Gene SNPs and Detox: What You Need To Know

Folate is a great thing - it's vitamin B9 and your body needs it to make new cells, replicate DNA, and so much more. But there are risks of too much folate, so how much folic acid is too much? And how dangerous is it to take high dose folic acid over time? The research exists for high dose folic acid, but what about L-5MTHF, or methyl folate? Does high dose methyl folate have the same risks as high dose folic acid? We have so many questions, and very few definitive answers, but there is lots of information that we do have. This episode of the To Health With That! podcast will cover the risks of high dose folic acid, the risks of high dose methyl folate, the risks of high dose L-5MTHF, and what we do and don't know from the research. Thanks for watching! Here are some other links that you might like. Genetic Rockstars - a community for people making the most of their favorite genes and getting better together (first month free for YouTubers!): https://community.tohealthwiththat.com/plans/204575?bundle_token=4da8ed9c5f00a92363bcd15ad2ac26dd&utm_source=manual FREE MTHFR Basics course: https://courses.tohealthwiththat.com/p/mthfr-basics I would appreciate it so much if you would support this channel by using affiliate links when you buy supplements and resources (I heart you!): Seeking Health:  https://bit.ly/3afXYH4 Amazon: https://www.amazon.com/s?k=Health+best+sellers&i=stripbooks&camp=1789&creative=9325&linkCode=ur2&linkId=29fff6e3ea954499d2eed32d46428454&tag=tohealthwitht-20 Queen of The Thrones Castor Oil Packs:  https://shop.queenofthethrones.com/amy-tohealthwiththat  For 10% off any order of $59 or more, use the code AMY_TOHEALTHWITHTHAT10

That's right - season 4 of the To Health With That podcast is finished, so let's talk about what you should be doing this summer (having fun), what I should be doing in the fall (writing), and what kind of episodes you can expect. I'd like to call it To Health With That! Season One BONUS Episodes. Thanks so much for being here and adding so much in terms of comments and questions - I couldn't do this without you. In September we'll have occasional episodes about methylation and MTHFR, maximum safe doses of methyl folate, methylation adaptogens, and a few other big topics that come up. Agent? Editor? Just have a comment? Email me! amy @ tohealthwiththat.com In the season four finale of the 'To Health With That' podcast, host Dr. Amy Neuzil wraps up the season which focused on fatigue - discussing its causes and solutions. She announces a summer break for listeners to enjoy, expressing gratitude for their engagement and inviting them to stay in touch. Amy reveals plans for a reduced schedule next season due to her focus on writing a book, with occasional bonus episodes centered on MTHFR and methylation. Amy also expresses interest in connecting with agents and publishers for her book project and promises updates in the future. The podcast will return with irregular episodes and content mainly focused on MTHFR and methylation topics. 00:00 - Intro 00:35 - Season Four Wrap-Up and Summer Plans 01:09 - A Heartfelt Thank You and How to Stay in Touch 01:32 - Looking Ahead: Season One Bonus Episodes and Book Plans 02:40 - Signing Off: See You After the Break! GENETIC ROCKSTARS (an MTHFR community): community.tohealthwiththat.com FREE COURSE: MTHFR Basics: https://to-health-with-that.teachable.com/p/mthfr-basics GROUP COACHING: https://www.tohealthwiththat.com/group-coaching/ WEBSITE: https://tohealthwiththat.com/ AFFILIATE LINKS: I appreciate you using these links to purchase products you would buy anyway, because they allow me to keep putting information out there. Thank you! SEEKING HEALTH (metylation and histamine support supplements - these ship internationally): https://bit.ly/3afXYH4 STRATEGENE REPORT (detailed genetics using 23andme or ancestry raw data): https://bit.ly/3retbm5 FULLSCRIPT (professional grade supplements): https://us.fullscript.com/welcome/thwt QUEEN OF THE THRONE (castor oil and castor oil packs):  https://shop.queenofthethrones.com/amy-tohealthwiththat use code AMY_TOHEALTHWITHTHAT10 for 10% off of any order of $59 or more

