The Discovery of Glucagon-Like Peptide 1 (GLP-1)

Fever is associated with worse outcomes in patients with stroke, but whether preventing fever improves outcomes is unclear. David M. Greer, MD, MA, speaks with JAMA Associate Editor Jeffrey L. Saver, MD, about fever prevention in patients with acute stroke and its impact on functional outcomes. Related Content: Fever Prevention in Patients With Acute Vascular Brain Injury Feasibility of Fever Prevention in Vascular Brain Injury

The 2024 Lasker–DeBakey Clinical Medical Research Award has been presented for the discovery of GLP-1 and its application to the treatment of obesity. Lasker winner Svetlana Mojsov, PhD, discusses her role in this innovative discovery and more with JAMA Senior Editor Anne Rentoumis Cappola, MD, ScM. Related Content: Chemistry Matters—From a Putative Peptide to Effective Treatments for Diabetes and Obesity Discovery of cGAS as a DNA-Sensing Enzyme That Triggers Inflammation GLP-1 for Treating Obesity—Origin, History, and Evolution AIDS in Africa—Impact of Research

Palliative care is an essential component to high-quality care for patients with cancer. How can access to palliative care be expanded? Eduardo Bruera, MD, from MD Anderson Cancer Center speaks with JAMA Editor in Chief Kirsten Bibbins-Domingo about 2 new trials in JAMA that address access to care and what more it will take for executives, insurers, and regulators to support palliative care programs. Related Content: Improving Palliative Care Access for Patients With Cancer Telehealth vs In-Person Early Palliative Care for Patients With Advanced Lung Cancer

A new trial assessed whether balloon angioplasty plus aggressive medical management was superior to aggressive medical management alone for patients with symptomatic intracranial atherosclerotic stenosis. Author Zhongrong Miao, MD, PhD, from Beijing Tiantan Hospital, discusses the BASIS randomized clinical trial with JAMA Deputy Editor Christopher C. Muth, MD. Related Content: Balloon Angioplasty vs Medical Management for Intracranial Artery Stenosis Is Balloon Angioplasty the Future for Intracranial Stenosis? Read Transcript

The abating COVID-19 pandemic brings attention to rising mortality rates from non-COVID causes in the US, a trend that predates the COVID-19 pandemic. Viewpoint author Steven H. Woolf, MD, MPH, discusses this and more with JAMA Executive Editor Gregory Curfman, MD. Related Content: Increasing Mortality Rates in the US, but Not From COVID-19

Nonhormonal treatments for menopausal vasomotor symptoms may benefit symptomatic patients who cannot take or prefer to avoid systemic hormones. Author JoAnn V. Pinkerton, MD, MSCP, discusses the efficacy and safety of elinzanetant for the treatment of moderate to severe vasomotor symptoms associated with menopause with JAMA Deputy Editor Linda Brubaker, MD, MS. Related Content: Elinzanetant for the Treatment of Vasomotor Symptoms Associated With Menopause A New Era in Menopause Management?

To address the need to characterize long COVID in children and adolescents, the National Institutes of Health funded a pediatric program in the Researching COVID to Enhance Recovery (RECOVER) Initiative. Editorialist Suchitra Rao, MBBS, MSCS, University of Colorado School of Medicine and Children’s Hospital Colorado, Aurora, discusses this and more with JAMA Senior Editor Tracy A. Lieu, MD, MPH. Related Content: Uncovering Long COVID in Children Characterizing Long COVID in Children and Adolescents

A new study looks at uterus transplant to determine if it is safe, feasible, and results in births of healthy infants. Editorialist Emily Jungheim, MD, MSCI, Northwestern University, discusses this innovative treatment with JAMA Deputy Editor Linda Brubaker, MD, MS. Related Content: Uterus Transplant—The Frontier of Innovative Fertility Treatment Uterus Transplant in Women With Absolute Uterine-Factor Infertility

Ten percent of US adolescents use e-cigarettes, and many want to quit. However, evidence on the effectiveness of vaping cessation interventions is lacking. Amanda L. Graham, PhD, of the Truth Initiative discusses with JAMA Senior Editor Tracy Lieu, MD, MPH, how a tailored, interactive text message intervention increased vaping cessation among adolescents recruited via social media channels. Related Content: A Vaping Cessation Text Message Program for Adolescent E-Cigarette Users Supporting Adolescents’ Desire to Quit E-Cigarettes What Are E-Cigarettes? Variability in Constituents of E-Cigarette Products Containing Nicotine Analogues E-Cigarette Use in Adults Controversial FDA Decision Authorizes Menthol-Flavored E-Cigarettes Despite Risks to Youth Vaping in Youth E-Cigarette Use in Adolescents and Adults—A JAMA Collection

Gestational age estimation is foundational for obstetric care. In resource-limited settings, an integrated AI tool allows novice users to improve gestational age estimates. Author Jeffrey Stringer, MD, University of North Carolina, joins JAMA Deputy Editor Linda Brubaker, MD, MS, to discuss Diagnostic Accuracy of an Integrated AI Tool to Estimate Gestational Age From Blind Ultrasound Sweeps. Related Content: Diagnostic Accuracy of an Integrated AI Tool to Estimate Gestational Age From Blind Ultrasound Sweeps Enhancing Obstetric Ultrasonography With Artificial Intelligence in Resource-Limited Settings