20VC: Leading Anthropic's First Ever Round | Will Open Source Threaten Anthropic's Business | Do Margins Matter in a World of AI | Why Triple, Triple, Double, Double is Not Good Enough Today | Why Series A is Hard Today with Matt Murphy @ Menlo

Matt Murphy is a Partner at Menlo Ventures, who just raised $3 billion in fresh capital, its largest pool ever. Matt's portfolio includes Anthropic, Lovable, Legora, OpenRouter, Chai Discovery, Axiom, OpenEvidence and more. AGENDA:  00:00 Why Menlo Broke All Its Investing Rules to Back Anthropic 09:00 Why Ownership Matters Less in an Outlier-Driven Venture Market 13:00 Do We Have an SPV Problem in Venture Today? 20:00 Do Margins Still Matter in AI? 23:00 Why Open Source Won't Derail Anthropic's Growth 26:00 Does Every Model Provider Need to Build Its Own Chips? 29:00 Why Anthropic Is Not a Threat to Legora 32:00 Why Series A Is the Hardest Place to Invest Today 36:00 Why Signalling Is B.S. and Every Fund Is Going Full Stack 42:00 Why Building a Company in Europe Is Hard Mode 47:00 Why Triple-Triple-Double-Double Is No Longer Venture-Scale Growth  

Osvald Nitski is the Chief Product Officer at Mercor, the AI-training and expert-data marketplace powering frontier-model development. Mercor last raised a $350 million Series C at a $10 billion valuation, and is reportedly in discussions for a new round at a $20 billion valuation. Mercor crossed $2BN in ARR in June; doubling from $1 billion in only four months. AGENDA:  00:04:00 Will open-source models kill the data-provider business? 00:07:00 Are enterprises still terrified of working with frontier model companies? 00:09:00 Does every company end up with its own specialised AI model? 00:10:00 Do enterprises actually have an AI ROI problem? 00:11:00 How should founders balance AI performance against exploding token bills? 00:14:00 Does AI mean product teams build 10x more—or ruthlessly simplify? 00:15:00 What does it now take to be a great product manager in an AI-native world? 00:20:00 Is the boom in AI services and forward-deployed engineers here to stay? 00:37:00 Can Mercor escape its dependence on a handful of frontier-model customers? 00:47:00 Are AI-generated code and agents creating a cybersecurity arms race? 00:56:00 When will robotics have its real "ChatGPT moment"?  

AGENDA: 00:04 China's Kimi and Qwen Put Frontier AI on Notice00:08 Washington Debates Whether Chinese AI Models Should Be Banned 00:17 Can America Build a Profitable Open-Weight AI Champion? 00:21 OpenRouter's Moment: Is This the Perfect Time to Sell? 00:31 Fireworks' $1.5B Raise Signals the Real AI Money Is in Infrastructure 00:39 Why Every Great AI App May Need to Build Its Own Model 00:50 Stripe's Bold Play to Buy PayPal 01:01 The AI Funding Frenzy: Why Late-Stage Venture Is Winning 01:12 Nuclear Startups Go Wild While Databricks and Stripe Stay Private 01:15 The AI Supply Chain War: TSMC, ASML, DRAM—and Nvidia's Next Move  

Lin Qiao is the Co-Founder and CEO of Fireworks AI, the leading specialized intelligence and AI inference platform that last week raised $1.5BN at a whopping $17BN valuation. With just 200 people, the company has hit $1BN in ARR and expects to hit $2BN before the end of the year. Prior to Fireworks, Lin spent several years at Meta including on the founding team of PyTorch.  AGENDA: 00:07 — Why Did Fireworks Bet on Inference When Everyone Else Was Chasing Training? 00:13 — Can Open-Source Models Turn AI Infrastructure into a Commodity? 00:19 — Should Enterprises Trust Chinese Open Models With Their Most Sensitive Data? 00:25 — Will Model Progress Keep Moving This Fast—or Are We Nearing a Plateau? 00:28 — Will the Multi-Model World Create a $100BN Routing Layer? 00:37 — How Much Will AI Token Usage Explode Over the Next Two Years? 00:43 — Will Token Costs Fall 10x—and Unleash 100x More Demand? 00:49 — Does Fireworks Eventually Have to Build Its Own Data Centres? 01:02 — What Is the Real Bottleneck Holding Back the AI Economy?  

Fred Turner is the Founder and CEO @ Curative, one of the wildest stories in tech. Fred scaled a COVID testing business from $0 to $5BN in revenue and took the team from 7 to 7,000 employees in just 9 months. They did over 206,000 COVID tests in a single day and signed contracts in the 100s of $Ms with several of the largest states. Today, Curative is a unicorn health insurance business taking on the incumbents for one of the largest markets in healthcare.  AGENDA: 00:00 How Did a Spare-Time COVID Test Become a $5BN Business? 07:00 How Do You Go From Testing Cows to STDs, Sepsis and COVID? 21:00 When Did Fred Realise COVID Was Massive—and How Did Curative Scale to $5BN? 36:00 Why Pivot Into Health Insurance—and What Is Broken About US Healthcare? 40:00 How Is AI Rebuilding Curative—and Which Departments Go to Zero? 45:00 Is SaaS Dead? Why Is Curative Cutting 80% of Its Software Spend? 48:00 Are Legacy Insurers Screwed? What Will Anthropic Be Worth in Three Years? 59:00 Will AI Make Companies Smaller? Which Jobs Will Survive? 1:10:00 Why Nuclear—and Could Subcritical Become Bigger Than Curative? 1:17:00 What Have Marriage and Fatherhood Taught Fred? What Has He Changed His Mind On?    