Gentle MTHFR Detox Protocol A gentle six-week detoxification protocol tailored for individuals with MTHFR polymorphism. She explains how decreased methylation in MTHFR polymorphism sufferers leads to toxin accumulation and stresses the importance of detoxification. The protocol includes preparatory steps, recommended supplements like NAC and liposomal glutathione, dietary adjustments, and lifestyle changes aimed at supporting the body's detox process. Additionally, she discusses the health benefits of detoxification, such as weight loss and improved sleep, and provides practical tips for easing into detox. The episode also addresses potential detox symptoms and the importance of consulting with a practitioner before starting the protocol. Here's the protocol in written form so you don't have to take notes: https://www.tohealthwiththat.com/gentle-six-week-detoxification-protocol-for-mthfr/ Here's more about castor oil packs: https://www.tohealthwiththat.com/castor-oil-for-mthfr/ GENETIC ROCKSTARS (an MTHFR community): community.tohealthwiththat.com FREE COURSE: MTHFR Basics: https://to-health-with-that.teachable.com/p/mthfr-basics GROUP COACHING: https://www.tohealthwiththat.com/group-coaching/ WEBSITE: https://tohealthwiththat.com/ AFFILIATE LINKS: I appreciate you using these links to purchase products you would buy anyway, because they allow me to keep putting information out there. Thank you! SEEKING HEALTH (metylation and histamine support supplements - these ship internationally): https://bit.ly/3afXYH4 STRATEGENE REPORT (detailed genetics using 23andme or ancestry raw data): https://bit.ly/3retbm5 FULLSCRIPT (professional grade supplements): https://us.fullscript.com/welcome/thwt QUEEN OF THE THRONE (castor oil and castor oil packs):  https://shop.queenofthethrones.com/amy-tohealthwiththat use code AMY_TOHEALTHWITHTHAT10 for 10% off of any order of $59 or more 00:00 - Intro 00:30 - Why do a detox 02:07 - Detox Essentials: What You'll Need 03:45 - Pre-Detox Preparation: Weeks 1 and 2 07:02 - The Active Detox Phase: Weeks 3 to 6 10:21 - Closing Thoughts and Community Invitation

In Season 4, Episode 21 of the To Health With That podcast, naturopathic doctor Amy Neuzil discusses strategies to combat fatigue by focusing on adrenal health. The episode covers the concept of adrenal fatigue, identifying it in various phases, and introduces a holistic approach to healing the adrenals, emphasizing the role of supplements such as Vitamin C, Magnesium, B Vitamins, and melatonin, along with a special focus on adaptogens like Siberian ginseng, ashwagandha, and holy basil. Neuzil stresses the importance of incorporating these supplements alongside necessary lifestyle changes to prevent the eventual collapse of adrenal health. Additionally, fat-soluble antioxidants are highlighted as beneficial for individuals experiencing adrenal fatigue. The episode serves as a comprehensive guide to understanding and managing adrenal fatigue, but Neuzil reminds listeners to consult healthcare professionals before starting any medical regimen and acknowledges the recovery process is a slow, diligent journey akin to the duration of time taken to develop adrenal fatigue. GENETIC ROCKSTARS (an MTHFR community): community.tohealthwiththat.com FREE COURSE: MTHFR Basics: https://to-health-with-that.teachable.com/p/mthfr-basics GROUP COACHING: https://www.tohealthwiththat.com/group-coaching/ WEBSITE: https://tohealthwiththat.com/ AFFILIATE LINKS: I appreciate you using these links to purchase products you would buy anyway, because they allow me to keep putting information out there. Thank you! SEEKING HEALTH (metylation and histamine support supplements - these ship internationally): https://bit.ly/3afXYH4 STRATEGENE REPORT (detailed genetics using 23andme or ancestry raw data): https://bit.ly/3retbm5 FULLSCRIPT (professional grade supplements): https://us.fullscript.com/welcome/thwt QUEEN OF THE THRONE (castor oil and castor oil packs):  https://shop.queenofthethrones.com/amy-tohealthwiththat use code AMY_TOHEALTHWITHTHAT10 for 10% off of any order of $59 or more 00:00 - Welcome to Season Four: Tackling Fatigue 00:35 - Exploring Adrenal Fatigue: Understanding and Healing 01:05 - Nutritional Support for Your Adrenals 01:26 - Vitamin C, Magnesium, B vitamins 02:43 - Melatonin to balance cortisol 03:06 - The Power of Adaptogens in Balancing Cortisol 04:38 - Choosing the Right Supplements for You 05:19 - The Journey to Recovery: Timeline and Expectations 05:49 - Final Thoughts and Medical Disclaimer

