Hemophilia Treatment: When the Bleed Isn’t What Hurts the Most

“All clear” isn’t always the end. Melanoma’s ability to recur months or years after surgery is shifting how clinicians think about treatment timelines. DDx host Raj Bhardwaj, MD, and Omid Hamid, MD, chief of translational research and immunotherapy at The Angeles Clinic and Research Institute in Los Angeles, explore strategies for identifying patients at high risk for melanoma recurrence, new therapeutic approaches before and after surgery, and what these developments mean for the future of melanoma care.

A woman walks into a clinic, she’s eight months pregnant: tired, pale, anemic. Her last pregnancy ended early—an emergency C-section at 32 weeks. This time, her obstetrician happens to flip through an old chart and finds a diagnosis so rare, most doctors will never encounter it. In this episode, follow a multidisciplinary team’s race to design a complex care plan that, despite many challenges, keeps mother and baby safe.

A young man walks into a hemophilia treatment center. He’s limping, certain his ankle is bleeding again—same as always. But this time, the team discovers the pain may be coming from something else, something that isn’t in the patient’s chart. In this story, we explore the many ways and forms pain can present, and the importance of treating the whole person.

Transitioning hemophilia care from pediatric to adult care sounds simple enough. At home, though, it can be complicated—habits run deep, and for parents of children with hemophilia, the line between protection and independence isn’t always clear. In this episode, we’ll explore how hemophilia treatment centers put transition care into practice to help teens and young adults with bleeding disorders navigate taking ownership of their treatment and their first steps toward independence.

A young boy goes to urgent care, he’s fallen and his knee is swollen – likely a soft tissue trauma or at worst a minor joint bleed. He’s given a brace, told to rest. At follow up, everything is as expected – until a nurse reviews his chart and sees the child has hemophilia. We’re no longer talking about a minor joint bleed, we’re talking about a joint bleed, that, if left untreated, could lead to permanent damage.

A young man calls his doctor – he has hemophilia and joint pain – he knows what this is, he’s had it before: it’s a knee bleed. He’s given himself three doses of blood clotting factor, but it’s not working. When he arrives at the hemophilia treatment center, his care team takes a closer look – and what they find will change everything.

If you work in healthcare, you’ve felt it—that moment when communication breaks down. This season on DDx, we’re going inside hemophilia treatment centers—places where teamwork isn’t optional. It’s what holds everything together. You’ll hear stories from the people who do this work every day—how collaboration really works, what it looks like in real time, and how filling gaps in communication helps ensure patients get the care they deserve. Coming soon, season 12 of DDx.

A man walks into his doctor’s office with flu-like symptoms—and walks out with a lung cancer diagnosis. What happens next opens up a broader conversation about early detection, access to screening, and the clinical nuances of treating non-small cell lung cancer.In this episode, Dr. Raj Bhardwaj brings you a candid discussion between oncologists Dr. Sanjay Juneja and Dr. Eric Singhi. They unpack a real patient case and explore the practical, diagnostic, and systemic challenges that shape lung cancer care today.

This is a trailer for a special bonus episode of DDx—not part of Season 12.While we work on our next season, we’re bringing you a powerful standalone case: a patient arrives with flu-like symptoms—but the diagnosis is something far more serious.In this bonus episode, Dr. Raj Bhardwaj brings you a conversation between two leading oncologists, Dr. Sanjay Juneja and Dr. Eric Singhi, as they unpack a case that challenges assumptions and reveals how great clinicians think through the unexpected.Stay tuned—the full episode drops soon.

Last time, we spoke with the co-creator of DAX Copilot, Dr. Jared Pelo, about what DAX can actually do and the questions it raises about AI and the future of medicine. But today, we’re not just continuing that conversation—we have news. Dr. Pelo is back to share a major development, and talk about what this news means for physicians, patients and the future of clinical practice.