Enzyme linked with brain evolution

Implications of a mutation in modern humans Science Sessions are brief conversations with cutting-edge researchers, National Academy members, and policymakers as they discuss topics relevant to today's scientific community. Learn the behind-the-scenes story of work published in the Proceedings of the National Academy of Sciences (PNAS), plus a broad range of scientific news about discoveries that affect the world around us. In this episode, Xiangchun Ju and Svante Pääbo explore the evolutionary implications of a mutation that separates modern humans from ancestral hominins. In this episode, we cover: •[00:00]  •[01:22] Neurobiologist Xiangchun Ju introduces the enzyme adenylosuccinate lyase, or ADSL, and its role in the synthesis of purine. •[02:09] Evolutionary anthropologist Svante Pääbo talks about the discovery of the A429V mutation, which is present in modern humans but not Neanderthals or Denisovans. •[03:38] Ju and Pääbo talk about the methods to humanize mice in order to study the evolutionary importance of the A429V mutation. •[05:04] They explain the results of the behavioral studies of the humanized mice. •[06:27] Pääbo explores the takeaways from the study.  •[08:05] He contextualizes the study alongside other studies of modern human development. •[09:17] Pääbo and Ju list the caveats and limitations of the study. •[10:14] Conclusion. About Our Guests: Xiangchun Ju Postdoctoral scholar Okinawa Institute of Science and Technology Svante Pääbo Director Max Planck Institute for Evolutionary Anthropology View related content here: https://www.pnas.org/doi/10.1073/pnas.2508540122 Follow us on Spotify, Apple Podcasts, or wherever you get your podcasts for more captivating discussions on scientific breakthroughs! Visit Science Sessions on PNAS.org: https://www.pnas.org/about/science-sessions-podcast  Follow PNAS: Twitter/X Facebook LinkedIn YouTube Sign up for the PNAS Highlights newsletter

Where primates evolved Science Sessions are brief conversations with cutting-edge researchers, National Academy members, and policymakers as they discuss topics relevant to today's scientific community. Learn the behind-the-scenes story of work published in the Proceedings of the National Academy of Sciences (PNAS), plus a broad range of scientific news about discoveries that affect the world around us. In this episode, Jorge Avaria-Llautureo and Chris Venditti explain why the evolution of primates likely occurred in cold, dry climates rather than in tropical forests. In this episode, we cover: •[00:00] Introduction •[00:58] Evolutionary biologist Jorge Avaria-Lautureo explains the prevailing hypothesis that primates evolved in a tropical climate •[02:54] Evolutionary biologist Chris Venditti introduces evidence suggesting a different origin climate. •[03:54] Avaria discusses how the researchers reconstructed the climate of early primate species. •[05:05] Venditti and Avaria explain why it was important to use standardized climate definitions in this study. •[07:29] Avaria describes the results of the study. •[08:18]Venditti talks about the importance of understanding early primates’ climates. •[09:21] Avaria and Venditti talk about the study’s caveats and limitations. •[10:22] Conclusion. About Our Guests: Jorge Avaria-Llautureo Postdoctoral scholar University of Reading Chris Venditti Professor University of Reading View related content here: https://www.pnas.org/doi/10.1073/pnas.2423833122 Follow us on Spotify, Apple Podcasts, or wherever you get your podcasts for more captivating discussions on scientific breakthroughs! Visit Science Sessions on PNAS.org: https://www.pnas.org/about/science-sessions-podcast Follow PNAS: Twitter/X Facebook LinkedIn YouTube Sign up for the PNAS Highlights newsletter

Climate change and lake oxygenation Science Sessions are brief conversations with cutting-edge researchers, National Academy members, and policymakers as they discuss topics relevant to today's scientific community. Learn the behind-the-scenes story of work published in the Proceedings of the National Academy of Sciences (PNAS), plus a broad range of scientific news about discoveries that affect the world around us. In this episode, Joachim Jansen explains how climate change altered cycles of oxygenation in lakes. In this episode, we cover: •[00:00] Introduction. •[00:56] Limnologist Joachim Jansen introduces us to the cycles of oxygenation in lakes throughout the seasons. •[02:35] He describes previous hypothesis about climate change and lake oxygenation and introduces the methods and datasets of the study.  •[04:59] Jansen introduces the results of the study, including key differences between large and small lakes. •[06:54] He talks about the consequences of deoxygenation.  •[09:03] Jansen explains the caveats and limitations of the study. •[09:37] Conclusion. About Our Guest: Joachim Jansen Postdoctoral Researcher  University of Helsinki View related content here: https://www.pnas.org/doi/10.1073/pnas.2426140122 Follow us on Spotify, Apple Podcasts, or wherever you get your podcasts for more captivating discussions on scientific breakthroughs! Visit Science Sessions on PNAS.org: https://www.pnas.org/about/science-sessions-podcast  Follow PNAS: Twitter/X Facebook LinkedIn YouTube Sign up for the PNAS Highlights newsletter