In season four of the 'To Health With That' podcast, hosted by naturopathic doctor Amy Noozle, the focus shifts to understanding and combating fatigue, with a specific emphasis on adrenal fatigue. This episode discusses the importance of healing your adrenals from phase two (tired but wired) or phase three (burning down) without the immediate use of adrenal hormones or supplements, reserving such treatments for more severe cases. Doctor Neuzil emphasizes lifestyle changes as a crucial step towards adrenal recovery, advocating for consistent sleep schedules, reducing screen time before bed, ensuring exposure to bright light in the morning, and adjusting dietary habits to support adrenal health. The significance of mindset and doing less than one is capable of to avoid further stress on the adrenals is highlighted as the hardest yet most vital part of recovery. The episode promises to cover supplements in the following installment. GENETIC ROCKSTARS (an MTHFR community): https://community.tohealthwiththat.com FREE COURSE: MTHFR Basics: https://to-health-with-that.teachable.com/p/mthfr-basics GROUP COACHING: https://www.tohealthwiththat.com/group-coaching/ WEBSITE: https://tohealthwiththat.com/ AFFILIATE LINKS: I appreciate you using these links to purchase products you would buy anyway, because they allow me to keep putting information out there. Thank you! SEEKING HEALTH (metylation and histamine support supplements - these ship internationally): https://bit.ly/3afXYH4 STRATEGENE REPORT (detailed genetics using 23andme or ancestry raw data): https://bit.ly/3retbm5 FULLSCRIPT (professional grade supplements): https://us.fullscript.com/welcome/thwt QUEEN OF THE THRONE (castor oil and castor oil packs):  https://shop.queenofthethrones.com/amy-tohealthwiththat use code AMY_TOHEALTHWITHTHAT10 for 10% off of any order of $59 or more 00:00 - Welcome to Season Four: Tackling Fatigue 00:29 - Healing Your Adrenals: Lifestyle Over Supplements 01:23 - Understanding Adrenal Fatigue: Tired but Wired to Burned Out 02:25 - Adrenal Healing Lifestyle: From Sleep to Diet 03:14 - Restoring Circadian Rhythm 03:51 - Morning Light, Evening Dark 04:33 - Water and Salt Balance 04:58 - Adrenal Health Diet 05:27 - Now Isn't The Time To Be A Marathoner 06:47 - Mindset: The Key to Healing Adrenal Fatigue 07:40 - Looking Ahead: Supplements for Adrenal Support

In this episode of the 'To Health With That' podcast, host Amy Neuzil, a naturopathic doctor, explores adrenal fatigue, a widespread issue attributed to the constant stress of modern life. The episode delves into the four stages of adrenal fatigue: 'Crushing it,' where individuals feel highly productive and energized due to high cortisol levels; 'Tired but wired,' marked by emerging fatigue and anxiety; 'Burning down,' where symptoms worsen, including greater fatigue and sleep issues; and 'Burned out,' a phase of significant functional impairment. Neuzil emphasizes the importance of early detection and intervention to prevent reaching the burnout stage. The episode aims to educate listeners on recognizing the signs of adrenal fatigue and offers a lead into the next episode, which will focus on non-hormonal strategies for nourishing and healing the adrenals. GENETIC ROCKSTARS (an MTHFR community): community.tohealthwiththat.com FREE COURSE: MTHFR Basics: https://to-health-with-that.teachable.com/p/mthfr-basics GROUP COACHING: https://www.tohealthwiththat.com/group-coaching/ WEBSITE: https://tohealthwiththat.com/ AFFILIATE LINKS: I appreciate you using these links to purchase products you would buy anyway, because they allow me to keep putting information out there. Thank you! SEEKING HEALTH (metylation and histamine support supplements - these ship internationally): https://bit.ly/3afXYH4 STRATEGENE REPORT (detailed genetics using 23andme or ancestry raw data): https://bit.ly/3retbm5 FULLSCRIPT (professional grade supplements): https://us.fullscript.com/welcome/thwt QUEEN OF THE THRONE (castor oil and castor oil packs):  https://shop.queenofthethrones.com/amy-tohealthwiththat use code AMY_TOHEALTHWITHTHAT10 for 10% off of any order of $59 or more 00:00 Welcome to Season Four: Unpacking Fatigue 00:36 Exploring Adrenal Fatigue: Understanding the Basics 01:49 Stage 1: Crushing It with High Cortisol 03:22 Stage 2: The Tired but Wired Phase 05:00 Stage 3: The Burnout Begins 06:24 Stage 4: Total Burnout - The Final Stage 07:36 Recovery and Prevention Tips 07:53 Wrapping Up and What's Next

