shipping across the US with code: THEGUTSHOW.   @fodzyme is the world's first enzyme supplement specialized to target FODMAPs.   When sprinkled on or mixed with high-FODMAP meals, FODZYME's novel patent-pending enzyme blend breaks down fructan, GOS and lactose before they can trigger bloating, gas and other digestive issues.    With FODZYME, enjoy garlic, onion, wheat, brussels sprouts, beans, dairy and more — worry free! Discover the power of FODZYME's digestive enzyme blend and eat the foods you love and miss.   Visit fodzyme.com and save 20% off your first order with code THEGUTSHOW. One use per customer.   @mbiotaelemental is the next generation of the elemental diet. Developed with leading gastroenterologists and food scientists, it's the first formula that's both clinically effective AND genuinely easy to drink.   If you're looking for an option to support SIBO or your gut, mBIOTA Elemental may be one to consider. Learn more at mbiota.com and save 20% on their two-week protocol with code GUTIVATE

Acupuncture....can it actually help digestive symptoms?   On this episode of The Gut Show we explore what acupuncture is, what it can help with, the research behind it, and the big question: Will acupuncture resolve all of my IBS symptoms?   Conntect with Erin:  MASTER Method Membership FREE IBS Warrior Summit Take the quiz: What's your poop personality? Instagram   Thank you to our partners: @fodzyme is the world's first enzyme supplement specialized to target FODMAPs.   When sprinkled on or mixed with high-FODMAP meals, FODZYME's novel patent-pending enzyme blend breaks down fructan, GOS and lactose before they can trigger bloating, gas and other digestive issues.    With FODZYME, enjoy garlic, onion, wheat, brussels sprouts, beans, dairy and more — worry free! Discover the power of FODZYME's digestive enzyme blend and eat the foods you love and miss.   Visit fodzyme.com and save 20% off your first order with code THEGUTSHOW. One use per customer.   @mbiotaelemental is the next generation of the elemental diet. Developed with leading gastroenterologists and food scientists, it's the first formula that's both clinically effective AND genuinely easy to drink.   If you're looking for an option to support SIBO or your gut, mBIOTA Elemental may be one to consider. Learn more at mbiota.com and save 20% on their two-week protocol with code GUTIVATE.     @imodifyhealth is the leader in evidence-based, medically-tailored meal delivery offering Monash Certified low FODMAP, Gluten free, and Mediterranean meals - expertly crafted to help you achieve better symptom control AND improve overall health.    The best part? They make it easy by doing all prep work for you. Simply choose the meals you want, stock your fridge or freezer when meals arrive at your door, then heat and enjoy when you're ready. Delicious meals. Less stress. Complete peace of mind.   Check out modifyhealth.com and save 35% off your first order plus free shipping across the US with code: THEGUTSHOW.      

MCAS. POTS. Hypermobility. GI symptoms that don't quite fit the usual boxes.   On this episode of The Gut Show, Dr. Alexis Cutchins joins us to unpack what cardiology has to do with GI—and why these systems are far more connected than most people realize.   We dive into the emerging overlap between cardiology, gastroenterology, and immune-driven conditions, exploring why these patterns so often show up together, what red flags clinicians should be watching for, and why GI symptoms may actually start far beyond the gut—especially when dysautonomia, heart palpitations, dizziness, and persistent fatigue are part of the picture.   Mentioned in this episode:  MASTER Method Membership FREE IBS Warrior Summit Take the quiz: What's your poop personality? MCAS episode   About our guest:  Dr. Alexis Cutchins is a board-certified Cardiologist and founder of Cutchins Cardiovascular Medicine. I began this work after years of caring for patients with POTS, MCAS, hypermobility, and other conditions that many doctors were not prepared to manage. My dedication to this patient community is what led me to build a practice centered on their needs. I wanted to create something different for people who are often under-recognized and left without answers. At Cutchins Cardiovascular Medicine, we provide inclusive, high quality support for those living with complex chronic illness. Follow on Instagram   Thank you to our partners:   @imodifyhealth is the leader in evidence-based, medically-tailored meal delivery offering Monash Certified low FODMAP, Gluten free, and Mediterranean meals - expertly crafted to help you achieve better symptom control AND improve overall health.    The best part? They make it easy by doing all prep work for you. Simply choose the meals you want, stock your fridge or freezer when meals arrive at your door, then heat and enjoy when you're ready. Delicious meals. Less stress. Complete peace of mind.   Check out modifyhealth.com and save 35% off your first order plus free shipping across the US with code: THEGUTSHOW.     @fodzyme is the world's first enzyme supplement specialized to target FODMAPs.   When sprinkled on or mixed with high-FODMAP meals, FODZYME's novel patent-pending enzyme blend breaks down fructan, GOS and lactose before they can trigger bloating, gas and other digestive issues.    With FODZYME, enjoy garlic, onion, wheat, brussels sprouts, beans, dairy and more — worry free! Discover the power of FODZYME's digestive enzyme blend and eat the foods you love and miss.   Visit fodzyme.com and save 20% off your first order with code THEGUTSHOW. One use per customer.   @mbiotaelemental is the next generation of the elemental diet. Developed with leading gastroenterologists and food scientists, it's the first formula that's both clinically effective AND genuinely easy to drink.   If you're looking for an option to support SIBO or your gut, mBIOTA Elemental may be one to consider. Learn more at mbiota.com and save 20% on their two-week protocol with code GUTIVATE.    

