Intellectually Curious podcast

How Claude Helped Map a Vault Particle

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In 1986, two researchers spotted a tiny structure whose curved ribs reminded them of a cathedral ceiling. They called it a vault. Forty years later, scientists are still working out what these tiny barrels do in our cells.

We follow a team at Anthropic that used Claude to search for relatives of these hollow protein shells. One promising lead came from a virus that infects bacteria. The researchers grew its protein in E. coli and used an electron microscope to see how 96 copies fit together into a closed barrel. Inside the wall they spotted a pocket holding a molecule they have yet to identify. That pocket gives them something concrete to investigate as they work out what vaults are for.


Note:  This podcast was AI-generated, and sometimes AI can make mistakes.  Please double-check any critical information.

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