Understanding and Addressing Adrenal Fatigue Adrenal fatigue is everywhere in modern culture, but why is that? It comes down to the difference between threats in our ancestral (geneticly adapted) cultures and threats in modern life. Dr. Amy explains the role of the adrenal glands, located like hats on the kidneys, in secreting hormones that regulate our stress response and circadian rhythms. She discusses how modern stressors, unlike ancestral dangers, continuously trigger our fight or flight response without the necessary physical release, leading to what is commonly referred to as adrenal fatigue. Symptoms range from overwhelming fatigue to more severe conditions like Addison's disease in extreme cases. The episode finishes with a mention of Debbie Moon's book, 'Histamine Life Hacks,' recommending it for further reading on histamine issues. Future episodes promise to explore the stages of adrenal fatigue, its impact on health, and potential recovery strategies. 00:00 - Intro 00:29 - Diving Deep into Adrenal Fatigue 01:00 - Understanding Your Adrenals: The Basics 03:25 - The Modern World vs. Our Adrenal Health 05:39 - Symptoms and Testing for Adrenal Fatigue 08:20 - A Quick Book Recommendation: Histamine Life Hacks 08:59 - Looking Ahead: Navigating Adrenal Fatigue Here's the amazong link (affiliate) for Histamine Lifehacks: https://amzn.to/3QtduV5 Thanks for watching this video! Here are some links you might like. Schedule a free 15-minute meet and greet with Dr. Amy to see if we’re a good fit to work together in group coaching: https://calendly.com/amy-tohealthwiththat/15min More about group coaching: https://www.tohealthwiththat.com/group-coaching/ Genetic Rockstars (first month free for my YouTube peeps!): https://community.tohealthwiththat.com/plans/204575?bundle_token=4da8ed9c5f00a92363bcd15ad2ac26dd&utm_source=manual FREE MTHFR Basics course: https://courses.tohealthwiththat.com/p/mthfr-basics Support our work by using affiliate links when you buy supplements and resources: Seeking Health: https://bit.ly/3afXYH4 Amazon: https://www.amazon.com/s?k=Health+best+sellers&i=stripbooks&camp=1789&creative=9325&linkCode=ur2&linkId=29fff6e3ea954499d2eed32d46428454&tag=tohealthwitht-20 Fullscript (for other supplements): https://ca.fullscript.com/welcome/aneuzil Queen of The Thrones Castor Oil Packs:  https://shop.queenofthethrones.com/amy-tohealthwiththat For 10% off any order of $59 or more, use the code AMY_TOHEALTHWITHTHAT10

Doing a good detox protocol takes some preparation and some of the best preparation you can do is finding out if your genes are making detoxification harder for you somewhere. Some gene SNPs have the potential to make detox harder by interfering with phase two conjugation reactions. These include MTHFR, MTR, MTRR, GST, GPX, COMT, HNMT, UGT1A1, SULT genes, NAT1, and NAT2. With each category of gene SNP, I will also give suggestions for improving that aspect of your phase two detoxification reactions. 00:00 - Intro 00:49 - Why SNPs matter and how to test 02:08 - Genes that affect methylation and how to help 02:46 - Genes that affect glutathione and how to help 03:38 - Genes that affect sulfation and how to help 04:20 - Genes that affect glucuronidation and how to help 05:52 - Genetic Rockstars walkthrough 07:42 - Genes that affect acetylation and how to help 08:11 - Amino acid conjugation GENETIC ROCKSTARS (an MTHFR community): community.tohealthwiththat.com FREE COURSE: MTHFR Basics: https://to-health-with-that.teachable.com/p/mthfr-basics WORK WITH DR. AMY ONE-ON-ONE: Set up a free meet and greet appointment to see if we’re a good fit to work together, or if group coaching, community, or something else might be a better option: https://calendly.com/amy-tohealthwiththat/15min GROUP COACHING: https://www.tohealthwiththat.com/group-coaching/ WEBSITE: https://tohealthwiththat.com/ AFFILIATE LINKS: I appreciate you using these links to purchase products you would buy anyway, because they allow me to keep putting information out there. Thank you! SEEKING HEALTH (methylation and histamine support supplements - these ship internationally): https://bit.ly/3afXYH4 STRATEGENE REPORT (detailed genetics using 23andme or ancestry raw data): https://bit.ly/3retbm5 FULLSCRIPT (professional grade supplements): https://us.fullscript.com/welcome/thwt QUEEN OF THE THRONE (castor oil and castor oil packs):  https://shop.queenofthethrones.com/amy-tohealthwiththat use code AMY_TOHEALTHWITHTHAT10 for 10% off of any order of $59 or more

