Tolerability, Safety, and Efficacy of Atogepant Versus Topiramate in Adults with Migraine

Dr. Aaron Zelikovich discusses how gefurulimab may offer an effective and convenient treatment option for adults with generalized myasthenia gravis. Show citation: Gwathmey KG, Saccà F, Howard JF Jr, et al. Efficacy and Safety of Gefurulimab in Generalized Myasthenia Gravis: The PREVAIL Phase 3 Randomized Clinical Trial. JAMA Neurol. 2026;83(9):841-850. doi:10.1001/jamaneurol.2026.2333 

Dr. Andy Southerland and Dr. Matthew Gusler discuss how emergent interfacility transfers for ischemic stroke have changed and the factors associated with which patients are transferred.  Show citation: Gusler MT, Deligkaris C, Zha AM, Burke JF. Trends in Emergent Interfacility Ischemic Stroke Transfers, 2016-2022. Neurology. 2026;107(7):e218499. doi:10.1212/WNL.0000000000218499

Dr. Zohaib Siddiqi and Dr. Michel Toledano discuss the diagnosis and management of infectious rhombencephalitis in patients receiving immunomodulatory therapy. Show citation: Trentadue T, Martinez Sosa S, Itoh CY, et al. Clinical Reasoning: A 30-Year-Old Female Patient With Multiple Sclerosis Presenting With Rapidly Progressive Cranial Neuropathies, Weakness, and Ataxia. Neurology. 2025;105(12):e214429. doi:10.1212/WNL.0000000000214429 

Dr. Tesha Monteith shares practical tips for improving outcomes for patients with episodic cluster headache.

Dr. Tesha Monteith discusses growing evidence supporting CGRP-targeted therapies as first-line preventive treatment options for people with migraine. Show citation:  Reuter U, Dycke AV, Versijpt J, et al. Tolerability, safety, and efficacy of atogepant versus topiramate in adults with migraine (TEMPLE): a randomised, head-to-head, phase 3b trial. Lancet Neurol. 2026;25(9):806-817. doi:10.1016/S1474-4422(26)00214-0 

Dr. Casey Kozak discusses why most patients referred with seronegative NMOSD ultimately receive alternative diagnoses, underscoring the challenges of accurate diagnosis in antibody-negative cases.  Show citation: Lang MV, Welk GM, Tajfirouz DA, et al. Unveiling Misdiagnosis: Rethinking Seronegative NMOSD. Mult Scler. 2025;31(11):1381-1384. doi:10.1177/13524585251360648 

Dr. Katie Krulisky and Dr. Kelsey Smith discuss the impact of menopause on women with epilepsy, including therapeutics and clinical management during midlife. Show citation:  Smith KM, Faubion SS, Vadlamudi L, et al. The Menopause Transition and Epilepsy: A Focus on Therapeutics. Neurol Clin Pract. 2026;16(5):e200650. doi:10.1212/CPJ.0000000000200650

Dr. Katie Krulisky and Dr. Kelsey Smith discuss the impact of menopause on women with epilepsy, including therapeutics and clinical management during midlife. Show citation:  Smith KM, Faubion SS, Vadlamudi L, et al. The Menopause Transition and Epilepsy: A Focus on Therapeutics. Neurol Clin Pract. 2026;16(5):e200650. doi:10.1212/CPJ.0000000000200650

Dr. Casey Kozak discusses a new scoring system for MOGAD identification.  Show citation: Vilaseca A, Filippatou AG, Said Y, et al. TRUE-MOGAD Score: A Novel Scoring System to Identify MOGAD Among Positive MOG-IgG Test Results. Neurol Neuroimmunol Neuroinflamm. 2026;13(5):e200617. doi:10.1212/NXI.0000000000200617 

Dr. Hailey Katulski discusses limb compression therapy and chemotherapy-induced peripheral neuropathy in women with gynecologic cancers.  Show citation: Başkurt K, Uyar GC, Yeşilbaş E, et al. Limb Compression Therapy and Chemotherapy-Induced Peripheral Neuropathy in Women With Gynecologic Cancers: A Prospective Self-Controlled Study(NEURO-GLOVE Trial). Int J Cancer. 2026;159(9):2300-2313. doi:10.1002/ijc.70601