A city at three in the morning can look almost motionless. Yet street sweepers, sanitation crews, maintenance teams, and deliveries are already preparing it for the next day. Sleep may be the brain’s version of that hidden shift—not a shutdown, but a change in what work becomes possible.
Jack and Janet explore the glymphatic hypothesis, the distinction between cerebrospinal and interstitial fluid, the relationship between slow-wave sleep and brain-fluid dynamics, and studies examining amyloid-beta and tau after sleep loss. They also explain why the mouse-to-human leap matters and why scientists continue to debate exactly how clearance changes during sleep.
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