Tumor-targeted pan-RAS inhibition as a novel biologic therapy for diffuse midline glioma

What if a tumor's hidden dependence on Ras could become its biggest vulnerability? In this episode, Dr. Stephanie Grace Spurgeon and Dr. Cynthia Hawkins explain how their team engineered a targeted biologic to shut down Ras signaling in diffuse midline glioma—and what their preclinical findings reveal about reaching these aggressive tumors, including disease that spreads beyond the brainstem. Could this approach open a new path toward treatment? Listen to find out.

Interviewer: Dr. Jiasen He
Guests: Drs. Stefanie-Grace Sbergio, Cynthia Hawkins, Jiasen He