Dr. Rezaie is on The Gut Show to talk about all things SIBO and what the latest research is actually showing. If you've ever wondered what the elemental diet is, why it is used, or how long the results last, this episode is for you!   Mentioned in this episode: MASTER Method Membership FREE IBS Warrior Summit Take the quiz: What's your poop personality? SIBO episode   About our guest: Ali Rezaie is a physician-scientist in Los Angeles. Dr. Rezaie has published more than 200 peer-reviewed papers that have been cited over 11,000 times. His research focuses on microbiome, elemental diet, IBS, SIBO, IMO, medical device development and internal UV therapy. His inventions have been recognized by multiple organizations, including TIME magazine's "Best Inventions of 2025" for palatable elemental diet. Elemental Diet as a Therapeutic Modality: A Comprehensive Review Effect, Tolerability, and Safety of Exclusive Palatable Elemental Diet in Patients With Intestinal Microbial Overgrowth     Thank you to our partners: @mbiotaelemental is the next generation of the elemental diet. Developed with leading gastroenterologists and food scientists, it's the first formula that's both clinically effective AND genuinely easy to drink.   If you're looking for an option to support SIBO or your gut, mBIOTA Elemental may be one to consider. Learn more at mbiota.com and save 20% on their two-week protocol with code GUTIVATE.   @imodifyhealth is the leader in evidence-based, medically-tailored meal delivery offering Monash Certified low FODMAP, Gluten free, and Mediterranean meals - expertly crafted to help you achieve better symptom control AND improve overall health.    The best part? They make it easy by doing all prep work for you. Simply choose the meals you want, stock your fridge or freezer when meals arrive at your door, then heat and enjoy when you're ready. Delicious meals. Less stress. Complete peace of mind.   Check out modifyhealth.com and save 35% off your first order plus free shipping across the US with code: THEGUTSHOW.   @fodzyme is the world's first enzyme supplement specialized to target FODMAPs.   When sprinkled on or mixed with high-FODMAP meals, FODZYME's novel patent-pending enzyme blend breaks down fructan, GOS and lactose before they can trigger bloating, gas and other digestive issues.    With FODZYME, enjoy garlic, onion, wheat, brussels sprouts, beans, dairy and more — worry free! Discover the power of FODZYME's digestive enzyme blend and eat the foods you love and miss.   Visit fodzyme.com and save 20% off your first order with code THEGUTSHOW. One use per customer.

Hot flashes aren't the whole story. Perimenopause and menopause can impact your gut, hormones, and chronic illness symptoms - you're not imagining it. Listen to this episode of The Gut Show as we talk with Casey Farlow about what menopause is, how to get support, and more!   In this episode, we cover: Perimenopause and menopause [3:20] Introducing our guest [4:40] What is menopause? [6:01] Changes to gut health [8:53] Other symptoms [11:14] Monitoring estrogen and progesterone [13:53] Birth control [15:41] Can you stabilize hormones? [17:54] Hormone therapy & breast cancer [20:23] Is it hopeless? [21:30] Chronic illness & things getting worse [26:35] Hormone therapy and breast cancer [30:12] Who monitors this? [32:18] Labwork [35:20] Bone density screening [38:11]   Mentioned in this episode: MASTER Method Membership FREE IBS Warrior Summit Take the quiz: What's your poop personality?   About our guest: Casey Farlow, MPH, RDN is a registered dietitian and nationally recognized perimenopause nutrition expert who helps women stop fighting their bodies and start working with them during the hormonal transition of perimenopause. As the founder of The Perimenopause Nutritionist, Casey supports women struggling with stubborn weight gain, fatigue, sleep disruption, mood changes, and food frustration through hormone-aware nutrition, blood sugar regulation, and nervous system support. Connect with Casey   Thank you to our partners: ModifyHealth is the leader in evidence-based, medically-tailored meal delivery offering Monash Certified low FODMAP, Gluten free, and Mediterranean meals - expertly crafted to help you achieve better symptom control AND improve overall health.  The best part? They make it easy by doing all prep work for you. Simply choose the meals you want, stock your fridge or freezer when meals arrive at your door, then heat and enjoy when you're ready. Delicious meals. Less stress. Complete peace of mind. Check out modifyhealth.com and save 35% off your first order plus free shipping across the US with code: THEGUTSHOW.   mBIOTA is the next generation of the elemental diet. Developed with leading gastroenterologists and food scientists, it's the first formula that's both clinically effective and genuinely easy to drink. Pure, easily absorbed nutrients are essential, but the mBIOTA difference is in the details: from their proprietary Amino Taste Modification Technology (ATMT), to their fully vegan and gluten-free ingredients, mBIOTA provides balanced daily nutrition backed by science.  The result is a game-changing medical-grade formula that helps restore GI function in patients with SIBO, IMO, IBS, Crohn's, EoE and more. Learn more at mbiota.com and save 20% off their 2 week protocol with the code GUTIVATE.   FODZYME is the world's first enzyme supplement specialized to target FODMAPs. When sprinkled on or mixed with high-FODMAP meals, FODZYME's novel patent-pending enzyme blend breaks down fructan, GOS and lactose before they can trigger bloating, gas and other digestive issues.  With FODZYME, enjoy garlic, onion, wheat, brussels sprouts, beans, dairy and more — worry free! Discover the power of FODZYME's digestive enzyme blend and eat the foods you love and miss. Visit fodzyme.com and save 20% off your first order with code THEGUTSHOW. One use per customer.   Connect with Erin Judge, RD:  Instagram TikTok Work with Erin FREE symptom tracker