#165: We are finally talking about this ingredient: GLUTATHIONE!

CHECK OUT DOUBLE PLAY!: https://chemistconfessions.com/products/double-play-retinol-face-eye-treatment We are wrapping up our hyperpigmentation series by diving into the science of resorcinol and its various derivatives. We explore the history of this "ancient" molecule, its uses in treatments like designer peels and acne prescriptions, and why the industry has shifted toward modern derivatives to avoid skin irritation. 01:28 | What is resorcinol?  01:50 | Resorcinol in acne treatments and designer peels  02:13 | Why is resorcinol used in hair dyes?  02:33 | The shift toward resorcinol derivatives for skin safety  02:54 | EU SCC regulations on resorcinol concentrations  22:30 | Hyperpigmentation serum scenarios and skin discomfort 23:05 | Preview: Hexylresorcinol and Diamond Oil Do We Absorb Sunscreen Filters into Our Bloodstreams? https://chemistconfessions.com/blogs/controversy-corner-do-we-absorb-sunscreen-filters-into-our-bloodstreams  Follow us: IG:   / chemist.confessions   INTERWEB: https://chemistconfessions.com/ TIKTOK: https://www.tiktok.com/@chemistconfes... Skincare questions for the podcast? Leave your question in the comments and it could be featured in our next episode! #chemistconfessions #skincarescience #chemistconfessionspodcast #skincarehack

We are back for a follow-up to our glutathione deep dive! We review five specific glutathione-heavy products, four from the K-beauty world and one popular Amazon find, to see if they truly deliver on their antioxidant and brightening claims. 00:00 | Intro: Hashtags & antioxidant claims 00:24 | Welcome back to Chemist Confessions Podcast 00:30 | Glutathione deep dive follow-up 00:56 | Product lineup: 4 K-beauty + 1 Paula’s Choice 02:05 | Price points & supply differences 03:40 | Texture notes: neutral, not hydrating 05:03 | Fragrance issues & masking glutathione scent 06:05 | Stability concerns & 2-week shelf life 07:23 | Paula’s Choice texture & film discussion 08:25 | The infamous “eggy with undertone of death” scent 10:16 | Clinical claims & before/after photos skepticism 12:04 | Niacinamide + tranexamic acid doing the heavy lifting 17:57 | Tulsa Wound serum: 2% glutathione, suspicious photos 21:03 | Abib serum: percentages, encapsulation, and clinical data Product Shoutout: Double Play Retinol Face and Eye Treatment: https://chemistconfessions.com/products/double-play-retinol-face-eye-treatment Enrichment Content: Sunscreen Layering Guide https://www.youtube.com/watch?v=IQ0Dlb0WXvc Do We Absorb Sunscreen Filters into Our Bloodstreams? https://chemistconfessions.com/blogs/controversy-corner-do-we-absorb-sunscreen-filters-into-our-bloodstreams  Follow us: IG:   / chemist.confessions   INTERWEB: https://chemistconfessions.com/ TIKTOK: https://www.tiktok.com/@chemistconfes... Skincare questions for the podcast? Leave your question in the comments and it could be featured in our next episode! #chemistconfessions #skincarescience #chemistconfessionspodcast #skincarehack    

WE HEARD YOU! We explore the science behind one of the most requested and hyped ingredients skincare sector: glutathione. We break down what this "master antioxidant" actually is. 01:25 | What is Glutathione? Breaking down the tri-peptide  01:54 | Why is it called the "Master Antioxidant"?  02:43 | Mechanisms: Tyrosinase inhibition and skin whitening  03:16 | The Stability Struggle: Why pH and temperature matter  06:18 | Half-life study: How quickly does it degrade in your products?  08:12 | Gold Standard Age Booster: Tactical hyperpigmentation tool  08:40 | Does it actually work? Reviewing topical clinical studies  12:35 | Study Deep Dive: 0.5% GSH vs. placebo on Indonesian women  17:36 | Oxidized Glutathione (GSSG): Is a more stable version better? Product Shoutout: Double Play Retinol Face and Eye Treatment: https://chemistconfessions.com/products/double-play-retinol-face-eye-treatment Enrichment Content: Sunscreen Layering Guide https://www.youtube.com/watch?v=IQ0Dlb0WXvc Do We Absorb Sunscreen Filters into Our Bloodstreams? https://chemistconfessions.com/blogs/controversy-corner-do-we-absorb-sunscreen-filters-into-our-bloodstreams  Follow us: IG:   / chemist.confessions   INTERWEB: https://chemistconfessions.com/ TIKTOK: https://www.tiktok.com/@chemistconfes... Skincare questions for the podcast? Leave your question in the comments and it could be featured in our next episode! #chemistconfessions #skincarescience #chemistconfessionspodcast #skincarehack

