EUVC podcast

E642 | Lucanus Polagnoli & Stephanie Urbanski, Calm/ Storm: Digital Health, Not Hype - Building, Backing & Staying Calm Through the Cycle

2025-10-28
0:00
49:47
Spola tillbaka 15 sekunder
Spola framåt 15 sekunder

Welcome back to the EUVC Podcast, where we bring you the people and perspectives shaping European venture.

Today we’re joined by Lucanus Polagnoli (Founding Partner & CEO) and Stephanie Urbanski (Managing Director) of Calm/Storm — a specialist early-stage fund backing software-only digital health across Europe. Fresh off the close of Fund II, we dive into how they’ve evolved from a solo-GP experiment into a community-powered platform, why they keep the scope digital-only, and how they navigate regulation, AI and the post-COVID reality without losing the plot.

🎯 This Episode’s Themes

  • Same, same — but sharper: Fund II doubles down on pre-seed/seed, software-only digital health, with bigger checks and higher ownership.

  • Community as a product: 60+ “supporting partners” and 110+ LPs powering 100+ co-invests — founder-to-founder help on demand.

  • Specialist by design: Why digital health (no molecules, no hardware) lets a small fund move fast and add tangible value.

  • Regulation ≠ roadblock: In health, approvals can protect moats — if you have the patience and the cash plan.

  • AI without the buzzwords: Companion to clinicians, not a replacement; curated, longitudinal data beats generic LLM advice.

  • Europe’s moment (still): Later-stage money does show up now; e-prescriptions and rails are here; US health is just as complex.

  • Logo gravity matters: Follow-on quality (Sequoia, Balderton, Creandum et al.) is the strongest portfolio predictor.

⏱️ Here’s what’s covered

  • 00:24 | Names & origins - how to say “Polagnoli” (and why words matter)

  • 01:24 | Fund II - same stage/sector/geo; larger tickets (€400–500k initial), higher ownership, co-lead when conviction is high

  • 03:30 | Supporting partners - 60+ founder-operators + LPs as an on-call help network

  • 05:45 | Why Calm/Storm - the gap they saw in 2019; launching Feb 5, 2020, right before the pandemic wave

  • 08:52 | Post-COVID reality - rails stayed (e-scripts, digital flows), tourists left; real followers now fund B/C rounds in Europe

  • 11:08 | Longevity & prevention - out-of-pocket willingness, AI unlocking insights from dormant data

  • 13:21 | Team split - Stefanie’s operator engine + community execution; Lucanus on strategy and navigation

  • 16:10 | Why digital-only - software speed, small teams, low capex; pass on molecules/hardware for fund construction reasons

  • 22:45 | Regulation as moat - ThinkSono’s 8-year climb on DVT ultrasound automation; Europe vs. US complexity myths

  • 26:44 | AI in health - pattern recognition, prep and triage; risks of generic LLMs for personal diagnosis

  • 31:10 | Adoption & incentives - public vs. private delivery, prevention economics, and Europe’s risk-capital bottleneck

  • 36:26 | Where AI wins first - curated data, longitudinal monitoring, workflow copilots; the missing top-10 health app

  • 42:58 | Community receipts - burnout averted, board-level engagements, LPs turning co-investors

  • 45:27 | Portfolio & follow-ons - Nelly, Lindus, 9am Health; why “who picks you up” predicts outcomes

  • 48:56 | Exit math & fund design - earlier liquidity via M&A/secondaries; co-lead over “winner-takes-all”; stay early-stage by choice

Fler avsnitt från "EUVC"