Liver-Pancreas Crosstalk: The Silent Breakdown Driving Insulin Resistance

What if the first signs of insulin resistance have nothing to do with glucose?In this episode of ReInvent Healthcare, Dr. Ritamarie uncovers the hidden metabolic dialogue between the liver and pancreas. It’s a connection that begins to break down long before glucose or A1C raise red flags. Beneath the surface of “normal labs” lies a growing storm: insulin buildup, glucagon misfires, and early beta-cell stress that quietly unravel metabolic balance.If you're only testing blood sugar, you're missing the real story.Discover the overlooked markers that reveal the dysfunction most practitioners miss. This episode will change the way you view insulin resistance and give you the tools to catch it before the spiral begins.What’s Inside This Episode?What most practitioners miss by focusing only on glucose, A1C, or symptomsHow to spot early-stage metabolic collapse while there’s still time to reverse itWhy blood sugar may be the last thing to change and what starts breaking down long beforeThe overlooked conversation between two metabolic powerhouses and what happens when it goes quietHow hidden hormone signals spark a chain reaction of dysfunction no one’s talking aboutThe surprising reason some clients wake up with high glucose even on a “perfect” dietClues your clients are missing the mark, not because of willpower, but because of broken feedback loopsResources and Links:Download our FREE Glucagon, Insulin, and Blood Sugar chart.  Download our FREE Proinsulin, Insulin, and C-Peptide ChartJoin the Next-Level Health Practitioner Facebook group here for free resources and community supportReserve your spot for The REINVENT HEALTHCARE Intensive Learn Proven,​​ Leading-Edge Frameworks to Enhance Clinical Skills, Improve Visit INEMethod.com for advanced health practitioner training and tools to elevate your clinical skills and grow your practice by getting life-changing results. Check out other podcast episodes hereWhat’s Inside This Episode?A conversation your client’s blood sugar is already having—between liver, pancreas, insulin, and glucoseWhy fatty liver disrupts insulin clearance and leads to silent hyperinsulinemiaThe glucagon paradox: how this “forgotten hormone” can drive glucose production even in the fed stateBeta-cell stress decoded: how proinsulin and C-peptide ratios uncover hidden dysfunctionThe truth about "normal" A1C—and why it may just mean the pancreas is compensatingWhat poor insulin clearance looks like—and how to spot liver stress using routine labsHow and when to use labs like proinsulin, fasting glucagon, and FIB-4Natural strategies to restore liver-pancreas harmony with fasting, circadian alignment, and targeted nutrients

Hot flashes, mood swings, and brain fog. Too often, these symptoms are brushed off as inevitable signs of aging. What if these are your client’s early warning system of deeper hormonal chaos already underway?In this episode of ReInvent Healthcare, Dr. Ritamarie sits down with hormone specialist and bestselling author Dr. Mariza Snyder to discuss the critical phase of perimenopause. Long before menopause sets in, subtle shifts in hormone function can disrupt mood, metabolism, sleep, and more.If you’re only testing estrogen and progesterone, you’re missing the bigger picture. This conversation challenges outdated assumptions and exposes the hidden patterns that masquerade as anxiety, depression, and burnout, so you can catch the real root cause before it’s too late.What You’ll Discover Inside:The Silent Phase That Sets the StageWhy the most critical hormonal changes start years before menopause and go unnoticed by most providers.The Missing Piece in Hormone TestingA key hormone marker that can reveal perimenopausal shifts early but is rarely measured.When Stress Becomes the Master HormoneHow modern life drives the adrenal-hormone feedback loop and what to watch for in burned-out clients.The Blood Sugar–Estrogen LinkWhy metabolic balance is non-negotiable for hormonal balance and how to spot trouble before it spirals.What Most Practitioners Miss About HRT TimingThe real risks of waiting too long and why “not yet” can be just as dangerous as “not at all.”Resources and Links:Download the transcript hereDownload our FREE guides:Metabolic Health Guide here.&nbsp;&nbsp;Protein ChartsJoin the Next-Level Health Practitioner Facebook group here for free resources and community supportVisit INEMethod.com for advanced health practitioner training and tools to elevate your clinical skills and grow your practice by getting life-changing results.&nbsp;Check out other podcast episodes hereDr. Mariza Snyder’s Resources and Links:Visit Dr Mariza’s website: www.drmariza.comCheck out her books hereGrab her Free Hormone Quiz + Gifts: https://www.drmariza.com/hormone-quizListen to her podcast: Essentially You with Dr. Mariza SnyderFind her on social media platforms:&nbsp;Follow her on Instagram: @drmarizaFacebook: @drmarizasnyder&nbsp;Insta: @drmariza&nbsp;YouTubeTwitter: @drmariza<a...