We explore the science of skincare as we review five affordable, drugstore-priced arbutin products. In this episode, we break down everything from texture and clinical claims and ingredient lists of popular brands to help you find the right formula for your skin. TIMESTAMPS:  01:27 | Texture Analysis: Why is Arbutin so Sticky? 03:01 | Texture Face-Off: Oily vs. Dry Skin Reactions 04:48 | Is the Beauty of Joseon Serum a Moisturizer? 06:01 | Chemist Notes: Breaking Down the Cosrx Formula 06:57 | Analyzing Clinical Claims: Inner and Outer Melanin? 09:57 | Instrumental Measurements: Reducing Dark Spots 13:01 | Deep Dive: Beauty of Joseon Ingredients 14:56 | The Truth About "Pregnancy Safe" Marketing 16:25 | The Ordinary & Naturium: Simple Serum Breakdown Product Shoutout: Double Play Retinol Face and Eye Treatment: https://chemistconfessions.com/products/double-play-retinol-face-eye-treatment Enrichment Content: Sunscreen Layering Guide https://www.youtube.com/watch?v=IQ0Dlb0WXvc Do We Absorb Sunscreen Filters into Our Bloodstreams? https://chemistconfessions.com/blogs/controversy-corner-do-we-absorb-sunscreen-filters-into-our-bloodstreams  Follow us: IG:   / chemist.confessions   INTERWEB: https://chemistconfessions.com/ TIKTOK: https://www.tiktok.com/@chemistconfes... Skincare questions for the podcast? Leave your question in the comments and it could be featured in our next episode! #chemistconfessions #skincarescience #chemistconfessionspodcast #skincarehack

We are diving deep into the science of skincare to explore the role of Arbutin in treating hyperpigmentation. In this human conversation, we break down what exactly Arbutin is, analyze the existing data on its efficacy, and provide a comprehensive guide on what you should consider when shopping for these products.     Product Shoutout: Double Play Retinol Face and Eye Treatment: https://chemistconfessions.com/products/double-play-retinol-face-eye-treatment Enrichment Content: Sunscreen Layering Guide https://www.youtube.com/watch?v=IQ0Dlb0WXvc Do We Absorb Sunscreen Filters into Our Bloodstreams? https://chemistconfessions.com/blogs/controversy-corner-do-we-absorb-sunscreen-filters-into-our-bloodstreams  Follow us: IG:   / chemist.confessions   INTERWEB: https://chemistconfessions.com/ TIKTOK: https://www.tiktok.com/@chemistconfes... Skincare questions for the podcast? Leave your question in the comments and it could be featured in our next episode! #chemistconfessions #skincarescience #chemistconfessionspodcast #skincarehack

In this episode, we take a deep dive into the world of K-beauty azelaic acid products. We explore the science behind three popular contenders—Anua, Purito, and medicube—while decoding their ingredient lists, analyzing clinical testing data, and discussing the tricky chemistry of azelaic acid solubility.  We provide a chemist’s perspective on how to choose the right formula for your skincare routine. 00:00 | Introducing K-Beauty Azelaic Acid Contenders   00:02 | The "Ouch" Factor: Testing medicube’s Needle Technology  00:04 | Sensation vs. Science: Do Spicules Improve Penetration?   00:05 | Texture Breakdown: Puridose Oil Droplets vs. Anua Watery Serum   00:08 | Decoding Ingredient Lists: Tea Tree Oil vs. Leaf Water   00:13 | Analyzing Anua’s Clinical Studies for Redness Reduction   00:18 | Is 4-Week Acne Testing Actually Meaningful?   00:23 | Bacterial Exosomes and the Future of Skincare Sourcing   00:29 | Chemist Corner: The Difficulty of Azelaic Acid Solubility   00:32 | Final Verdict: Choosing Suspensions vs. Soluble Formulas

