Genflow Biosciences CEO says second European patent application opens more opportunities

Anteris Technologies CEO Wayne Paterson joined Steve Darling from Proactive to share a major milestone in the company’s development of DurAVR®, its groundbreaking aortic valve replacement technology designed to transform treatment for patients suffering from aortic stenosis — a fatal heart disease for which no pharmacotherapy options exist. Paterson explained that DurAVR® was designed from the ground up following extensive collaboration with leading cardiologists and cardiac surgeons. The result is a biomimetic, balloon-expandable valve engineered to replicate natural valve anatomy and physiology — a radical advancement over traditional bioprosthetic devices. “We developed one that is physiologically and anatomically correct. It gives you pre-disease mean gradients — that’s been established across 130 patients now,” Paterson said, underscoring the valve’s ability to restore near-normal cardiac function. The company recently secured its first regulatory clearance in Europe, paving the way for broader international approvals in the near term. This clearance allows Anteris to initiate its global PARADIGM pivotal trial, which will evaluate DurAVR® across low-, medium-, and high-risk patient groups. The study will also feature a valve-in-valve registry and target a non-inferiority primary endpoint, aligning with global regulatory pathways for approval. Paterson highlighted that medical device trials carry far less risk than pharmaceutical studies, with Anteris already demonstrating highly consistent patient outcomes. The company has also laid significant groundwork for clinical expansion, including site preparation and an upcoming investigator meeting at the TCT conference in San Francisco. Built on Anteris’ proprietary ADAPT® tissue platform, DurAVR® has shown 20–30% clinical superiority in objective performance metrics. Paterson noted that the company has achieved what physicians have long demanded: clinical superiority combined with balloon-expandable delivery. “This milestone moves us closer to our goal of redefining valve replacement therapy,” Paterson said. “DurAVR® represents the future of aortic valve technology — designed by physicians, built for patients, and proven by data.”

Argentina Lithium CEO Nikolaos Cacos joined Steve Darling from Proactive to unveil the company’s first-ever Mineral Resource estimate for its Rincon West lithium brine project located in Salta Province, Argentina—a key step forward in advancing the company’s lithium portfolio within the heart of the “Lithium Triangle.” The inaugural resource estimate, completed for the West Block properties—including the Villanoveño II and Rinconcita II mining concessions covering 2,931 hectares—marks a significant milestone for Argentina Lithium. The estimate excludes the Paso de Sico concessions to the north, which add another 3,742.9 hectares of prospective ground at the Rincon Salar, representing future upside for the project. The resource was defined through 14 exploration boreholes totaling 4,823.2 metres of diamond drilling and one production well extending 470 metres. Based on this work, the company reports: Measured and Indicated Resources: 0.15 km³ of brine averaging 296 mg/L lithium, equivalent to 238,000 tonnes of Lithium Carbonate Equivalent (LCE). Inferred Resources: 0.08 km³ of brine averaging 216 mg/L lithium, equivalent to 64,000 tonnes of LCE. Cacos emphasized that the results demonstrate Rincon West’s potential as a scalable, high-quality lithium asset within one of the world’s most prolific brine districts. “This maiden resource lays a solid foundation for our next phase of development as we work toward building a sustainable, high-value lithium operation capable of generating long-term returns,” he said. As the company moves ahead with Preliminary Economic Assessment (PEA) studies and evaluates advanced direct lithium extraction (DLE) technologies, exploration teams will also target deeper drilling below the current resource boundary—where geologic data indicates open mineralization at depth and significant room for expansion. With a strong technical foundation and growing land position, Argentina Lithium is positioning Rincon West as a key contributor to Argentina’s emerging lithium supply chain, supporting the accelerating global demand for electric vehicle and energy storage materials. #proactiveinvestors #argentinalithium&energycorp #tsxv #lit #otcqx #lilif #proactiveinvestors #argentinalithium&energycorp #tsxv #lit #otcqx #lilif

