
PCA Deep Dive: When the Evidence Changes, Rethinking Spine Injections for Chronic Pain
PCA Deep Dive: When the Evidence Changes, Rethinking Spine Injections for Chronic Pain
The Spinal Chat Podcast: PCA Deep Dive Series examines 2025 BMJ evidence on routine interventional procedures for chronic non-cancer spine pain and asks: When the evidence changes, should the way we deliver and pay for care change with it?
A major BMJ systematic review and network meta-analysis included 132 eligible studies, with 81 randomized trials and 7,977 patients contributing to the quantitative analysis. It found that commonly used interventional procedures generally produced little to no clinically meaningful pain relief compared with sham procedures for chronic axial or radicular spine pain. A companion guideline issued strong recommendations against routine use, while interventional pain specialists have raised concerns about patient selection and responsive subgroups.
The episode explores sham and contextual effects, regression to the mean, approximately $9 billion in annual U.S. spending on epidural injections, systemic incentives, and guideline-supported conservative care including exercise, education, self-management, rehabilitation, psychological approaches, and manual therapy.
00:00 Welcome and Big Question
01:42 Scope and Red Flags
03:05 BMJ Review Breakdown
06:30 Sham Effects Explained
09:59 Specialist Backlash
12:53 Nine Billion Economics
13:55 How We Got Here
17:44 Conservative Care Pathway
20:25 Spinal Manipulation Role
22:59 Policy and Self Advocacy
24:57 Final Challenge and Wrap
Key Sources
Wang X, Martin G, Sadeghirad B, et al. Common interventional procedures for chronic non-cancer spine pain: a systematic review and network meta-analysis of randomized trials. BMJ. 2025;388:e079971. DOI: 10.1136/bmj-2024-079971
Busse JW, Genevay S, Agarwal A, et al. Commonly used interventional procedures for non-cancer chronic spine pain: a clinical practice guideline. BMJ. 2025;388:e079970. DOI: 10.1136/bmj-2024-079970
Qaseem A, Wilt TJ, McLean RM, Forciea MA. Noninvasive Treatments for Acute, Subacute, and Chronic Low Back Pain. Ann Intern Med. 2017;166(7):514-530. DOI: 10.7326/M16-2367
Ballantyne JC. Spinal interventions for chronic back pain: Do negative findings demand action? BMJ. 2025;388:r179. DOI: 10.1136/bmj.r179
Pennsylvania Chiropractic Association www.pennchiro.org [email protected]
Created and produced by Mike Barba for the Pennsylvania Chiropractic Association. AI-assisted tools were used in the production of this content. Final content was reviewed and approved by PCA.
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