Episode 511: Vascular Disease at Age 23 (Protect Our Young)

This week, Dr. Kahn returns to one of his passion topics: educating young people about healthy lifestyles beginning in middle school and high school, if not earlier, and setting them up for a healthy future. A new study finds that the risk of heart disease and actual changes in the arteries are both common by age 23. It's a tragic reality. Other topics include dry cleaning and Parkinson's disease, amino acids and prostate cancer risk, meal timing and longevity, cooking classes and healthy diets (PlantRN), statins at age 80, exercise and the reversal of artery disease, lipoprotein(a) and heart disease, and alcohol versus healthy lifestyles in relation to the risk of sudden cardiac death.  Thanks to WellBean for sponsoring this episode. Use the discount code DrKahn15 on delicious and healthy food bars made with legumes. They're my favorite snack.

This week, Dr. Kahn discusses the triglyceride-to-HDL (TG/HDL) ratio and how this simple lab measurement can help predict insulin resistance, type 2 diabetes, liver disease, and heart disease. It is also a marker of visceral fat and an easy, readily available way to add valuable risk information to your health journey. Dr. Kahn also discusses how genetics can influence the TG/HDL ratio. Other topics include tomatoes for the liver, tirzepatide for the heart, lifestyle for the heart, junk food and prostate cancer, belly fat and the heart, alcohol and the heart, and the power of climbing stairs. Thanks to our sponsor, WellBean. Their delicious bean-based bars make it easy to add more plant-based nutrition to your day. Visit wellbean.life and use discount code DrKahn15 to save on your order.

This week, Dr. Kahn discusses new research showing that after just 4 weeks of eating a whole-food, plant-based diet, sophisticated measures of gene activity demonstrate a reversal in aging and a reduction in inflammation. In another study, the calorie advantage of a plant-based diet is discussed, with the equation H=N/C (Health = Nutrition/Calories) proving to be a useful reminder. Finally, athletic performance in college athletes eating plant-based or omnivore diets was equivalent, which is reassuring to many. Dr. Kahn and his wife will begin their 50th year of plant-based diets in September. Other topics include more conversation on advanced glycation end products, dietary protein, finerenone for the kidneys, the top 3 modifiable risk factors for dementia and heart attacks, red hair color and heart disease, Viagra and statins for the prevention of cancer metastases, and fatty liver disease. Thanks to our sponsor, WellBean, and the discount code DrKahn15 for sponsoring this week's episode.

This week, Dr. Kahn discussed new research on advanced glycation end-products (AGEs) and cooking methods. High levels of AGEs promote many disease states and can be avoided with water-based cooking methods like steaming, boiling, and pressure cooking. Other topics include visceral fat loss and brain health, bitter hops extract for weight loss, the Planetary Health Diet, fructose in the diet and cancer growth, a failed study on inflammation, and the role of multivitamins in cardiac health.  Thanks to the Fresh Pressed Olive Oil Club and the $1 offer at getfreshDrKahn.com.

This week, Dr. Kahn discusses new data from the amazing Valter Longo, PhD, and his colleagues regarding optimizing diet for both longevity and strong muscles. In a new publication, Dr. Longo used mouse models to show that animals fed a Longevity Diet, as described in his book, lived longer. However, when moderate amounts of methionine, an amino acid, were included in the diet, frailty was avoided. He then analyzed a dataset of 200,000 health professionals in the United States and found that those consuming the highest amounts of animal protein had double the risk of type 2 diabetes, as well as higher rates of obesity and hypertension, compared with those consuming more plant protein. You can learn more about Dr. Longo's L-Protein powder (with methionine) at prolonlife.com/drkahn. Other topics include PCOS and heart disease, aortic dissection, artificial sweeteners and memory loss, optimal medical treatment for high cholesterol, GLP-1 agonist use and hair loss, TMAO and the risk of atrial fibrillation, statins and better cognitive function in women, and how plant mitochondria may improve our own cellular function. Amazing.  Thanks to the Fresh Pressed Olive Oil Club. Learn more at getfreshDrKahn.com.  Dr. Kahn's new book can be found here: amazon.com/dp/B0HBGJ4J59

In this bonus episode, Dr. Kahn interviews functional medicine specialist Ivan Rusilko about the importance of advanced lab panels. Together, they explore the full spectrum of cardiac lab testing, with a special focus on inflammation, insulin resistance, and how these markers can uncover hidden cardiovascular risk. If you are a health care practitioner, set up an account at accessmedlab.com. Mention the Heart Doc VIP Podcast when creating your new practitioner account to receive 50% off CardioPro™ Advanced Diagnostic Panels, providing unparalleled insights into patient health.