Anthony Ginsberg, CEO of GinsGlobal Index Fund, recently spoke with Steve Darling from Proactive to discuss recent updates to the firm’s Tech Megatrend ETF, a globally diversified fund designed to capture growth across the world’s most transformative technology themes. Ginsberg explained that the ETF maintains a global benchmark with just over 50% exposure to the U.S. and nearly 20% to Asia, including China and Japan. The fund spans ten key technology subthemes such as cybersecurity, cloud computing, artificial intelligence, and blockchain, providing investors with broad access to multiple innovation-driven sectors. In a significant enhancement, the ETF has now added quantum computing and defense technology to its portfolio. “Quantum is really changing the speed of innovation across industries—from financial services and pharmaceuticals to R&D—helping companies find faster, smarter, and more cost-effective solutions,” Ginsberg said. The fund now includes five quantum-focused companies, each with a minimum market cap of $200 million. The addition of defense technology reflects a growing trend among governments to allocate more of their defense budgets toward cybersecurity and digital defense infrastructure. Ginsberg noted that 1.5% of NATO countries’ defense GDP is now being directed toward defense technology initiatives, underscoring the increasing convergence of tech innovation and national security. When discussing performance, Ginsberg pointed to blockchain as the ETF’s top performer in 2025 so far, posting gains exceeding 50%, followed by cybersecurity and digital entertainment, each returning around 25–30%. He also highlighted the ETF’s diversified structure, distinguishing it from typical U.S.-centric tech funds. “We only have about a 6% weighting in the ‘Magnificent Seven,’” Ginsberg noted, emphasizing the ETF’s broader exposure across emerging innovators and lower concentration risk within its top holdings. With these updates, GinsGlobal’s Tech Megatrend ETF continues to position itself at the forefront of the global technology evolution, offering investors access to high-growth sectors driving the next wave of digital transformation. #TechMegatrendETF, #AnthonyGinsberg, #FourthIndustrialRevolution, #AI, #Cybersecurity, #CloudComputing, #SocialMedia, #FutureCars, #Robotics, #InterestRateCuts, #Diversification, #GlobalHoldings, #Nasdaq,

Pinnacle Silver and Gold CEO Robert Archer joined Steve Darling from Proactive to announce the appointment of Carlos Castro Villalobos as Project Manager for the company’s El Potrero gold-silver project in Durango, Mexico. The addition of Castro—an accomplished Mining Engineer with more than 45 years of experience building and operating mines across Mexico—marks a major step forward in advancing El Potrero toward production. Castro’s extensive background includes leadership roles with several of Mexico’s most respected mining companies, such as Peñoles, Luismin, Great Panther, and First Majestic Silver. Over his career, he has held senior positions ranging from Mine Superintendent to General Manager, and notably, while with Rochester Resources, he successfully oversaw the construction of a 300-tonne-per-day processing plant in just seven months—a skill set that will be especially valuable as Pinnacle looks to accelerate development at El Potrero. Archer also confirmed that Jorge Ortega, the Qualified Person (QP) for the project and author of the NI 43-101 technical report, continues in his role as Exploration Manager. Ortega is actively supervising a geological team that has already collected more than 1,000 surface and underground samples, significantly enhancing the company’s understanding of the high-grade, low-sulphidation epithermal gold-silver system at the project. Located in western Mexico, El Potrero is strategically positioned just 35 kilometres from four producing mines, including the 4,000-tonne-per-day Ciénega Mine. Pinnacle will earn an initial 50% interest upon the commencement of production, with the potential to increase ownership to 100%, subject to a 2% net smelter return. #proactiveinvestors #pinnaclesilverandgoldcrp #robertarcher #tsxv #pinn #otc #psgcf #PinnacleSilverAndGold #MiningMexico #SilverMining #GoldMining #JuniorMiners #MiningExploration #ElPotrero #MineRestart #PreciousMetals #MiningStocks #ResourceSector

