Everything I do for Healthspan (and why I skip THESE Supplements)

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/As we close out 2025, I'm sharing a comprehensive and honest review of my personal health optimization protocol. I break down the exact lifestyle habits, supplements, and medications I use daily, and just as importantly, which popular ones I avoid and why.I detail the massive impact of my "Four Pillars" and explain the thought process behind each item in my regimen, from Omega-3s and creatine to testosterone, SGLT2 inhibitors, and rapamycin.If you've ever wondered what a data-driven, no-BS approach to longevity looks like in practice, this is it.*Timestamps:*00:00 - Podcast Start / Topic Overview01:16 - Philosophy: Focus on Foundations, Not Hype02:10 - The Four Pillars of Healthspan (Eat, Move, Sleep, Connect)03:27 - My Personal Pillars Assessment04:33 - Avoiding Risky Behaviors (Alcohol, Drugs, Environment)06:44 - Pillar 1: EAT - My Rules, Keto Bread, Protein Sources09:51 - Pillar 2: MOVE - Weekly Exercise Routine (Zone 2, Weights, HIIT)12:19 - Pillar 3: SLEEP - Routine & The Alcohol Effect13:29 - Pillar 4: CONNECT - Relationships & Personal Growth14:52 - SUPPLEMENTS: My Skeptical Philosophy16:43 - Supplement Disclosures (Past/Present Company Ties)17:47 - My Daily Supplements List: Omega-3, Vitamin D, Rejuvent (CA-AKG), Lithium, Methylfolate, Creatine23:03 - Supplements I DON'T Take: Magnesium, Collagen, Fiber, Ashwagandha, NAD+ Boosters, Senolytics & Why28:42 - How to Choose a Supplement Brand (ConsumerLab Warning)30:19 - MEDICATIONS & PREVENTATIVE DRUGS30:48 - Testosterone Therapy: My Protocol, Impact, & Monitoring33:49 - Jardiance (Empagliflozin): SGLT2 Inhibitor for Biomarkers35:55 - Repatha (PCSK9 Inhibitor): For Heart Disease Prevention37:47 - Tirzepatide (Mounjaro/Zepbound): My Microdosing Experience40:01 - Rapamycin (Sirolimus): My Cyclical Protocol & Stance on Recent News41:41 - Tadalafil (Cialis) & Metformin: Why I'm Off/Against Them For Now46:08 - Final Summary & Take-Home Principles46:50 - The Importance of a Good Doctor & Rational Risk/Reward48:48 - Wrap-Up & Holiday WishesThis video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:https://onebillionmedia.com/DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispan_/TikTok: https://www.tiktok.com/@optispan

Subscribe to our channel:    / @optispan  Get Our Newsletter (It's Free): https://www.optispan.life/They call it the "whorebath" test. 🛁 We call it a massive misunderstanding of science.ing biological age tests.In this episode, Dr. Matt cuts through the noise to explain what ageing clocks actually are, what they measure, and more importantly, what they DON'T. You'll learn why that $500 direct-to-consumer test is likely giving you meaningless noise, why seeing a drop in your "biological age" is often a statistical illusion, and what to do if your doctor recommends one.By the end, you'll understand ageing clocks better than 95% of the supposed experts and influencers out there. You'll also learn about the type of clock that shows real promise for personalized health today.This video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:https://onebillionmedia.com/Timestamps0:00 - Introduction1:18 - What Inspired This Deep Dive1:54 - My Actual Position on Ageing Clocks7:49 - Take Home #1: What is a Clock, Really?10:30 - How Biomarkers (Like VO2 Max) Correlate to Age15:32 - The Problem: My "Age" is 40 AND 6925:22 - Take Home #2: The Many Flavors of Clocks36:53 - Take Home #3: Clocks Do NOT Measure Ageing38:15 - Take Home #4: Clocks ARE Useful... For Research39:52 - Take Home #5: Why They're Useless Outside Research42:05 - Precision vs. Accuracy: The Fatal Flaw48:38 - A Statistical Nightmare: Your Quarterly Test Results53:50 - BONUS: The Clocks That Might Actually Work (PhenoAge, ENABLE Age, LinAge₂)1:01:06 - The 5 Take-Home Messages Summarized1:02:03 - Final Advice & A Question for DoctorsDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter:   / mkaeberlein  Linkedin:   / optispan  Instagram:   / optispan_  TikTok:   / optispan  https://www.optispan.life/