Detox is amazing for your body, so why does it feel so awful? The great news is that symptoms of detoxification may be helpful in giving your signals about what is happening. We'll quickly review phases I - III of detoxification, why things can feel bad, where detoxification gets stuck, and how to plan for an easier detoxification. 00:00 - Intro 00:58 - 3 phases of detox 02:54 - detox uses energy and resources 04:24 - Four reasons why detox feels bad 06:31 - Plan ahead for easier detox 07:21 - Symptoms of detox GENETIC ROCKSTARS (an MTHFR community): community.tohealthwiththat.com FREE COURSE: MTHFR Basics: https://to-health-with-that.teachable.com/p/mthfr-basics WORK WITH DR. AMY ONE-ON-ONE: Set up a free meet and greet appointment to see if we’re a good fit to work together, or if group coaching, community, or something else might be a better option: https://calendly.com/amy-tohealthwiththat/15min GROUP COACHING: https://www.tohealthwiththat.com/group-coaching/ WEBSITE: https://tohealthwiththat.com/ AFFILIATE LINKS: I appreciate you using these links to purchase products you would buy anyway, because they allow me to keep putting information out there. Thank you! SEEKING HEALTH (methylation and histamine support supplements - these ship internationally): https://bit.ly/3afXYH4 STRATEGENE REPORT (detailed genetics using 23andme or ancestry raw data): https://bit.ly/3retbm5 FULLSCRIPT (professional grade supplements): https://us.fullscript.com/welcome/thwt QUEEN OF THE THRONE (castor oil and castor oil packs):  https://shop.queenofthethrones.com/amy-tohealthwiththat use code AMY_TOHEALTHWITHTHAT10 for 10% off of any order of $59 or more

In the last episode, we discussed the fact that toxins come from food, air, water, personal care products, and pretty much everything we encounter. Detoxification is an ongoing process that is always at work in your body. Here are the basics about how detoxification happens, what resources your body needs, and why it sometimes feels yucky. Detoxification happens in three phases. Phase one involves chemical reactions, mostly in the cytochrome P450 system. Phase two comprises conjugation reactions so that substances can be transported out of the tissues, and phase three is the active transport of these toxins out of your tissues and into waste material. 00:00 - intro 00:29 - Why Detox is easy to get wrong 01:19 - Three phases of detoxification 01:40 - Detoxification Phase one and cytochrome P450 system 02:31 - Genetic Rockstars quick walk-through 04:36 - Detoxification Phase two, conjugation reactions, and gene SNPS 05:15 - Phase three reactions and toxin transport 05:43 - You have to eliminate to detox 06:26 - Water and detox 06:50 - Limit toxin exposure 08:05 - Detox uses energy and nutrients 09:01 - Practitioner support and detox kits GENETIC ROCKSTARS (an MTHFR community): community.tohealthwiththat.com FREE COURSE: MTHFR Basics: https://courses.tohealthwiththat.com/p/mthfr-basics WORK WITH DR. AMY ONE-ON-ONE: Set up a free meet and greet appointment to see if we’re a good fit to work together, or if group coaching, community, or something else might be a better option: https://calendly.com/amy-tohealthwiththat/15min GROUP COACHING: https://www.tohealthwiththat.com/group-coaching/ WEBSITE: https://tohealthwiththat.com/ AFFILIATE LINKS: I appreciate you using these links to purchase products you would buy anyway, because they allow me to keep putting information out there. Thank you! SEEKING HEALTH (metylation and histamine support supplements - these ship internationally): https://bit.ly/3afXYH4 STRATEGENE REPORT (detailed genetics using 23andme or ancestry raw data): https://bit.ly/3retbm5 FULLSCRIPT (professional grade supplements): https://us.fullscript.com/welcome/thwt QUEEN OF THE THRONE (castor oil and castor oil packs):  https://shop.queenofthethrones.com/amy-tohealthwiththat use code AMY_TOHEALTHWITHTHAT10 for 10% off of any order of $59 or more