What if the first signs of metabolic breakdown aren’t in the pancreas or the blood sugar but hidden deep in the liver?In this episode of ReInvent Healthcare, Dr. Ritamarie takes you inside the metabolic feedback loop few practitioners are trained to detect. Long before glucose rises or A1C shifts, subtle signals in the liver may already be pointing to a much bigger problem. They’re easy to miss, unless you know where to look. Discover the early biochemical whispers of insulin resistance, the hidden drivers of liver fat accumulation, and the lab markers most clinicians overlook. If your clients “look normal” on paper but still struggle, this is the episode you can’t afford to skip.What’s Inside This Episode?The silent organ shift that can signal metabolic trouble before blood sugar ever changesA hidden fat-making process your body might be running without your consentHow a sweet addiction quietly derails liver function and energy productionThe overlooked lab markers that whisper metabolic distress long before diagnosisA little-known score that could change how you assess “normal” labsSimple but strategic actions that tip the scales from fatty liver to functional healthHow small shifts in timing and nutrients may unlock powerful liver regenerationWhy stable glucose isn’t the full story, and the signal you might be missingResources and Links:Download our FREE Metabolic Health Guide here.&nbsp;&nbsp;Here is a FIB-4 Calculator Tool&nbsp;FIB-4 = (Age × AST) / (Platelets × √ALT)NAFLD fibrosis score (NFS) = -1.675 + (0.037 × age) + (0.094 × BMI) + (1.13 × hyperglycemia) + (0.99 × AST/ALT ratio) - (0.013 × platelet count) - (0.66 × albumin)Join the Next-Level Health Practitioner Facebook group here for free resources and community supportVisit INEMethod.com for advanced health practitioner training and tools to elevate your clinical skills and grow your practice by getting life-changing results.&nbsp;Check out other podcast episodes here

What if your client’s labs show everything is “normal,” but their symptoms are screaming otherwise? In this episode of ReInvent Healthcare, Dr. Ritamarie sits down with holistic nutritionist and restorative wellness practitioner Divya Gupta to uncover the hidden truths behind thyroid dysfunction.Drawing from her own journey with Hashimoto’s and gallbladder surgery—while juggling a high-stress corporate career—Divya reveals the overlooked patterns that block healing, the functional markers that actually matter, and how personalized nutrition can change the trajectory of thyroid health.This conversation is a wake-up call for any practitioner who wants to go beyond the TSH trap and uncover what the body is really trying to say.What’s Inside This Episode?The “Normal” Lab LieA common lab result that’s often misread—and why it could be delaying your client’s healing.Thyroid Clues in DisguiseWhat symptoms and organ systems often point to thyroid dysfunction before the labs ever do.The Gallbladder-Thyroid ConnectionWhy losing this one organ may set off a hormonal cascade—and what most providers miss in post-op recovery.How Corporate Stress Masks as Chronic FatigueWhat happened when one high-achieving woman finally decoded her burnout—and why it’s more common than you think.Functional Testing That Speaks the TruthWhich labs and lifestyle markers Divya trusts most to uncover hidden patterns in thyroid and metabolic dysfunction.Resources and Links:Download our FREE guides:&nbsp;Get the Optimize Thyroid Function Guide here.&nbsp;&nbsp;Get the Cardiovascular Risk Assessment here.Join the Next-Level Health Practitioner Facebook group here for free resources and community supportVisit INEMethod.com for advanced health practitioner training and tools to elevate your clinical skills and grow your practice by getting life-changing results.&nbsp;Check out other podcast episodes hereDivya Gupta’s Resources and LinksFind Divya on her Website: divyagupta.netInstagram: _divguptaFacebook: Divya GuptaDownload her Free Guide: Hypothyroidism Symptoms &amp; Labs GuideGuest BioAbout Divya GuptaBoard Certified Holistic Nutritionist &amp; Restorative Wellness Practitioner, Divya helps ambitious professionals create healthier futures than their parents experienced through personalized functional nutrition. Having overcome her own health challenges—gallbladder removal and Hashimoto's—while balancing corporate demands, she understands the limitations of conventional healthcare.Her personal transformation fuels her passion for guiding clients to reclaim their well-being. When...