Subscribe to our channel:    / @optispan  Get Our Newsletter (It's Free): https://www.optispan.life/Join Matt and Dr. Nicole (Nicki) Byrne, Clinic Director at Optispan, for a deep dive into preventative Healthspan Medicine. In this episode, they discuss why traditional reactive healthcare is failing us, what true preventative care looks like, and the comprehensive, data-driven approach used at Optispan to catch risks early and optimize long-term health. From advanced diagnostics to lifestyle pillars and evidence-based medications, learn how to shift from treating disease to building resilience.🔬 Topics Covered:The moment Dr. Byrne realized traditional medicine was focused on the wrong end of the problem.The dangers and gaps in the current "longevity medicine" ecosystem.A complete walkthrough of Optispan's Gateway Day assessment: advanced bloodwork, genetics, point-of-care ultrasound, DEXA scans, CGM, sleep tracking, and more.Real patient examples of conditions caught early that standard care would have missed (e.g., insulin resistance, fatty liver, plaque buildup).How data from multiple sources creates a personalized health blueprint.The philosophy behind using medications (like GLP-1s, SGLT2 inhibitors, Rapamycin) and supplements preventatively.The critical pillars of health: Eat, Move, Sleep, and Connect.A vision for how healthcare should work in the next five years.This video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:https://onebillionmedia.com/Timestamps1:04 Meet Dr. Nicki Byrne3:25 The 80-Year-Old With "Hormones of a 25-Year-Old"4:41 "People Think I'm a Snake Oil Salesman"9:52 She Looked Healthy—Then We Found Plaque13:56 The Danger of a "Negative" Cancer Screening17:00 Why Your "Normal" Lab Results Might Not Be Normal for You25:44 What Actually Happens During a 5-Hour Health Day33:29 What Your 3am Blood Sugar Spike Is Really Telling You35:09 You're Probably Lying to Yourself About Sleep38:24 Insulin Resistance: The Root of All Evil43:07 Wealthy, Successful… and Lonely51:08 Peptides From a Sketchy Website? Here's What to Know1:06:20 The Rapamycin Skin Cream Experiment1:08:05 What Should Be "Normal" Healthcare in 5 YearsDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter:   / mkaeberlein  Linkedin:   / optispan  Instagram:   / optispan_  TikTok:   / optispan  https://www.optispan.life/

This is an AMA episode where Dr Matt answers the pressing questions audience had. In this episode, Matt shares candid updates on his TRT journey and physique, debates rapamycin protocols vs. extreme fasting, and separates the scary headlines from the science on microplastics and "magic" mushrooms. Plus: why he wakes up at 4:30 AM, the truth about HBOT, and a surprising update on his books.Timestamps0:00 Intro1:00 Is Matt Still Taking Rapamycin?6:09 Best Time of Day to Take Rapamycin8:29 48-Hour Fasting vs. Rapamycin for Longevity11:44 Why Matt Wakes Up at 4:30 AM14:43 Supplement Updates: Creatine, Astaxanthin & Glycine19:27 Hyperbaric Oxygen Therapy for Brain Health26:04 Epigenetic Clocks vs. Functional Biomarkers30:54 Microplastics: How Worried Should You Be?37:55 Matt's TRT Results After 6 Months43:00 TRT Side Effects: Hair Loss, Blood Work & HDL ChangesThis video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:https://onebillionmedia.com/DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter:   / mkaeberlein  Linkedin:   / optispan  Instagram:   / optispan_  TikTok:   / optispan  https://www.optispan.life/

This podcast episode is part three of a travel series where Matt recounts his recent trips to longevity and healthspan conferences in Geneva, Chicago, and Mauritius. He shares his experiences with jet lag, workouts, and the contrasting cultures of these events, from the more "alternative medicine" feel of the Geneva summit to the more scientifically-grounded Mauritius conference. A major theme is his critique of the current state of the longevity field, where he advocates for evidence-based approaches and calls out what he sees as misinformation, specifically regarding the overhyping of peptides, stem cells, and the misuse of epigenetic "aging clocks."This video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:https://onebillionmedia.com/DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter:   / mkaeberlein  Linkedin:   / optispan  Instagram:   / optispan_  TikTok:   / optispan  https://www.optispan.life/

