How Engineered Yeast Could Reduce Biomanufacturing Costs
In biomanufacturing, recovering intracellular bioproducts after fermentation can be a costly and energy-intensive process. To address this challenge, researchers are developing new approaches to reduce energy consumption and waste during downstream processing, one of the largest hidden costs in biomanufacturing.
This episode of Off Script looks at a BioMADE-funded project — a collaboration between bioalternatives company Manus and the University of Texas at Austin (UT Austin) – that successfully demonstrated programmed lysis of cell walls during yeast fermentation to improve the recovery of intracellular products. In this episode we spoke with Joe Shaw, senior vice president of research and development at Manus, and Penny Norquist, program director of technology at BioMADE, about how this approach reduced reliance on hazardous solvents and demonstrated a reduction in mechanical energy required for recovering bioproducts. They also discussed how the new approach achieved improved product yields and safety, in addition to the benefits of enabling lower production costs and improving sustainability, as well as other applications that could benefit from this approach.
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