What if a key regulator of blood sugar, fat storage, and insulin sensitivity was hiding in plain sight, active only in the dark?In this episode of ReInvent Healthcare, Dr. Ritamarie explores one of the most overlooked hormonal players in metabolic function. It’s not a supplement, not a medication, and not a superfood, but it profoundly influences metabolic health. It plays a role in glucose uptake, mitochondrial health, and inflammatory balance. You’ll discover how this nighttime signal impacts leptin and insulin and why testing and personalization matter more than ever.If your clients are doing “all the right things” and still struggling with stubborn weight or glucose spikes, this might be the missing piece.What’s Inside This Episode?A deep dive into the circadian hormone that influences insulin sensitivity and mitochondrial functionHow nighttime habits, light exposure, and stress blunt metabolic recoveryThe unexpected impact of this hormone on appetite regulation and fat storageWhy common supplement protocols may backfire without genetic contextNutrient and lifestyle strategies that enhance endogenous production safelyTesting options to assess hormonal circadian alignment and insulin responseResources and LinksDownload the transcript hereDownload our FREE Metabolic Health Guide hereJoin the Next-Level Health Practitioner Facebook group here for resources and community supportVisit INEMethod.com for advanced practitioner training and clinical mentorshipExplore other podcast episodes hereReferencesReiter RJ, et al. Melatonin in mitochondria: roles in oxidative stress and aging. J Pineal Res. 2010.Cipolla-Neto J, et al. Melatonin and energy metabolism. Mol Cell Endocrinol. 2014.Lane JM, et al. MTNR1B gene variant and glucose metabolism. Diabetes. 2016.Tuomi T, et al. MTNR1B variants impair beta-cell function. Cell Metab. 2016.Anderson G, et al. Melatonin’s role in insulin sensitivity. Sleep Med Rev. 2015.Gómez-Abellán P, et al. Circadian rhythms and metabolic regulation. Int J Obes. 2020.Arendt J. Human circadian rhythms and melatonin. J Endocrinol. 2005.Khan A, et al. Cinnamon improves glucose and lipid metabolism. Diabetes Care. 2003.

What if a key regulator of blood sugar, fat storage, and insulin sensitivity was hiding in plain sight, active only in the dark?In this episode of ReInvent Healthcare, Dr. Ritamarie explores one of the most overlooked hormonal players in metabolic function. It’s not a supplement, not a medication, and not a superfood, but it profoundly influences metabolic health. It plays a role in glucose uptake, mitochondrial health, and inflammatory balance. You’ll discover how this nighttime signal impacts leptin and insulin and why testing and personalization matter more than ever.If your clients are doing “all the right things” and still struggling with stubborn weight or glucose spikes, this might be the missing piece.What’s Inside This Episode?A deep dive into the circadian hormone that influences insulin sensitivity and mitochondrial functionHow nighttime habits, light exposure, and stress blunt metabolic recoveryThe unexpected impact of this hormone on appetite regulation and fat storageWhy common supplement protocols may backfire without genetic contextNutrient and lifestyle strategies that enhance endogenous production safelyTesting options to assess hormonal circadian alignment and insulin responseResources and LinksDownload our FREE Metabolic Health Guide hereJoin the Next-Level Health Practitioner Facebook group here for resources and community supportVisit INEMethod.com for advanced practitioner training and clinical mentorshipExplore other podcast episodes hereReferencesReiter RJ, et al. Melatonin in mitochondria: roles in oxidative stress and aging. J Pineal Res. 2010.Cipolla-Neto J, et al. Melatonin and energy metabolism. Mol Cell Endocrinol. 2014.Lane JM, et al. MTNR1B gene variant and glucose metabolism. Diabetes. 2016.Tuomi T, et al. MTNR1B variants impair beta-cell function. Cell Metab. 2016.Anderson G, et al. Melatonin’s role in insulin sensitivity. Sleep Med Rev. 2015.Gómez-Abellán P, et al. Circadian rhythms and metabolic regulation. Int J Obes. 2020.Arendt J. Human circadian rhythms and melatonin. J Endocrinol. 2005.Khan A, et al. Cinnamon improves glucose and lipid metabolism. Diabetes Care. 2003.