This week, we're starting our series on hyperpigmentation answering one of the most common questions many of us will encounter which is, "Is azelaic acid better than hydroquinone for my hyperpigmentation 00:00 | Introduction: 2026 Skincare Kickoff 03:45 | Investigating the PNAS Combination Study 08:12 | Deep Dive: Azelaic Acid vs. Hydroquinone 12:50 | The Challenge of Finding Full Research Papers 18:30 | Patient Compliance: The 16-Week Milestone 22:15 | Why Visual Improvements Take Time 27:00 | Analyzing Study Abstracts vs. Full Data 31:10 | Dual Therapy Overkill: 5% Concentration Discussion 31:50 | Motivation and Routine Consistency for Results Product Shoutout: Double Play Retinol https://chemistconfessions.com/products/double-play-retinol-face-eye-treatment Enrichment Content: Chemists’ Guide to Choosing an Exfoliating Toner https://chemistconfessions.com/blogs/how-to-choose-the-right-exfoliating-toner-for-your-skin Follow us: IG:   / chemist.confessions   INTERWEB: https://chemistconfessions.com/ TIKTOK: https://www.tiktok.com/@chemistconfes... Skincare questions for the podcast? Leave your question in the comments and it could be featured in our next  

The Chemist Confessions podcast year-end review is here! We blitz through the 103 skincare products tested in 2025! We reveal our favorite and least favorite categories, discuss surprising finds like Hypochlorite Acid, and give our honest takes on individual products, including the Banana Boat Light as Air Sunscreen and the La Roche-Posay Cicaplast Sunscreen, and of course, Animal Corner! Timestamps:  00:00 | Welcome to Chemist Confessions Podcast & Year-End Review 01:07 | How Many Skincare Products Did We Test in 2025? (103 products!) 03:55 | Favorite Skincare Product Categories We Tested This Year 07:27 | What is Our Least Favorite Skincare Product Category? 10:07 | Why is K-Beauty C-Fu Dupe Testing Boring? 12:21 | Most Surprising Skincare Category: Cleansing Oils & Hypochlorite Acid 18:11 | Best Product of the Year: Banana Boat Light As Air Sunscreen Review 21:48 | Worst Product of the Year: La Roche-Posay Cicaplast Sunscreen Pill Test 25:54 | Most Surprising Product: What is A0X or 2X Intense? 28:17 | Are Cushion Foundations Good Sunscreens? Tarte Cushion Review Products Discussed this 2025 Podcast Season *a small portion of your purchase through these links goes to feeding a chemist. https://shopmy.us/collections/1280514 Recommended 30 for 30 Sunscreens 2025 *a small portion of your purchase through these links goes to feeding a chemist. https://shopmy.us/collections/1766357 Product Shoutout: Blank Slate Gentle Gel Cleanser https://chemistconfessions.com/products/blank-slate-cleanser Enrichment Content: Sunscreen Layering Guide https://www.youtube.com/watch?v=IQ0Dlb0WXvc Do We Absorb Sunscreen Filters into Our Bloodstreams? https://chemistconfessions.com/blogs/controversy-corner-do-we-absorb-sunscreen-filters-into-our-bloodstreams  Follow us: IG:   / chemist.confessions   INTERWEB: https://chemistconfessions.com/ TIKTOK: https://www.tiktok.com/@chemistconfes... Skincare questions for the podcast? Leave your question in the comments, and it could be featured in our next episode! #chemistconfessions  #skincarescience  #chemistconfessionspodcast  #skincarehacks