The physics of the squash nick shot Science Sessions are brief conversations with cutting-edge researchers, National Academy members, and policymakers as they discuss topics relevant to today's scientific community. Learn the behind-the-scenes story of work published in the Proceedings of the National Academy of Sciences (PNAS), plus a broad range of scientific news about discoveries that affect the world around us. In this episode, Roberto Zenit explains the physics behind the unanswerable nick shot in the game of squash. In this episode, we cover: •[00:00] Introduction. •[00:56] Engineer Roberto Zenit introduces the game of squash, including his participation in the sport, and introduces the nick shot. •[02:11] He talks about the background and methods of the study.  •[04:50] Zenit describes the mechanics of a nick shot. •[06:01] He talks about the implications of the study for squash players and for other applications. •[08:52] Zenit recounts the caveats and limitations of the study. •[09:41] Conclusion. About Our Guests: Roberto Zenit Professor Brown University View related content here: https://www.pnas.org/doi/10.1073/pnas.2505715122  Follow us on Spotify, Apple Podcasts, or wherever you get your podcasts for more captivating discussions on scientific breakthroughs! Visit Science Sessions on PNAS.org: https://www.pnas.org/about/science-sessions-podcast  Follow PNAS: Twitter/X Facebook LinkedIn YouTube Sign up for the PNAS Highlights newsletter

A pterosaur and its ecosystem at the end of the Triassic Science Sessions are brief conversations with cutting-edge researchers, National Academy members, and policymakers as they discuss topics relevant to today's scientific community. Learn the behind-the-scenes story of work published in the Proceedings of the National Academy of Sciences (PNAS), plus a broad range of scientific news about discoveries that affect the world around us. In this episode, Kay Behrensmeyer and Ben Kligman describe what a fossil bone bed in Arizona reveals about a 209-million-year-old pterosaur and its ecosystem. In this episode, we cover: •[00:00] Introduction •[01:01] Paleoecologist Kay Behrensmeyer and paleontologist Ben Kligman describe the discovery of this fossil bone bed. •[03:10] Kligman and Behrensmeyer introduce a previously undescribed pterosaur. •[05:00] They talk about what this specimen says about the ecology and evolution of pterosaurs. •[06:15] Kligman and Behrensmeyer talk about the importance of studying this fossil community. •[07:52] They explain how their methods can improve paleontology and discovery of small fossils. •[09:08] Behrensmeyer and Kligman talk about the study’s caveats and limitations. •[10:10] Conclusion. About Our Guests: Kay Behrensmeyer Curator of Paleobiology National Museum of Natural History, Smithsonian Institution Ben Kligman Postdoctoral Fellow National Museum of Natural History, Smithsonian Institution View related content here: https://www.pnas.org/doi/10.1073/pnas.2505513122 Follow us on Spotify, Apple Podcasts, or wherever you get your podcasts for more captivating discussions on scientific breakthroughs! Visit Science Sessions on PNAS.org: https://www.pnas.org/about/science-sessions-podcast  Follow PNAS: Twitter/X Facebook LinkedIn YouTube Sign up for the PNAS Highlights newsletter

