Anastasia Theodosiou on controlled human infection with Neisseria lactamica in pregnancy

Phoebe Ashley-Norman talks with Zakiul Hassan and Prof Tahmina Shirin about the findings of "Interpreting the natural history and pathogenesis of Nipah virus disease through clinical data, to inform clinical trial design: a systematic review", by Zakiul Hassan and colleagues. We also discuss Nipah virus disease more broadly, talking about recent phylogenetic findings, diagnostics, therapeutics, vaccines, and ongoing challenges. Read the systematic review here: https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(25)00223-X/fulltext We also touched on some past Lancet publications, which you can explore here: https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(23)00361-0/fulltext https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00262-7/fulltext https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00765-5/fulltext https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(23)00707-7/fulltext https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(24)00270-2/fulltext

Elena Dalla Vecchia talks with Claas Kirchhelle and Lloyd Czaplewski about the current antimicrobial resistance (AMR) governance (with a historical perspective on how it came to be), the 2015 WHO Global Action Plan (GAP) on AMR and the draft for the 2026 updated GAP, the role of social sciences in addressing AMR, the financing mechanisms in antibiotic research and development (including push and pull incentives with public and philantropic funding), and perspectives on the future of the fight against AMR.  Click here to read the full article: https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(25)00243-5/fulltext https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(25)00216-2/fulltext Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/company/the-lancet https://youtube.com/thelancettv

Elisa Pucu from The Lancet Microbe interviews Dr. Magnus Unemo of Örebro University about the clinical implications and key findings from his research. They discuss about the the microbiological analysis and whole genome sequencing of treatment failures from the zoliflodacin phase 3 clinical trial for gonorrhea—revealing insights that could change the future of treatment and antibiotic resistance.  Click here to read the full articles: https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(25)00198-3/fulltext https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01953-1/fulltext Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/company/the-lancet https://youtube.com/thelancettv

Phoebe Ashley-Norman of The Lancet Microbe speaks to Amber Barton about the neglected tropical disease, yaws. Efforts to eradicate yaws were first made in the 1950s through a WHO and UNICEF campaign that reduced yaws prevalence by 90%, but it remained endemic in some regions.  Global efforts involving the mass drug administration of azithromycin continue in pursuit of the WHO 2030 yaws eradication goal. In this podcast, Amber discusses how genomic epidemiology can be used to investigate the effectiveness of yaws eradication strategies, detect sublineages of yaws at higher resolution, and improve our understanding of macrolide resistance. Click here to read the full article: https://www.thelancet.com/journals/lanmic/article/piiS2666-5247(25)00157-0/fulltext Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/company/the-lancet https://youtube.com/thelancettv

Elena Dalla Vecchia of The Lancet Microbe speaks to Dr Britt Koskella about bacteriophages and phageome, their role in modulating the bacteriome, their potential use as signatures of microbiome health and dysbiosis, and hence, indirectly, as markers of host health and disease status.  From an ecological perspective, parasites (such as bacteriophages) are key drivers of the evolution of their hosts (bacteria), and so one might expect to find diverse and rich bacteriomes in the presence of a highly diverse and thriving microbiome: Britt has been exploring this possibility and discusses it in this episode. Click here to read the full article: https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(25)00124-7/fulltext Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/company/the-lancet https://youtube.com/thelancettv

Rebecca Barksby of The Lancet Microbe speaks to Dr Christian Malaka and Dr Livia Patrono on mpox in the Central African Republic and how researchers are using genomic surveillance to provide insights into the epidemiology of the virus. Read the full article: https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(25)00101-6/fulltext Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/company/the-lancet https://youtube.com/thelancettv

Elena Dalla Vecchia talks with Dr Sam Lipworth and Prof Nicole Stoesser about the challenges and variability in genotypic predictions of antimicrobial resistance in Escherichia coli, about which they have published two papers in The Lancet Microbe: “Exploring uncatalogued genetic variation in antimicrobial resistance gene families in Escherichia coli: an observational analysis” and “Estimating the association of antimicrobial resistance genes with minimum inhibitory concentration in Escherichia coli, an observational study”. Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/company/the-lancet https://youtube.com/thelancettv

Rebecca Barksby of The Lancet Microbe speaks to Dr Anastasia Theodosiou about performing a controlled human infection study in pregnant women investigating mother-to-infant transmission of Neisseria lactamica. Read the full article: https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(24)00254-4/fulltext?dgcid=buzzsprout_icw_podcast_generic_lanmic Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/company/the-lancet https://youtube.com/thelancettv

Elena Dalla Vecchia of The Lancet Microbe speaks to Susan Meiring, Vanessa Quan, and Nelesh Govender about bloodstream infections in neonates at lower-tier South African hospitals. Read the full paper, Pathogen aetiology and risk factors for death among neonates with bloodstream infections at lower-tier South African hospitals: a cross-sectional study, at https://www.thelancet.com/journals/lanmic/article/PIIS2666-5247(24)00257-X/fulltext Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/company/the-lancet https://youtube.com/thelancettv

Rebecca Barksby of The Lancet Microbe speaks to Professor Laurence Armand-Lefevre and Professor Luc Hervé Samison about implementing the WHO Tricycle Protocol in Madagascar for the surveillance of extended-spectrum β-lactamase producing Escherichia coli in humans, chickens, and the environment. Read the full article: https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00228-1/fulltext?dgcid=buzzsprout_icw_podcast_generic_eclinm Continue this conversation on social! Follow us today at... https://thelancet.bsky.social/ https://instagram.com/thelancetgroup https://facebook.com/thelancetmedicaljournal https://linkedIn.com/company/the-lancet https://youtube.com/thelancettv