
In the vast darkness of space, Earth 4.2 billion years ago was an alien world of molten rock, toxic gases, and storms. Yet, somewhere in these hellish landscapes—perhaps deep beneath an ocean vent or in warm terrestrial hot springs—the first whispers of life stirred.
In this episode, we explore the Last Universal Common Ancestor (LUCA), the deep genetic connection and common root in the Tree of Life shared by every plant, animal, bacterium, and archaean.
We examine Carl Woese’s revolutionary 1970s discovery using ribosomal RNA that restructured life into three domains (Bacteria, Archaea, and Eukarya), alongside how horizontal gene transfer meant early life operated more like a tangled web than a simple tree.
Finally, we trace recent 2024 findings by Edmund Moody and collaborators, which suggest that LUCA emerged around 4.2 billion years ago with a surprisingly complex genome of over 2,000 genes and a rudimentary antiviral defense system.
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