KEFI Gold and Copper PLC (AIM:KEFI, OTC:KFFLF) executive chairman Harry Anagnostaras-Adams talked with Proactive's Stephen Gunnion about the company’s significant progress in securing funding and advancing development at the Tulu Kapi gold project in Ethiopia. Anagnostaras-Adams confirmed the company has secured a US$240 million debt package, marking a major milestone. With all regulatory and governmental approvals now in place, KEFI is focused on closing the equity component to trigger full project drawdown. He noted, “We’ve allocated about a month to do that, to close that off, call the shareholders meeting to ratify everything. And we're away.” Construction preparations are already underway. KEFI has worked with the Ethiopian government to establish essential infrastructure and security, while engineering firm Lycopodium has been mobilised for procurement and construction. Community resettlement will begin shortly, followed by phased development throughout 2026 and into 2027. Production is targeted for late 2027, with gold commissioning expected by the end of that year. Anagnostaras-Adams highlighted that, at conservative gold prices, the project could deliver **over $1 billion in net cash flow** over seven years, with potential for much more if prices remain high. He concluded: “It’s arguably the best margin gold project going into development in Africa today.” For more updates from KEFI Gold and Copper, visit Proactive’s YouTube channel. Don’t forget to like the video, subscribe, and turn on notifications for the latest news and interviews. #KEFI #GoldMining #Copper #EthiopiaMining #MiningInvestment #GoldProject #TuluKapi #ResourceDevelopment #GoldProduction #JuniorMining #MiningAfrica #MiningNews #ProactiveInvestors

Genflow Biosciences PLC (LSE:GENF, OTCQB:GENFF) CEO Dr Eric Leire talked with Proactive's Stephen Gunnion about the company's latest milestone – the granting of its second European patent, which he says is a key part of Genflow’s intellectual property strategy in the longevity and metabolic disease space. Leire explained that the patent strengthens the company’s position by providing protection not only for the composition of matter but also for specific methods of use, all focused around Sirtuin-6, a core element in the company’s technology platform. He stated, “We’re building a layer portfolio that combines property, construct, delivery method, and specific applications for human health.” The new patent covers a variant for NASH (non-alcoholic steatohepatitis), but Leire noted that the Sirtuin-6 platform has broader relevance for multiple age-related diseases, including glaucoma, sarcopenia, and other metabolic conditions. He emphasised that strong IP is essential for entering into licensing and partnership discussions with pharmaceutical companies, adding, “Without strong IP protection, there's no potential deal with pharma.” Looking ahead, Leire said that Genflow is prioritising its ongoing dog study and will soon undertake a strategic review to determine which of the many potential indications to pursue further. Visit Proactive's YouTube channel for more company interviews. Don’t forget to like this video, subscribe to the channel, and enable notifications so you never miss an update. #GenflowBiosciences #Longevity #BiotechNews #Sirtuin6 #MetabolicDisease #BiotechInvesting #NASH #IPStrategy #PharmaPartnerships #AgeRelatedDiseases

Faron Pharmaceuticals Limited (AIM:FARN) CEO Dr Juho Jalkanen talked with Proactive's Stephen Gunnion about the latest clinical data presented at the European Society for Medical Oncology (ESMO) Congress in Barcelona on its lead asset, bexmarilimab, in high-risk myelodysplastic syndromes (MDS). Jalkanen described the data as “truly game changing,” highlighting that combining bexmarilimab with hypomethylating agents (HMAs) yielded an 85% response rate—compared to 40% with standard of care alone. Importantly, the complete remission rate reached 45%, which he described as “one of the highest ever seen in this field.” The company has secured orphan drug designation and received clear FDA guidance supporting the possibility of accelerated approval based on response rate, particularly complete remission. Jalkanen emphasised the importance of normalising blood counts in this patient population, many of whom are severely anaemic and neutropenic. He also discussed new biomarker data showing strong Clever-1 engagement, especially in bone marrow—where disease often hides from traditional chemotherapy. Jalkanen said this highlights bexmarilimab as a “truly disease-modifying agent.” On funding, Jalkanen confirmed Faron is well capitalised into next year, with further financing under exploration to support the upcoming registration trial, including partnering and fundraising initiatives. For more interviews and updates, head over to Proactive’s YouTube channel. Don’t forget to like this video, subscribe to our channel, and turn on notifications so you never miss future content. #FaronPharmaceuticals #Bexmarilimab #MDS #BiotechNews #ClinicalTrials #FDAApproval #OrphanDrug #Immunotherapy #CancerResearch #ProactiveInvestors