AGENDA: 00:00 – Apple SUES OpenAI: Did They Steal Apple's Biggest Secrets? 05:10 – Is OpenAI's $6BN Hardware Bet Already Dead? 12:50 – Zuckerberg Is Back: Meta Finally Takes On OpenAI 18:05 – The AI Spending Bubble Nobody Is Talking About 23:45 – Claude Is Coming for Designers, Product Managers & Figma 27:15 – Anthropic's $50BN Explosion: Have We Already Hit AI's TAM? 36:00 – The $26BN AI IPO Powering the Entire Industry 40:00 – Seed Investing Is Dead? Jason Calacanis Changes Strategy 57:00 – SaaS Is in Trouble: AI Is Accelerating Terminal Decay 01:15:00 – Why Greylock Said No to Billions of Extra Dollars  

Avishai Abrahami is the Co-Founder and CEO of Wix, the NASDAQ-listed website creation platform serving millions of businesses worldwide. Today, Wix generates more than $2BN in ARR and has a market capitalization of approximately $2.1BN, after reaching a peak valuation of $17BN over the past two years. The company also acquired Base44, one of the fastest-growing AI application-building platforms, scaling it to $150M in ARR in record time. AGENDA: 00:00 The SaaS Apocalypse: What Does Wall Street Still Not Understand About Wix? 07:00 Is the Market Valuing Wix's Core Business at Less Than Zero? 12:55 Will AI Kill Wix... or Make Base44 Bigger Than the Entire Company? 19:15 "You Are NOT Going to Vibe Code Shopify" — Why Everyone Is Getting AI Wrong 23:00 Would You Really Pay $80M for a One-Person Startup? 24:15 The Buyback Disaster: Would Avishai Do It All Again? 31:00 Why Every AI Customer Support Startup Keeps Failing (According to Wix) 37:00 Should a 22-Year-Old Still Learn to Code in the Age of AI? 42:20 Has AI Been Overhyped? Avishai's Most Controversial Prediction Yet 49:00 The Hardest Lessons on Leadership, Marriage & Building Through Chaos  

Arvind Jain is the Founder & CEO of Glean, the enterprise AI leader valued at $7.2 billion after raising more than $770 million from investors including Kleiner Perkins, DST Global, and more. Before Glean, Arvind co-founded Rubrik, helping build it into one of the world's leading cloud infrastructure companies before its successful IPO. Prior to that, he spent over a decade at Google as a Distinguished Engineer, working across Search, Maps, and YouTube. AGENDA: 00:00 – The Shocking Truth About Frontier AI: 90% Is Already a Commodity 02:04 – Can OpenAI & Anthropic Own Enterprise AI? The Battle for the Workplace Begins 10:18 – Will OpenAI and Anthropic Win the App Layer 18:03 – Microsoft Is the Real Enemy… Not OpenAI? 20:53 – "Where's the ROI?" Why Enterprises Are Starting to Question the AI Hype 26:00 – Will AI Replace Your Job? Harry & Arvind's Heated Clash Over the Future of Work 33:43 – The Billion-Dollar Mistake Every AI Company Is Making on Token Spend 39:20 – The AI Land Grab Is On: Why Founders Must Move Now or Lose Forever 42:20 – China vs America: Who Really Wins the AI Race? 47:20 – Rapid Fire: The Future of Computer Science, Hiring, Fundraising & AI's Biggest Winners  

AGENDA: 05:00 Washington Just Put Frontier AI on a Leash 06:30 Sam Altman's Wild 5% Government Stake Idea 19:00 The AI Funding Bubble: Why Founders No Longer Fear Dilution 28:00 Alex Karp's Brutal Warning: Enterprises Don't Trust Frontier AI 33:00 Meta's Shock Pivot: Has Zuck Accidentally Built the Next CoreWeave? 41:00 Nvidia's Dangerous New Game: "Compute Now, Pay Later" 45:00 Anthropic & DeepSeek Go After Nvidia's Crown 48:00 Kling vs Sora: Did China Just Win AI Video? 52:00 Is China Secretly Winning the Open Source AI War? 01:02:00 Microsoft & Amazon's $6B Bet: AI Still Needs Humans 01:11:00 Ashton Kutcher Walks Away From Sound Ventures 01:16:00 The New Startup Talent War: No Liquidity, No Chance 01:20:00 Final Thoughts: Who Wins the AI Endgame?

Mike Mignano is a General Partner at Union Square Ventures, one of the most iconic venture firms in the world, whose investments include Coinbase, Stripe, Etsy, Twilio, Cloudflare. Before joining USV, Mike was a Partner at Lightspeed, where he backed breakout AI companies including Granola and Suno. Prior to investing, he co-founded Anchor, acquired by Spotify.  AGENDA: 00:00 Is Fear of Failure the Secret Weapon Behind Great Founders? 07:20 Why Leave Lightspeed for USV — and Is Thesis-Driven Venture Still Alive? 09:50 Is the Real AI Money Still in Infrastructure, or Are Apps Finally About to Explode? 13:00 Who Wins the AI Model War: OpenAI, Anthropic, Open Source, or the "Rebel Alliance"? 19:00 Are We About to Hand Our Entire Lives Over to AI Agents? 21:00 Can Anthropic Keep Growing Like This — or Will Token Spend Break the Model? 26:00 Can AI Routing Become a $50BN Company, or Is It Just a Commodity Pipe? 30:00 Will the AI Energy Crisis Create the Next Monster Venture Outcomes? 36:00 Can Startups Survive Microsoft, OpenAI, and the Brutal Power of Bundling? 45:00 Should VCs Ignore Price When Backing Generational Companies? 55:30 Is Traditional Media Dead — and Who Becomes the New Tech Kingmaker?