Subscribe to our channel:    / @optispan  Get Our Newsletter (It's Free): https://www.optispan.life/Dive into the future of longevity research with Dr. Ben Blue, CEO of Ora Biomedical. We explore how Ora's high-throughput "Wormbot" platform is conducting the world's largest unbiased search for longevity interventions, moving beyond the narrow focus on established pathways like mTOR.In this episode, we discuss:• The ambitious Million Molecule Challenge and why it could revolutionize the field.• Surprising discoveries already made, including molecules that outperform rapamycin.• Ora's strategic pivot to radiation resistance, with applications for astronauts, pilots, and human health.• How their data-driven approach is uncovering interventions for resilience against toxins and other stresses.• The journey from worm models to potential clinical trials and what's next for the company.Learn how Ora is scaling drug discovery to tackle aging and age-related diseases.https://orabiomedical.com/https://x.com/OraBiomedical  / ora-biomedical-inc  This video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:https://onebillionmedia.com/Timestamps00:00 – Intro01:13 – Welcome & Disclosure02:40 – Ora Biomedical & the Longevity Mission04:04 – How the Wormbot Was Born06:43 – Matt's Perspective on the Wormbot09:22 – Automating Lifespan Experiments at Scale12:29 – The Million Molecule Challenge15:03 – Success Stories from the Challenge16:10 – A Better mTOR Inhibitor Than Rapamycin19:05 – Ora's Molecule Beats Rapamycin20:08 – 60% Lifespan Extension Discovery24:03 – Ivermectin & Surprising Findings24:55 – From Longevity to Anti-Parasite Drugs31:09 – Hot Take: Discovery vs. Mechanism35:22 – The Million Molecule Challenge Database40:45 – Radiation Resistance: A New Focus44:57 – Space Travel & Longevity Medicine49:18 – Testing Resilience to Toxins & Stress56:54 – What Thousands of Tests Reveal About Aging Pathways01:00:41 – False Positives vs. False Negatives in Screening01:04:45 – Skin Health & Anti-Aging Potential01:07:59 – What's Next for Ora BiomedicalDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter:   / mkaeberlein  Linkedin:   / optispan  Instagram:   / optispan_  TikTok:   / optispan  https://www.optispan.life/

Happy thanksgiving from the Optispan Team!

Longevity scientist Dr. Andrew Steele sits down with Dr. Matt Kaeberlein to make the provocative case that aging should be treated as humanity's greatest challenge, even bigger than climate change. In this deep conversation, they explore why two-thirds of all deaths are caused by aging, the cutting-edge science that's already extending healthy lifespan in animals, and what it would really mean to add decades of vitality to human life. From CRISPR gene therapies to senescent cell clearance, from the ethics of radical life extension to practical steps you can take today, this is an unflinching look at whether we can (and should) slow down aging itself.Timestamps00:00 – Why Aging Is the Biggest Problem We’re Not Solving01:33 – Is Aging Actually Fixable? What the Science Shows04:01 – Overpopulation Myths vs. Longevity Reality09:02 – Can We Slow Aging? What’s Working Now14:39 – Inside the Longevity Divide: Hope vs. Hype18:45 – Healthspan vs. Lifespan: What Really Matters29:12 – Chronic Disease and the True Cost of Aging36:21 – The Most Promising Longevity Therapies Today56:56 – Biological Age Tests: What You Can Actually Trust01:53:17 – The Future of Longevity: AI, Innovation, and What’s NextConnect with Dr. Andrew SteeleWebsite: https://andrewsteele.co.uk/YouTube:    / drandrewsteele  Instagram:   / andrewjsteele  Twitter:   / statto  LinkedIn:   / andrewsteele  Bluesky: https://bsky.app/profile/statto.bsky....Mastodon: https://mas.to/@stattoThis video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:https://onebillionmedia.com/DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter:   / mkaeberlein  Linkedin:   / optispan  Instagram:   / optispan_  TikTok:   / optispan  https://www.optispan.life/