This week, Dr. Kahn discusses the FDA approval of the first oral PCSK9 inhibitor, Lipfendra (enclicitide), taken as a 20 mg daily tablet. In a study of nearly 3,000 patients with elevated LDL cholesterol despite treatment with statins and, in many cases, ezetimibe, LDL-C dropped by more than 50% while Lipoprotein(a) levels fell by 28%, with an excellent safety profile. The medication is expected to retail for approximately $315 per month and will be available in pharmacies soon. A larger outcomes trial evaluating its impact on heart attack and stroke rates is currently underway. Other topics include oatmeal for diabetes, avocados for cholesterol, ketogenic diets and cancer, serotonin and heart valve disease, air pollution and cardiovascular events, and the relationship between sweetened beverages, fruit juice, and high blood pressure. Dr. Kahn also mentions the air filtration system he uses at home and in his office, available at: airdoctorpro.com Finally, thanks to this week's sponsor, the Fresh Pressed Olive Oil Club. Learn more at getfreshDrKahn.com.

This week, Dr. Joel Kahn explores important new research showing how elevated inflammation, measured by Interleukin-6 (IL-6), may dramatically increase cardiovascular risk in people with high Lipoprotein(a), or Lp(a). He explains why IL-6 is emerging as an important biomarker and reviews the other inflammation tests he routinely uses at the Kahn Center, including hs-CRP, MPO, Lp-PLA2, NT-proBNP, fibrinogen, ferritin, the sedimentation rate, and the white blood cell count. Dr. Kahn also discusses Lilly's newly approved oral weight loss medication, the ABCDEF framework for cardiovascular prevention, the growing evidence linking erectile dysfunction and sleep apnea to heart disease, new research on cannabis use and coronary artery plaque, and intriguing early findings on creatine's potential role in supporting the immune system and anti-tumor activity. Finally, thanks to this week's sponsor, the Fresh Pressed Olive Oil Club. Visit getfreshDrKahn.com to take advantage of their special introductory offer and experience the health benefits of fresh, polyphenol-rich olive oil.

Dr. Joel Kahn explores the latest science on supplements that may help slow or reverse atherosclerosis, building on a recent discussion from Simon Hill's The Proof podcast. He takes a closer look at the evidence behind vitamin K2, niacin, pycnogenol with centella asiatica, beta-cyclodextrin, and bergamot, explaining where the research is strongest and what it could mean for heart health. Additional topics include new research on nutrient deficiencies to watch for in vegan diets, the potential kidney risks of certain calcium channel blockers, the health benefits of onions, advanced plaque measurements from coronary CT angiography, the connection between periodontal disease and kidney disease, and how fasting-mimicking diets may improve gum health. Dr. Kahn also reviews encouraging early results from an emerging Lipoprotein(a)-lowering therapy that could reduce the need for lipoprotein apheresis.  Dr. Kahn is leading a group PROLON fasting-mimicking diet beginning this Sunday, July 12, and continuing for five days. A PROLON kit is required and can be purchased at prolonlife.com/drkahn. The NextGen version is recommended.  Finally, a giant thanks to this week's sponsor, Igennus. Learn more at igennus.com/drkahn.

This week, Dr. Kahn reviews important new research showing that the commonly prescribed antidepressant Prozac (fluoxetine) may disrupt cholesterol metabolism, injure the endothelium (the delicate lining of arteries), and potentially increase cardiovascular risk. He also examines growing evidence linking proton pump inhibitors (PPIs) and several common cancer therapies to endothelial damage, emphasizing that patients should always discuss the risks and benefits of these medications with their healthcare team rather than stopping treatment on their own. Other topics include new Harvard research showing that combining aerobic exercise, strength training, and less time spent watching television can reduce the risk of type 2 diabetes by up to 60%; promising data on niacin for glioblastoma brain cancer; predicting statin-related muscle injury; the protective effects of plant-based diets against heart disease, dementia, and several cancers; tea consumption and lower cardiovascular risk; vitamin K-rich leafy greens and lung health; whole grains and breast cancer prevention; and the latest research on red meat, inflammatory bowel disease, and hypertension.  Thanks to igennus.com/drkahn for this week's podcast sponsorship featuring their vegan Super B Complex.