We did a product head-to-head comparing occlusive balms, all with a petrolatum base! Following our beef tallow deep dive, we are breaking down the texture, transfer, price, and complex chemist notes of Vaseline, Aquaphor, CeraVe, Prequel, and our own Bon Voyage. Which formula is best for sensitive, compromised, dry, or oily skin, and why a simple formula isn't always best! 00:00 | Welcome to Chemist Confessions Podcast! 00:37 | What is an occlusive balm and why does petrolatum matter? 01:09 | Vaseline vs Aquaphor: Price and ingredient breakdown 03:25 | How does Vaseline’s texture change with application amount? 06:01 | Is Aquaphor better than Vaseline for lips and transfer resistance? 07:55 | Why is CeraVe Healing Ointment less shiny than other balms? 11:31 | How do dry vs oily skin types react to occlusive balms? 14:47 | Why does Vaseline have a drug facts label? 16:07 | Should you avoid complex balm formulas for compromised skin? 23:07 | Are occlusive balms temperature sensitive? Storage tips for warmer climates Products Discussed this 2025 Podcast Season *a small portion of your purchase through these links goes to feeding a chemist. https://shopmy.us/collections/1280514 Recommended 30 for 30 Sunscreens 2025 *a small portion of your purchase through these links goes to feeding a chemist. https://shopmy.us/collections/1766357 Product Shoutout: Blank Slate Gentle Gel Cleanser https://chemistconfessions.com/products/blank-slate-cleanser Enrichment Content: Sunscreen Layering Guide https://www.youtube.com/watch?v=IQ0Dlb0WXvc Do We Absorb Sunscreen Filters into Our Bloodstreams? https://chemistconfessions.com/blogs/controversy-corner-do-we-absorb-sunscreen-filters-into-our-bloodstreams  Follow us: IG:   / chemist.confessions   INTERWEB: https://chemistconfessions.com/ TIKTOK: https://www.tiktok.com/@chemistconfes... Skincare questions for the podcast? Leave your question in the comments and it could be featured in our next episode! #chemistconfessions #skincarescience #chemistconfessionspodcast #skincarehack

This week, we tackle one of the most requested ingredients: Beef Tallow in skincare. We break down the science, compare its characteristics to other popular ingredients like shea butter, and look at the actual topical studies (or lack thereof). 00:00 | What Is Beef Tallow and Why Is It in Skincare? 00:43 | Is Beef Tallow Really Similar to Human Skin Lipids? 02:09 | How Beef Tallow Is Made: The Science Behind the Fat 03:22 | Melting Point Breakdown: Beef Tallow vs Human Sebum 05:47 | How Extraction Methods Affect Skincare Ingredient Quality 09:37 | What Do Saponification and Iodine Values Mean for Skin? 20:25 | Does Beef Tallow Have Any Proven Skin Benefits? 37:18 | What Happened When I Put Beef Tallow on My Face? 40:56 | Shea Butter, Cocoa Butter, or Beef Tallow — What’s Best for Dry Skin? Products Discussed this 2025 Podcast Season *a small portion of your purchase through these links goes to feeding a chemist. https://shopmy.us/collections/1280514 Recommended 30 for 30 Sunscreens 2025 *a small portion of your purchase through these links goes to feeding a chemist. https://shopmy.us/collections/1766357 Product Shoutout: Blank Slate Gentle Gel Cleanser https://chemistconfessions.com/products/blank-slate-cleanser Enrichment Content: Sunscreen Layering Guide https://www.youtube.com/watch?v=IQ0Dlb0WXvc Do We Absorb Sunscreen Filters into Our Bloodstreams? https://chemistconfessions.com/blogs/controversy-corner-do-we-absorb-sunscreen-filters-into-our-bloodstreams Follow us: IG: / chemist.confessions INTERWEB: https://chemistconfessions.com/ TIKTOK: https://www.tiktok.com/@chemistconfes... Skincare questions for the podcast? Leave your question in the comments and it could be featured in our next episode! #chemistconfessions #skincarescience #chemistconfessionspodcast #skincarehack