What if your patient’s persistent symptoms aren’t fully explained by labs, imaging, or even your best root-cause protocols? In this episode of ReInvent Healthcare, Dr. Ritamarie sits down with rheumatologist-turned-integrative-healer Dr. Isabelle Amigues to explore the deeper messages the body is trying to send—through pain, illness, and resistance to healing.&nbsp;Drawing from her unique lens as both a Western-trained physician and a stage IV cancer thriver, Dr. Amigues unpacks the emotional and energetic patterns she believes often underlie autoimmune disease, chronic pain, and unexplainable fatigue. This conversation challenges conventional clinical thinking and invites practitioners to go beyond the physical and into the subtle—but powerful—world of body-based wisdom.What You’ll Discover Inside:What Traditional Labs Are MissingThe surprising clues hiding in plain sight when test results don’t explain your client’s symptoms.A Hidden Language of HealingWhy some patients respond to treatments others don’t—and how the answer may lie beyond the physical.The Unexpected Roots of Chronic IllnessA silent influence that can drive inflammation, fatigue, and autoimmunity—without ever showing up on a lab report.A Case Study That Changes EverythingWhat happened when one physician applied this overlooked approach to her own life-threatening diagnosis.How to Listen When the Body SpeaksThe skillset every practitioner needs to uncover what standard protocols never address.Resources and Links:Download the transcript hereDownload our FREE Guide: Immune Modulation Strategies GuideJoin the Next-Level Health Practitioner Facebook group here for free resources and community supportVisit INEMethod.com for advanced health practitioner training and tools to elevate your clinical skills and grow your practice by getting life-changing results.&nbsp;Check out other podcast episodes hereDr. Isabelle Amigues’ Resources &amp; Links:Visit Isabelle’s website at www.unabridgedMD.comGet her free meditation resourceFollow her on InstagramCheck out her TEDx talkBioIsabelle Amigues, MD, is a rheumatologist based in Denver, Colorado. She honed her expertise by studying in Paris, as well as at Columbia University in New York City. At age 40, she was diagnosed with stage IV metastatic breast cancer. A timely meeting with a non-traditionally trained practitioner taught her a different approach to disease, where she experienced the power of meditation,...

If your clients are gaining weight in their 40s or 50s despite clean eating and regular movement, it’s not simply “aging” or “hormones.”In this episode of ReInvent Healthcare, Dr. Ritamarie explores a metabolic adaptation that occurs during midlife and alters how the body responds to glucose, insulin, and stress. There’s a multi-system shift that rewires fat storage, energy production, and appetite regulation.What if one of the most overlooked drivers of insulin resistance in women is also one of the most correctable?What’s Inside This Episode?A surprising hormonal connection that rewires the body’s response to glucose and insulinWhy most blood sugar protocols fall short in midlife and what’s often missingThe under-discussed cascade that turns food into fat even when eating “healthy”How specific plant-based foods and herbs can influence metabolic rhythmWhy personalizing protocols is non-negotiable during this life stageKey markers to watch when tracking metabolic shifts in women 40+Resources and LinksDownload our FREE Metabolic Health Guide hereJoin the Next-Level Health Practitioner Facebook group here for resources and community supportVisit INEMethod.com for advanced health practitioner training and clinical mentorshipCheck out other podcast episodes hereReferencesBarros RP, Gustafsson JÅ. Estrogen and metabolic regulation. Cell Metab. 2011.Mauvais-Jarvis F. Estrogen and androgen receptors in metabolic disease. Nat Rev Endocrinol. 2015.Khan A, et al. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care. 2003.Zhang Q, et al. Berberine reduces insulin resistance and improves glucose metabolism. Metabolism. 2008.Li SS, et al. Flaxseed and hormonal modulation in women. Nutrients. 2021.