Creatine is being called a "cognitive super-drug" that feels like "speed without the speed." Influencers are telling you to mega-dose 20 grams a day for brain power, bone health, and more. But what does the science actually say?In this episode, we go beyond the hype and fact-check the wildest creatine claims taking over the internet. I break down the real evidence on mega-dosing, and put the cognitive benefits to the testI react to clips from Paul Saladino, Jeff Cavalier, Rhonda Patrick, and Dave Asprey to separate proven fact from marketing fiction. Discover the simple, science-backed creatine protocol that actually works, and save your money (and your gut) in the process.This video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:https://onebillionmedia.com/00:01:23 - High-Level Reality Check on Creatine00:03:12 - Hosts' Personal Histories with Creatine00:05:17 - How to Evaluate Health Influencers & Their Claims00:08:40 - Paul Saladino (MD): Analysis of Mega-Dosing Claims (20g/day) for Brain & Bones00:23:16 - Jeff Cavaliere (Physical Therapist): Claims on Depression, Parkinson's, and MS00:31:22 - Discussion on Creatine for Sleep Deprivation & High Stress00:34:28 - The "No Downside" Myth & Side Effects (GI Issues, Microbiome)00:37:29 - Rhonda Patrick (PhD): "Feels Like Speed" Claim & Brain Aging00:46:00 - Dave Asprey: "Most Powerful Cognitive Drug" Claim00:53:02 - How Creatine Actually Works (The "Backup Battery" Analogy)00:53:49 - Final Take-Home Messages & Summary00:56:00 - Q&A: Best Time to Take Creatine & What to Do If You Miss a Day00:57:42 - Final Thoughts on Influencer HypeDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispan_/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/

Subscribe to our channel:    / @optispan  Get Our Newsletter (It's Free): https://www.optispan.life/Join me for a fascinating conversation with Dr. Jamie Justice, Executive Director of the $101 Million XPRIZE Healthspan. In this podcast, we discuss the world of longevity science, from the ambitious goals of this global competition to the lessons learned from the stalled TAME trial.Dr. Justice explains how the XPRIZE is structured to find real-world solutions to extend human healthspan.Chapters:00:01:31 - Jamie's Role & The Mission of XPRIZE Healthspan00:02:29 - What is the XPRIZE Foundation?00:05:36 - The Genesis of the Healthspan Prize00:09:39 - Why Commercial Success Matters for the Prize00:10:51 - How to Win: The Competition Structure & Timeline00:18:50 - The 3 Key Healthspan Pillars: Cognitive, Physical, and Immune Function00:22:03 - Clinical Trial Design: Crossover Trials & "Responder" Analysis00:27:12 - The Types of Teams & Interventions (From Gene Therapy to Public Health)00:32:06 - Handling "Wild West" Clinics & The Importance of Data Transparency00:35:02 - How Many Teams Will Make it to the Finals?00:37:41 - Safety, Ethics, and Regulatory Hurdles00:43:42 - The FDA's Role and the Challenge of Approving "Aging" Interventions00:51:18 - The Story of the TAME Trial: Goals, Design, and Why It Stalled00:58:23 - The Real Reasons TAME Wasn't Funded (NIH Peer Review & More)01:07:09 - The Future of Large-Scale Aging Trials01:13:25 - The Good, The Bad, and The "Pheromones": Crazy XPRIZE Submissions01:16:49 - Breakdown of Finalist Categories: Drugs, Biologics, Supplements, and Multimodal Approaches01:22:20 - A Companion Prize for Biomarker Discovery01:27:30 - The Problem with "Biological Age" and Epigenetic Clocks01:31:44 - The Ethics of Using Direct-to-Consumer Age Tests in ClinicsAbout XPRIZE:XPRIZE's mission is to inspire and empower humanity to achieve breakthroughs that accelerate an equitable, abundant future.Website: https://www.xprize.org/Get Involved: https://www.xprize.org/get-involvedLinkedIn:   / x-prize-foundation  YouTube:    / xprize  X: http://x.com/xprizeInstagram:   / xprize  TikTok:   / xprize  Facebook:   / xprize  This video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:https://onebillionmedia.com/DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter: https://x.com/mkaeberlein Linkedin:   / optispan  Instagram:   / optispan_   TikTok:   / optispan  https://www.optispan.life/Discover how teams worldwide are competing to prove they can reverse human aging by 10+ years, and why the winner might not be a drug at all.