HIVE Digital Technologies (TSX-V:HIVE, NASDAQ:HIVE) executive chairman Frank Holmes talked with Proactive's Stephen Gunnion about the company’s 100MW hydro expansion in Paraguay and its broader strategy to scale Bitcoin mining and AI infrastructure. Holmes explained that the new capacity will help push HIVE’s mining power to 35 Exahash by 2026, representing close to 3% of the global Bitcoin network. “This maintains that momentum we have,” he said, noting that the company’s hashrate has already grown from 6 to 22 Exahash, with 25 targeted by American Thanksgiving. Holmes highlighted that all of HIVE’s new infrastructure is powered by renewable hydro energy. This focus, he said, is essential for both sustainability and commercial relationships, particularly in Europe and Canada. “It was important when we created the first ASAIC chip with Intel… because we are green only and focused,” he added. Beyond Bitcoin, HIVE is targeting a fivefold expansion in its Canadian HPC operations, including its AI-focused partnership with Bell Canada. The infrastructure build is starting in Manitoba and expanding to Toronto, with HIVE aiming to become the largest HPC player in the country. Looking ahead, Holmes outlined HIVE’s financial aspirations: $500 million in revenue and $300 million in EBITDA based on current Bitcoin prices and HPC projections. For more interviews like this, visit Proactive’s YouTube channel. Don’t forget to like the video, subscribe to the channel, and hit the notification bell for future updates. #HIVEDigital #BitcoinMining #CryptoNews #AIInfrastructure #GreenEnergy #ParaguayMining #Exahash #HPC #BellCanada #FrankHolmes #SustainableMining #BlockchainTechnology

Nextech3D.ai CEO Evan Gappelberg talked with Proactive's Stephen Gunnion about the early launch of the company’s blockchain ticketing solution and how it aligns with its broader event technology strategy. Gappelberg explained that the initiative builds on Nextech3D.ai’s recent Eventdex acquisition and its AI-powered event suite. He said: “It really adds transparency, eliminates fraud, opens up new revenue streams through the resale and royalties of tickets.” The Ethereum-based platform is designed to support global events, especially blockchain-focused ones, by enabling borderless ticketing capabilities. Gappelberg emphasised that this technology is not just a milestone, but a “revenue accelerator” for the company. Looking ahead, Nextech3D.ai is already exploring expansion beyond ticketing to areas such as credentials for continuing education and asset verification. The company is also quoting large AI matchmaking deals and sees potential to generate between $5 million and $10 million in blockchain-related revenue from 2026 onwards. Despite the focus on blockchain, Gappelberg highlighted that the business remains diversified, running over 500 events annually. The company continues to upsell services such as white-label apps, AI matchmaking, and ticketing to increase average order values. Gappelberg also mentioned that new 3D modelling and event contracts are expected to be announced within the next 30 to 60 days. For more updates like this, visit Proactive's YouTube channel. Don’t forget to **like the video, subscribe to the channel, and turn on notifications** to stay informed. #Nextech3D #BlockchainTicketing #EventTech #AIinEvents #EvanGappelberg #3DModeling #Ethereum #TechInvesting #DigitalTickets #Eventdex #ProactiveInvestors #Web3 #RevenueGrowth #BlockchainEvents #AIMatchmaking

First Phosphate Corp. (CSE:PHOS, OTCQX:FRSPF) CEO John Passalacqua talked with Proactive's Stephen Gunnion about the company’s newly launched 30,000-metre accelerated drill program and its role in advancing a vertically integrated LFP battery supply chain in Quebec. Passalacqua said the goal is to “define fully the resource” at once to support downstream planning, including a future feasibility study. He confirmed that drilling is fully funded and will run through to April 2026, with a planned break around the winter months to accommodate seasonal conditions. The program involves two drill crews — one from a First Nations group and another from the local region. The CEO said, “We’re just out there, you know, nailing it,” as the company looks to move as quickly as possible. Discussing broader integration plans, Passalacqua explained how this drill campaign links to the company’s goal of producing phosphate concentrate, iron powder, purified phosphoric acid, and eventually lithium iron phosphate (LFP) cathode active material — all from its Bégin-Lamarche property. He also addressed the geopolitical significance of building a domestic supply chain in light of potential disruptions from China, which has threatened to cut off LFP battery exports. To stay updated on First Phosphate and other mining developments, visit Proactive's YouTube channel. Don’t forget to like the video, subscribe to the channel, and enable notifications for future content. #FirstPhosphate #BatteryMetals #QuebecMining #LFPBatteries #PhosphateMining #ResourceDrilling #VerticalIntegration #CleanEnergyMaterials #MiningInvestment #CriticalMinerals