Are hot flashes just an inconvenience—or a warning sign of deeper dysfunction? In this episode of ReInvent Healthcare, Dr. Ritamarie Loscalzo sits down with triple board-certified hormone expert Dr. Lorraine Maita to challenge outdated myths around hormone replacement therapy (HRT) and menopause care.From debilitating mood swings and memory lapses to hidden bone loss and cardiovascular risks, Dr. Maita reveals why conventional medicine is failing midlife women—and what functional practitioners must do differently. If you’ve ever wondered if you should recommend HRT, how to test properly, or how to prepare the body for hormones, this conversation is a must-listen.What You’ll Discover Inside:The Hot Flash Red Flag:Why menopausal symptoms are more than a nuisance—and what they’re really signaling about your health.The Hormone Testing Trifecta:What Dr. Maita uses to map hormone metabolism—and why timing is everything.What To Do First:The critical step most practitioners skip before adding hormones—and how other conditions can make or break outcomes.Estrogen’s Bad Reputation—Debunked:The real story behind the Women’s Health Initiative study and bioidentical estrogen’s safety..Beyond the Bandaid:Why functional practitioners must stop swapping pills for supplements—and start building personalized, root-cause strategies.When HRT Goes Wrong:Why pellets can backfire, when progesterone alone is enough, and how even “natural” hormones can go toxic if pathways are blocked.Resources &amp; LinksGrab Our Free Guide to &nbsp;Unlock the Power of Optimal EnergyJoin the Next-Level Health Practitioner Facebook Group for free tools and trainingVisit INEMethod.com for advanced health practitioner training and tools to elevate your clinical skills and grow your practiceExplore More Episodes on hormone balancing on ReInvent Healthcare and Functional Endocrinology hereDr. Lorraine Maita’s Resources &amp; LinksVisit The Feel Good Again Institute for courses and coachingExplore her medical practice at Vibrance for LifeHRT4U Course and Ultimate Hormone Reset: Course Links HereFollow Dr. Maita on:FacebookInstagramLinkedInYouTubeDr. Lorraine Maita’s...

What if your clients’ metabolic struggles weren’t just related to insulin, cortisol, or diet but a deeper, overlooked hormone that bridges the gap?In this episode of ReInvent Healthcare, Dr. Ritamarie pulls back the curtain on one of the most underestimated players in metabolic function: oxytocin. You’ll discover why this “feel-good” hormone is far more than a bonding chemical and why ignoring it could mean missing a key piece in your client’s healing.If you aren't factoring in connection, community, and nervous system regulation, you might be overlooking one of the most powerful metabolic modulators nature has to offer.What’s Inside This Episode?The Connection Between Love and GlucoseWhat science reveals about the link between emotional connection and blood sugar balance.Why More Protein and Exercise Aren’t Always the AnswerHow ignoring this hormone could cause your best health plans to fall flat.The Secret Saboteur of Metabolic Recovery A hidden form of stress that blocks oxytocin and what to do about it.Natural Ways to Boost This Overlooked Hormone How to stimulate oxytocin through functional strategies.Resources and Links:Join the Next-Level Health Practitioner Facebook group here for free resources and community supportVisit INEMethod.com for advanced health practitioner training and tools to elevate your clinical skills and grow your practice by getting life-changing results.&nbsp;Check out other podcast episodes here