The postglacial history of the Saimaa ringed seal Science Sessions are brief conversations with cutting-edge researchers, National Academy members, and policymakers as they discuss topics relevant to today's scientific community. Learn the behind-the-scenes story of work published in the Proceedings of the National Academy of Sciences (PNAS), plus a broad range of scientific news about discoveries that affect the world around us. In this episode, Jaakko Pohjoismäki, Jukka Jernvall, and Ari Löytynoja discuss the evolutionary history of the Saimaa ringed seal. In this episode, we cover: •[00:00] Introduction •[01:06] Molecular biologist Jaakko Pohjoismäki introduces Lake Saimaa and the Saimaa ringed seal. •[02:30] Zoologist Jukka Jernvall talks about the characteristics of species isolated by glaciation. •[03:27] Evolutionary biologist and bioinformatician Ari Löytynoja explains the genetic and demographic methods of the study. •[04:11] Löytynoja and Jernvall explain why the results were surprising and where the study turned next. •[06:20] Pohjoismäki and Löytynoja describe the study’s implications for biodiversity in postglacial habitats. •[07:50] Jernvall and Löytynoja talk about the study’s caveats and limitations. •[10:14] Conclusion. About Our Guests: Jaakko Pohjoismäki Professor University of Eastern Finland Jukka Jernvall Professor University of Helsinki Ari Löytynoja University Lecturer University of Helsinki View related content here: https://www.pnas.org/doi/abs/10.1073/pnas.2503368122 Follow us on Spotify, Apple Podcasts, or wherever you get your podcasts for more captivating discussions on scientific breakthroughs! Visit Science Sessions on PNAS.org: https://www.pnas.org/about/science-sessions-podcast  Follow PNAS: Twitter/X Facebook LinkedIn YouTube Sign up for the PNAS Highlights newsletter

Managing eastern black rhinoceros populations with genetic studies Science Sessions are brief conversations with cutting-edge researchers, National Academy members, and policymakers as they discuss topics relevant to today's scientific community. Learn the behind-the-scenes story of work published in the Proceedings of the National Academy of Sciences (PNAS), plus a broad range of scientific news about discoveries that affect the world around us. In this episode, Barbara Mable and Ronald Mellya show how allowing endangered rhinos to move between populations enhances genetic diversity. In this episode, we cover: •[00:00] Introduction •[01:00] Evolutionary geneticist Barbara Mable explains why is genetic diversity important in managing small, isolated populations of rhinos. •[02:59] Park warden Ronald Mellya describes how his firsthand experience with rhino management led to this study. •[04:52] Mable explains the methods of the study and the contributions of co-author Anubhab Khan. •[06:20] Mable talks about the results. •[07:24] Mellya tells how the study has changed rhino management in Tanzania. •[08:37] Mable and Mellya enumerate the caveats and limitations of the study. •[10:20] Conclusion. About Our Guests: Barbara Mable Professor University of Glasgow Ronald Mellya Park Warden Tanzania National Parks View related content here: https://www.pnas.org/doi/abs/10.1073/pnas.2414412122 Follow us on Spotify, Apple Podcasts, or wherever you get your podcasts for more captivating discussions on scientific breakthroughs! Visit Science Sessions on PNAS.org: https://www.pnas.org/about/science-sessions-podcast  Follow PNAS: Twitter/X Facebook LinkedIn YouTube Sign up for the PNAS Highlights newsletter

A reference genome aids efforts to rescue the northern white rhinoceros Science Sessions are brief conversations with cutting-edge researchers, National Academy members, and policymakers as they discuss topics relevant to today's scientific community. Learn the behind-the-scenes story of work published in the Proceedings of the National Academy of Sciences (PNAS), plus a broad range of scientific news about discoveries that affect the world around us. In this episode, Franz-Josef Müller explains genomic tools to aid the functionally extinct northern white rhinoceros. In this episode, we cover: •[00:00] Introduction •[01:11] Multidisciplinary scientist Franz-Josef Müller introduces the northern white rhinoceros. •[01:55] He introduces induced pluripotent stem cells and why they’re important in efforts to save the northern white rhinoceros. •[04:20] He talks about the genomic risks of using induced pluripotent stem cells •[05:21] Müller tells the story of how he and his colleagues came together to complete the study. •[06:36] He explains how the northern white rhino’s genome was sequenced. •[07:58] He talks about the results and implications for stem cell genomic integrity. •[08:51] Müller enumerates the caveats and limitations of the study. •[10:24] Conclusion. About Our Guest: Franz-Josef Müller Professor University Hospital Schleswig-Holstein View related content here: https://www.pnas.org/doi/full/10.1073/pnas.2401207122 Follow us on Spotify, Apple Podcasts, or wherever you get your podcasts for more captivating discussions on scientific breakthroughs! Visit Science Sessions on PNAS.org: https://www.pnas.org/about/science-sessions-podcast  Follow PNAS: Twitter/X Facebook LinkedIn YouTube Sign up for the PNAS Highlights newsletter

