339! Medical Experiments

How far would you be willing to go to experiment with your health? This week, Joey and Jess talk about peptides, biohacking, Silicon Valley libertarian culture, Bryan Johnson, exercise, and salt. They don’t talk about The Gelflings. references Confirmations Department: Yes, Tears for Fears Vectorculture: Not For Human Consumption Peptide Mounjaro Wired: Bryan Johnson Is Going to Die Food & Wine: Morton vs. Diamond Crystal Kosher Salt: What’s the Difference? Solid Wiggles 

Why do we keep using short-form video? This week, Joey and Jess talk about dopamine culture, friction, flow state, floating, smoking, and green juice. They don’t talk about cannolis. references American Psychological Association: Feeds, Feelings, and Focus: A Systematic Review and Meta-Analysis Examining the Cognitive and Mental Health Correlates of Short-Form Video Use Designing Friction Bad UX World Cup The Perfect Date Picker Soy Boy Face / Soyjak Canelé 

How do you dress for success? This week, Aaron and Joey talk about fashion plates, professionalism, drag, archetyping, navigating differences, and respect. They don’t talk about Rufio. references Fashion plate Professionalism as a Racial Construct Economic Policy Institute: The CROWN Act Paris is Burning Underground ball culture Everyday Feminism: You Call It Professionalism; I Call It Oppression in a Three-Piece Suit 

This week, Aaron, Jess and Joey revisit their 2025 prognogs from Episode 296. They talk about the micro social media surge, cynicism, platform madness, informed styling, blockbusters, weaponized compliance, non-apocalyptic runaway AI moments, and our AI overlords. They don’t talk about eggprogs. references If I ruled the world ... People: Bob Mackie Says 'People Were Horrified' by Cher's 'Naked' 1974 Met Gala Dress, Even Ripping Her Photo off Magazine Covers Tasting ultra-aged eggnog America's Test Kitchen: How to Make the Absolute Best Eggnog Louis Pasteur Memphis Group Conan O'Brien Needs A Friend Podcast: Conan Blames Jason Bateman For His Dad's Death Clair Obscur: Expedition 33 Split Fiction AAA (video game industry) quod erat demonstrandum The New York Times: Gonzo Fans Have Made ‘Dungeon Crawler Carl’ Into a Global Blockbuster Michiko Kakutani's 1995 The New York Times book review of Wicked: Let's Get This Straight: Glinda Was the Bad One? (paywall) Bloomberg: OpenAI's Nvidia, AMD Deals Boost $1 Trillion AI Boom With Circular Deals (paywall) The Food Lab: How to Roast the Best Potatoes of Your Life 

What does your Zero Farts Land future look like? This week, Aaron, Joey, and Jess talk about fucks. And farts. references Empire: Jamie Lee Curtis Is Done Compromising – And She’s Not Slowing Down George Wallace (not George Wallace) Kenan Thompson on We Might Be Drunk with Normand and Morril Janelle James on Conan O'Brien Needs A Friend The Subtle Art of Not Giving a F*ck by Mark Manson 

How do you strategy? This week, Aaron and Joey talk about Elliott Kalan, the School of Let's Figure It Out, emotional distance from work, working in teams, meandering, and strategy that bleeds. They don’t talk about Jamesy P. references Pure Moods Joke Farming: How to Write Comedy and Other Nonsense by Elliott Kalan 99% Invisible Podcast Episode 646: Interview with Elliott Kalan Corrections Department: Les has never ever ever heard, touched, or even seen a copy of Pure Moods and now fears his colleagues do not understand him at all. 

Why do we expect the worst? This week, Aaron and Jess talk about simple solutions, Karen moments, assuming malice, Thanos, Falkland's Law, and lemmings. They don’t talk about the famous former power forward for the Boston Celtics or the Hamburger Peddler's rhyming buddy. references Corrections Department: Camila Cabello "I'll Be Home for [Quizmois]" Glee's Kevin McHale Kevin McHale on the Loss of Naya Rivera Hanlon’s Razor Guillermo del Toro's Frankenstein Cringe Blvd. Slow Horses Falkland's Law 

How has technology made us less sure of ourselves? This week, Jess and Joey talk about technological change, Christmas cards, scraping, phone numbers, friendships, and FaceTime. They don’t talk about beepers. references Ski-ba-bop-ba-dop-bop Rolodex propinquity Don't lose that number, Jenny Sternberg’s Triangular Theory and The 8 Types of Love Mr. Postman Desiigner "LOD Freestyle" 

Is it better to generalize or to specialize? This week, Joey and Jess talk about polymaths, running, functional fitness, idea people, curiosity, and Starship Troopers. They don’t talk about dilettantes. references Specialization is for insects. Stardew Valley Forbes: Going Pi-Shaped: How To Prepare For The Work Of The Future 129 Ways to Get a Life Robert A. Heinlein 

Are there actually interesting life innovations that are coming out of the content creation boom? This week, Joey and Jess talk about homemade pop tarts, learning letters, the power of song, TikTok, mastering movements, and apple dumplings. They don’t talk about Action Bronson. references The recipe is the sooonnggg. cool.missp: ABCs Turn Up EBITDA What Are Popovers And What Do They Taste Like? Pepperidge Farm Bakery Frozen Spiced Apple Dumplings Pastry