Episode 501: The Surprising Science of Gratitude and Heart Health

This week, Dr. Kahn reviews important new research showing that the commonly prescribed antidepressant Prozac (fluoxetine) may disrupt cholesterol metabolism, injure the endothelium (the delicate lining of arteries), and potentially increase cardiovascular risk. He also examines growing evidence linking proton pump inhibitors (PPIs) and several common cancer therapies to endothelial damage, emphasizing that patients should always discuss the risks and benefits of these medications with their healthcare team rather than stopping treatment on their own. Other topics include new Harvard research showing that combining aerobic exercise, strength training, and less time spent watching television can reduce the risk of type 2 diabetes by up to 60%; promising data on niacin for glioblastoma brain cancer; predicting statin-related muscle injury; the protective effects of plant-based diets against heart disease, dementia, and several cancers; tea consumption and lower cardiovascular risk; vitamin K-rich leafy greens and lung health; whole grains and breast cancer prevention; and the latest research on red meat, inflammatory bowel disease, and hypertension.  Thanks to igennus.com/drkahn for this week's podcast sponsorship featuring their vegan Super B Complex.

Can a simple gratitude practice improve your heart health? This week, Dr. Kahn explores the growing science linking gratitude to better well-being, improved sleep, lower inflammation, and even enhanced cardiac function. He shares his own gratitude practices and offers practical ways to incorporate them into daily life.  Also covered in this episode: how adherence to Life's Essential 8 is associated with longevity, even among the ultra-elderly; the importance of identifying cholesterol hyperabsorbers; the connection between obesity and cancer risk; the relationship between sleep apnea and Lipoprotein(a); why strength training is especially important for women; and the link between hypothyroidism and elevated homocysteine levels.  Thanks to IGENNUS for their support of this episode, featuring their vegan Pro-Collagen Powder. Learn more at igennus.com/drkahn.

In this special 500th episode of Heart Doc VIP, Dr. Joel Kahn reflects on the personal and professional journey that shaped his 36-year career in cardiology and preventive medicine. From his childhood in Detroit and medical training at the University of Michigan to founding the Kahn Center for Cardiac Longevity, Dr. Kahn shares the mentors, experiences, and lessons that influenced his approach to patient care. He also reviews new research on heart disease mortality in the United States, vitamin K2 and coronary artery calcium progression, plant-based diets for chronic kidney disease, factors influencing carotid intima-media thickness (CIMT), and emerging advances in calcium scoring technology.  Thank you to Igennus for sponsoring this milestone episode. Visit Igennus.com/DrKahn and use code DRKAHN for savings on their vegan-certified supplements.

In Episode 499, Dr. Joel Kahn explores the growing importance of apolipoprotein B (ApoB) testing as a powerful tool for assessing cardiovascular risk. He reviews new research highlighting why ApoB may provide a more complete picture of atherosclerosis risk than traditional cholesterol measurements alone and explains how it relates to LDL-C and Lp(a). Dr. Kahn also discusses several noteworthy studies in preventive medicine and longevity, including research linking GLP-1 medications to lower cancer risk, the potential DNA-protective effects of melatonin, and new findings on stroke and clot prevention in patients with atrial fibrillation. Additional topics include the relationship between very low Lp(a) levels and diabetes risk, the benefits of organic produce for breast cancer prevention, Pilates training for blood pressure management, and the connection between processed meat consumption and gastrointestinal cancers. The episode concludes with a look at Endothelin-1 (ET-1), an important marker involved in vascular health and cardiovascular disease, along with a discussion of Vinia grape powder and its potential role in lowering ET-1 levels. Thanks to Igennus.com and their Triple Vitamin K Complex using the discount code DrKahn

Dr. Joel Kahn dives into a groundbreaking Phase 1 trial of Verve 102, a one-time intravenous gene-editing treatment that silences the PCSK9 gene to produce lasting LDL cholesterol reduction. Among 35 participants, the high-dose group saw LDL drop by 62% with mostly mild side effects — promising results, though Phase 2 and 3 trials and 15 years of follow-up still lie ahead. Also covered: updated colorectal cancer screening guidelines now starting at age 45, healthy lifestyle habits cutting mortality risk in cancer survivors by one-third, real-world weight regain data after stopping GLP-1 medications, why your B12 "normal" range may be too low, a blood test that may predict Alzheimer's years in advance, and a longevity preparedness tool from MIT AgeLab. Sponsored by Igennus — visit igennus.com/drkahn for 20% off.