Water and the possibility of life on Mars Science Sessions are brief conversations with cutting-edge researchers, National Academy members, and policymakers as they discuss topics relevant to today's scientific community. Learn the behind-the-scenes story of work published in the Proceedings of the National Academy of Sciences (PNAS), plus a broad range of scientific news about discoveries that affect the world around us. In this episode, researchers explain what we know about the potential for water and life on Mars and what we might learn from analysis of returned samples. In this episode, we cover: •[00:00] Introduction •[01:04] Mark Thiemens explains the importance of bringing samples from Mars back to Earth. •[02:37] Arya Udry explains the current gaps and limitations in the geological record provided by Martian meteorites. •[03:55] Bruce Jakosky explains what we currently know about the presence and history of water on Mars. •[05:26] Monica Grady explains how analyzing volatile species in Martian samples could provide insight into the planet’s past climate. •[06:58] Rachel Slank describes the potential presence of liquid brines on Mars. •[08:27] Vashan Wright used recordings from a seismometer onboard NASA’s InSight lander to estimate the volumes of liquid water that might be contained in the Martian mid-crust. •[10:14] Mark Sephton explains what biomarkers are and what kinds we might expect to find in Martian samples. •[11:34] Caroline Freissinet describes the discovery of long-chain organic molecules on Mars and the difficulties of conclusively identifying organic molecules as biomarkers. •[13:32] Thiemens explains the potentially far-reaching value of continuing to support the Mars Sample Return mission. •[14:37] Final thoughts and conclusion. About Our Guest: Mark Thiemens  Distinguished Professor of Chemistry and Biochemistry University of California at San Diego Arya Udry Associate Professor – Graduate coordinator University of Nevada, Las Vegas Bruce Jakosky Professor Emeritus University of Colorado Boulder Monica Grady Professor Emirita  Open University Rachel Slank Postdoctoral Fellow Lunar and Planetary Institute Vashan Wright Assistant Professor University of California, San Diego Mark Sephton Professor Imperial College London Caroline Freissinet Researcher Laboratory for Atmospheres, Observations, and Space French National Centre for Scientific Research View related content here: https://www.pnas.org/doi/10.1073/pnas.2421996121 https://www.pnas.org/doi/10.1073/pnas.2415280121 https://www.pnas.org/doi/full/10.1073/pnas.2404254121 https://www.pnas.org/doi/full/10.1073/pnas.2321080121 https://www.pnas.org/doi/full/10.1073/pnas.2404260121 https://www.pnas.org/doi/full/10.1073/pnas.2321067121 https://www.pnas.org/doi/full/10.1073/pnas.2409983121 https://www.pnas.org/doi/full/10.1073/pnas.2404256121 https://www.pnas.org/doi/full/10.1073/pnas.2420580122 Follow us on Spotify, Apple Podcasts, or wherever you get your podcasts for more captivating discussions on scientific breakthroughs! Visit Science Sessions on PNAS.org: https://www.pnas.org/about/science-sessions-podcast  Follow PNAS: Twitter/X Facebook LinkedIn YouTube Sign up for the PNAS Highlights newsletter

Using reinforcement learning to plan for an uncertain climate future Science Sessions are brief conversations with cutting-edge researchers, National Academy members, and policymakers as they discuss topics relevant to today's scientific community. Learn the behind-the-scenes story of work published in the Proceedings of the National Academy of Sciences (PNAS), plus a broad range of scientific news about discoveries that affect the world around us. In this episode, Ning Lin talks about how reinforcement learning methods plant to mitigate climate risk despite uncertainty in climate change risk forecasts. In this episode, we cover: •[00:00] Introduction •[1:04] Civil engineer Ning Lin introduces why climate forecast uncertainty complicates risk management planning. •[02:41] Lin explains how reinforcement learning works. •[03:26] She talks about why the team studied risk management for Manhattan. •[04:54] Lin explains the results of the reinforcement learning study. •[05:40] She recounts the results that surprised her. •[07:25] Lin explains the takeaways from the study for emergency planners. •[09:00] She enumerates the caveats and limitations of the study. •[10:11] Conclusion. About Our Guest: Ning Lin Professor Princeton University View related content here: https://www.pnas.org/cgi/doi/10.1073/pnas.2402826122 Follow us on Spotify, Apple Podcasts, or wherever you get your podcasts for more captivating discussions on scientific breakthroughs! Visit Science Sessions on PNAS.org: https://www.pnas.org/about/science-sessions-podcast  Follow PNAS: Twitter/X Facebook LinkedIn YouTube Sign up for the PNAS Highlights newsletter