In this episode of HeartDoc VIP, Dr. Joel Kahn breaks down the newly released — but not yet fully published — results from the highly anticipated Triumph-1 study on retatrutide, an investigational weight loss medication that's already generating major buzz in the cardiometabolic world. The reported weight loss results at 80 and 104 weeks are remarkable, with side effects appearing consistent with other medications in this class, including semaglutide and tirzepatide. Dr. Kahn discusses what's known so far, what questions still remain, and why the full peer-reviewed publication is so important before drawing final conclusions on risks and benefits. FDA approval may not be far away. Other topics in this packed episode include the troubling rise in fatal heart attacks among younger adults, a modified Mediterranean diet linked to lower diabetes risk, the connection between food preservatives and heart disease, atrial fibrillation in athletes, nitric oxide's role in brain health, fatty liver disease and cardiovascular risk, and how the American Heart Association's Life's Essential 8 score may predict diabetes risk in women. Thanks to Igennus for sponsoring this episode. Visit their site and use promo code DRKAHN to save on high-quality supplements.

This week, Dr. Kahn discusses Bryan Johnson's efforts to reverse his "biological age" and the 41 lessons he has shared along the way. These are valuable insights that Dr. Kahn largely endorses. Other topics include the sit-to-stand test; how PCOS can become PMOS; therapies for Peyronie's disease and PSA testing; plant-based diets and aging; plant-based diets during pregnancy; pregnancy complications; and the cardiac health of offspring.  A big thanks to Igennus for supporting the podcast. Use discount code DrKahn to save on the BeKind line of plant-based nutritional products.

This week, Joel Kahn, MD, dives into fascinating new research on aged garlic extract and its potential role in healthy aging, muscle function, and cardiovascular wellness. He reviews a recent study showing how aged garlic extract improved muscle and aging markers in mice while also activating the NAMPT pathway in humans, which may help boost NAD+ production. Dr. Kahn also breaks down several newer studies highlighting the cardiovascular benefits of aged garlic extract, a supplement he's used at the Kahn Center for more than a decade. He discusses the specific Kyolic formula available here: Kyolic Aged Garlic Extract Additional topics include dietary nitrates from greens and nitric oxide production, the Mediterranean diet and longevity, high-intensity interval training and heart health, visual acuity and lifespan, plant-based diets and breast cancer outcomes, and the connection between poor sleep and survival rates.  This episode is brought to you by VINIA and their line of heart-supporting products.

This week, Dr. Kahn discusses his long-standing interest in the amino acid glycine and its potential health benefits. Sleep is a key focus, highlighted by a new report on the widespread difficulty adults face in getting a full night's rest. Glycine may also offer favorable cardiovascular support. Additional topics include coffee and aging, methamphetamines and heart attacks, Lipoprotein(a) and cardiovascular risk, yoga and overall health, a tribute to Eugene Braunwald, MD, TMAO and atherosclerosis, and a new study on the benefits of adopting heart-healthy habits early in life.  Thanks to the Fresh Pressed Olive Oil Club and the special discount offer at getfreshdrkahn.com

This week, Dr. Kahn reviews new data from the Global Burden of Disease study analyzing the relationship between diet and death from heart disease. In 2023, an estimated 5.9 million deaths worldwide were linked to poor dietary choices, led by excessive sodium intake and insufficient consumption of fruit and whole grains. It's a fascinating and important study with clear takeaways. Other topics include stents for angina, causes of sudden cardiac death, daytime napping and health outcomes, plastic-free diets, PCSK9 inhibitors vs. statins, calcium supplements, and the purity of fish oil samples. Thanks to the Fresh Pressed Olive Oil Club. Visit getfreshdrkahn.com for an incredible introductory offer.